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1. 发明申请

WO2010144602A2 ANTIGEN-NOROVIRUS P-DOMAIN MONOMERS AND DIMERS, ANTIGEN-NOROVIRUS P-PARTICLE MOLECULES, AND METHODS FOR THEIR MAKING AND USE 审中-公开
标题翻译：抗逆转录病毒单核细胞和二聚体，抗逆转录病毒颗粒分子及其制备和使用方法
公开(公告)号：WO2010144602A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/038008
申请日：2010-06-09
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , JIANG, Xi , TAN, Ming
发明人： JIANG, Xi , TAN, Ming
IPC分类号： C07K19/00 , C12N15/63 , A61K39/295 , A61P37/00
CPC分类号： C07K7/06 , A61K38/00 , A61K39/12 , A61K39/125 , A61K2039/5258 , A61K2039/542 , A61K2039/543 , A61K2039/55566 , A61K2039/58 , A61K2039/6075 , A61K2039/645 , A61K2039/70 , C07K5/10 , C12N2720/12334 , C12N2770/16034
摘要： A substituted Norovirus capsid protein monomer, having only the P-domain and called an antigen-Norovirus P-domain monomer, includes a foreign antigen inserted into one or more of three surface loops present on each P-domain monomer by molecular cloning. The antigen-P-domain monomer can assemble spontaneously into an octahedral form, called an antigen-Norovirus P-particle, that is composed of 24 copies of the antigen-P-domain monomer. Each substituted P-domain monomer will contain one to three copies of the foreign antigen, for a total of 24-72 antigen copies on each antigen-P-particle. The antigen-P-particle is useful in methods for diagnosing, immunizing and treating individuals infected with a foreign virus, for example Rotavirus, and can serve as a carrier for presentation of foreign antigens for development of novel vaccines against many infectious and non-infectious diseases. The substituted Norovirus P-particles can be readily produced in E. coli and yeast, are highly stable and tolerate a wide range of physio-chemical conditions. A modified Norovirus P-domain monomer includes one or more restriction recognition sites inserted within one or more of the three loops of the P-domain monomers, to provide user-friendly cloning cassettes for conveniently inserting candidate foreign antigens into the surface loops. The P-particle-VP8 chimeras may also serve as a dual vaccine against both rotavirus and norovirus.
摘要翻译：仅具有P-结构域并称为抗原 - 诺如病毒P-结构域单体的取代的诺如病毒衣壳蛋白单体包括通过分子克隆插入每个P-结构域单体上存在的三个表面环中的一个或多个的外源抗原。抗原-P结构域单体可以自发组装成称为抗原 - 诺如病毒P颗粒的八面体形式，其由24个抗原-P结构域单体组成。每个取代的P-结构域单体将含有一至三个拷贝的外源抗原，每个抗原-P-粒子上共有24-72个抗原拷贝。抗原-P颗粒可用于诊断，免疫和治疗感染外来病毒的个体的方法，例如轮状病毒（Rotavirus），并且可以用作外源抗原的载体，用于开发针对许多感染性和非感染性的新型疫苗疾病。取代的诺如病毒P颗粒可以容易地在大肠杆菌和酵母中产生，高度稳定并且耐受广泛的生理化学条件。修饰的诺如病毒P结构域单体包括插入在P结构域单体的三个环中的一个或多个环内的一个或多个限制性识别位点，以提供方便地将候选外源抗原插入到表面环中的用户友好的克隆盒。 P粒子VP8嵌合体也可以用作针对轮状病毒和诺如病毒的双重疫苗。

2. 发明申请

WO2005001627A3 RELATIONAL LOGIC MANAGEMENT SYSTEM 审中-公开
标题翻译：关系逻辑管理系统
公开(公告)号：WO2005001627A3
公开(公告)日：2009-03-26
申请号：PCT/US2004017947
申请日：2004-06-04
申请人： RULESPOWER INC , MINSKY STEVEN , FORGY CHARLES , TAN MING
发明人： MINSKY STEVEN , FORGY CHARLES , TAN MING
IPC分类号： G06F17/00 , G06F20060101 , G06N5/02 , G06Q10/06
CPC分类号： G06Q10/06 , G06Q10/0633 , G06Q10/06375 , G06Q10/067
摘要： In one aspect, the invention relates to a method to propagate relations between a first rule set and a second rule set wherein the first and second rule sets are invoked by a common workflow model (10). The method includes tracing paths forward through the workflow model from the first rule set to the second rule set ( 13a, 13b, 13c 13d). Enumerating relations that extend forward from the first rule set to the second rule set is anothe step in the method (19, 20). Additionally, using multi-valued logic, calculating the effects on the relations of control flow through the workflow model from the first rule set to the second rule set, tracing paths backwards through the workflow model from the second rule set to the first rule set, enumerating relations the extend backward from the second rule set to the first rule set, and using multi-valued logic, claculating the effects on the relations of control flow backwards through the workflow model from the second rule set to the first rule set are also steps in the method.
摘要翻译：一方面，本发明涉及一种传播第一规则集和第二规则集之间的关系的方法，其中第一和第二规则集由公共工作流模型（10）调用。该方法包括通过工作流模型从第一规则集（13a，13b，13c 13d）向前跟踪路径。枚举从第一个规则集延伸到第二个规则集的关系是方法（19,20）中的一个步骤。另外，使用多值逻辑，计算对从第一规则集合到第二规则集合的通过工作流模型的控制流的关系的影响，从第二规则集追溯到通过工作流模型的路径到第一规则集，枚举从第二规则集向后延伸到第一规则集的关系，并且使用多值逻辑，将通过工作流模型向后的控制流的关系从第二规则集合到第一规则集的影响也是步骤在该方法中。

