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1. 发明申请

WO2009047494A1 APPARATUS FOR STEREOTACTIC NEUROSURGERY 审中-公开
标题翻译：装置神经外科手术
公开(公告)号：WO2009047494A1
公开(公告)日：2009-04-16
申请号：PCT/GB2008/003397
申请日：2008-10-06
申请人： RENISHAW PLC , DERRICK, Hugo, George , FIELDER, Paul, David , GILL, Steven, Streatfield
发明人： DERRICK, Hugo, George , FIELDER, Paul, David , GILL, Steven, Streatfield
IPC分类号： A61B19/00 , A61B17/34
CPC分类号： A61B17/3403 , A61B17/3415 , A61B17/3423 , A61B90/11 , A61B2017/3407 , A61B2090/103
摘要： A skull mount (50;150;170;200;300) is described that is attachable to a hole (60) formed in the skull. The skull mount (50;150;170;200;300) comprises an alignment guide (62;152;172;216;306) defining an alignment axis (22;210;312) along which neurosurgical instruments can be passed. The skull mount, when attached to a hole in a skull, is arranged such that it does not substantially protrude from the outermost surface of the skull and does not extend into the brain parenchyma. Also described is a neurosurgical alignment instrument (30,206) for aligning such a skull mount (50;150;170;200;300) that comprises an elongate shaft (32) and an element (34,36) protruding from the distal end of the elongate shaft (32) for engaging and aligning the alignment guide (62;152;172;216;306) of an associated skull mount (50;150;170;200;300). When the alignment instrument is engaged with a skull mount attached to a hole formed in the skull, the protruding element passes through the alignment guide of the skull mount and into the cortex of the subject's brain.
摘要翻译：描述了可附接到形成在颅骨中的孔（60）的颅骨支座（50; 150; 170; 200; 300）。颅骨支架（50; 150; 170; 200; 300）包括限定可以通过神经外科器械的对准轴线（22; 210; 312）的对准引导件（62; 152; 172; 216; 306）颅骨安装件当附着在颅骨中的孔时被布置成使得其不会从颅骨的最外表面突出并且不延伸到脑实质中。还描述了一种用于对准这样的颅骨支架（50; 150; 170; 200; 300）的神经外科对准仪器（30,206），所述颅骨支架包括细长轴（32）和从所述头部远端突出的元件（34,36）细长轴（32），用于接合和对准相关联的颅骨支架（50; 150; 170; 200; 300）的对准引导件（62; 152; 172; 216; 306）。当对准仪器与附接到形成在颅骨中的孔的颅骨支架接合时，突出元件穿过颅骨支架的对准引导件并进入受试者大脑的皮层。

2. 发明申请

WO2008062173A1 NEUROLOGICAL APPARATUS COMPRISING A PERCUTANEOUS ACCESS DEVICE 审中-公开
标题翻译：包含PERCUTANEUSUS访问设备的神经病学设备
公开(公告)号：WO2008062173A1
公开(公告)日：2008-05-29
申请号：PCT/GB2007/004438
申请日：2007-11-21
申请人： RENISHAW PLC , GILL, Steven, Streatfield , FIELDER, Paul, David
发明人： GILL, Steven, Streatfield , FIELDER, Paul, David
IPC分类号： A61M1/00
CPC分类号： A61M39/0247 , A61M2039/025 , A61M2039/0264 , A61M2039/0276 , A61M2039/0282 , A61M2039/0285 , A61M2039/0291 , A61M2210/0693
摘要： Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus comprises at least one intracranial catheter and a percutaneous access device (50;140;150;160). The percutaneous access device comprises a body (10;52;152) having at least one extracorporeal surface (22;68) and at least one subcutaneous surface, the body (10;52) defining at least one port (12;116) for connection to an implanted intracranial catheter. The port (12;116) is accessible from the extracorporeal surface (22;68) of the device, but is provided with a seal (14;112;142;146) such as a rubber bung between the lumen of the port and the extracorporeal surface (22;68). The percutaneous access device may have more than two ports (12;116) and/or a flange (26;54). A method of implanting the percutaneous access device(50;140;150;160) is also described.
摘要翻译：描述了将治疗剂递送到受试者的中枢神经系统的装置。该装置包括至少一个颅内导管和经皮进入装置（50; 140; 150; 160）。经皮进入装置包括具有至少一个体外表面（22; 68）和至少一个皮下表面的本体（10; 52; 152），所述主体（10; 52）限定至少一个端口（12; 116），用于连接到植入的颅内导管。端口（12; 116）可从装置的体外表面（22; 68）接近，但是设置有密封件（14; 112; 142; 146），例如在端口的内腔和体外表面（22; 68）。经皮进入装置可以具有多于两个的端口（12; 116）和/或凸缘（26; 54）。还描述了植入经皮进入装置（50; 140; 150; 160）的方法。

