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1. 发明申请

WO0204620A2 METHOD FOR ISOLATING NUCLEIC ACIDS 审中-公开
标题翻译：方法分离核酸
公开(公告)号：WO0204620A2
公开(公告)日：2002-01-17
申请号：PCT/EP0108066
申请日：2001-07-12
申请人： QIAGEN GMBH , WEBER MARTIN , SINGER THORSTEN , COSAERT SARAH
发明人： WEBER MARTIN , SINGER THORSTEN , COSAERT SARAH
IPC分类号： C12N15/09 , C12N15/10 , C12N15/00
CPC分类号： C12N15/1006
摘要： The invention relates to a method for isolating nucleic acids from a solution, wherein the nucleic acids are adsorbed on a surface containing SiO2 in the presence of alkali halides and alcohol. The invention also relates to the use of a buffer solution containing alkali halides for isolating nucleic acids on a carrier containing SiO2, in addition to a kit for implementing a method for isolating nucleic acids from a solution.
摘要翻译：本发明涉及一种用于从溶液中，其中所述核酸在碱金属卤化物和醇的存在下吸附在含SiO 2的表面上的分离核酸的方法。此外，本发明涉及使用含有碱金属卤化物用于核酸含SiO2载体上分离和用于从溶液中分离核酸执行一种方法的试剂盒的缓冲液。

2. 发明申请

WO2006053683A3 GENE SILENCING USING SENSE DNA AND ANTISENSE RNA HYBRID CONSTRUCTS COUPLED TO PEPTIDES FACILITATING THE UPTAKE INTO CELLS 审中-公开
标题翻译：使用感染DNA的基因沉默和与促进细胞摄取的肽连接的抗体RNA混合构建体
公开(公告)号：WO2006053683A3
公开(公告)日：2006-08-03
申请号：PCT/EP2005012100
申请日：2005-11-11
申请人： QIAGEN GMBH , WEBER MARTIN , ANDREOU IOANNA , BEZAY NICOLE
发明人： WEBER MARTIN , ANDREOU IOANNA , BEZAY NICOLE
IPC分类号： C12N15/11 , C12N15/115 , C12N15/87
CPC分类号： C12N15/115 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/3513 , C12N2320/32
摘要： The present invention generally relates to gene silencing using sense DNA (sDNA) - antisense RNA (aRNA) hybrids wherein the sense DNA strand is coupled to a peptide which facilitates the uptake of the hybrid into cells.
摘要翻译：本发明一般涉及使用有义DNA（sDNA） - 反义RNA（aRNA）杂交体的基因沉默，其中有义DNA链与促进杂交体进入细胞的肽偶联。

3. 发明申请

WO9819709A3 CATIONIC REAGENTS FOR TRANSFECTION 审中-公开
标题翻译：用于转运的阳离子试剂
公开(公告)号：WO9819709A3
公开(公告)日：1998-07-30
申请号：PCT/EP9706035
申请日：1997-11-03
申请人： QIAGEN GMBH , ERBACHER CHRISTOPH , WEBER MARTIN
发明人： ERBACHER CHRISTOPH , WEBER MARTIN
IPC分类号： C12N15/09 , A61K9/127 , A61K47/48 , A61K48/00 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1272 , A61K47/54 , A61K47/543 , A61K47/544 , A61K48/00
摘要： The present invention relates to cationic cytofectins and liposomes comprising the same for use in delivering exogenous compounds into cells in vitro and in vivo. The liposome may comprise: (a) a neutral lipid such as dioleoylphosphatidylethanolamine (DOPE) or similar lipid-like compounds such as 1,2-dioleoyloxiphosphatidylethanolamine or other lipid-like structures and (b) one or more of the cationic cytofectins provided herein. The present invention also provides transfection kits and methods of delivery comprising the same. 00000
摘要翻译：本发明涉及阳离子细胞增生素和脂质体，其包含其用于体外和体内将外源化合物递送至细胞中。脂质体可以包含：（a）中性脂质，例如二油酰磷脂酰乙醇胺（DOPE）或类似的脂质样化合物，例如1,2-二油酰磷脂酰乙醇胺或其它类脂结构，和（b）本文提供的一种或多种阳离子细胞生物素。本发明还提供了转染试剂盒和包含其的递送方法。 00000

