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1. 发明申请

WO1997005900A1 CELL DERIVED ANTIGEN PRESENTING VESICLES 审中-公开
标题翻译：细胞衍生的抗原产生的抗生素
公开(公告)号：WO1997005900A1
公开(公告)日：1997-02-20
申请号：PCT/NL1996000317
申请日：1996-08-05
申请人： RIJKSUNIVERSITEIT TE LEIDEN , RIJKSUNIVERSITEIT UTRECHT , GEUZE, Johannes, J. , MELIEF, Cornelis, J., M.
发明人： RIJKSUNIVERSITEIT TE LEIDEN , RIJKSUNIVERSITEIT UTRECHT
IPC分类号： A61K39/385
CPC分类号： A61K39/39 , A61K39/04 , A61K2039/5154 , A61K2039/55555
摘要： The invention provides a novel vehicle for vaccination, in particular peptide vaccination. The new vehicle has been termed an exosome. Exosomes are vesicles derived from MHC class II enriched compartments in antigen presenting cells. The exosomes possess MHC II and/or MHC I molecules at their surface and possibly peptides derived from processed antigens in said MHC's. Thus the exosome is a perfect vaccination vehicle in that it presents the peptide in a natural setting. The peptides present in the exosome in the MHC molecule may be processed by the antigen presenting cell from which the exosome is derived. Empty MHC molecules on exosomes may also be loaded with peptides afterwards.
摘要翻译：本发明提供了用于疫苗接种，特别是肽疫苗接种的新载体。新车被称为外来体。外来体是来自抗原提呈细胞中MHC II类富集区的囊泡。外来体在其表面具有MHC II和/或MHC I分子，并且可能在所述MHC中具有衍生自加工抗原的肽。因此，外来体是完美的疫苗接种载体，因为它在自然环境中呈现肽。存在于MHC分子中的外来体中的肽可以由衍生外来体的抗原呈递细胞进行加工。外来体上的空的MHC分子也可以随后加载肽。

2. 发明申请

WO1988003649A1 PROCESS FOR DETECTING, IDENTIFYING AND/OR QUANTIFYING OF CIRCULATING IMMUNE COMPLEXES IN BLOOD SERUM 审中-公开
标题翻译：血清中循环免疫复合物检测，鉴定和/或定量的方法
公开(公告)号：WO1988003649A1
公开(公告)日：1988-05-19
申请号：PCT/NL1987000034
申请日：1987-11-12
申请人： RIJKSUNIVERSITEIT UTRECHT , VAN DIJK, Hans , BLOEMBERGEN, Peter
发明人： RIJKSUNIVERSITEIT UTRECHT
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N33/537
摘要： Process for detecting, identifying and/or quantifying of immune complexes in blood serum by contacting the serum with a polyanionic, by which the immune complexes present in the serum are bound to this substance, and thereafter detecting them by the specific reagents for certain, immune complexes.
摘要翻译：通过使血清与聚阴离子接触来检测，鉴定和/或定量血清中的免疫复合物的方法，通过该方法，存在于血清中的免疫复合物与该物质结合，然后通过特异性试剂检测它们以确定免疫复合物。