3. 发明申请

WO2008097192A1 BEDSHEET RETAINER 审中-公开
标题翻译： BEDSHEET保持器
公开(公告)号：WO2008097192A1
公开(公告)日：2008-08-14
申请号：PCT/SG2007/000040
申请日：2007-02-08
申请人： TAN, Ming Loon Glenford
发明人： TAN, Ming Loon Glenford
IPC分类号： A47C21/02 , A47G9/04
CPC分类号： A47C21/022 , A47G9/02
摘要： The invention discloses a bedsheet retainer system for securing a bedsheet in position on a mattress. The system includes a bedsheet having an attachment means on a side, and a complementary attachment means on the mattress for receiving the attachment means of the bedsheet. In addition, the invention is a method for removably securing a bedsheet in position on a mattress. The method includes the steps of providing the bedsheet having an attachment means, providing a mattress having a complementary attachment means on the mattress, the attachment means and the complementary attachment means when in contact or otherwise communication with one another secures one to the other. This method positions and secures the bedsheet on the mattress using minimal effort effectively.
摘要翻译：本发明公开了一种用于将床单固定在床垫上的位置的床单保持器系统。该系统包括在一侧具有附接装置的床单，以及用于接收床单的附接装置的床垫上的互补附接装置。此外，本发明是一种将床单可移动地固定在床垫上的适当位置的方法。该方法包括以下步骤：提供具有附接装置的床单，提供在床垫上具有互补附接装置的床垫，附接装置和互补附接装置当彼此接触或以其它方式彼此连通时将彼此固定在一起。该方法使用最小的努力有效地将床单定位并固定在床垫上。

4. 发明申请

WO2006138514A3 NOVEL NOROVIRUS PARTICLE FOR USE AS AN ANTIVIRAL OR VACCINE 审中-公开
标题翻译：用作抗病毒剂或疫苗的新型尿毒症颗粒
公开(公告)号：WO2006138514A3
公开(公告)日：2007-06-07
申请号：PCT/US2006023407
申请日：2006-06-15
申请人： CHILDRENS HOSP MEDICAL CENTER , JIANG XI , TAN MING
发明人： JIANG XI , TAN MING
IPC分类号： A61K39/12 , A61K39/125 , C12Q1/70
CPC分类号： G01N33/56983 , A61K39/00 , A61K2039/5258 , C07K14/005 , C12N2770/16022 , C12N2770/16023
摘要： Norovirus capsid protein monomers having only the P domain, and not the hinge or S domain, can assemble spontaneously into an icosahedral form herein called the P-particle. Factors affecting the formation and stability of the P-particle, as well as providing methods for diagnosing and treating Norovirus-infected individuals and creating a vaccine for prevention of Norovirus infection are presented.
摘要翻译：仅具有P结构域，而不是铰链或S结构域的诺如病毒衣壳蛋白单体可以自发地组装成本文称为P颗粒的二十面体形式。提出了影响P颗粒形成和稳定性的因素，以及提供诊断和治疗诺如病毒感染个体以及创造用于预防诺如病毒感染的疫苗的方法。

5. 发明申请

WO2006138514A2 NOVEL NOROVIRUS PARTICLE FOR USE AS AN ANTIVIRAL OR VACCINE 审中-公开
标题翻译：用作抗病毒剂或疫苗的新型尿毒症颗粒
公开(公告)号：WO2006138514A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/023407
申请日：2006-06-15
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , JIANG, Xi , TAN, Ming
发明人： JIANG, Xi , TAN, Ming
IPC分类号： A61K39/12
CPC分类号： G01N33/56983 , A61K39/00 , A61K2039/5258 , C07K14/005 , C12N2770/16022 , C12N2770/16023 , Y02A50/472 , Y02A50/52
摘要： Norovirus capsid protein monomers having only the P domain, and not the hinge or S domain, can assemble spontaneously into an icosahedral form herein called the P-particle. Factors affecting the formation and stability of the P-particle, as well as providing methods for diagnosing and treating Norovirus-infected individuals and creating a vaccine for prevention of Norovirus infection are presented.
摘要翻译：仅具有P结构域而不是铰链或S结构域的诺如病毒衣壳蛋白单体可以自发地组装成本文称为P颗粒的二十面体形式。提出了影响P颗粒形成和稳定性的因素，以及提供诊断和治疗诺如病毒感染个体以及创造用于预防诺如病毒感染的疫苗的方法。

