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1. 发明申请

WO2016130923A1 IMMUNOASSAYS FOR DIFFRENTIAL DETECTION OF CLOSTRIDIUM DIFFICILE 审中-公开
标题翻译：免疫缺陷病毒的免疫荧光检测
公开(公告)号：WO2016130923A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017758
申请日：2016-02-12
申请人： QUANTERIX CORPORATION , BETHISAREL DEACONESS MEDICAL CENTER, INC.
发明人： POLLOCK, Nira , KEELY, Ciaran , DUFFY, David, C. , SONG, Linan , ZHAO, Mingwei
IPC分类号： G01N33/569 , C07K14/33 , C07K16/12
CPC分类号： C07K14/33 , C07K16/1282 , C07K2317/33 , G01N33/56911 , G01N2333/33
摘要： Ultrasensitive and quantitative assays for detecting toxins of Clostridium difficile , which may involve digital ELISA, are provided. Also provided herein are differential detection assays that allow for distinguishing toxin B of highly virulent Clostridium difficile strains from toxin B of less virulent strains.
摘要翻译：提供了可能涉及数字ELISA的用于检测艰难梭状芽孢杆菌毒素的超敏感和定量测定。本文还提供了差异检测测定法，其允许区分毒性较强毒株毒素B的高毒力艰难梭菌菌株的毒素B.

2. 发明申请

WO2019199865A1 QUANTIFICATION OF BIOMARKERS PRESENT IN DRIED PHYSIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2019199865A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/026636
申请日：2019-04-09
申请人： QUANTERIX CORPORATION
发明人： HRUSOVSKY, Edward, Kevin , WILSON, David , SHAN, Dandan , CHANG, Lei , SONG, Linan , JEROMIN, Andreas , TOBOS, Carmen, Ioana , PATEL, Purvish, Prahlad
IPC分类号： G01N33/53 , A61B5/00
摘要： The present disclosure relates to digital immunoassays performed on diluted samples obtained from dried blood spots, for example dried capillary blood samples, to detect the presence or absence of a physiological condition by quantifying one or a combination of biomarkers at concentrations indicative of the condition.

3. 发明申请

WO2010039180A3 HIGH SENSITIVITY DETERMINATION OF THE CONCENTRATION OF ANALYTE MOLECULES OR PARTICLES IN A FLUID SAMPLE 审中-公开
公开(公告)号：WO2010039180A3
公开(公告)日：2010-04-08
申请号：PCT/US2009/005250
申请日：2009-09-22
申请人： QUANTERIX CORPORATION , DUFFY, David, C. , RISSIN, David, M. , SONG, Linan , WALT, David, R.
发明人： DUFFY, David, C. , RISSIN, David, M. , SONG, Linan , WALT, David, R.
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/58
摘要： The present invention relates to methods, systems, and kits for detecting, quantifying and/or analyzing a fluid sample comprising molecules or particles at low concentration. In certain embodiments, the methods for detection and/or quantifying analyte molecules in a sample comprise capturing a plurality of analyte molecules on a substrate (e.g., an array comprising a plurality of reaction vessels). The substrate may then be exposed to additional reaction components such as at least one binding ligand. The substrate may additionally be exposed to a precursor labeling agent molecule, wherein the precursor labeling agent molecule, in some cases, is converted to a labeling agent molecule, which may be detected, either directly or indirectly, which determination may be related to the presence of and/or may be employed to quantify the analyte molecules. Although the various aspects of the present invention may use a number of different assay formats, in one embodiment, the assays are conducted in a plurality of reaction vessels defined, at least in part, by the distal ends of fiber optic strands.

4. 发明申请

WO2019199871A1 QUANTIFICATION OF NEUROFILAMENT LIGHT CHAIN IN PHYSIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2019199871A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/026642
申请日：2019-04-09
申请人： QUANTERIX CORPORATION
发明人： HRUSOVSKY, Edward, Kevin , WILSON, David , SHAN, Dandan , CHANG, Lei , SONG, Linan , JEROMIN, Andreas , TOBOS, Carmen, Ioana , PATEL, Purvish, Prahlad
IPC分类号： G01N21/64 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/543 , G01N33/68
摘要： The present disclosure relates to immunoassays for NF-L performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L determinations at concentrations indicative of the condition.