3. 发明申请

WO1998024424A1 CISPLATINUM COMPRISING PHARMACEUTICAL 审中-公开
标题翻译：包含药物的CISPLATINUM
公开(公告)号：WO1998024424A1
公开(公告)日：1998-06-11
申请号：PCT/NL1996000474
申请日：1996-12-03
申请人： RIJKSUNIVERSITEIT UTRECHT , SEED CAPITAL INVESTMENTS-2 B.V. , DE KRUIJFF, Ben , SPEELMANS, Gelske , STAFFHORST, Rutger, Willibrordus, Hendricus, Maria , REEDIJK, Jan
发明人： RIJKSUNIVERSITEIT UTRECHT , SEED CAPITAL INVESTMENTS-2 B.V.
IPC分类号： A61K31/28
CPC分类号： A61K31/685 , A61K9/1271 , A61K9/1272 , A61K31/282 , A61K31/555 , A61K31/675
摘要： A pharmaceutical composition for use in treatment of a subject having neoplasms with a view to reducing size and/or number of neoplasms, said pharmaceutical composition comprising a complex of a cytostatic compound of the cisplatinum family and an anionic organic compound as a complexed form of the active pharmaceutical component, said complex having general formula (1) wherein Q = -CO- or -PO(O )-; Y = -CHR'-, -CO-, -PO(O )- or a direct bond; Z1, Z2 = independently 0 or NR', R1,R2 = H or a hydrocarbon group optionally substituted, optionally linked to each other or to R3 and/or R4, wherein R3, R4=H or hydrocarbon group optionally substituted, optionally linked to each other or to R1 and/or R2, wherein R'=H, or a hydrocarbon group optionally substituted and wherein R''=hydrocarbon group substituted by a group capable of liposome formation.
摘要翻译：一种药物组合物，用于治疗具有肿瘤的受试者，以减少肿瘤的大小和/或数量，所述药物组合物包含顺铂族的细胞生长抑制化合物和阴离子有机化合物的复合物作为复合形式的活性药物组分，所述具有通式（1）的络合物，其中Q = -CO-或-PO（O - ） - ; Y = -CHR'-，-CO-，-PO（O - ） - 或直接键; Z 1，Z 2 =独立地为0或NR'，R 1，R 2 = H或任选取代的任选取代的烃基，或任选地相互连接或与R 3和/或R 4连接，其中R 3，R 4 = H或任选取代的烃基，或R 1和/或R 2，其中R'= H，或任选取代的烃基，其中R“=被能够形成脂质体的基团取代的烃基。

4. 发明申请

WO1985004807A1 A PHARMACEUTICAL PRODUCT HAVING AN ANTI-TUMOR ACTIVITY; THE USE OF A PHARMACEUTICAL PRODUCT OR OF PHARMACEUTICAL COMPOSITIONS IN AN ANTI-TUMOR THERAPY 审中-公开
标题翻译：具有抗肿瘤活性的药物产品; 药物制剂或药物组合物在抗肿瘤治疗中的应用
公开(公告)号：WO1985004807A1
公开(公告)日：1985-11-07
申请号：PCT/NL1985000015
申请日：1985-04-16
申请人： RIJKSUNIVERSITEIT UTRECHT , BLOKSMA, Marie, Anna , HOFHUIS, Franciscus, Maria, Albertus , WILLERS, Johannes, Maria, Nicolaas
发明人： RIJKSUNIVERSITEIT UTRECHT
IPC分类号： A61K37/02
CPC分类号： A61K38/14 , A61K38/168 , A61K38/04 , A61K31/70 , A61K2300/00
摘要： A pharmaceutical product having anti-tumor activity. Said product contains a combination of (a) at least one substance selected from the group consisting of non-toxic or acceptably toxic lectins, non-toxic or acceptably toxic analogs thereof, non-toxic or acceptably toxic synthetic double-strand RNA molecules, and non-toxic or acceptably toxic analogs thereof, and (b) muramyl dipeptide (MDP) or a non-pyrogenic or acceptably pyrogenic analog or prodrug form thereof in quantities which, on the one hand, are toxicologically acceptable and, one the other hand, have an effective anti-tumor activity.
摘要翻译：具有抗肿瘤活性的药物。所述产品包含（a）至少一种选自无毒或可接受毒性的凝集素，无毒或可接受毒性类似物，无毒性或可接受毒性的合成双链RNA分子的物质的组合，以及无毒或可接受的毒性类似物，和（b）胞壁酰二肽（MDP）或非致热原或可接受的热原类似物或前药形式，其一方面在毒理学上是可接受的，另一方面，具有有效的抗肿瘤活性。