4. 发明申请

WO2007031877A3 MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF SHORT INTERFERING RIBONUCLEIC ACID (SIRNA) BY NUCLEOTIDE MODIFICATION 审中-公开
标题翻译：通过核苷酸修饰调节短暂干扰核糖核酸（SIRNA）的免疫学性质
公开(公告)号：WO2007031877A3
公开(公告)日：2007-08-30
申请号：PCT/IB2006003356
申请日：2006-09-15
申请人： COLEY PHARM GMBH , QIAGEN GMBH , UHLMANN EUGEN , JURK MARION , VOLLMER JORG , SCHETTER CHRISTIAN , WEBER MARTIN
发明人： UHLMANN EUGEN , JURK MARION , VOLLMER JORG , SCHETTER CHRISTIAN , WEBER MARTIN
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/17 , C12N2310/352 , C12N2310/353 , C12N2320/50 , C12Y207/11024
摘要： Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2' sugar modifications and, optionally, internucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention.
摘要翻译：修饰双链短干扰核糖核酸（siRNA）以降低或消除其免疫刺激作用，而不显着影响其基因沉默效应。修饰的siRNA包括一个或多个2'糖修饰物，并且任选地在有义链上包含核苷酸间键。公开了含有修饰的siRNA的组合物和制备和使用经修饰的siRNA的方法。可以合成新的和以前表征的siRNA以掺入根据本发明的修饰。

5. 发明申请

WO0176633A2 TARGETED TRANSFECTION OF CELLS USING A BIOTINYLATED DENDRIMER 审中-公开
标题翻译：生物素化的树枝状细胞有针对性的转染
公开(公告)号：WO0176633A2
公开(公告)日：2001-10-18
申请号：PCT/EP0103746
申请日：2001-04-03
申请人： QIAGEN GMBH , WEBER MARTIN , DENNIG JOERG , ERBACHER CHRISTOPH
发明人： WEBER MARTIN , DENNIG JOERG , ERBACHER CHRISTOPH
IPC分类号： A61K47/48 , C12N15/87 , A61K47/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6898 , C08G83/004 , C12N15/87
摘要： The invention relates to a method for carrying out the targeted transfection of cells, to compositions, which can be used for such methods, and to corresponding medicaments for use in gene therapy. The invention particularly relates to a method for introducing nucleic acid into cells involving the following steps: (a) mixing a nucleic acid with a dendrimer, whereby a portion of the dendrimer molecules is biotinylated; mixing the prepared complex, which consists of a nucleic acid and a dendrimer, with a second complex, which consists of an avidin or a streptavidin and of a biotinylated target-specific binding molecule, and; (c) incubating the complex prepared in step (b) with cells. Dendrimers that are well-suited for the invention are, for example, partially solvolyzed polyamidoamine (PAMAM) dendrimers. Target-specific binding molecules are, in particular, cell type-specific markers also of the cell surface of the target cells.
摘要翻译：本发明涉及一种用于细胞的靶向的转染方法，一种能够被用于这样的程序，以及用于基因治疗的相应的药物组合物。特别地，本发明涉及一种用于将核酸导入包括以下步骤的细胞：（a）混合核酸与树枝状聚合物，其特征在于树枝状聚合物分子的比例是生物素化; （B）混合所得的核酸和树枝状聚合物用由抗生物素蛋白或链霉亲和生物素化的靶标特异性结合分子的第二复合物的复合物; 和（c）在步骤（b）温育的细胞所得到的复合物。例如部分solvolysierte是聚酰胺胺（PAMAM）树枝状聚合物，本发明非常适合于树枝状聚合物。靶特异性结合分子是特定细胞类型特异性标志物和靶细胞的细胞表面。