5. 发明申请

WO2019199869A1 QUANTIFICATION OF BIOMARKERS PRESENT IN PHYSIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2019199869A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/026640
申请日：2019-04-09
申请人： QUANTERIX CORPORATION
发明人： HRUSOVSKY, Edward, Kevin , WILSON, David , SHAN, Dandan , CHANG, Lei , SONG, Linan , JEROMIN, Andreas , TOBOS, Carmen, Ioana , PATEL, Purvish, Prahlad
IPC分类号： G01N21/64 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/543 , G01N33/68
摘要： PCT/US2018/0636 The present disclosure relates to immunoassays for NF-L, GFAP, UCH L1, and Tau performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L, GFAP, UCH L1, and Tau at concentrations indicative of the condition.

6. 发明申请

WO2014113502A1 DETECTION OF DNA OR RNA USING SINGLE MOLECULE ARRAYS AND OTHER TECHNIQUES 审中-公开
标题翻译：使用单分子阵列和其他技术检测DNA或RNA
公开(公告)号：WO2014113502A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/011730
申请日：2014-01-15
申请人： QUANTERIX CORPORATION
发明人： DUFFY, David, C. , SONG, Linan , SHAN, Dandan , ZHAO, Mingwei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2563/131 , C12Q2563/143
摘要： Described herein are methods and systems for detecting DNA or RNA using single molecules array or other techniques. DNA or RNA from the sample may be fragmented and exposed to a first type of binding ligand and a second type of binding ligand that comprise nucleic acid sequences complimentary at least a portion of a sequence contained in the target DNA or RNA. At least a portion of the fragmented DNA or RNA associates with at least one of the first type of binding ligand and/or the second type of binding ligand, wherein the first type of binding ligand and second type of binding ligand comprises nucleic acid sequences complimentary to a different portions of a sequence contained in the DNA or RNA. A portion of the sample exposed to the binding ligands is analyzed to determine the number of fragmented DNA or RNA sequences.
摘要翻译：本文描述了使用单分子阵列或其它技术检测DNA或RNA的方法和系统。来自样品的DNA或RNA可以被片段化并暴露于第一类型的结合配体和第二类型的结合配体，其包含与靶DNA或RNA中包含的序列的至少一部分互补的核酸序列。至少一部分片段化的DNA或RNA与至少一种第一类型的结合配体和/或第二类型的结合配体缔合，其中第一类型的结合配体和第二类型的结合配体包含互补的核酸序列涉及包含在DNA或RNA中的序列的不同部分。分析暴露于结合配体的一部分样品以确定片段化的DNA或RNA序列的数目。

7. 发明申请

WO2012142300A3 METHODS OF DETERMINING A TREATMENT PROTOCOL FOR AND/OR A PROGNOSIS OF A PATIENT'S RECOVERY FROM A BRAIN INJURY RESULTING FROM A HYPOXIC EVENT 审中-公开
公开(公告)号：WO2012142300A3
公开(公告)日：2012-10-18
申请号：PCT/US2012/033338
申请日：2012-04-12
申请人： QUANTERIX CORPORATION , WILSON, David , SONG, Linan
发明人： WILSON, David , SONG, Linan
IPC分类号： G01N33/68 , G01N33/53 , G01N33/58
摘要： The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of beta-amyloid peptide in a patient sample containing or suspected of containing beta-amyloid peptide.

8. 发明申请

WO2011109372A1 ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS 审中-公开
标题翻译：使用双重检测方法进行超声检测分子
公开(公告)号：WO2011109372A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026657
申请日：2011-03-01
申请人： QUANTERIX CORPORATION , DUFFY, David, C. , RISSIN, David, M. , WALT, David, R. , SONG, Linan , CHANG, Lei
发明人： DUFFY, David, C. , RISSIN, David, M. , WALT, David, R. , SONG, Linan , CHANG, Lei
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/5306
摘要： Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.
摘要翻译：本文描述了用于检测和/或确定流体样品中分析物分子或颗粒的浓度的测量的系统和方法。在某些情况下，系统和方法采用技术来减少或限制与非特异性结合事件相关的负面影响。本发明的某些方法包括将分析物分子与至少第一类型的结合配体和至少第二类型的结合配体相关联，并将分析物分子空间分离成表面上的多个位置。可以通过确定第一类型的结合配体和第二类型的结合配体的存在来确定在位置处或位置处的分析物分子的存在。

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