5. 发明申请

WO1986000288A1 A METHOD FOR NEUTRALIZING WASTE SULFURIC ACID BY ADDING A SILICATE 审中-公开
标题翻译：一种通过添加硅酸中和硫酸的方法
公开(公告)号：WO1986000288A1
公开(公告)日：1986-01-16
申请号：PCT/NL1985000026
申请日：1985-06-27
申请人： RIJKSUNIVERSITEIT UTRECHT , SCHUILING, Roelof, Dirk
发明人： RIJKSUNIVERSITEIT UTRECHT
IPC分类号： C02F01/66
CPC分类号： A62D3/36 , A62D2101/47 , C02F1/66
摘要： It has been shown that magnesiumsilicates, particularly Mg-rich olivine, is very proper to neutralize waste sulfuric acid. In said process a silicagel and a Fe/Mg-containing liquid are formed. The experiments show that a distinct separation of the silicagel from the Fe-containing liquid is possible in case the neutralization process is performed in an inert atmosphere. After separation of the SiO2-rich gel a Fe-V precipitate may be formed by means of aeration. The SiO2 gel may be rinsed well, so that an acceptable product is formed that e.g. is useful in the concrete industry. The liquids formed are MgSO4 rich. They may be drained simply into sea-water.
摘要翻译：已经表明，硅酸镁，特别是富镁橄榄石，非常适合中和废硫酸。在所述方法中，形成硅胶和含Fe / Mg的液体。实验表明，在惰性气氛中进行中和处理的情况下，硅胶与含Fe液体的分离是可能的。在分离富含SiO 2的凝胶之后，可以通过曝气形成Fe-V沉淀物。可以很好地冲洗SiO 2凝胶，从而形成例如可接受的产物。在具体行业有用。形成的液体富含MgSO4。它们可能会被简单地排入海水中。

6. 发明申请

WO1995025744A1 PEPTIDE FRAGMENTS OF MICROBIAL STRESS PROTEINS AND PHARMACEUTICAL COMPOSITION MADE THEREOF FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗和预防炎症疾病的微生物应激蛋白及其药物组合物的肽片段
公开(公告)号：WO1995025744A1
公开(公告)日：1995-09-28
申请号：PCT/NL1995000108
申请日：1995-03-21
申请人： RIJKSUNIVERSITEIT UTRECHT , ANDERTON, Stephen, Mark , VAN DER ZEE, Ruurd , VAN EDEN, Willem
发明人： RIJKSUNIVERSITEIT UTRECHT
IPC分类号： C07K14/35
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K16/2833 , C07K2317/76
摘要： Peptides are provided which are useful for protection against or treatment of an inflammatory disease, including autoimmune diseases, such as diabetes, arthritic diseases, atherosclerosis, multiple sclerosis, myasthenia gravis, or inflammatory responses due to tumour or transplant rejection. The peptides contain a part of the aminoacid sequence of a microbial protein having a conserved mammalian stress protein homologue, wherein the overall aminoacid sequence identity between the microbial and the mammalian homologues is at least 25 %, and the sequence identity between the microbial and the mammalian homologues of an area of at least 75 consecutive aminoacids is at least 30 %, said part comprising at least 5 aminoacids which are in the same relative position as the same aminoacids in a T cell epitope of said stress protein, which epitope contains at least 4 consecutive aminoacids which are identical with the corresponding mammalian stress protein aminoacids. Nucleotide sequences, expression systems, antibodies and pharmaceutical and diagnostic compositions derived from these peptides are provided as well.
摘要翻译：提供了可用于保护或治疗炎性疾病，包括自身免疫性疾病如糖尿病，关节炎疾病，动脉粥样硬化，多发性硬化，重症肌无力或由于肿瘤或移植排斥引起的炎症反应的肽。肽含有具有保守的哺乳动物应激蛋白同源物的微生物蛋白质的氨基酸序列的一部分，其中微生物和哺乳动物同系物之间的总氨基酸序列同一性至少为25％，微生物与哺乳动物之间的序列同一性至少75个连续氨基酸的区域的同系物为至少30％，所述部分包含至少5个氨基酸，它们与所述应激蛋白的T细胞表位中相同的氨基酸位于相同的相对位置，该表位含有至少4个连续的氨基酸与相应的哺乳动物应激蛋白氨基酸相同。还提供了源自这些肽的核苷酸序列，表达系统，抗体以及药物和诊断组合物。

