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1. 发明申请

WO2017087789A1 FUNCTIONAL ANTIBODY FRAGMENT COMPLEMENTATION FOR A TWO-COMPONENTS SYSTEM FOR REDIRECTED KILLING OF UNWANTED CELLS 审中-公开
标题翻译：功能性抗体片段补偿的双组分系统重新杀死未知细胞
公开(公告)号：WO2017087789A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062748
申请日：2016-11-18
申请人： REVITOPE LIMITED , COBBOLD, Mark
发明人： COBBOLD, Mark
IPC分类号： A61K39/395 , A61K45/06 , A61K47/48 , A61P35/00 , C07K14/47 , C07K16/26
CPC分类号： C07K16/2809 , A61K38/00 , A61K39/39558 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K16/2896 , C07K16/30 , C07K16/303 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/94
摘要： A targeted T-cell engaging agent for treating a condition characterized by the presence of unwanted cells includes (a) a targeting moiety that is capable of targeting the unwanted cells; (b) a first T-cell engaging domain capable of T-cell engaging activity when binding a second T-cell engaging domain, wherein the second T-cell engaging domain is not part of the agent; (c) at least one inert binding partner capable of binding to the first T-cell engaging domain such that the first T-cell engaging domain does not bind to the second T-cell engaging domain unless the inert binding partner is removed; and (d) at least one cleavage site separating the first T-cell engaging domain and the inert binding partner, wherein the cleavage site is: (i) cleaved by an enzyme expressed by the unwanted cells; (ii) cleaved through a pHsensitive cleavage reaction inside the unwanted cell; (iii) cleaved by a complementdependent cleavage reaction.
摘要翻译：用于治疗以存在不需要的细胞为特征的病症的靶向T细胞接合剂包括（a）能够靶向不需要的细胞的靶向部分; （b）当绑定第二T细胞参与域时能够进行T细胞参与活动的第一T细胞参与域，其中所述第二T细胞参与域不是所述代理的一部分; （c）至少一个能够结合第一T细胞参与结构域的惰性结合配偶体，使得第一T细胞参与结构域不结合第二T细胞参与结构域，除非除去了惰性结合配偶体; （d）至少一个分离第一T细胞接合结构域和惰性结合配偶体的切割位点，其中切割位点是：（i）被不需要的细胞表达的酶切割; （ii）通过不需要的细胞内的pH敏感裂解反应裂解; （iii）被补体依赖性切割反应切割。

2. 发明申请

WO2008067654A1 METHOD AND SYSTEM FOR COMMUNICATING BETWEEN DEVICES 审中-公开
标题翻译：用于在设备之间进行通信的方法和系统
公开(公告)号：WO2008067654A1
公开(公告)日：2008-06-12
申请号：PCT/CA2007/002178
申请日：2007-12-05
申请人： NORTEL NETWORKS LIMITED , COBBOLD, Mark
发明人： COBBOLD, Mark
IPC分类号： H04L29/02 , H04L12/16 , H04L12/58 , H04Q7/22
CPC分类号： H04W4/18 , H04L51/04 , H04L51/066 , H04L65/103 , H04L65/4061 , H04W4/10 , H04W8/18 , H04W76/45 , H04W92/02
摘要： A communication service is provided that enables end-users to interactively communicate over a communication channel using individually selected communication interfaces at each end-point of the channel. Each end-user may select a receive interface that presents communications to the end-user in a format that is most desirable to the end-user. As a result, an end-user is no longer subjected to the interface selected by an initiator of a communication. The communication service may be used to allow users of instant messaging (IM) services to seamlessly communicate with users of voice services such as Push-to-Talk-over-Cellular (PoC) services.
摘要翻译：提供了一种通信服务，其使最终用户能够在通道的每个端点处使用单独选择的通信接口通过通信信道进行交互式通信。每个最终用户可以选择以最终用户最需要的格式向最终用户呈现通信的接收接口。结果，最终用户不再受到由通信的发起者选择的接口的影响。通信服务可以用于允许即时消息（IM）服务的用户与语音服务的用户无缝地通信，例如一键通蜂窝（PoC）服务。

