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    • 2. 发明申请
    • A KINASE CAPABLE OF SITE-SPECIFIC PHOSPHORYLATION OF I'kappa'B'alpha'
    • 一种可以进行I kappa Bα的位点特异性磷酸化的激酶
    • WO1997035014A1
    • 1997-09-25
    • PCT/US1997004195
    • 1997-03-19
    • PROSCRIPT, INC.
    • PROSCRIPT, INC.CHEN, Zhijian, J.
    • C12N15/54
    • C12N9/1205A01K2217/05A01K2217/075A61K38/00A61K48/00Y10S435/81
    • The present invention relates, in general, to a kinase which in its activated state is capable of site-specific phosphorylation of I kappa B alpha , I kappa B alpha kinase. In particular, the present invention relates to the purified kinase, purified polypeptide subunits of the kinase, nucleic acid molecules coding for the purified polypeptide subunits; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to the kinase or its polypeptide subunits; hybridomas containing the antibodies; nucleic acid probes for the detection of the nucleic acid encoding the kinase; a method of detecting nucleic acids encoding the kinase or polypeptides of the kinase in a sample; and kits containing nucleic acid probes or antibodies. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with an undesired activation of NF- kappa B. This invention also relates to ligands, agonists, and antagonists of the kinase, and diagnostic and therapeutic uses thereof. This invention also relates to bioassays using the kinase or polypeptides of the kinase of this invention to identify ligands, agonists, and antagonists. More specifically, this invention relates to selective inhibitors of the kinase and to structure-based design of ligands, agonists, and antagonists of the kinase. This invention further relates to gene therapy using the nucleic acids of the invention.
    • 本发明一般涉及在其活化状态下能够进行IκBα,IκBα激酶的位点特异性磷酸化的激酶。 特别地,本发明涉及激酶的纯化的激酶,纯化的多肽亚基,编码纯化的多肽亚基的核酸分子; 重组核酸分子; 含有重组核酸分子的细胞; 具有与激酶或其多肽亚基特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码激酶的核酸的核酸探针; 检测样品中激酶或激酶多肽的核酸的检测方法; 和含有核酸探针或抗体的试剂盒。 本发明进一步涉及使用本发明的核酸序列,蛋白质或抗体来诊断,评估或预测患有NF-κB不希望的活化的哺乳动物的生物测定。本发明还涉及配体,激动剂和拮抗剂 激酶及其诊断和治疗用途。 本发明还涉及使用本发明激酶的激酶或多肽鉴定配体,激动剂和拮抗剂的生物测定。 更具体地,本发明涉及激酶的选择性抑制剂和激酶的配体,激动剂和拮抗剂的基于结构的设计。 本发明还涉及使用本发明的核酸的基因治疗。