7. 发明申请

WO1985004808A1 A PHARMACEUTICAL PRODUCT HAVING AN ANTI-TUMOR ACTIVITY; THE USE OF A PHARMACEUTICA PRODUCT OR OF PHARMACEUTICAL COMPOSITIONS IN AN ANTI-TUMOR THERAPY 审中-公开
标题翻译：具有抗肿瘤活性的药物产品; 药物制剂或药物组合物在抗肿瘤治疗中的应用
公开(公告)号：WO1985004808A1
公开(公告)日：1985-11-07
申请号：PCT/NL1985000016
申请日：1985-04-16
申请人： RIJKSUNIVERSITEIT UTRECHT , BLOKSMA, Marie, Anna , HOFHUIS, Franciscus, Maria, Albertus , WILLERS, Johannes, Maria, Nicolaas
发明人： RIJKSUNIVERSITEIT UTRECHT
IPC分类号： A61K37/02
CPC分类号： A61K38/14 , A61K38/04 , A61K35/74 , A61K2300/00
摘要： A pharmaceutical product having anti-tumor activity. Said product contains a combination of (a) at least one detoxified endotoxin or a synthetic non-toxic or acceptably toxic analogue thereof, and (b) muramyl dipeptide (MDP), or a non-pyrogenic or acceptably pyrogenic analogue or prodrug form thereof, in quantities which, on the one hand, are toxicologically acceptable and, on the other hand, possess an effective anti-tumor activity.
摘要翻译：具有抗肿瘤活性的药物。所述产物包含（a）至少一种解毒的内毒素或其合成的无毒或可接受的毒性类似物的组合，和（b）胞壁酰二肽（MDP）或非致热原或可接受的致热原类似物或前药形式，其一方面在毒理学上是可接受的，另一方面具有有效的抗肿瘤活性。

8. 发明申请

WO1998024425A1 CISPLATINUM COMPRISING PHARMACEUTICAL 审中-公开
标题翻译：包含药物的CISPLATINUM
公开(公告)号：WO1998024425A1
公开(公告)日：1998-06-11
申请号：PCT/NL1997000661
申请日：1997-12-03
申请人： RIJKSUNIVERSITEIT UTRECHT , SEED CAPITAL INVESTMENTS-2 B.V. , DE KRUIJFF, Ben , SPEELMANS, Gelske , STAFFHORST, Rutger, Willibrordus, Hendricus, Maria , REEDIJK, Jan
发明人： RIJKSUNIVERSITEIT UTRECHT , SEED CAPITAL INVESTMENTS-2 B.V.
IPC分类号： A61K31/28
CPC分类号： A61K31/685 , A61K9/1271 , A61K9/1272 , A61K31/282 , A61K31/555 , A61K31/675
摘要： A pharmaceutical composition for use in treatment of a subject having neoplasms with a view to reducing size and/or number of neoplasms, said pharmaceutical composition comprising a complex of a cytostatic compound of the cis platinum family and an anionic organic compound as a complexed form of the active pharmaceutical component, said complex having general formula (1) wherein Q = -CO- or -PO(O )-; Y = -CHR'-, -CO-, -PO(O )- or a direct bond; Z1, Z2 = independently O or NR', R1, R2=H or a hydrocarbon group optionally substituted, optionally linked to each other or to R3 and/or R4 wherein R3, R4=H or hydrocarbon group optionally substituted, optionally linked to each other or to R1 and/or R2, wherein R'=H, or a hydrocarbon group optionally substituted and wherein R''=hydrocarbon group substituted by a group capable of liposome formation.
摘要翻译：用于治疗具有肿瘤的受试者的药物组合物，以减少肿瘤的大小和/或数量，所述药物组合物包含顺式铂族的细胞抑制化合物和阴离子有机化合物的复合物作为复合形式所述活性药物组分，所述具有通式（1）的络合物，其中Q = -CO-或-PO（O - ） - ; Y = -CHR'-，-CO-，-PO（O - ） - 或直接键; Z 1，Z 2独立地为O或NR'，R 1，R 2 = H或任选取代的任选取代的烃基，任选地彼此连接或者R 3和/或R 4，其中R 3，R 4 = H或任选取代的烃基， R 1和/或R 2，其中R'= H，或任选取代的烃基，其中R“=被能够形成脂质体的基团取代的烃基。

