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1. 发明申请

WO2005065585A1 APPARATUS AND METHODS FOR HEART VALVE REPLACEMENT 审中-公开
标题翻译：用于心瓣置换的装置和方法
公开(公告)号：WO2005065585A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/041513
申请日：2004-12-10
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , BRANDT, Brian , MOREJOHN, Dwight, P. , MICHLITSCH, Kenneth, J. , SAUL, Tom
发明人： SALAHIEH, Amr , BRANDT, Brian , MOREJOHN, Dwight, P. , MICHLITSCH, Kenneth, J. , SAUL, Tom
IPC分类号： A61F2/06
CPC分类号： A61F2/013 , A61F2/2418 , A61F2/2439 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008
摘要： Apparatus (10) for protecting a patient against embolization during endovascular replacementduring endvascular replacement of the patient's heart valve is provided, the apparatus including a replacement valve (20) configured for endovascular delivery and deployment, and an embolic filter configured for disposal downstream of the replacement valve (20) during deployment of the valve. Apparatus including a delivery catheter having an expandable replacement valve (20) disposed therein, and an embolic filter advanceable along the delivery catheter for diverting emboli released during endovascular deployment of the replacement valve (20) is also provided. Furthermore, methods for protecting a patient against embolization during endovascular replacement of the patient's heart valve are provided, the methods including the steps of endovascularly deploying an embolic filter downstream of the heart valve, and endovascularly deploying the replacement valve.
摘要翻译：提供了一种用于在血管内置换期间保护患者免受栓塞的装置（10），其中，所述装置包括构造成用于血管内递送和展开的置换瓣膜（20），以及构造成用于在所述置换阀门（20）在展开阀门期间。还提供了包括具有设置在其中的可扩张置换瓣膜（20）的递送导管的装置，以及沿输送导管可推进的栓塞过滤器，用于在置换瓣膜（20）的血管内展开期间释放栓塞。此外，提供了用于在患者心脏瓣膜的血管内置换期间保护患者免受栓塞的方法，所述方法包括在心脏瓣膜下游血管内部署栓塞过滤器并且血管内部署替换瓣膜的步骤。

2. 发明申请

WO2005062980A2 REPOSITIONABLE HEART VALVE 审中-公开
标题翻译：可重复使用的心脏瓣膜
公开(公告)号：WO2005062980A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043607
申请日：2004-12-22
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , BRANDT, Brian, D. , MOREJOHN, Dwight, P. , HAUG, Ulrich, R. , DUERI, Jean-Pierre , VALENCIA, Hans, F. , GESHLIDER, Robert, A. , KROLIK, Jeff , SAUL, Tom , ARGENTO, Claudio , HILDEBRANT, Daniel
发明人： SALAHIEH, Amr , BRANDT, Brian, D. , MOREJOHN, Dwight, P. , HAUG, Ulrich, R. , DUERI, Jean-Pierre , VALENCIA, Hans, F. , GESHLIDER, Robert, A. , KROLIK, Jeff , SAUL, Tom , ARGENTO, Claudio , HILDEBRANT, Daniel
IPC分类号： A61F2/01 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0067 , A61F2230/0078 , A61F2250/006
摘要： One aspect of the invention provides a method for endovascularly replacing a heart valve of a patient. In some embodiments the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; expanding the anchor to a deployed configuration in which the anchor contacts tissue at an anchor site; optionally repositioning the anchor in the anchor site; and deploying the anchor at the anchor site. In some embodiments the deploying step include the steps of actively foreshortening the anchor via an actuation force delivered by a deployment tool and thereafter releasing the anchor from the deployment tool. The delivering step may include the step of delivering the replacement heart valve coupled to the anchor or, alternatively, separate from the anchor, in which case the method further includes the step of attaching the replacement valve to the anchor. The anchor may be made from an expandable braid. In some embodiments, the apparatus herein further comprises a lock or a plurality of locks configured to maintain expansion of the braid. The anchor and valve may also be retrieved into a delivery catheter.
摘要翻译：本发明的一个方面提供一种用于血管内替换患者的心脏瓣膜的方法。在一些实施例中，该方法包括以非发展构造将血管内递送替代瓣膜和可膨胀锚固件传递到心脏瓣膜附近的步骤; 将锚扩展到展开构型，其中锚固件在锚固部位处接触组织; 任选地在锚定位置重新定位锚点; 并在锚点部署锚。在一些实施例中，展开步骤包括以下步骤：通过由展开工具传递的致动力主动地缩短锚，然后从展开工具释放锚。递送步骤可以包括递送与锚固件相连接的置换心脏瓣膜的步骤，或者替代地与锚固件分开，在这种情况下，该方法还包括将更换瓣膜附接到锚固件的步骤。锚可以由可膨胀的编织物制成。在一些实施例中，本文的装置还包括配置成保持编织物的膨胀的锁或多个锁。锚栓和阀也可以被取回到输送导管中。