6. 发明申请

WO2004077735A2 FRAME SYNCHRONIZATION AND SCRAMBLING CODE IDENTIFICATION IN WIRELESS COMMUNICATIONS SYSTEMS AND METHODS THEREFOR 审中-公开
标题翻译：无线通信系统中的框架同步和屏蔽代码识别及其方法
公开(公告)号：WO2004077735A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/006059
申请日：2004-02-25
申请人： MOTOROLA INC. , STORM, Brian , GUO, Qiang , TAN, Ming D. , ZHOU, Xuping , ZHU, Mang
发明人： STORM, Brian , GUO, Qiang , TAN, Ming D. , ZHOU, Xuping , ZHU, Mang
IPC分类号： H04L
CPC分类号： H04B1/70735
摘要： A mobile wireless communications device and methods therefore, including receiving a signal (710), storing a portion of the received signal (730), identifying all possible pilot signals by determining slot boundary information for the stored signal portion (720), determining frame boundary information and/or scrambling code information (760) of the stored signal portion by correlating the stored signal portion with the scrambling codes based on the slot boundary information. In other embodiments, the search is performed in real-time without storing the signal.
摘要翻译：因此，移动无线通信设备和方法包括：接收信号（710），存储接收信号的一部分（730），通过确定所存储的信号部分（720）的时隙边界信息来识别所有可能的导频信号，确定帧边界信息和/或加扰码信息（760），通过基于时隙边界信息将存储的信号部分与扰码相关联。在其他实施例中，实时地执行搜索而不存储信号。

7. 发明申请

WO2016073415A3 MICROSCALE PLASMA SEPARATOR 审中-公开
公开(公告)号：WO2016073415A3
公开(公告)日：2016-05-12
申请号：PCT/US2015/058731
申请日：2015-11-03
申请人： WAINAMICS, INC. , TAN, Ming , ZAUGG, Frank , KEMEN, Peter
发明人： TAN, Ming , ZAUGG, Frank , KEMEN, Peter
IPC分类号： A61M1/36 , B01D35/26 , B01D61/38 , B01D63/06 , C02F1/44
摘要： Methods and devices for efficient separation of plasma from whole blood which are suitable for point of care use in resource poor environments. Elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port: (b) a filter chamber having an inlet and an outlet, and containing at least one filler capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in fluid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber.

8. 发明申请

WO2010144602A3 ANTIGEN-NOROVIRUS P-DOMAIN MONOMERS AND DIMERS, ANTIGEN-NOROVIRUS P-PARTICLE MOLECULES, AND METHODS FOR THEIR MAKING AND USE 审中-公开
标题翻译：抗逆转录病毒单核细胞和二聚体，抗逆转录病毒颗粒分子及其制备和使用方法
公开(公告)号：WO2010144602A3
公开(公告)日：2011-05-19
申请号：PCT/US2010038008
申请日：2010-06-09
申请人： CHILDRENS HOSP MEDICAL CENTER , JIANG XI , TAN MING
发明人： JIANG XI , TAN MING
IPC分类号： C07K19/00 , A61K39/295 , A61P37/00 , C12N15/63
CPC分类号： C07K7/06 , A61K38/00 , A61K39/12 , A61K39/125 , A61K2039/5258 , A61K2039/542 , A61K2039/543 , A61K2039/55566 , A61K2039/58 , A61K2039/6075 , A61K2039/645 , A61K2039/70 , C07K5/10 , C12N2720/12334 , C12N2770/16034
摘要： A substituted Norovirus capsid protein monomer, having only the P-domain and called an antigen-Norovirus P-domain monomer, includes a foreign antigen inserted into one or more of three surface loops present on each P-domain monomer by molecular cloning. The antigen-P-domain monomer can assemble spontaneously into an octahedral form, called an antigen-Norovirus P-particle, that is composed of 24 copies of the antigen-P-domain monomer. Each substituted P-domain monomer will contain one to three copies of the foreign antigen, for a total of 24-72 antigen copies on each antigen-P-particle. The antigen-P-particle is useful in methods for diagnosing, immunizing and treating individuals infected with a foreign virus, for example Rotavirus, and can serve as a carrier for presentation of foreign antigens for development of novel vaccines against many infectious and non-infectious diseases. The substituted Norovirus P-particles can be readily produced in E. coli and yeast, are highly stable and tolerate a wide range of physio-chemical conditions. A modified Norovirus P-domain monomer includes one or more restriction recognition sites inserted within one or more of the three loops of the P-domain monomers, to provide user-friendly cloning cassettes for conveniently inserting candidate foreign antigens into the surface loops. The P-particle-VP8 chimeras may also serve as a dual vaccine against both rotavirus and norovirus.
摘要翻译：仅具有P-结构域并称为抗原 - 诺如病毒P-结构域单体的取代的诺如病毒衣壳蛋白单体包括通过分子克隆插入每个P-结构域单体上存在的三个表面环中的一个或多个的外源抗原。抗原-P结构域单体可以自发组装成称为抗原 - 诺如病毒P颗粒的八面体形式，其由24个抗原-P结构域单体组成。每个取代的P-结构域单体将含有一至三个拷贝的外源抗原，每个抗原-P-粒子上共有24-72个抗原拷贝。抗原-P颗粒可用于诊断，免疫和治疗感染外来病毒的个体的方法，例如轮状病毒（Rotavirus），并且可以用作外源抗原的载体，用于开发针对许多感染性和非感染性的新型疫苗疾病。取代的诺如病毒P颗粒可以容易地在大肠杆菌和酵母中产生，高度稳定并且耐受广泛的生理化学条件。修饰的诺如病毒P结构域单体包括插入在P结构域单体的三个环中的一个或多个环内的一个或多个限制性识别位点，以提供方便地将候选外源抗原插入到表面环中的用户友好的克隆盒。 P粒子VP8嵌合体也可以用作针对轮状病毒和诺如病毒的双重疫苗。

