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    • 2. 发明申请
    • METHODS OF PRODUCING CROSS-LINKED POLYSACCHARIDE PARTICLES
    • 生产交联多糖颗粒的方法
    • WO2010014219A1
    • 2010-02-04
    • PCT/US2009/004374
    • 2009-07-29
    • RHODIA, INC.LUCZAK, KraigMABILLE, Caroline
    • LUCZAK, KraigMABILLE, Caroline
    • C08F251/00
    • C08B37/0096A61K8/737A61K2800/54A61Q5/02C08J3/24
    • A substantially boron-free method for making a cationic guar comprising: reacting particles of polysaccharide with a derivatizing agent to produce derivatized polysaccharide particles, washing the particles, and contacting, prior to or after the step of washing, the particles with a crosslinking agent compound. Also disclosed are methods for making crosslinked derivatized polysaccharides that include contacting particles of a polysaccharide with a first crosslinking agent and/or second cross-linking agent in an aqueous medium under conditions appropriate to intra-particulately crosslink the particles. The first and/or second crosslinking agent can include a copper compound, a magnesium compound, a calcium compound, an aluminum compound, p-benzoquinone, glyoxal, a titanium compound, a dicarboxylic acid, a dicarboxylic acid salt, a phosphite compound or a phosphate compound. The crosslinked polysaccharide of the present invention is especially useful in personal care formulations, especially formulations comprising silicone since it improves silicone deposition.
    • 一种用于制备阳离子瓜耳胶的基本上无硼的方法,包括:使多糖颗粒与衍生剂反应以产生衍生的多糖颗粒,洗涤颗粒,并在洗涤步骤之前或之后使用交联剂化合物 。 还公开了制备交联的衍生多糖的方法,其包括使多糖的颗粒与第一交联剂和/或第二交联剂在水性介质中在适于使颗粒特别交联的条件下接触。 第一和/或第二交联剂可以包括铜化合物,镁化合物,钙化合物,铝化合物,对苯醌,乙二醛,钛化合物,二羧酸,二羧酸盐,亚磷酸酯化合物或 磷酸盐化合物。 本发明的交联多糖特别可用于个人护理制剂,特别是包含硅酮的制剂,因为它改善了硅氧烷沉积。
    • 4. 发明申请
    • CROSSLINKED POLYSACCHARIDES AND METHODS OF PRODUCTION THEREOF
    • 交联多糖及其生产方法
    • WO2009099567A2
    • 2009-08-13
    • PCT/US2009/000617
    • 2009-01-30
    • RHODIA INC.MABILLE, CarolineLUCZAK, Kraig
    • MABILLE, CarolineLUCZAK, Kraig
    • A61K31/715C07H1/00
    • C07H1/00
    • A substantially boron-free method for making a cationic guar comprises reacting particles of polysaccharide with a derivatizing agent to produce derivatized polysaccharide particles, washing the derivatized polysaccharide particles, and contacting, prior to or after the washing step, the particles with a glyoxal compound in order to crosslink the derivatized polysaccharide particles. Also disclosed are methods for making crosslinked derivatized polysaccharides, comprising (a) contacting particles of a polysaccharide with a titanium compound in an aqueous medium having an alkaline pH under conditions appropriate to intra-particulately crosslink the particles; (b) reacting, prior to or after the step of contacting the particles of polysaccharide with the titanium compound, the particles of polysaccharide with a derivatizing agent under conditions appropriate to produce derivatized polysaccharide particles; (c) washing the titanium crosslinked and derivatized particles; (d) contacting, concurrently with or after the step of washing the titanium crosslinked and derivatized particles, such particles with an aqueous medium having an acidic pH under conditions appropriate to substantially de-crosslink the particles; and (e) contacting, concurrently with or after step (d), the de-crosslinked particles with a glyoxal compound under conditions appropriate to intra-particulately crosslink the particles. The crosslinked cationic guar of the present invention is especially useful in home and personal care formulations, especially formulations comprising silicone since it improves silicone deposition.
    • 用于制备阳离子瓜尔胶的基本上无硼的方法包括使多糖的颗粒与衍生化试剂反应以产生衍生化的多糖颗粒,洗涤衍生的多糖颗粒,以及在洗涤步骤之前或之后将所述颗粒与乙二醛化合物接触 以使衍生的多糖颗粒交联。 还公开了制备交联的衍生多糖的方法,其包括(a)在适于使颗粒特异性交联的条件下,在具有碱性pH的水性介质中使多糖的颗粒与钛化合物接触; (b)在使多糖颗粒与钛化合物接触的步骤之前或之后使多糖的颗粒与衍生剂在适于产生衍生化多糖颗粒的条件下反应; (c)洗涤钛交联和衍生的颗粒; (d)在使钛交联和衍生的颗粒洗涤步骤的同时或之后与具有酸性pH的水性介质在适于使颗粒基本上脱交的条件下接触; 和(e)在步骤(d)的同时或之后使脱乙烯基化合物在适于使颗粒特异性交联的条件下接触。 本发明的交联阳离子瓜尔胶在家用和个人护理制剂中尤其有用,特别是含有硅酮的制剂,因为它改善了硅氧烷沉积。