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1. 发明申请

WO2023083723A1 NOVEL MONOCLONAL ANTIBODIES DIRECTED AGAINST L-THYROXINE AND DIAGNOSTIC USES THEREOF 审中-公开
公开(公告)号：WO2023083723A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/080897
申请日：2022-11-07
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GERG, Michael , HIRZEL, Klaus , HOJER, Caroline Dorothea , JOSEL, Hans-Peter , JUCKNISCHKE, Ute , LEHMANN, Holger , MARKINA, Anastasia , PRENCIPE, Giuseppe , VON PROFF, Leopold , SCHRAEML, Michael , HALLDÓRSSON, Steinar
IPC分类号： C07K16/26 , G01N33/53 , G01N33/78
摘要： The present invention provides a novel monoclonal antibody specifically binding to L-Thyroxine (T4) and compositions and kits comprising such antibodies. Furthermore, provided are polynucleotides encoding such monoclonal antibodies, host cells expressing said antibodies, methods of producing such antibodies and diagnostic methods using such monoclonal antibodies. The monoclonal antibody of the invention comprises a heavy chain variable domain (VH) comprising V or A in position 33; Y in position 50; W in position 52; I in position 98, G, A or V in position 99; Y in position 100; and I in position 100b; and a light chain variable domain (VL) comprising amino acids H or Y in position 28; N or K in position 29; W in position 32; G or A in position 91; Y, W or F in position 92; S or T in position 93;Y or F in position 95b; N, S, T or Q in position 95c; and H in position 96, wherein the positions of the amino acids in the VH and the VL are indicated according to the Kabat numbering scheme, respectively.

2. 发明申请

WO2021165465A1 DETECTION METHOD OF CIRCULATING BMP10 (BONE MORPHOGENETIC PROTEIN 10) 审中-公开
公开(公告)号：WO2021165465A1
公开(公告)日：2021-08-26
申请号：PCT/EP2021/054139
申请日：2021-02-19
申请人： UNIVERSITEIT MAASTRICHT , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ACADEMISCH ZIEKENHUIS MAASTRICHT , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： ENGEL, Alfred , GERG, Michael , JUCKNISCHKE, Ute , KARL, Johann , KASTNER, Peter , MEIER, Thomas , HILLRINGHAUS, Lars , SCHOTTEN, Ulrich , ROLNY, Vinzent , WIENHUES-THELEN, Ursula-Henrike , ZIEGLER, Andre , LATINI, Roberto , MEESSEN, Jennifer Marie Theresia Anna
IPC分类号： C07K16/22 , G01N33/68 , G01N33/74
摘要： The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of BMP10 in a sample from the subject, and comparing the amount of BMP10 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure based on the determination of BMP10 in a sample from a subject. Further, the present invention relates to a method for predicting the risk of a subject of hospitalization due to heart failure based on the determination of a BMP10-type peptide in a sample from a subject. The present invention further pertains to antibodies which bind to one or more BMP10-type peptides such as NT-proBMP10.

3. 发明申请

WO2018122205A3 NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF 审中-公开
公开(公告)号：WO2018122205A3
公开(公告)日：2018-07-05
申请号：PCT/EP2017/084541
申请日：2017-12-22
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GERG, Michael , HEINDL, Dieter , HILLRINGHAUS, Lars , HIRZEL, Klaus , HOJER, Caroline Dorothea , HUBER, Florian , JOSEL, Hans-Peter , MEIER, Thomas , SCHRAEML, Michael , VOSS, Edgar
IPC分类号： C07K16/44 , C07D495/04 , G01N33/82 , A61K47/51 , A61K31/4188 , C07K16/00 , C07K16/40 , G01N33/53
摘要： The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

4. 发明申请

WO2021058718A1 ANTI-CSF-1R ANTIBODY 审中-公开
公开(公告)号：WO2021058718A1
公开(公告)日：2021-04-01
申请号：PCT/EP2020/076850
申请日：2020-09-25
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： CASAGOLDA VALLRIBERA, David , GERG, Michael , SCHRAEML, Michael
IPC分类号： C07K16/24 , C07K14/715 , C07K16/28 , A61K39/00
摘要： The present invention relates to a monoclonal antibody, or fragment thereof, which binds to CSF-1R (Colony stimulating factor 1 receptor), in particular to human CSF-1R. The present invention further relates to the in vitro use of the monoclonal antibody, or fragment thereof, of the present invention for the detection of CSF-1R in a sample. Further encompassed by the present invention is a complex comprising the monoclonal antibody, or fragment thereof, of the present invention and CSF-1R such as the human CSF-1R polypeptide.

