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1. 发明申请

WO2013076646A1 A NEW DIAZA-BENZOFLUORANTHENE DERIVATIVE AS DRUG 审中-公开
标题翻译：新的DIAZA-BENZOFLUORANTHENE衍生物作为药物
公开(公告)号：WO2013076646A1
公开(公告)日：2013-05-30
申请号：PCT/IB2012/056561
申请日：2012-11-20
申请人： RICHTER GEDEON NYRT.
发明人： ÉLES, János , BORZA, István , TIHANYI, Károly , HORVÁTH, Csilla Mária , BALÁZS, Ottília , VASTAG, Mónika , LASZY, Judit , GYERTYÁN, István , KOCSIS, Pál
IPC分类号： C07D461/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D461/00
摘要： The present invention relates to a new 16-tetrazolyl-eburnamenine of formula (I) or pharmaceutically acceptable salt thereof and/or hydrates and/or solvates thereof. The invention also relates to the pharmaceutical compositions containing the compound of formula (I) or hydrates or solvates thereof as active ingredient. The invention also relates to the synthesis of compounds of formula (I), and the chemical and pharmaceutical manufacture of medicaments containing these compounds, as well as the methods of treatment of mammals - including human - with these compounds. There is still further provided methods for the treatment of neurological, neurodegenerative and psychiatric diseases or conditions as well as comprising the step of administering to human, in need of such treatment and/or prophylaxis a pharmaceutical composition comprising a therapeutically effective amount of compound of formula (I) or pharmaceutically acceptable salts thereof alone or together with at least one and a pharmaceutically acceptable carrier and/or diluent.
摘要翻译：本发明涉及式（I）的新的16-四唑基 - 本白他宁或其药学上可接受的盐和/或其水合物和/或溶剂合物。本发明还涉及含有式（I）化合物或其水合物或溶剂合物作为活性成分的药物组合物。本发明还涉及式（I）化合物的合成，以及包含这些化合物的药物的化学和药物制备以及用这些化合物治疗哺乳动物（包括人）的方法。还有进一步提供治疗神经系统疾病，神经退行性疾病和精神病学疾病或病症的方法，并且还包括向人类施用需要这种治疗和/或预防药物组合物的步骤，所述药物组合物包含治疗有效量的式（I）或其药学上可接受的盐单独或与至少一种和药学上可接受的载体和/或稀释剂一起。

2. 发明申请

WO2008142461A1 METABOLITES OF (THIO)CARBAMOYL-CYCLOHEXANE DERIVATIVES 审中-公开
标题翻译：（THIO）羧甲基环己烷衍生物的代谢物
公开(公告)号：WO2008142461A1
公开(公告)日：2008-11-27
申请号：PCT/HU2008/000046
申请日：2008-05-15
申请人： RICHTER GEDEON NYRT. , ÁGAINÉ CSONGOR, Éva , KIRSCHNER, Norbert, Antal , SCHMIDT, Éva , GYERTYÁN, István , KISS, Béla
发明人： ÁGAINÉ CSONGOR, Éva , KIRSCHNER, Norbert, Antal , SCHMIDT, Éva , GYERTYÁN, István , KISS, Béla
IPC分类号： C07D295/155 , C07D295/24 , A61K31/495 , A61P25/00
CPC分类号： C07D295/135 , C07D295/24
摘要： The present invention relates to metabolites of(thio)-carbamoyl cyclohexane derivatives, particularly, metabolites of tr a ns -4-{2-[4-(2 , 3-dichlorophenyl)-piperazin-1-yl]- ethyl}-N , N-dimemylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing the same and to their use in the treatment and/or prevention of a conditions which requires modulation of dopamine receptors.
摘要翻译：本发明涉及（硫代） - 氨基甲酰基环己烷衍生物，特别是tr的代谢物的代谢物