3. 发明申请

WO2006134357A1 RF COIL ASSEMBLY FOR USE IN MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：射频线圈组件用于磁共振成像
公开(公告)号：WO2006134357A1
公开(公告)日：2006-12-21
申请号：PCT/GB2006/002179
申请日：2006-06-14
申请人： RENISHAW PLC , GILL, Steven, Streatfield , STRATTON, Mathew, David, Frederick
发明人： GILL, Steven, Streatfield , STRATTON, Mathew, David, Frederick
IPC分类号： G01R33/28
CPC分类号： G01R33/28 , G01R33/34046
摘要： An RF coil assembly (70) for use with magnetic resonance imaging (MRI) apparatus is described. The RF coil assembly (70) comprises one or more coil elements (30, 32, 34, 36; 50, 52, 54, 56, 58, 60; 72, 74, 76, 78) capable of receiving electromagnetic radiation and is capable of being directly attached to a stereotactic base ring (84). The RF coil assembly may comprise a localiser box (10) having fiducial markers (22). A corresponding attachment apparatus (86) is also described for optimising the attachment position of a stereotactic base ring (84) to a subject's head. The attachment apparatus (86) comprises one or more fixing elements (85) that allow the attachment apparatus (86) to be releasably attached to a stereotactic base ring (84). In one embodiment, the internal dimensions of the attachment apparatus (86) are selected to be substantially the same as the internal dimensions of an RF coil assembly (70). Corresponding methods are also described.
摘要翻译：描述了用于磁共振成像（MRI）装置的RF线圈组件（70）。 RF线圈组件（70）包括能够接收电磁辐射的一个或多个线圈元件（30,32,34,36; 50,52,54,56,58,60,72,74,76,78），并且能够直接连接到立体定向基环（84）上。 RF线圈组件可以包括具有基准标记（22）的定位盒（10）。还描述了相应的附接装置（86），用于优化立体定向基环（84）与被检者头部的连接位置。附接装置（86）包括一个或多个固定元件（85），其允许附接装置（86）可释放地附接到立体定向基环（84）。在一个实施例中，附接装置（86）的内部尺寸被选择为与RF线圈组件（70）的内部尺寸基本相同。还描述了相应的方法。

4. 发明申请

WO2007093778A1 IMPLANTABLE FLUID DISTRIBUTION DEVICE AND METHOD OF FLUID DELIVERY 审中-公开
标题翻译：可植入流体分配装置和流体输送方法
公开(公告)号：WO2007093778A1
公开(公告)日：2007-08-23
申请号：PCT/GB2007/000496
申请日：2007-02-13
申请人： RENISHAW PLC , GILL, Steven, Streatfield , STRATTON, Mathew, David, Frederick , DERRICK, Hugo, George
发明人： GILL, Steven, Streatfield , STRATTON, Mathew, David, Frederick , DERRICK, Hugo, George
IPC分类号： A61M5/142 , A61M39/22 , A61M25/00
CPC分类号： A61M5/14276 , A61M31/002 , A61M39/223 , A61M39/285 , A61M2210/0693 , A61M2210/1021
摘要： An implantable fluid distribution device (32;132;300) is described. The device includes a first inlet (40;310) for receiving fluid under pressure from a remote pump (30;130). A plurality of outlets (50;312) are also provided, each outlet being connectable to a fluid delivery catheter (36). A valve mechanism (42;150;170;190;200) is arranged to control the passage of fluid from the first inlet to the plurality of outlets. Apparatus including the fluid distribution device, an implantable pump (30;130) and a plurality of drug delivery catheters (36) is also described. The fluid distribution device (32;132;300) can be used to delivery drug to multiple regions in the body and the sequential delivery of drugs to different sites in the brain is disclosed.
摘要翻译：描述了可植入流体分配装置（32; 132; 300）。该装置包括用于从远程泵（30; 130）接收压力的流体的第一入口（40; 310）。还设置有多个出口（50; 312），每个出口可连接到流体输送导管（36）。布置有阀机构（42; 150; 170; 190; 200）以控制流体从第一入口到多个出口的通过。还描述了包括流体分配装置，可植入泵（30; 130）和多个药物输送导管（36）的装置。流体分配装置（32; 132; 300）可以用于将药物递送到身体中的多个区域，并且公开了将药物顺序递送到脑中的不同部位。