9. 发明申请

WO1988005464A1 PhoE PROTEIN WITH AN INSERTED ANTIGENIC DETERMINANT 审中-公开
标题翻译： Phoe蛋白与插入的抗原决定因子
公开(公告)号：WO1988005464A1
公开(公告)日：1988-07-28
申请号：PCT/NL1988000002
申请日：1988-01-20
申请人： RIJKSUNIVERSITEIT UTRECHT , STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , TOMMASSEN, Johannes, Petrus, Maria
发明人： RIJKSUNIVERSITEIT UTRECHT , STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT
IPC分类号： C12N15/00
CPC分类号： C07K14/005 , A61K39/00 , C07K14/245 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N2770/32122 , Y02A50/466 , Y02A50/472
摘要： Recombinant DNA comprising the genetic information for PhoE protein of Enterobacteriaceae bacteria and, in a part thereof coding for a region of the PhoE protein localized at the cell surface, the genetic information for a foreign antigenic determinant. Enterobacteriaceae bacteria containing and expressing such recombinant DNA contain in their outer membrane PhoE with a cell-surface exposed foreign antigenic determinant. Such bacteria or the modified PhoE protein recovered therefrom can be used as a diagnostic aid or as a vaccine.
摘要翻译：包含肠杆菌科细菌的PhoE蛋白的遗传信息的重组DNA，并且在编码位于细胞表面的PhoE蛋白的区域的一部分中，是外源抗原决定簇的遗传信息。含有和表达这种重组DNA的肠杆菌科细菌在其外膜PhoE中含有细胞表面暴露的外源抗原决定簇。这样的细菌或从其回收的经修饰的PhoE蛋白质可以用作诊断辅助剂或疫苗。

10. 发明申请

WO1984000109A1 VACCINES AGAINST PATHOGENIC BACTERIA WITH CAPSULAR POLYSACCHARIDES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：杀虫剂及其制剂的制备方法
公开(公告)号：WO1984000109A1
公开(公告)日：1984-01-19
申请号：PCT/NL1983000024
申请日：1983-06-22
申请人： RIJKSUNIVERSITEIT UTRECHT , SNIPPE, Harm , WILLERS, Johannes, Marius, Nicolaas , VAN HOUTEN, Arend-Jan , KAMERLING, Johannes, Paulus , VLIEGENTHART, Johannes, Frederik, Gerardus , VAN DAM, Jan, Evert, Gerard
发明人： RIJKSUNIVERSITEIT UTRECHT
IPC分类号： A61K39/02
CPC分类号： A61K9/1271 , A61K9/127 , A61K39/092 , A61K2039/55555 , A61K2039/6018
摘要： Vaccines against pathogenic bacteria with capsular polysaccharides comprising oligosacharides which are anchored in a liposome via amines, as well as a process for preparing such vaccines wherein capsular polysaccharides are hydrolyzed to oligosaccharides with 6-10 monosaccharide units, thereafter selected oligosaccharides with antigenic properties are reductively aminated and the obtained glycolipids are anchored in a liposome.

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