3. 发明申请

WO2008125891A3 PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3 /D2 RECEPTOR LIGANDS 审中-公开
公开(公告)号：WO2008125891A3
公开(公告)日：2008-10-23
申请号：PCT/HU2008/000032
申请日：2008-04-10
申请人： RICHTER GEDEON NYRT , BARTÁNÉ SZALAI, Gizella , ÁGAINÉ CSONGOR, Éva , DOMÁNY, György , GYERTYÁN, István , KISS, Béla , LASZY, Judit , SÁGHY, Katalin , SCHMIDT, Éva , FARKAS, Sándor , KOMLÓDI, Zsolt
发明人： BARTÁNÉ SZALAI, Gizella , ÁGAINÉ CSONGOR, Éva , DOMÁNY, György , GYERTYÁN, István , KISS, Béla , LASZY, Judit , SÁGHY, Katalin , SCHMIDT, Éva , FARKAS, Sándor , KOMLÓDI, Zsolt
IPC分类号： C07D239/48 , A61K31/506 , A61P25/00
摘要： The present invention relates to new dopamine D 3 and D 2 ligands of formula (I): wherein Rl, R2 and Q are as described herein, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof. The invention also relates to processes for preparing the same, to compositions containing the same and to their use in the treatment and/or prevention of conditions which requires modulation of dopamine receptors.

4. 发明申请

WO2010001185A1 THIENO [2,3-B] PYRIDINE COMPOUNDS WITH MGLUR ACTIVITY 审中-公开
标题翻译：噻吩[2,3-B]吡啶化合物与MGLUR活性
公开(公告)号：WO2010001185A1
公开(公告)日：2010-01-07
申请号：PCT/HU2009/000052
申请日：2009-06-25
申请人： RICHTER GEDEON NYRT. , GYERTYÁN, István , NÓGRÁDI, Katalin , ELEKES, Ottília , VASTAG, Mónika , BOBOK, Amrita, Ágnes , SÁGHY, Katalin
发明人： GYERTYÁN, István , NÓGRÁDI, Katalin , ELEKES, Ottília , VASTAG, Mónika , BOBOK, Amrita, Ágnes , SÁGHY, Katalin
IPC分类号： C07D495/04 , A61K31/4365 , A61P1/04 , A61P9/00 , A61P13/10 , A61P21/00 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/02
CPC分类号： C07D495/04
摘要： A compound of formula (I), wherein X is Cl or F or hydrates, solvates, or salts thereof for use treating of mGluR1 and mGluR5 receptor-mediated disorders.
摘要翻译：式（I）化合物，其中X为Cl或F或其水合物，溶剂合物或其盐，用于治疗mGluR1和mGluR5受体介导的病症。

5. 发明申请

WO2008075118A1 NOVEL CB1 ANTAGONISTS AND THEIR PREPARATION 审中-公开
标题翻译：新的CB1拮抗剂及其制备
公开(公告)号：WO2008075118A1
公开(公告)日：2008-06-26
申请号：PCT/HU2007/000126
申请日：2007-12-19
申请人： RICHTER GEDEON NYRT. , FISCHER, János , SZEMZÖ, Attila , SZABÓ, György , ERDÉLYI, Péter , VARGA, Balázs , GYERTYÁN, István , SZIKRA, Judit , VASTAG, Mónika
发明人： FISCHER, János , SZEMZÖ, Attila , SZABÓ, György , ERDÉLYI, Péter , VARGA, Balázs , GYERTYÁN, István , SZIKRA, Judit , VASTAG, Mónika
IPC分类号： C07D401/12 , C07D231/14
CPC分类号： C07D231/14 , C07D401/12 , C07D403/12
摘要： The invention relates to new compounds of general formula (I) acting as CB1 antagonists and to their preparation. The compounds according to this invention can be used for the treatment of obesity, behavioral addictions, psychiatric and metabolic disorders.
摘要翻译：本发明涉及作为CB1拮抗剂的通式（I）的新化合物及其制备。根据本发明的化合物可用于治疗肥胖症，行为成瘾症，精神病学和代谢性疾病。

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