5. 发明申请

WO2018083238A1 NOVEL ANTI-PY792-DDR1 ANTIBODIES 审中-公开
标题翻译：新型抗PY792-DDR1抗体
公开(公告)号：WO2018083238A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/078184
申请日：2017-11-03
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , CHUGAI SEIYAKU KABUSHIKI KAISHA , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GERG, Michael , SCHRAEML, Michael , HILLRINGHAUS, Lars
IPC分类号： C07K16/28
CPC分类号： C07K16/2851 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to an antibody as characterized in the appended claims, wherein the antibody specifically binds to the discoidin domain receptor 1 (DDR1) which is phosphorylated at the tyrosine in position 792 of the DDR1 sequence represented in SEQ ID NO:15. The present invention further relates to nucleic acid molecules encoding the light chain variable region or the heavy chain variable region of the antibody of the invention, as well as vectors comprising said nucleic acid molecules. The invention further relates to a host cell or non-human host comprising the vector(s) of the invention, as well as to a method for the production of an antibody according to the invention comprising culturing the host cell of the invention under suitable conditions and isolating the antibody produced. Furthermore, the present invention relates to an antibody obtainable by the method of the invention, to a composition comprising at least one of the antibody of the invention, the nucleic acid molecule of the invention, the vector of the invention, the host cell of the invention or the antibody produced by the method of the invention. The present invention also relates to the use of the antibody of the invention for determining phosphorylation of DDR1 at the tyrosine in position 792 of the DDR1 sequence represented in SEQ ID NO:15 as well as to a method of determining phosphorylation of DDR1 at the tyrosine in position 792 of the DDR1 sequence represented in SEQ ID NO:15.
摘要翻译：本发明涉及如所附权利要求书中所表征的抗体，其中所述抗体特异性结合盘基蛋白结构域受体1（DDR1），其在所代表的DDR1序列的792位的酪氨酸处被磷酸化在SEQ ID NO：15中。本发明进一步涉及编码本发明抗体的轻链可变区或重链可变区的核酸分子，以及包含所述核酸分子的载体。本发明进一步涉及包含本发明载体的宿主细胞或非人宿主，以及用于产生根据本发明的抗体的方法，所述方法包括在合适的条件下培养本发明的宿主细胞并分离产生的抗体。此外，本发明涉及可通过本发明的方法获得的抗体，包含本发明的抗体，本发明的核酸分子，本发明的载体，发明或由本发明的方法产生的抗体。本发明还涉及本发明的抗体用于测定DDR1在SEQ ID NO：15中所示的DDR1序列的第792位的酪氨酸处的磷酸化以及测定DDR1在酪氨酸处的磷酸化的方法的用途在SEQ ID NO：15所示的DDR1序列的第792位中。

6. 发明申请

WO2015049355A1 ANTIBODIES SPECIFICALLY BINDING TO HER3 审中-公开
标题翻译：抗体特异性绑定到她3
公开(公告)号：WO2015049355A1
公开(公告)日：2015-04-09
申请号：PCT/EP2014/071204
申请日：2014-10-02
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , VENTANA MEDICAL SYSTEMS, INC. , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： SOUKUPOVA, Monika , SCHRAEML, Michael , BOSSENMAIER, Birgit , ROCHE, Patrick C. , GERG, Michael , DZIADEK, Sebastian
IPC分类号： C07K16/32
CPC分类号： C07K16/2863 , C07K16/3023 , C07K16/3046 , C07K16/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , G01N1/30 , G01N33/57492 , G01N33/74 , G01N2001/302 , G01N2333/71
摘要： The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin- fixed paraffin embedded tissue (FFPET) sample.
摘要翻译：本发明涉及与人HER3结合的分离的抗体或其抗原部分。新型抗体具有很好的实用性，因为它们允许对人HER3的敏感和特异性检测。即使当这样的组织样品是福尔马林固定的石蜡包埋组织（FFPET）样品时，人类HER3的检测也可能在组织样品中。

7. 发明申请

WO2019012019A1 NEW BINDING AGENT AND ASSAY FOR PIVKA 审中-公开
公开(公告)号：WO2019012019A1
公开(公告)日：2019-01-17
申请号：PCT/EP2018/068871
申请日：2018-07-12
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： ECKERT, Bernhard , GERG, Michael , KARL, Johann , KAUFMANN, Martin , RIEDLINGER, Julia , SWIATEK-DE LANGE, Magdalena , HILLRINGHAUS, Lars , HIRZEL, Klaus , LISY, Marcus-Rene
IPC分类号： C07K16/36 , C07K16/30 , C07K16/40
摘要： The present disclosure relates to specific binding agents binding to different PIVKA-II forms as compared to antibodies known so far in the art.