6. 发明申请

WO2013045268A3 HIGH-STRENGTH BLENDS BASED ON POLYARYLENE ETHERS 审中-公开
标题翻译：基于多芳基化合物的高固定率共混物
公开(公告)号：WO2013045268A3
公开(公告)日：2013-05-16
申请号：PCT/EP2012067778
申请日：2012-09-12
申请人： BASF SE , WEBER MARTIN , MALETZKO CHRISTIAN , HENNENBERGER FLORIAN
发明人： WEBER MARTIN , MALETZKO CHRISTIAN , HENNENBERGER FLORIAN
IPC分类号： C08G75/23 , C08L67/00 , C08L81/06
CPC分类号： C08G75/23 , C08L81/06
摘要： The present invention relates to moulding compounds comprising (A) from 29 to 89% by weight of at least one polyarylene ether sulphone, having a mean number of phenolic end groups per chain from 0 to 0.2, (B) from 0.5 to 20% by weight of a thermotropic polymer, (C) from 0.5 to 10% by weight of a polyarylene ether having predominantly OH end groups, (D) from 10 to 70% by weight of at least one fibrous or particulate filler, (E) from 0 to 40% by weight of additive or processing auxiliaries, wherein the sum of the weight fractions gives 100% by weight, based on the thermoplastic moulding compound.
摘要翻译：本发明涉及模塑组合物，其包含（A）29-89重量％的至少一种聚芳撑醚砜的％，具有从0至0.2％链酚端基的平均数量，0.5（B）到20重量％一热致变聚合物，（C）0.5至主要具有OH端基的聚亚芳基醚的10％重量。（d）10至至少一种纤维材料或颗粒填料的70％（重量），（E）0至40重量％添加剂或加工助剂，基于热塑性模塑组合物，重量份的总和为100重量％。

7. 发明申请

WO2011003900A2 METHOD FOR PRODUCING FIBER-REINFORCED COMPOSITE MATERIALS FROM POLYAMIDE 6 AND COPOLYAMIDES MADE OF POLYAMIDE 6 AND POLYAMIDE 12 审中-公开
标题翻译：用于生产纤维增强复合材料的尼龙6和共聚酰胺选自聚酰胺6和聚酰胺12
公开(公告)号：WO2011003900A2
公开(公告)日：2011-01-13
申请号：PCT/EP2010059628
申请日：2010-07-06
申请人： BASF SE , SCHERZER DIETRICH , KORY GAD , WEBER MARTIN
发明人： SCHERZER DIETRICH , KORY GAD , WEBER MARTIN
IPC分类号： B29B15/12
CPC分类号： B29C70/521 , B29B15/125 , B29C67/246 , B29K2077/00 , C08J5/24 , C08J2377/02
摘要： The present invention relates to a method for producing fiber-reinforced composite materials, by saturating a plurality of continuous filaments or woven fabrics, optionally together with reinforcement materials, containing caprolactam and other starting materials for polyamide 6, or other starting materials for copolymers of the caprolactam, passing the materials through at temperatures between 70 and 100ºC, and anionically polymerizing them at temperatures between 100 and 190ºC, and optionally re-polymerizing them at temperatures between 90 and 170ºC.
摘要翻译：本发明涉及一种用于制造纤维增强复合材料，通过任选地与增强材料，含有己内酰胺和其它起始材料为聚酰胺6或用于浸渍多根连续长丝或组织的己内酰胺的共聚物等原料，在70〜100℃的温度的方法 C分别通过传递和在100的温度下阴离子聚合至190℃，和任选地在90的温度下进行聚合后，以170℃