9. 发明申请

WO2009152391A3 METHOD OF REMOVING CUTTERS 审中-公开
公开(公告)号：WO2009152391A3
公开(公告)日：2009-12-17
申请号：PCT/US2009/047123
申请日：2009-06-11
申请人： WEATHERFORD/LAMB, INC. , BEATTIE, Scott , TWARDOWSKI, Eric, Michael , TAN, Ming, Zo
发明人： BEATTIE, Scott , TWARDOWSKI, Eric, Michael , TAN, Ming, Zo
IPC分类号： E21B17/14
摘要： A method for enhanced degradation of a cutting structure on a drill shoe is provided. The cutting structure may be degraded at an accelerated rate after achieving a desired objective. Degradation of the cutting structures on the drill shoe may facilitate the eventual drill out of the drill shoe. In one embodiment, a method of degrading the cutting structure includes operating the drill shoe using a reduced flow rate of drilling fluid. In another embodiment, a method of degrading the cutting structure includes operating the drill shoe at an increased rotary speed. In yet another embodiment, a method of degrading the cutting structure includes operating the drill shoe with an increased weight on bit. In yet another embodiment, a method of degrading the cutting structure includes any combination of one or more of the enhanced degradation methods described herein.

10. 发明申请

WO2009152391A2 METHOD OF REMOVING CUTTERS 审中-公开
标题翻译：移除切割机的方法
公开(公告)号：WO2009152391A2
公开(公告)日：2009-12-17
申请号：PCT/US2009047123
申请日：2009-06-11
申请人： WEATHERFORD LAMB , BEATTIE SCOTT , TWARDOWSKI ERIC MICHAEL , TAN MING ZO
发明人： BEATTIE SCOTT , TWARDOWSKI ERIC MICHAEL , TAN MING ZO
IPC分类号： E21B17/14
CPC分类号： E21B17/14
摘要： A method for enhanced degradation of a cutting structure on a drill shoe is provided. The cutting structure may be degraded at an accelerated rate after achieving a desired objective. Degradation of the cutting structures on the drill shoe may facilitate the eventual drill out of the drill shoe. In one embodiment, a method of degrading the cutting structure includes operating the drill shoe using a reduced flow rate of drilling fluid. In another embodiment, a method of degrading the cutting structure includes operating the drill shoe at an increased rotary speed. In yet another embodiment, a method of degrading the cutting structure includes operating the drill shoe with an increased weight on bit. In yet another embodiment, a method of degrading the cutting structure includes any combination of one or more of the enhanced degradation methods described herein.
摘要翻译：提供了一种用于增强钻头上的切割结构的劣化的方法。切割结构可以在实现期望的目标之后以加速的速度降级。钻具上的切割结构的降级可能有助于最终钻出钻床。在一个实施例中，降低切割结构的方法包括使用钻井液的流量降低来操作钻具。在另一个实施例中，降低切割结构的方法包括以增加的旋转速度操作钻床。在另一个实施例中，降低切割结构的方法包括以钻头重量增加操作钻床。在另一个实施方案中，降解切割结构的方法包括本文所述的一种或多种增强的降解方法的任何组合。

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