5. 发明申请

WO2007104953A1 APPARATUS FOR FLUID DELIVERY WITH IMPLANTABLE HOUSING OPENABLE FOR PROVIDING ACCESS TO A FLUID CONNECTOR 审中-公开
标题翻译：用于流体输送的装置，具有可移动的壳体，用于提供对流体连接器的访问
公开(公告)号：WO2007104953A1
公开(公告)日：2007-09-20
申请号：PCT/GB2007/000850
申请日：2007-03-12
申请人： RENISHAW PLC , GILL, Steven, Streatfield
发明人： GILL, Steven, Streatfield
IPC分类号： A61M1/00 , A61M39/00
CPC分类号： A61M39/0208 , A61M5/14 , A61M5/1408 , A61M5/142 , A61M5/14244 , A61M39/0247 , A61M39/10 , A61M2039/0205 , A61M2039/0229 , A61M2039/0232 , A61M2039/025 , A61M2039/1066 , A61M2205/04 , A61M2210/0693
摘要： Fluid delivery apparatus (2,4) is described for the delivery of fluids to regions of the body, especially for delivery to regions of the brain. The apparatus includes a first length of implantable tubing (6) having a first end and a first fluid connector portion (8) attached to the first end of the first length of implantable tubing (6). The first fluid connector portion (8) is releaseably connectable to a complementary second fluid connector portion (18). An implantable housing (36) is also provided for enclosing and protecting the first fluid connector portion (8). The implantable housing (36) is openable to provide access to the first fluid connector portion (8). For example, the housing (36) may have a hinged lid or cover portion. A corresponding method is also described.
摘要翻译：流体输送装置（2,4）被描述为用于将流体输送到身体的区域，特别是用于输送到大脑的区域。该装置包括具有第一端的第一长度的可植入管（6）和连接到第一长度可植入管（6）的第一端的第一流体连接器部分（8）。第一流体连接器部分（8）可释放地连接到互补的第二流体连接器部分（18）。还设置可植入壳体（36）以封闭和保护第一流体连接器部分（8）。可植入壳体（36）可打开以提供对第一流体连接器部分（8）的通路。例如，壳体（36）可以具有铰接盖或盖部分。还描述了相应的方法。

6. 发明申请

WO2007104961A1 A FLUID CONNECTOR FOR FLUID DELIVERY APPARATUS 审中-公开
标题翻译：一种用于流体输送装置的流体连接器
公开(公告)号：WO2007104961A1
公开(公告)日：2007-09-20
申请号：PCT/GB2007/000862
申请日：2007-03-12
申请人： RENISHAW PLC , GILL, Steven, Streatfield
发明人： GILL, Steven, Streatfield
IPC分类号： A61M39/00 , A61M39/10 , F16L39/02
CPC分类号： F16L39/02 , A61M39/10 , A61M39/105 , A61M2039/1072 , A61M2039/1077 , A61M2039/1083 , A61M2039/1088 , Y10S604/905
摘要： A connector (100) is described that comprises a male connector portion (18) that is releaseably connectable to a complimentary female connector portion (8). The male fluid connector portion (18) comprises a plurality of hollow needles (47) that are each in fluid communication with a lumen of the associated tubing (16). The female connector portion (8) comprises plurality of chambers or apertures that comprise a septum seal (84) through which a hollow needle can be passed. Tubing (6) having a plurality of lumens is coupled to the female connector portion (8) and each lumen is in fluid communication with one of said chambers. The male and/or female connector portions also include an alignment guide (50,52, 80, 82) that allows the hollow needles of the male part to be uniquely aligned with the corresponding septum seals of the female part. The use of the connector (100) for medical purposes is described.
摘要翻译：描述了一种连接器（100），其包括可释放地连接到互补的母连接器部分（8）的阳连接器部分（18）。阳性流体连接器部分（18）包括多个中空针（47），每个空心针与相关联的管（16）的内腔流体连通。阴连接器部分（8）包括多个腔室或孔，其包括隔膜密封件（84），空心针可以穿过其中。具有多个管腔的管道（6）联接到阴连接器部分（8），并且每个管腔与所述腔室之一流体连通。阳和/或阴连接器部分还包括对准引导件（50,52,80,82），其允许阳部件的空心针与阴部件的相应的隔垫密封件唯一地对准。描述了用于医疗目的的连接器（100）的使用。

7. 发明申请

WO2004105839A1 IMPLANTABLE PUMP 审中-公开
标题翻译：可植入泵
公开(公告)号：WO2004105839A1
公开(公告)日：2004-12-09
申请号：PCT/GB2003/002339
申请日：2003-05-29
申请人： GILL, Steven, Streatfield
发明人： GILL, Steven, Streatfield
IPC分类号： A61M5/142
CPC分类号： A61M5/14232 , A61M5/14276 , A61M39/0208 , A61M2205/7518 , A61M2210/0693
摘要： The pump includes a metering pump (23) including a rotor (34), at least two lengths of tubing (36) against which the rotor is movable to urge the drug therethrough, and an outlet port associated with each of the at least two lengths of tubing. In this way, a drug may be supplied to more than one neurological target.
摘要翻译：所述泵包括计量泵（23），所述计量泵（23）包括转子（34），至少两个长度的管道（36），所述转子可移动到所述至少两个长度上以推动所述药物通过其中;以及出口与所述至少两个长度的管道。以这种方式，可以向多于一个的神经系统靶标提供药物。

