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1. 发明申请

WO1988000339A1 OXYGEN CONCENTRATION PROBE 审中-公开
标题翻译：氧气浓度探测
公开(公告)号：WO1988000339A1
公开(公告)日：1988-01-14
申请号：PCT/JP1987000463
申请日：1987-07-03
申请人： RIKAGAKU KENKYUSHO , TERUMO KABUSHIKI KAISHA , KANEKO, Masao , NAKAMURA, Hideki
发明人： RIKAGAKU KENKYUSHO , TERUMO KABUSHIKI KAISHA
IPC分类号： G01N21/77
CPC分类号： G01N21/643 , G01N21/78 , G01N31/22 , G01N31/221 , G01N31/225
摘要： An oxygen concentration probe which measures an oxygen concentration in a solution or a gas in accordance with equation (1) below by utilizing extinction of light by oxygen, said light being generated by excitation of light through immobilization of a polypyridine metal complex. Namely, the invention provides an oxygen concentration probe which can be readily miniaturized and consists of immobilized polypyridine metal complex which can be prepared from an economical material for visible rays of light as a photoconductor or optical material since the excited light and emitted light are visible rays of light and can be used stably even when it is dipped directly into a solution, or the like, without any protective film such as an oxygen-permeable film. I0/I = 1 + K[O2] (1), where I0 and I each represent the intensity of emitted light (with the proviso that I0 is the intensity of the emitted light when the oxygen concentration is substantially zero), K is a constant and [O2] is an oxygen concentration. I0 and K are constants that are independent of the oxygen concentration of a sample.

2. 发明申请

WO1989009400A1 LIGHT EMITTING PROBE COMPLEX FOR MEASURING PH AND METHOD OF PH MEASUREMENT 审中-公开
标题翻译：用于测量PH的发光探针复合物和PH测量方法
公开(公告)号：WO1989009400A1
公开(公告)日：1989-10-05
申请号：PCT/JP1989000314
申请日：1989-03-24
申请人： RIKAGAKU KENKYUSHO , TERUMO KABUSHIKI KAISHA , KANEKO, Masao , ASAKURA, Tetsuo , NAKAMURA, Hideki , SIMOMURA, Takeshi , SUGISE, Hiroshi
发明人： RIKAGAKU KENKYUSHO , TERUMO KABUSHIKI KAISHA
IPC分类号： G01N31/22
CPC分类号： G01N31/221
摘要： This invention relates to a light emitting probe complex for measuring pH consisting essentially of a polypyridine ligand having an ionizable substituent on a ring carbon atom and a transition metal ion selected from the elements of Group VIII of the Periodic Table; a light emitting probe film for measuring pH containing this probe complex in its polymer film; and a pH measurement instrument formed by fixing this probe film at the tip of an optical fiber and a pH measurement method utilizing this instrument. The present invention facilitates measurement of the pH at a microscopic part by using them.

3. 发明申请

WO1988006287A1 PROBE FOR MEASURING CONCENTRATION OF DISSOLVED OXYGEN 审中-公开
标题翻译：测量溶解氧浓度的探针
公开(公告)号：WO1988006287A1
公开(公告)日：1988-08-25
申请号：PCT/JP1988000174
申请日：1988-02-19
申请人： RIKAGAKU, Kenkyusho , TERUMO KABUSHIKI KAISHA , NAKAMURA, Hideki , KANEKO, Masao
发明人： RIKAGAKU, Kenkyusho , TERUMO KABUSHIKI KAISHA
IPC分类号： G01N21/77

4. 发明申请

WO1988008123A1 THERMOMETER 审中-公开
标题翻译：温度计
公开(公告)号：WO1988008123A1
公开(公告)日：1988-10-20
申请号：PCT/JP1988000361
申请日：1988-04-08
申请人： TERUMO KABUSHIKI KAISHA , NAKAMURA, Hideki
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： G01K11/20
CPC分类号： G01K11/3213
摘要： This invention discloses an optical thermometer. This thermometer is equipped with a light emitting member which emits the ray of light with an intensity which is dependent on temperature when light is applied thereto, radiation means for applying stable rays of light to said light emitting member, light receiving means for receiving the rays of light emitted from said light emitting member, conversion means for converting the intensity of emitted rays of light received by the light receiving means to a corresponding temperature value, and output means for outputting converted temperature data.

