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1. 发明申请

WO2006091762A1 METHOD FOR ENHANCING ATTENUATION CHARACTERISTIC OF ABSORBENT MATERIALS USEFUL WITH DERMAL AND TRANSDERMAL SUBSTANCE DELIVERY SYSTEMS 审中-公开
标题翻译：增加吸收材料的衰减特性的方法，可用于超导和超导物质输送系统
公开(公告)号：WO2006091762A1
公开(公告)日：2006-08-31
申请号：PCT/US2006/006508
申请日：2006-02-24
申请人： DERMISONICS, INC. , REDDING, Bruce, K. , ROY, Ram, B.
发明人： REDDING, Bruce, K. , ROY, Ram, B.
IPC分类号： A61B17/20
CPC分类号： A61M37/0092 , A61K9/703 , A61K9/7084
摘要： A method for preparing a patch containing at least one substance to be delivered into a user, the method including: providing an absorbent material; introducing the at least one substance into the material; placing the material inside the patch; and, sealing the substance holding material containing patch. The absorbent material may be insonified. The absorbent material may be freeze dried. The absorbent material may be chemically treated. The absorbent material may be cross-linked with the substance.
摘要翻译：一种制备包含至少一种待递送给使用者的物质的贴剂的方法，所述方法包括：提供吸收材料; 将至少一种物质引入材料中; 将材料放入贴片内; 并密封包含贴剂的物质保持材料。吸收材料可以被增强。吸收材料可以被冷冻干燥。可以对吸收材料进行化学处理。吸收材料可以与物质交联。

2. 发明申请

WO2006124957A2 SKIN TREATMENT METHOD AND SYSTEM 审中-公开
标题翻译：皮肤治疗方法与系统
公开(公告)号：WO2006124957A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/019015
申请日：2006-05-16
申请人： DERMISONICS, INC. , REDDING, Bruce, K.
发明人： REDDING, Bruce, K.
IPC分类号： A61B17/03
CPC分类号： A61B17/20 , A61M37/0092
摘要： A skin treatment device including: a housing; at least one ultrasonic transducer contained in the housing; a driver contained in the housing and electrically coupled to the at least one ultrasonic transducer and providing an excitation signal having alternating first and second waveform portions, wherein the first portion has an average imparted power greater than that of the second waveform portion; and, a cap detachably coupled to the housing and containing at least one substance to be delivered to the skin, the at least one substance being within a functional proximity to the transducers when the cap is attached to the housing; wherein, when the cap is attached to the housing and positioned adjacent to the skin, the at least one transducer emits ultrasound responsively to the excitation signal that impinges the substance and skin.
摘要翻译：一种皮肤治疗装置，包括：壳体; 包含在所述壳体中的至少一个超声换能器; 驱动器，其包含在所述壳体中并电耦合到所述至少一个超声换能器并提供具有交替的第一和第二波形部分的激励信号，其中所述第一部分具有比所述第二波形部分的平均赋予功率更大的平均赋予功率; 以及帽，其可拆卸地联接到所述壳体并且包含要被递送到皮肤的至少一种物质，当所述帽附接到所述壳体时，所述至少一种物质在与所述换能器功能接近的功能内; 其中，当所述帽附接到所述壳体并且定位成与所述皮肤相邻时，所述至少一个换能器响应于激发所述物质和皮肤的激发信号发射超声波。

3. 发明申请

WO2004073769A2 METHOD AND APPARATUS FOR TRANSDERMAL DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于超导药物递送装置的方法和装置
公开(公告)号：WO2004073769A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/004972
申请日：2004-02-18
申请人： ENCAPSULATION SYSTEMS, INC. , REDDING, Bruce, K.
发明人： REDDING, Bruce, K.
IPC分类号： A61M
CPC分类号： A61M37/0092
摘要： A transdermal substance delivery device, comprising at least one ultrasonic transducer for generating at least one ultrasonic transmission for inducing movement of at least one substance into a tissue the at least one ultrasonic transmission and the at least one sensor positioned with the at least one transducer to sense reflected ultrasound transmissions, wherein the sensed ultrasound transmissions are indicative of substance actually moved into the tissue. A method for transdermal substance delivery, comprising generating at least one ultrasonic transmission from at least one ultrasonic transducer for inducing movement of at least one substance into a tissue and positioning the at least one ultrasonic transmission and at least one sensor positioned with the at least one transducer to sense reflected ultrasonic transmissions and wherein, the sensed ultrasonic transmissions are indicative of substance actually moved into the tissue.
摘要翻译：一种透皮物质输送装置，包括至少一个超声波换能器，用于产生至少一个超声波传输装置，用于将至少一种物质移动到组织中，所述至少一个超声波传输装置和至少一个传感器与至少一个换能器定位成感测反射的超声波传输，其中所感测的超声波传输指示物质实际上移动到组织中。一种用于透皮物质递送的方法，包括从至少一个超声波换能器产生至少一个超声波传输器，用于引导至少一种物质移动到组织中并且定位所述至少一个超声波传播装置和至少一个位于所述至少一个换能器以感测反射的超声波传输，并且其中，所感测的超声波传输指示物质实际上移动到组织中。