8. 发明申请

WO2016091755A1 METHOD FOR MEASUREMENT OF VITAMIN D 审中-公开
标题翻译：维生素D的测定方法
公开(公告)号：WO2016091755A1
公开(公告)日：2016-06-16
申请号：PCT/EP2015/078693
申请日：2015-12-04
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： FAATZ, Elke , GERG, Michael , JOSEL, Hans-Peter , VOGL, Christian
IPC分类号： G01N33/537 , G01N33/541
CPC分类号： G01N33/537 , C07K16/26 , G01N33/541 , G01N33/82
摘要： The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin D 3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin D 3 and not binding to 25-hydroxyvitamin D.
摘要翻译：本发明涉及用于测量25-羟基维生素D的体外方法，其中潜在的干扰化合物24,25-二羟基维生素D3被特异性结合24,25-二羟基维生素D 3而不与25-羟基维生素D结合的结合剂阻断。

9. 发明申请

WO2022090455A1 SARS-COV-2 NUCLEOCAPSID ANTIBODIES 审中-公开
公开(公告)号：WO2022090455A1
公开(公告)日：2022-05-05
申请号：PCT/EP2021/080106
申请日：2021-10-29
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GERG, Michael , JUCKNISCHKE, Ute , KURTKAYA, Ulrike , MOCK, Thomas , SCHRAEML, Michael , STIEGLER, Sandrine Carolina
IPC分类号： C07K16/10 , G01N33/569 , G01N33/577
摘要： The present invention relates to monoclonal antibodies binding to the nucleocapsid protein of SARS-CoV-2 virus, nucleic acids encoding said antibody, host cells producing the same, compositions and kits comprising said antibodies, as well as method od detecting SARS-CoV-2 virus in a sample comprising using said antibodies.

10. 发明申请

WO2018083237A1 NOVEL ANTI-PY520-DDR1 ANTIBODIES 审中-公开
标题翻译：新型抗PY520-DDR1抗体
公开(公告)号：WO2018083237A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/078183
申请日：2017-11-03
申请人： ROCHE DIAGNOSTICS OPERATIONS INC. , ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： GERG, Michael , SCHRAEML, Michael , HILLRINGHAUS, Lars
IPC分类号： C07K16/28
CPC分类号： C07K16/2851 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to an antibody as characterized in the appended claims, wherein the antibody specifically binds to the discoidin domain receptor 1 (DDR1) which is phosphorylated at the tyrosine in position 520 of the DDR1 sequence represented in SEQ ID NO:58. The present invention further relates to nucleic acid molecules encoding the light chain variable region or the heavy chain variable region of the antibody of the invention, as well as vectors comprising said nucleic acid molecules. The invention further relates to a host cell or non-human host comprising the vector(s) of the invention, as well as to a method for the production of an antibody according to the invention comprising culturing the host cell of the invention under suitable conditions and isolating the antibody produced. Furthermore, the present invention relates to an antibody obtainable by the method of the invention, to a composition comprising at least one of the antibody of the invention, the nucleic acid molecule of the invention, the vector of the invention, the host cell of the invention or the antibody produced by the method of the invention. The present invention also relates to the use of the antibody of the invention for determining phosphorylation of DDR1 at the tyrosine in position 520 of the DDR1 sequence represented in SEQ ID NO:58 as well as to a method of determining phosphorylation of DDR1 at the tyrosine in position 520 of the DDR sequence represented in SEQ ID NO:58.
摘要翻译：本发明涉及如所附权利要求中所表征的抗体，其中所述抗体特异性结合在所代表的DDR1序列的520位的酪氨酸处被磷酸化的盘基蛋白结构域受体1（DDR1）在SEQ ID NO：58中。本发明进一步涉及编码本发明抗体的轻链可变区或重链可变区的核酸分子，以及包含所述核酸分子的载体。本发明进一步涉及包含本发明载体的宿主细胞或非人宿主，以及用于产生根据本发明的抗体的方法，所述方法包括在合适的条件下培养本发明的宿主细胞并分离产生的抗体。此外，本发明涉及可通过本发明的方法获得的抗体，包含本发明的抗体，本发明的核酸分子，本发明的载体，发明或由本发明的方法产生的抗体。本发明还涉及本发明的抗体用于测定DDR1在SEQ ID NO：58所示的DDR1序列的520位的酪氨酸磷酸化的用途，以及测定DDR1在酪氨酸处的磷酸化的方法在SEQ ID NO：58中所示的DDR序列的520位中。

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