3. 发明申请

WO2007097983A2 SYSTEMS AND METHODS FOR DELIVERING A MEDICAL IMPLANT 审中-公开
标题翻译：用于输送医疗植入物的系统和方法
公开(公告)号：WO2007097983A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/003992
申请日：2007-02-14
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , DUERI, Jean-pierre , VALENCIA, Hans, F. , HILDEBRAND, Daniel , BRANDT, Brian, D. , MOREJOHN, Dwight, P. , ARGENTO, Claudio , SAUL, Tom , HAUG, Ulrich, R.
发明人： SALAHIEH, Amr , DUERI, Jean-pierre , VALENCIA, Hans, F. , HILDEBRAND, Daniel , BRANDT, Brian, D. , MOREJOHN, Dwight, P. , ARGENTO, Claudio , SAUL, Tom , HAUG, Ulrich, R.
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0644 , A61B17/068 , A61B17/221 , A61B2017/22035 , A61B2017/2215 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/90 , A61F2002/9534 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0078 , A61F2230/008 , A61F2250/001
摘要： The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.
摘要翻译：本发明涉及用于在患者的天然心脏瓣膜内和/或穿过患者的天然心脏瓣膜内血管内递送和释放假体（例如主动脉假体）的装置和方法，以下称为替换患者的心脏瓣膜。在一些实施例中，递送系统包括多个第一致动元件，其适于以第一构造接合多个第二元件以在输送系统内捕获植入物，并且其中多个第一可致动元件适于接合多个第二可动元件元件处于第二配置并且从输送系统释放植入物。

4. 发明申请

WO2007035471A3 MEDICAL DEVICE DELIVERY SHEATH 审中-公开
公开(公告)号：WO2007035471A3
公开(公告)日：2007-03-29
申请号：PCT/US2006/036001
申请日：2006-09-14
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , LEUNG, Emma , HILDEBRAND, Daniel , LEPAK, Jonah , HAUG, Ulrich, R. , MOREJOHN, Dwight, P. , SAUL, Tom
发明人： SALAHIEH, Amr , LEUNG, Emma , HILDEBRAND, Daniel , LEPAK, Jonah , HAUG, Ulrich, R. , MOREJOHN, Dwight, P. , SAUL, Tom
IPC分类号： A61M25/01
摘要： A support member for a catheter sheath is disclosed. The support member has a series of ribs with a distal member having integrated fingers for providing radial compliance. The support member provides sufficient axial stiffness to provide a desired pushability of a minimally invasive device for replacing a heart valve. Various alternative embodiments are also described.

5. 发明申请

WO2007044285A3 METHODS AND APPARATUS FOR PERFORMING VALVULOPLASTY 审中-公开
公开(公告)号：WO2007044285A3
公开(公告)日：2007-04-19
申请号：PCT/US2006/038352
申请日：2006-10-02
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , MOREJOHN, Dwight, P. , HILDEBRAND, Daniel , SAUL, Tom
发明人： SALAHIEH, Amr , MOREJOHN, Dwight, P. , HILDEBRAND, Daniel , SAUL, Tom
IPC分类号： A61F2/24
摘要： The present invention relates to apparatus (10) and methods for performing valvuloplasty. In some embodiments, the apparatus (10) includes an expandable braid valvuloplasty device (30). In some embodiments, the methods and apparatus (10) maybe used as an adjunct to percutaneous heart valve replacement. In some embodiments, the apparatus (10) and methods may provide a medical practitioner with feedback, monitoring or measurement information, e.g., information relevant to percutaneous transatheter heart valve replacement.