4. 发明申请

WO2016191585A1 ULTRASONIC TREATMENT OF SEEDS 审中-公开
标题翻译：超声处理种子
公开(公告)号：WO2016191585A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/034397
申请日：2016-05-26
申请人： REDDING, Bruce, K.
发明人： REDDING, Bruce, K.
IPC分类号： A01C1/02 , A01C1/06 , G10K11/18
CPC分类号： A01G7/00 , A01C1/00 , A01C1/02 , G10K15/04
摘要： Seeds are subject to ultrasonic treatment to enhance and reduce the time for the germination process. In particular to this invention, the seeds are treated ultrasonically while the seeds are in a dry state. A dry sonification process for a dry seed and apparatus produces a sonically-treated dry seed having an enhanced germination characteristic and providing an enhanced growth characteristic to a plant resulting therefrom. The sonification process includes subjecting the dry seed to be sonically treated to sound energy at a frequency and energy density and applying for a sufficient time such that the sonically-treated dry seed has an enhanced germination characteristic and a plant resulting from the sonically-treated dry seed has an enhanced growth characteristic. The ultrasonic treatment can include applying the ultrasonic sound energy in different alternating waveforms, or in a batch or continuous process, with continuous flow through a helical flow path.
摘要翻译：种子经过超声处理以增强和减少萌发过程的时间。特别是对于本发明，种子处于干燥状态时，超声处理种子。用于干燥种子和设备的干燥超声处理方法产生具有增强的发芽特性的经声处理的干燥种子，并且对由其产生的植物提供增强的生长特性。超声处理方法包括使干燥的种子经受超声波处理，以频率和能量密度发声，并施加足够的时间，使得经过处理的干燥种子具有增强的发芽特性，并且由经声处理的干燥种子具有增强的生长特性。超声处理可以包括以不同的交替波形或以间歇或连续的方式施加超声波能量，连续流过螺旋流动路径。

5. 发明申请

WO2016004443A3 MODIFICATION OF PHARMACEUTICAL PREPARATIONS TO MAKE THEM MORE CONDUCIVE TO ULTRASONIC TRANSDERMAL DELIVERY 审中-公开
公开(公告)号：WO2016004443A3
公开(公告)日：2016-01-07
申请号：PCT/US2015/039831
申请日：2015-07-09
申请人： REDDING, Bruce, K.
发明人： REDDING, Bruce, K.
IPC分类号： A61K9/70
摘要： A method for improving the ultrasonic transdermal delivery of an drug by modifying the excipient solution to which an active ingredient is intermixed in a drug formulation, whereby the choice of excipient solution is modified to one which will be more conducive to ultrasound and will propagate the drug substance at a higher delivery speed through the skin under ultrasonic excitation An example of such an excipient change includes a conversion from a standard dibasic sodium phosphate containing formulation to one using far less sodium or less preservative compositions. Reduced dibasic sodium phosphate formulation. Responsively to insonification thereof, including: reducing the amount of dibasic sodium phosphate in the formulation to provide a reduced dibasic sodium phosphate formulation; and, making a substance in accordance with the reduced dibasic sodium phosphate formulation.

6. 发明申请

WO2012129545A1 SYSTEMS AND METHODS FOR ENHANCING THE DELIVERY OF COMPOUNDS TO SKIN PORES USING ULTRASONIC WAVEFORMS 审中-公开
标题翻译：使用超声波提高化合物对皮肤皮肤输送的系统和方法
公开(公告)号：WO2012129545A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/030463
申请日：2012-03-23
申请人： REDDING, Bruce, K.
发明人： REDDING, Bruce, K.
IPC分类号： A61M37/00
CPC分类号： A61M37/0092 , A61M2037/0007
摘要： The invention is a device for transmitting acoustical energy through the surface of the skin of a patient, coupled with the administration of a compound, for example an acne medication, for the purpose of temporarily expanding the patient's pore size and enhancing the delivery of the compound to the patient's pores. The ultrasonic transducer emits a sonic transmission of variable intensity and frequency for the purpose of enhancing the absorption of compounds that have first been deposited onto the surface of the skin and into skin pores that have been expanded by the ultrasound transmission.
摘要翻译：本发明是一种用于通过患者皮肤表面传递声能的装置，与施用化合物（例如痤疮药物）相结合，以暂时扩大患者的孔径并增强化合物的输送对病人的毛孔。超声波换能器发射可变强度和频率的声波传播，目的是增强首先沉积在皮肤表面上的化合物的吸收并进入由超声波传播扩张的皮肤孔隙中。

7. 发明申请

WO2007028114A2 WOUND TREATMENT METHOD AND SYSTEM 审中-公开
标题翻译：治疗方法和系统
公开(公告)号：WO2007028114A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034401
申请日：2006-09-01
申请人： ENCAPSULATION SYSTEMS, INC. , REDDING, Bruce, K.
发明人： REDDING, Bruce, K.
IPC分类号： A61B17/20
CPC分类号： A61M37/0092 , A61B17/54
摘要： A wound treatment device including: a housing; at least one ultrasonic transducer contained in the housing; a driver contained in the housing and electrically coupled to the at least one ultrasonic transducer and providing an excitation signal having alternating first and second waveform portions, wherein the first portion has an average imparted power greater than that of the second waveform portion; and, a cap detachably coupled to the housing and containing at least one wound care substance to be delivered, the at least one wound care substance being within a functional proximity to the transducers when the cap is attached to the housing; wherein, when the cap is attached to the housing and positioned adjacent to the skin, the at least one transducer emits ultrasound responsively to the excitation signal that impinges the substance and skin.
摘要翻译：一种伤口治疗装置，包括：壳体; 包含在所述壳体中的至少一个超声换能器; 驱动器，其包含在所述壳体中并电耦合到所述至少一个超声换能器并提供具有交替的第一和第二波形部分的激励信号，其中所述第一部分具有比所述第二波形部分的平均赋予功率更大的平均赋予功率; 以及可拆卸地联接到所述壳体并且包含要被输送的至少一个伤口护理物质的帽，当所述帽附接到所述壳体时，所述至少一个伤口护理物质在功能上接近所述换能器; 其中，当所述帽附接到所述壳体并且定位成与所述皮肤相邻时，所述至少一个换能器响应于激发所述物质和皮肤的激发信号发射超声波。

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