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    • 2. 发明申请
    • ABLATIVE, RENEWABLE, MULTI-FUNCTIONAL PROTECTIVE COATING FOR DENTAL SURFACES
    • 可口可乐,牙科表面多功能保护涂层
    • WO2016077710A1
    • 2016-05-19
    • PCT/US2015/060603
    • 2015-11-13
    • RHODIA OPERATIONSREIERSON, Robert, LeeBENDEJACQ, Denis
    • REIERSON, Robert, LeeBENDEJACQ, Denis
    • A61K8/55A61K8/49A61K8/72A61K8/02A61Q11/00
    • A61K8/817A61K8/8164A61K2800/28A61Q11/00C07F9/091C07F9/5721
    • An oral care composition in the form of a toothpaste, tooth gel, dentifrice, tooth powder, prophy paste, mouthwash, rinse, tooth mousse, dental floss, chewing gum, soluble oral care strip or film for direct application or attachment to an oral surface, or lozenge for combating dental caries, erosion, hypersensitivity, and/or staining that includes an orally acceptable carrier and a copolymer of a first a, β-ethylenically unsaturated phosphate compound (A); and one or more a, β-ethylenically unsaturated co- monomers, at least one of which is other than an allyl-functional co-monomer, wherein (A) is an allyl phosphate compound of formula (A): [CH 2 =CH-CH 2 -O(R 1 O) a (R 2 O) b ] x P(O)(OM) 3-x wherein, R 1 is a substituted or unsubstituted (C 2 -C 4 ) alkylene moiety; R 2 is a substituted or unsubstituted (C 2 -C 4 ) alkylene moiety; M is identical or different, hydrogen, alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid; X is 1 or 2, a is from 1 to 20; and b is from 0 to 20. Methods for combating dental caries, erosion, hypersensitivity, and/or staining are also provided.
    • 口腔护理组合物,其形式为牙膏,牙胶,洁牙剂,牙粉,漱口剂,漱口剂,漂洗剂,牙膏,牙线,口香糖,可直接使用或附着于口腔表面的可溶性口腔护理条或膜 ,或抗皱龋齿,侵蚀,超敏反应和/或染色的锭剂,包括口服可接受的载体和第一种α,β-烯属不饱和磷酸酯化合物(A)的共聚物; 和一种或多种α-烯属不饱和共聚单体,其中至少一种不是烯丙基官能的共聚单体,其中(A)是式(A)的烯丙基磷酸酯化合物:[CH 2 = CH- CH2-O(R1O)a(R2O)b] xP(O)(OM)3-x其中R1是取代或未取代的(C2-C4)亚烷基部分; R2是取代或未取代的(C2-C4)亚烷基部分; M是相同或不同的,氢,碱金属,铵,质子化的烷基胺,质子化的链烷醇胺或质子化的碱性氨基酸; X为1或2,a为1至20; 并且b为0至20.还提供了防止龋齿,侵蚀,超敏反应和/或染色的方法。