6. 发明申请

WO2006009690A1 EVERTING HEART VALVE 审中-公开
标题翻译：重要的心脏瓣膜
公开(公告)号：WO2006009690A1
公开(公告)日：2006-01-26
申请号：PCT/US2005/020947
申请日：2005-06-15
申请人： SADRA MEDICAL, INC. , HAUG, Ulrich, R. , VALENCIA, Hans, R. , GESHLIDER, Robert, A. , SAUL, Tom , SALAHIEH, Amr , MOREJOHN, Dwight, P. , MICHLITSCH, Kennth, J.
发明人： HAUG, Ulrich, R. , VALENCIA, Hans, R. , GESHLIDER, Robert, A. , SAUL, Tom , SALAHIEH, Amr , MOREJOHN, Dwight, P. , MICHLITSCH, Kennth, J.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.
摘要翻译：本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。所述装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。在一些实施例中，替换阀不连接到锚的可膨胀部分。在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。在一些实施例中，锚固件包括由单股线制成的编织物。在一些实施例中，该装置包括被配置成保持锚固扩展的锁。本发明还包括用于血管内替代患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。

7. 发明申请

WO2007092354A2 MEDICAL IMPLANT DELIVERY AND DEPLOYMENT TOOL 审中-公开
标题翻译：医疗植物输送和部署工具
公开(公告)号：WO2007092354A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/002970
申请日：2007-02-01
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , MOREJOHN, Dwight , HAUG, Uli , BRANDT, Brian , VALENCIA, Hans , SAUL, Tom
发明人： SALAHIEH, Amr , MOREJOHN, Dwight , HAUG, Uli , BRANDT, Brian , VALENCIA, Hans , SAUL, Tom
IPC分类号： A61F2/90
CPC分类号： A61F2/2439 , A61B17/068 , A61B2017/00243 , A61F2/2418 , A61F2/90 , A61F2002/9517
摘要： An apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes a replacement heart valve implant comprising a valve and an expandable anchor; and a deployment tool adapted to endovascularly deliver the replacement heart valve implant to an implant site within the patient, the deployment tool comprising an actuator adapted to exert an axially directed force on the anchor. The invention also provides a method for endovascularly replacing a heart valve of a patient. In some embodiments, the method includes the steps of endovascularly delivering a replacement heart valve implant having a valve and an anchor to an implant site within the patient; and applying an axially directed force from an actuator outside of the patient to the anchor. In invention also provides deployment tools for performing the method.
摘要翻译：一种用于血管内置换患者心脏瓣膜的装置。在一些实施例中，该装置包括置换心脏瓣膜植入物，其包括阀和可扩张锚; 以及适于将替代心脏瓣膜植入物血管内输送到患者体内的植入部位的部署工具，所述展开工具包括适于在锚固件上施加轴向力的致动器。本发明还提供一种用于血管内替换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：血管内递送具有瓣膜和锚固体的置换心脏瓣膜植入物到患者体内的植入部位; 以及将来自患者外部的致动器的轴向力施加到所述锚固件。本发明还提供了用于执行该方法的部署工具。