8. 发明申请

WO2008074687A2 THERMOPLASTIC MOULDING COMPOSITIONS HAVING IMPROVED DUCTILITY 审中-公开
标题翻译：具有改进的延性热塑性模塑材料
公开(公告)号：WO2008074687A2
公开(公告)日：2008-06-26
申请号：PCT/EP2007063662
申请日：2007-12-11
申请人： BASF SE , WEBER MARTIN , HOPFENSPIRGER XAVER , FUNKHAUSER STEFFEN , HECKMANN WALTER , SCHNORR JOERG , FERNANDEZ RODILES RAQUEL , KLENZ RAINER , STAWITZKI HAGEN , BRUCHMANN BERND
发明人： WEBER MARTIN , HOPFENSPIRGER XAVER , FUNKHAUSER STEFFEN , HECKMANN WALTER , SCHNORR JOERG , FERNANDEZ RODILES RAQUEL , KLENZ RAINER , STAWITZKI HAGEN , BRUCHMANN BERND
IPC分类号： C08L77/00 , C08L51/06 , C08L67/00 , C08L69/00 , C08L77/06
CPC分类号： C08L77/06 , C08L51/06 , C08L67/00 , C08L69/00 , C08L77/00 , C08L2205/03 , C08L2666/18 , C08L2666/02 , C08L2666/24
摘要： Thermoplastic moulding compositions comprising: A) from 40 to 96% by weight of a partly aromatic polyamide, B) from 2 to 30% by weight of a copolymer of B 1 ) from 35 to 89.9% by weight of ethylene, B 2 ) from 10 to 60% by weight of 1-octene or 1-butene or propylene or a mixture thereof and B 3 ) from 0.05 to 5% by weight of functional monomers selected from the group consisting of carboxylic acid, carboxylic anhydride, carboxylic ester, carboxamide, carboximide, amino, hydroxyl, epoxide, urethane and oxazoline groups and mixtures thereof, C) from 1 to 50% by weight of fibrous or particulate fillers or mixtures thereof, D) from 0.1 to 10% by weight of D 1 ) at least one highly branched or hyperbranched polycarbonate having an OH number of from 1 to 600 mg of KOH/g of polycarbonate (in accordance with DIN 53240, Part 2) or D 2 ) at least one highly branched or hyperbranched polyester of the A x B y type where x is at least 1.1 and y is at least 2.1 or a mixture thereof, E) from 0 to 15% by weight of an electrically conductive additive, F) from 0 to 30% by weight of further additives, where the sum of the percentages by weight of the components A) to F) is 100%.
摘要翻译：一种热塑性模塑组合物，包含：A）40乙_{的共聚物的96重量％的部分芳族聚酰胺的，B）2〜30重量％1 ）35〜89.9重量％乙烯的，乙_{2 ）10至60重量％的1-辛烯或1-丁烯或丙烯或它们的混合物和B _{3 0.05 ）至5重量％的官能其中官能单体选自量羧酸，羧酸酐，羧酸酯，羧酰胺，羧酰亚胺，氨基，羟基，环氧基，氨基甲酸乙酯或恶唑啉基或它们的混合物的单体，C）1〜50 纤维状或颗粒状填料或其混合物的.-％物，D）为0.1至10重量ð的％_{1 ）至少一种高度支化或具有1至600毫克KOH的羟值超支化聚碳酸酯 _{2 ）高（根据DIN 53240，第2部分），或至少一种/ g聚碳酸酯D或一个_{X 乙_{ý的超支化聚酯与 x至少为1.1，y是至少为2.1或它们的混合物，E）0至15重量％的导电性添加剂的，F）0至30重量％的其它添加剂，其中百分数以重量计的组分A）到F）的总和为100％。}}}}}}}