5. 发明申请

WO1989002072A1 METHOD AND APPARATUS FOR OPTICALLY MEASURING CONCENTRATION OF MATERIAL 审中-公开
标题翻译：光学测量材料浓度的方法和装置
公开(公告)号：WO1989002072A1
公开(公告)日：1989-03-09
申请号：PCT/JP1988000882
申请日：1988-09-02
申请人： TERUMO KABUSHIKI KAISHA , NAKAMURA, Hideki
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： G01N21/64
CPC分类号： G01N21/643 , G01N21/51 , G01N2021/6432 , G01N2021/6484 , Y10T436/207497
摘要： The present invention relates to a method and an apparatus for optically measuring the concentration of material characterized in that the concentration of a specific material in a liquid or a gas is detected optically by utilizing extinction of a light emitting member by the specific material or a material derived therefrom, wherein a second light emitting member (B) which is not substantially extinguished by the specific material or a material derived therefrom is added to a measuring system together with a first light emitting member (A) which is extinguished by the specific material or the material derived therefrom, an optical signal corresponding to the intensity (IA) of emission from the first light emitting member (A) and an optical signal corresponding to the intensity (IB) of emission from the second light emitting member (B) are measured and variable factors involved with light emission intensity are reduced by calculating the ratio between these optical signals. Thus, the present invention enables the concentration of the specific material to be detected with a high level of accuracy.

6. 发明申请

WO1997008161A1 ONCOGENE FUNCTION DEPRESSANT 审中-公开
标题翻译： ONCOGENE功能DEPRESSANT
公开(公告)号：WO1997008161A1
公开(公告)日：1997-03-06
申请号：PCT/JP1996002411
申请日：1996-08-28
申请人： TERUMO KABUSHIKI KAISHA , UMEZAWA, Kazuo , KOYANO, Takashi , TAKAHASHI, Hiroaki , YAMAMOTO, Takashi
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： C07D307/93
CPC分类号： C07D491/14 , C07D307/93
摘要： Novel compounds having the activity of depressing oncogene functions, i.e., aglaiastatins A (represented by chemical formula (1)), B and C, isolated from Aglaia odorata LOUR; and oncogene function depressants and anticancer drugs containing the same as the active ingredient.
摘要翻译：具有抑制致癌基因功能的新型化合物，即从Aglaia odorata LOUR中分离出来的aglaliastatins A（由化学式（1）表示））B和C; 和癌基因功能抑制剂和含有与活性成分相同的抗癌药物。

7. 发明申请

WO1996013497A1 TETRAHYDROISOQUINOLINE DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME 审中-公开
标题翻译：四氢喹啉衍生物和含有其的药物制剂
公开(公告)号：WO1996013497A1
公开(公告)日：1996-05-09
申请号：PCT/JP1995002201
申请日：1995-10-26
申请人： TERUMO KABUSHIKI KAISHA , KOHAMA, Hiromasa , NAKATA, Nobuyuki , SUZUKI, Masahiro , TERAJIMA, Youko
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： A tetrahydroisoquinoline derivative represented by formula (1), having a fibrinogen aggregation inhibiting effect and usable as an antithrombotic agent or a platelet aggregation inhibitor, and a medicinal preparation containing the same. In the said formula B and G represent each alkylene which may be substituted by alkyl, etc.; D represents hydrogen, alkyl, etc.; E represents 1,2,3,4-tetrahydroquinoline bonded to G at the 2-position which may be substituted by R1 to R4; R1 to R4 represent each alkyl, etc.; L represents hydroxy, etc.; A represents a substituent of formula (2); and C represents carbon, wherein M and R5 to R8 represent each hydrogen, alkyl, etc.
摘要翻译：由式（1）表示的具有纤维蛋白原聚集抑制作用并可用作抗血栓形成剂或血小板聚集抑制剂的四氢异喹啉衍生物和含有它的药物制剂。在所述式中，B和G表示可以被烷基等取代的各个亚烷基; D代表氢，烷基等; E表示与可以被R 1〜R 4取代的2位的G结合的1,2,3,4-四氢喹啉; R 1〜R 4表示各烷基等。 L代表羟基等; A表示式（2）的取代基; C代表碳，其中M和R 5至R 8表示各自的氢，烷基等。