8. 发明申请

WO2007058847A2 MEDICAL IMPLANT DEPLOYMENT TOOL 审中-公开
标题翻译：医用植物部署工具
公开(公告)号：WO2007058847A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/043484
申请日：2006-11-08
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , HAUG, Ulrich, R. , ARGENTO, Claudio , MOREJOHN, Dwight , HILDEBRAND, Daniel , SAUL, Tom
发明人： SALAHIEH, Amr , HAUG, Ulrich, R. , ARGENTO, Claudio , MOREJOHN, Dwight , HILDEBRAND, Daniel , SAUL, Tom
IPC分类号： A61B17/94 , A61F2/84
CPC分类号： A61F2/2418 , A61F2/2439 , A61F2002/9517 , A61F2230/0054 , A61M25/0136 , A61M25/0144 , A61M25/0147
摘要： A medical implant deployment tool and deployment method are disclosed. One aspect of the invention provides an implant system including an implant adapted for endovascular delivery and deployment; and a deployment tool adapted to deploy the implant, with the deployment tool having an actuation controller; a pluralit of actuation elements adapted to apply forces to one or more implant deployment mechanisms and each adapted to extend along an actuation element path within a patient's vasculature; and an actuation element compensation mechanism adapted to compensate for differences in length between the actuation element paths. Another aspect the invention provides a method of deploying an implant including the steps of endovascularly delivering an impla and implant deployment mechanisms to an implant site and applying an actuation force to the implant deployment mechanisms through actuation elements extending through the patient's vasculature while compensating for differences in length between actuation element path lengths to deploy the implant.
摘要翻译：公开了一种医用植入物部署工具和部署方法。本发明的一个方面提供一种植入系统，其包括适于血管内递送和展开的植入物; 以及适于部署所述植入物的展开工具，所述展开工具具有致动控制器; 多个致动元件，其适于将力施加到一个或多个植入物展开机构，并且每个适于沿着病人脉管系统内的致动元件路径延伸; 以及致动元件补偿机构，其适于补偿致动元件路径之间的长度差异。本发明的另一方面提供了一种部署植入物的方法，包括以下步骤：血管内递送植入物和植入部署机构到植入部位，并且通过延伸穿过患者脉管系统的致动元件向植入物展开机构施加致动力，同时补偿致动元件路径长度以部署植入物之间的长度。

9. 发明申请

WO2007053243A3 ENDOVASCULAR HEART VALVE REPLACEMENT COMPRISING TISSUE GRASPING ELEMENTS 审中-公开
公开(公告)号：WO2007053243A3
公开(公告)日：2007-05-10
申请号：PCT/US2006/036286
申请日：2006-09-18
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , HILDEBRAND, Daniel , SAUL, Tom
发明人： SALAHIEH, Amr , HILDEBRAND, Daniel , SAUL, Tom
IPC分类号： A61F2/24
摘要： The present invention provides an apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes an expandable anchor supporting a replacement valve, the anchor and replacement valve being adapted for percutaneous delivery and deployment to replace the patient's heart valve, the anchor having a braid having atraumatic grasping elements adapted to grasp tissue in a vicinity of the patient's heart valve.

10. 发明申请

WO2007033093A2 TWO-PART PACKAGE FOR MEDICAL IMPLANT 审中-公开
标题翻译：医疗植物的两部分包装
公开(公告)号：WO2007033093A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/035345
申请日：2006-09-11
申请人： SADRA MEDICAL, INC. , SALAHIEH, Amr , SAUL, Tom , GESHLIDER, Robert , JOHNSON, Andrea , MOREJOHN, Dwight , HILDEBRAND, Daniel , DUERI, Jean-paul
发明人： SALAHIEH, Amr , SAUL, Tom , GESHLIDER, Robert , JOHNSON, Andrea , MOREJOHN, Dwight , HILDEBRAND, Daniel , DUERI, Jean-paul
IPC分类号： A61F2/24
CPC分类号： B65D25/04 , A61F2/0095 , A61F2/2427 , A61F2002/9517 , B65B5/04 , B65B55/16 , B65D41/04 , B65D81/22
摘要： The invention provides a two-part package and method of use for a pre-attached medical implant and delivery tool system. The package includes a wet compartment and a dry compartment and allows a pre-attached implant and delivery tool system to be at least partially stored immersed in a fluid in the wet compartment and at least partially stored in the dry compartment. In one embodiment the implant comprises a replacement heart valve, and the heart valve is stored inside the wet compartment while the heart valve delivery tool remains dry in the dry compartment.
摘要翻译：本发明提供了用于预附接的医疗植入物和递送工具系统的两部分包装和使用方法。该包装包括湿室和干燥室，并且允许将预先附着的植入物和递送工具系统至少部分地储存在浸入湿室中的流体中并且至少部分储存在干燥室中。在一个实施例中，植入物包括置换心脏瓣膜，并且心脏瓣膜储存在湿室内，而心脏瓣膜递送工具在干燥室中保持干燥。

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