3. 发明申请

WO2010049672A2 METHODS AND PRODUCTS 审中-公开
标题翻译：方法和产品
公开(公告)号：WO2010049672A2
公开(公告)日：2010-05-06
申请号：PCT/GB2009/002523
申请日：2009-10-22
申请人： THE UNIVERSITY OF BIRMINGHAM , JEFFERIS, Royston , COBBOLD, Mark , PLANT, Timothy , GOODALL, Delia Margaret , DRAYSON, Mark Trehane
发明人： JEFFERIS, Royston , COBBOLD, Mark , PLANT, Timothy , GOODALL, Delia Margaret , DRAYSON, Mark Trehane
IPC分类号： G01N33/53 , C07K16/42
CPC分类号： C07K16/42 , C07K2317/56 , C07K2317/565 , G01N33/6857
摘要： The present invention provides improved methods for measuring the ratio of free K immunoglobulin light chain molecules to free λ immunoglobulin light chain molecules in a test sample, using a monoclonal antibody that specifically binds to free K and a monoclonal antibody that specifically binds to free λ. The application also provides specific monoclonal antibodies that can be used in the method of the invention, as well as kits containing said monoclonal antibodies.
摘要翻译：本发明提供了用于测量游离K免疫球蛋白轻链分子与游离κ的比例的改进方法。使用特异性结合游离K的单克隆抗体和特异性结合游离α的单克隆抗体，测试样品中的免疫球蛋白轻链分子。本申请还提供可用于本发明方法的特异性单克隆抗体，以及含有所述单克隆抗体的试剂盒。

4. 发明申请

WO2016126611A1 TARGETING MOIETY PEPTIDE EPITOPE COMPLEXES HAVING A PLURALITY OF T-CELL EPITOPES 审中-公开
标题翻译：靶向具有多种T细胞抗原决定簇的环肽类抗生素复合物
公开(公告)号：WO2016126611A1
公开(公告)日：2016-08-11
申请号：PCT/US2016/015983
申请日：2016-02-01
申请人： THE UNIVERSITY OF BIRMINGHAM , COBBOLD, Mark , MILLAR, David
发明人： COBBOLD, Mark , MILLAR, David
IPC分类号： A61K47/48 , A61P35/00 , A61P35/02 , A61P37/00
CPC分类号： A61K39/245 , A61K47/646 , A61K47/6811 , A61K47/6849 , A61K47/6881 , A61K2039/585 , A61K2039/6056 , C12N2710/16134
摘要： A variety of targeting moiety peptide epitope complexes (TPECs) are described in different embodiments. In each of the embodiments, however, a targeting moiety may be used to deliver the TPEC to an area of unwanted cells, allowing for a therapeutic effect to be delivered locally. The TPEC also contains a plurality of T-cell epitopes. The TPEC further comprises cleavage sites that release the T-cell epitopes from the targeting agent, and in some embodiments from each other, when they are in the microenvironment of the unwanted cells. Although the arrangement and number of T-cell epitopes varies in different embodiments described herein, once cleaved from the targeting agent (and any neighboring T-cell epitopes), the T-cell epitopes function by stimulating an immune response against the unwanted cells.
摘要翻译：在不同的实施方案中描述了各种靶向部分肽表位复合物（TPEC）。然而，在每个实施方案中，靶向部分可以用于将TPEC递送到不需要的细胞的区域，允许局部递送治疗效果。 TPEC还含有多个T细胞表位。 TPEC还包含从靶向剂释放T细胞表位的切割位点，并且在一些实施方式中，当它们处于不想要的细胞的微环境中时。虽然T细胞表位的排列和数量在本文描述的不同实施方案中变化，但是一旦从靶向剂（和任何相邻的T细胞表位）切割出来，T细胞表位通过刺激针对不需要的细胞的免疫应答起作用。