8. 发明申请

WO1989011309A1 SUBCUTANEOUSLY IMPLANTED CATHETER ASSEMBLY 审中-公开
标题翻译：小型嵌入式导管组件
公开(公告)号：WO1989011309A1
公开(公告)日：1989-11-30
申请号：PCT/JP1989000490
申请日：1989-05-15
申请人： TERUMO KABUSHIKI KAISHA , MORIUCHI, Yousuke
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： A61M37/00
CPC分类号： A61M39/0208 , A61M25/10 , A61M2039/0211 , A61M2039/0238 , A61M2205/582 , A61M2205/60 , A61M2205/6036
摘要： This invention relates to a subcutaneously implanted catheter assembly for therapeutical purpose by charging a medical fluid such as an anti-cancer drug into a body cavity such as a blood vessel. The subcutaneously implanted catheter assembly of the present invention consists of a medical fluid injector having an inlet and an outlet and a catheter connected to the outlet, and the catheter is inserted into a body cavity and left there with the medical fluid injector kept buried under the skin and used. Accordingly, the therapeutical operation can be repeated while the subcutaneously implanted catheter assembly is left inside the body and in comparison with the prior art method wherein a catheter is inserted and removed whenever therapy is conducted, a burden on a patient can be reduced drastically. Moreover, unlike the prior art method which inserts the catheter through the skin, there is no risk o the occurrence of infection during the therapy.

9. 发明申请

WO1989008468A1 SYRINGE AND SYRINGE DEVICE 审中-公开
标题翻译：注射器和注射装置
公开(公告)号：WO1989008468A1
公开(公告)日：1989-09-21
申请号：PCT/JP1989000284
申请日：1989-03-16
申请人： TERUMO KABUSHIKI KAISHA , MIYAGUCHI, Katsuhiko , FUKASAWA, Hiromichi , ANZAI, Noboru , ISHIDA, Noboru , NISHIMURA, Masato , ISHII, Ichiro
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： A61M05/18
CPC分类号： A61M5/3213 , A61M5/31511 , A61M5/31515 , A61M2005/31516 , A61M2005/5073
摘要： When a protector for protecting a needle is mounted on said needle, the needle is prevented from stabbing in the body by mistake and when the needle is used, the protector is prevented from being lost and the like. A push member (2) comprising a stringer and a syringe device is provided with a hollow portion (2C) having a length sufficient for housing a needle pipe (4) therein. After the syringe device has been used, at least the hollow portion formed in said push member is separated from the inside of the syringe body (1) and fitted over the needle pipe of a needle pipe assembly (B) mounted on the syringe body to fit a hub (5) comprising said needle pipe assembly or the syringe body in the inner wall of the hollow portion. Not only the push member has a function inherent therein but also after it has been used, it can be used as the protector for the needle pipe. In addition, a sufficient distance can be ensured between the needle pipe and the fingers by means of an opening of the hollow portion of the push member and thus the needle pipe can be safely covered.
摘要翻译：当用于保护针的保护器安装在所述针上时，防止针被错误地刺入身体，并且当使用针时，防止保护器丢失等。包括桁条和注射器装置的推动构件（2）设置有具有足以在其中容纳针管（4）的长度的中空部分（2C）。在使用注射器装置之后，至少形成在所述推动构件中的中空部分与注射器主体（1）的内部分离，并且装配在安装在注射器主体上的针管组件（B）的针管上，将包括所述针管组件或注射器主体的毂（5）装配在中空部分的内壁中。不仅推动构件具有固有的功能，而且在使用之后也可以用作针管的保护器。此外，通过推动构件的中空部分的开口，可以确保针管和手指之间的足够的距离，从而可以安全地覆盖针管。

10. 发明申请

WO1989008466A1 MEDICAL MATERIAL PERMITTING CELLS TO ENTER THEREINTO AND ARTIFICIAL SKIN 审中-公开
标题翻译：医疗材料允许细胞进入和人造皮肤
公开(公告)号：WO1989008466A1
公开(公告)日：1989-09-21
申请号：PCT/JP1989000258
申请日：1989-03-09
申请人： TERUMO KABUSHIKI KAISHA , YOSHISATO, Katsutoshi , KONISHI, Jun , KOIDE, Mikio , OYAMADA, Kaoru , OHSAKI, Kenichi , KATAKURA, Takeo , MORI, Yuichi , TATEBE, Ken
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： A61L27/00
CPC分类号： A61L27/3691 , A61F2310/00365 , A61L15/325 , A61L27/24 , A61L27/60
摘要： A medical material permitting cells to enter thereinto which comprises a modified collagen prepared by heat-treating collagen having a crosslinked structure in the presence of water is disclosed. An artificial skin using this medical material as a wound-contacting layer is also disclosed.

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