8. 发明申请

WO2002069827A1 PATIENT FRAME CONSTRUCTED FROM COMPOSITE MATERIAL 审中-公开
标题翻译：患者框架由复合材料构成
公开(公告)号：WO2002069827A1
公开(公告)日：2002-09-12
申请号：PCT/GB2002/000856
申请日：2002-02-27
申请人： GILL, Steven, Streatfield , GODBEHERE, Andrew, Paul
发明人： GILL, Steven, Streatfield , GODBEHERE, Andrew, Paul
IPC分类号： A61B19/00
CPC分类号： B29C35/0288 , A61B90/14 , B29L2031/753
摘要： The present invention relates to a frame for attaching to a patient. The present invention also relates to a stereoguide and a member for attaching to a patient. The present invention also relates to a method for manufacturing the frame, member and stereoguide of the present invention. The frame, member and stereoguide are constructed from a composite material comprising a matrix material and electromagnetically inert fibres.
摘要翻译：本发明涉及一种用于附接到患者的框架。本发明还涉及一种立体结构和用于附接到患者的构件。本发明还涉及本发明的框架，构件和立体结构体的制造方法。框架，构件和立体结构由包含基质材料和电磁惰性纤维的复合材料构成。

9. 发明申请

WO2005120548A1 METHOD OF TREATING PARKINSON’S DISEASE IN HUMANS BY DIRECT INFUSION OF GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR INTO THE ZONA INCERTA 审中-公开
标题翻译：通过直接输注细胞系衍生的神经营养因子进入人类的方法治疗帕金森氏病
公开(公告)号：WO2005120548A1
公开(公告)日：2005-12-22
申请号：PCT/GB2005/002332
申请日：2005-06-13
申请人： GILL, Steven, Streatfield
发明人： GILL, Steven, Streatfield
IPC分类号： A61K38/18
CPC分类号： A61K9/0085 , A61K38/185
摘要： A method of treating Parkinson’s disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to the SNc and at least one subthalamic region or, alternatively, to the SNc, at least one sub thalamic region, and at least one putaminal region of the brain of a human in need of treatment thereof. In one aspect of the present invention the GDNF is infused directly into at least one caudal zona incerta and at least one postero-dorsal putamen of the brain through indwelling intraparenchymal brain catheters connected to an implantable pump.
摘要翻译：公开了一种治疗人类帕金森病的方法，其中胶质细胞系衍生的神经营养因子（GDNF）被长期直接施用于SNc和至少一个下丘脑区域，或者替代地，至少一个亚丘脑区域，以及需要治疗的人的脑的至少一个壳蛋白区域。在本发明的一个方面，GDNF通过连接到可植入泵的留置实质内脑导管直接注入至少一个尾静脉和至少一个后背壳壳。

10. 发明申请

WO2003077785A1 CATHETER AND GUIDE TUBE FOR INTRACEREBRAL APPLICATION 审中-公开
标题翻译：导管和导管用于内镜应用
公开(公告)号：WO2003077785A1
公开(公告)日：2003-09-25
申请号：PCT/GB2003/001030
申请日：2003-03-11
申请人： GILL, Steven, Streatfield
发明人： GILL, Steven, Streatfield
IPC分类号： A61B19/00
CPC分类号： A61M39/0247 , A61B90/11 , A61B2090/103 , A61M25/00 , A61M25/02 , A61M2025/0042 , A61M2025/0233 , A61M2039/025 , A61M2039/0273 , A61M2039/0282 , A61M2210/0693
摘要： A catheter for use in neurosurgery, and a method of positioning neurosurgical apparatus. The catheter has a fine tube arranged for insertion into the brain parenchyma of a patient with an external diameter of not more than 1.0 mm. The catheter and method may be used in stereotactically targeting treatment of abnormalities of brain function, and for the infusion of therapeutic agents directly into the brain parenchyma. This is advantageous when a therapeutic agent would have widespread unwanted effects which could be avoided by confining the delivery to the malfunctioning or damaged brain tissue.
摘要翻译：用于神经外科的导管，以及定位神经外科装置的方法。该导管具有布置成插入外直径不大于1.0mm的患者的脑实质的细管。导管和方法可以用于立体定向靶向治疗脑功能异常，以及将治疗剂直接输注到脑实质中。当治疗剂具有广泛的不必要的作用时，这是有利的，这可以通过将输送限制到故障或损坏的脑组织来避免。

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