5. 发明申请

WO2008034264A1 METHOD AND APPARATUS FOR ENABLING COMMUTER GROUPS 审中-公开
标题翻译：用于启动通讯组的方法和装置
公开(公告)号：WO2008034264A1
公开(公告)日：2008-03-27
申请号：PCT/CA2007/001702
申请日：2007-09-24
申请人： NORTEL NETWORKS LIMITED , COBBOLD, Mark
发明人： COBBOLD, Mark
IPC分类号： G06Q50/00 , G06F19/00 , H04L12/16 , G08G1/00 , H04Q7/20
CPC分类号： G01C21/3691 , G01C21/34 , G01C21/3438 , G06Q10/10 , G08G1/202
摘要： A commuter groups service (CGS) allows commuters to join commuter groups so that they are able to socialize while commuting. Through the commuter groups, the users may share commuting routes, traffic updates, road conditions, and other information. Group members may arrange car pools, short term riding arrangements, and may anonymously or directly contact each other. The CGS may collect group member position information, e.g. GPS information, to enable the CGS to calculate traffic conditions and to select location specific information for group members. The system may include an on-line service accessible through a computer or wireless networking device. The user may log into the CGS, create or modify a user profile, and join groups of their choosing. Groups may be associated with specific events or with getting to/from work. Commuter groups may be formed for commuters that use private vehicles and/or public transportation.
摘要翻译：通勤团体服务（CGS）允许乘客加入通勤团体，使他们能够在通勤时进行社交。通过通勤组，用户可以共享通勤路线，交通更新，路况等信息。小组成员可以安排汽车游泳池，短期骑马安排，并可匿名或直接相互联系。 CGS可以收集组成员位置信息，例如 GPS信息，使CGS能够计算交通状况并选择组成员的位置特定信息。该系统可以包括通过计算机或无线网络设备可访问的在线服务。用户可以登录CGS，创建或修改用户配置文件，并加入他们选择的组。组可能与特定事件或上班/下班有关。可以为使用私家车和/或公共交通工具的通勤者组建通勤团体。

6. 发明申请

WO2012123755A1 RE-DIRECTED IMMUNOTHERAPY 审中-公开
标题翻译：重新定向免疫治疗
公开(公告)号：WO2012123755A1
公开(公告)日：2012-09-20
申请号：PCT/GB2012/050577
申请日：2012-03-15
申请人： THE UNIVERSITY OF BIRMINGHAM , COBBOLD, Mark , MILLAR, David
发明人： COBBOLD, Mark , MILLAR, David
IPC分类号： A61K47/48 , A61K39/12 , A61P37/00
CPC分类号： A61K47/48715 , A61K38/2013 , A61K38/2026 , A61K38/204 , A61K39/08 , A61K39/12 , A61K39/145 , A61K39/235 , A61K39/245 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/646 , A61K47/6811 , A61K47/6855 , A61K47/6867 , A61K47/6889 , A61K2039/505 , A61K2039/585 , A61K2039/6056 , A61K2039/627 , C07K14/005 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K2317/24 , C07K2317/622 , C07K2319/33 , C07K2319/50 , C12N7/00 , C12N2710/16134
摘要： The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.
摘要翻译：本发明提供了用于预防或治疗特征在于存在不想要的细胞的病症的药剂，所述药剂包含：（i）靶向部分，其能够靶向不需要的细胞; 和（ii）T细胞抗原，其中通过选择性裂解不想要的细胞附近的试剂中的切割位点，可以从靶向部分释放T细胞抗原。

7. 发明申请

WO2011149909A2 CLASS I MHC PHOSPHOPEPTIDES FOR CANCER IMMUNOTHERAPY AND DIAGNOSIS 审中-公开
标题翻译：第一类MHC磷酸化酶对于癌症的免疫和诊断
公开(公告)号：WO2011149909A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037699
申请日：2011-05-24
申请人： HUNT, Donald F. , SHABANOWITZ, Jeffrey , COTTINE, Jennifer , ENGLISH, Ann M. , NORRIS, Andrew , ENGELHARD, Victor H. , COBBOLD, Mark , CUMMINGS, Kara L. , ZARLING, Angela , OBENG, Rebecca C.
发明人： HUNT, Donald F. , SHABANOWITZ, Jeffrey , COTTINE, Jennifer , ENGLISH, Ann M. , NORRIS, Andrew , ENGELHARD, Victor H. , COBBOLD, Mark , CUMMINGS, Kara L. , ZARLING, Angela , OBENG, Rebecca C.
IPC分类号： C07K14/74 , C07K7/00 , C07K16/20 , A61K38/17 , A61K39/395 , G01N33/68 , A61P35/00
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0011 , C07K7/08 , C07K14/70539 , C07K16/18 , G01N33/5743 , G01N33/57492 , G01N33/6893 , G01N2333/70539 , G01N2440/14
摘要： A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.
摘要翻译：一组磷酸化肽由黑素瘤细胞表面上的HLA A * 0101，A * 0201，A * 0301，B * 4402，B * 2705，B * 1402和B * 0702呈现。它们具有（a）刺激对癌症的免疫应答的潜力，（b）在过继性T细胞治疗或疫苗中用作免疫治疗剂，（c）促进手术病理样品中肿瘤边界的抗体识别，和（d）作为早期检测疾病的生物标志物。磷酸化肽也可用于其他癌症。

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