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1. 发明申请

WO2018102471A1 METHOD AND APPARATUS FOR PROCESSING TISSUE SAMPLES 审中-公开
公开(公告)号：WO2018102471A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/063811
申请日：2017-11-29
申请人： S2 GENOMICS, INC. , JOVANOVICH, Stevan , CHEAR, Kaiwan , PEREIRA, Nathan , ZAUGG, Frank , MCINTOSH, Roger
发明人： JOVANOVICH, Stevan , CHEAR, Kaiwan , PEREIRA, Nathan , ZAUGG, Frank , MCINTOSH, Roger
IPC分类号： C12M3/00 , C12M3/06 , C12M3/08 , C12N1/08 , C12N15/09 , C12N15/10
摘要： A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells or nuclei in suspension or subcellular components including nucleic acids. In some embodiments, the titer of dissociated cells is monitored at intervals and the viability determined. In some embodiments, the processing is adjusted according to the measurements of the titer and viability. In some embodiments, the single-cells or nuclei in suspension are washed and resuspended in the buffer or media of choice. In some embodiments, the conditions are chosen to produce nuclei. In other embodiments, the single-cells or nuclei are purified by affinity paramagnetic bead processing. In some embodiments, matched bulk nucleic acid to the single-cells is produced. In other embodiments, single-cell libraries, or nuclei libraries, or matched bulk libraries, or bulk libraries are produced. The single cells or nuclei can then be further processed by FACS, DNA sequencing, mass spectrometry, fluorescence, or other methods. In other embodiments, the tissue processing is integrated with an analytical system to produce a sample-to-answer system such as a tissue-to-genomics system.

2. 发明申请

WO2009123592A1 DEVICE AND METHOD FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开
标题翻译：用于分析分析样品的装置和方法，分析分析内容
公开(公告)号：WO2009123592A1
公开(公告)日：2009-10-08
申请号：PCT/US2008/004372
申请日：2008-04-03
申请人： ZYOMYX, INC. , WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
发明人： WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
IPC分类号： C12Q1/00
CPC分类号： G01N33/558 , G01N33/54366
摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.
摘要翻译：一种用于确定样品中一种或多种分析物在含有流体的存在和/或浓度的系统和方法，所述系统包括含有样品入口或入口以及一个或多个分析物确定流路的基底，每个分析物确定流路包括限定的起始点和限定的末端，并且包含至少一个含有分析物的捕获剂的捕获区，所述捕获剂或试剂沿所述流动路径或路径的一部分被固定，所述流路或路径被设计成使得一个或多个分析物从样品中消耗并且结合到含有固定化捕获剂或试剂的流动路径或路径的部分，为分析物确定流路的开始和终点之间的每个分析物产生分析物耗尽端区。

3. 发明申请

WO2016073415A3 MICROSCALE PLASMA SEPARATOR 审中-公开
公开(公告)号：WO2016073415A3
公开(公告)日：2016-05-12
申请号：PCT/US2015/058731
申请日：2015-11-03
申请人： WAINAMICS, INC. , TAN, Ming , ZAUGG, Frank , KEMEN, Peter
发明人： TAN, Ming , ZAUGG, Frank , KEMEN, Peter
IPC分类号： A61M1/36 , B01D35/26 , B01D61/38 , B01D63/06 , C02F1/44
摘要： Methods and devices for efficient separation of plasma from whole blood which are suitable for point of care use in resource poor environments. Elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port: (b) a filter chamber having an inlet and an outlet, and containing at least one filler capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in fluid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber.

4. 发明申请

WO2009076235A4 CELL ASSAY KIT AND METHOD 审中-公开
公开(公告)号：WO2009076235A4
公开(公告)日：2009-06-18
申请号：PCT/US2008/085737
申请日：2008-12-05
申请人： ZYOMYX, INC. , ZAUGG, Frank , TOBIAS, Renee , KERNEN, Peter , RUIZ-TAYLOR, Laurence , WAGNER, Peter
发明人： ZAUGG, Frank , TOBIAS, Renee , KERNEN, Peter , RUIZ-TAYLOR, Laurence , WAGNER, Peter
IPC分类号： G01N33/543 , G01N33/49 , G01N33/569
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

5. 发明申请

WO2008156491A3 DEVICES AND METHODS FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开
公开(公告)号：WO2008156491A3
公开(公告)日：2008-12-24
申请号：PCT/US2007/080108
申请日：2007-10-01
申请人： ZYOMYX, INC. , WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
发明人： WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
IPC分类号： C12M1/34
摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a solid substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound in a non-linear manner to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.

6. 发明申请

WO2005024378A3 ION DETECTION USING A PILLAR CHIP 审中-公开
公开(公告)号：WO2005024378A3
公开(公告)日：2005-03-17
申请号：PCT/US2004/028622
申请日：2004-09-01
申请人： ZYOMIX, INC. , WAGNER, Peter , SCALF, Mark , ZAUGG, Frank
发明人： WAGNER, Peter , SCALF, Mark , ZAUGG, Frank
IPC分类号： G01N33/543
摘要： The present invention provides methods and assemblies for ion detection of samples using a chip with elevated sample zones. The elevated sample zones provide a number of ion detection advantages over chips with non-elevated sample zones. Embodiments of the invention have a number of applications in drug discovery, environmental analyses for tracking and the identification of contaminants, target discovery and/or validation as well as in diagnostics in a clinical setting for staging or disease progression. In addition, the invention may also be used with research and clinical microarray systems and devices.

7. 发明申请

WO2004081983A3 SUBSTRATE PROCESSING APPARATUS AND METHOD FOR THE CONTROLLED FORMATION OF LAYERS INCUDING SELF-ASSEMBLED MONOLYAERS 审中-公开
公开(公告)号：WO2004081983A3
公开(公告)日：2004-09-23
申请号：PCT/US2004/006851
申请日：2004-03-03
申请人： ZYOMYX INC. , HASSELBLATT, Markus , WAGNER, Peter , KERNEN, Peter , ZAUGG, Frank , DE LA SALLE, Olivier
发明人： HASSELBLATT, Markus , WAGNER, Peter , KERNEN, Peter , ZAUGG, Frank , DE LA SALLE, Olivier
IPC分类号： B32B27/04
摘要： Substrate processing methods and apparatuses are disclosed. One embodiment of the invention is directed to a substrate processing apparatus for processing an analytical substrate. The apparatus includes a substrate holder for holding a substrate and a processing chamber including an opening for receiving the substrate holder and the substrate. A fluid inlet and a fluid outlet are in the processing chamber. A washing device adapted to supply a wash liquid to the substrate while the substrate is in the processing chamber. A liquid removal device adapted to dry the substrate when the substrate is being withdrawn from the processing chamber.

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