9. 发明申请

WO2004009251A3 RADIATION-CURABLE PAINT SYSTEMS HAVING A LOWER LAYER WITH LOW-TEMPERATURE ELASTICITY 审中-公开
标题翻译：辐射硬化型涂料体系，具有耐温拉伸性能
公开(公告)号：WO2004009251A3
公开(公告)日：2004-04-01
申请号：PCT/EP0307709
申请日：2003-07-16
申请人： BASF AG , DIETSCHE FRANK , JAWOREK THOMAS , SCHWALM REINHOLD , WEBER MARTIN , STEININGER HELMUT
发明人： DIETSCHE FRANK , JAWOREK THOMAS , SCHWALM REINHOLD , WEBER MARTIN , STEININGER HELMUT
IPC分类号： B05D5/00 , B05D7/00 , C08J7/04
CPC分类号： B05D7/54 , B05D5/00 , B05D2701/00 , Y10T428/2495 , Y10T428/26 , Y10T428/31507 , Y10T428/31678 , Y10T428/31725 , Y10T428/31909 , Y10T428/31928 , Y10T428/31931 , Y10T428/31935 , Y10T428/31938 , Y10T428/31989
摘要： The invention relates to a multi-layer finish on a substrate, containing at least one radiation-curable paint system (F) and at least one elastic intermediate layer (D) which is located between the substrate and the radiation-curable paint system (F) and has a maximum glass transition temperature (Tg) of -20 DEG C.
摘要翻译：多层涂层位于衬底上，包括至少一个可辐射固化的涂布系统（F）和基板和具有-20℃或更低的玻璃化转变温度（Tg）可辐射固化的涂布系统（F）弹性中间层（d）之间的至少一个。

10. 发明申请

WO0142361A3 ISOTROPIC THERMOPLASTIC MOULDING MATERIALS BASED ON POLYCARBONATES AND STYRENE COPOLYMERS 审中-公开
标题翻译：各向同性热塑性模塑化合物基于聚碳酸酯和苯乙烯共聚物
公开(公告)号：WO0142361A3
公开(公告)日：2001-11-08
申请号：PCT/EP0012284
申请日：2000-12-06
申请人： BASF AG , WEBER MARTIN , HOPFENSPIRGER XAVER , LAUN MARTIN , HECKMANN WALTER
发明人： WEBER MARTIN , HOPFENSPIRGER XAVER , LAUN MARTIN , HECKMANN WALTER
IPC分类号： C08L25/02 , C08L25/12 , C08L51/04 , C08L69/00
CPC分类号： C08L69/00 , C08L25/02 , C08L25/12 , C08L51/04 , C08L2666/02
摘要： The invention relates to a thermoplastic moulding material containing a) 1 to 97.5 wt. % of at least one aromatic polycarbonate, b) 1 to 97.5 wt. % of at least one graft polymer consisting of optionally alkyl-substituted styrene and an unsaturated nitrile on an elastomeric graft base, c) 1 to 97.5 wt. % of at least one thermoplastic copolymerisate consisting of optionally alkyl-substituted styrene and an unsaturated nitrile, d) 0.5 to 50 wt. % of a copolymerisate, d1) consisting of a copolymer consisting of optionally alkyl-substituted styrene, an unsaturated nitrile and monomers with epoxy, hydroxy, carboxyl or oxazoline groups, and d2) 5 to 95 wt. % of at least one thermoplastic polyester, said copolymer d being producible by common extrusion of d1 and d2; and optionally, other ingredients.
摘要翻译：它声称的热塑性模塑组合物，其包含：a）1〜97.5重量％的至少一种芳族聚碳酸酯的％，b）由1至97.5重量可能烷基取代的苯乙烯中的至少一种接枝聚合物的％并且在不饱和腈弹性体接枝基，c）中为1〜97.5重量可能烷基取代的苯乙烯的共聚物的可能烷基取代的苯乙烯的至少一种热塑性共聚物和共聚物d1的0.5〜50重量％的不饱和腈，D））的％，具有5不饱和腈单体，环氧，羟基，羧基和/或恶唑啉基，和d2）至95重量％的至少一种热塑性聚酯的％，其中所述共聚物可以通过D1共挤出和d2，并任选地被制备含有其他成分。

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