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1. 发明申请

WO2015048334A2 EDIBLE SPECIES NUTRITIVE POLYPEPTIDES AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
标题翻译：食用物种营养多肽及其生产和使用方法
公开(公告)号：WO2015048334A2
公开(公告)日：2015-04-02
申请号：PCT/US2014057528
申请日：2014-09-25
申请人： PRONUTRIA INC
发明人： CHEN YING-JA , HAMILL MICHAEL , BASU SUBHAYU , VON MALTZAHN GEOFFREY , ROGERS JAMESON , BOGHIGIAN BRETT ADAM , VAIDYA VIMAL , SAMAYOA PHILLIP , KRAMARCZYK JOHN F , RAHMAN SHAILA , BERRY DAVID A , SILVER NATHANIEL W
CPC分类号： A61K38/1709 , A23L2/66 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/195 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K9/0075 , A61K9/0095 , A61K9/146 , A61K9/2054 , A61K9/2866 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/164 , A61K38/168 , A61K38/17 , A61K38/1703 , A61K38/1767 , A61K38/38 , A61K38/45 , A61K45/06 , C12Y207/04003 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2500/00 , G06F19/18
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
摘要翻译：本文提供营养多肽。还提供了各种其它实施方案，包括编码多肽的核酸，制备多肽的重组微生物，用于表达多肽的载体，使用重组微生物制备多肽的方法，包含多肽的组合物和制剂，以及使用多肽的方法，组合物和制剂。

2. 发明申请

WO2014134225A2 NUTRITIVE POLYPEPTIDES, FORMULATIONS AND METHODS FOR TREATING DISEASE AND IMPROVING MUSCLE HEALTH AND MAINTENANCE 审中-公开
标题翻译：营养多肽，治疗疾病的制剂和方法，改善肌肉健康和维持
公开(公告)号：WO2014134225A2
公开(公告)日：2014-09-04
申请号：PCT/US2014018807
申请日：2014-02-26
申请人： PRONUTRIA INC
发明人： SILVER NATHANIEL , HAMILL MICHAEL , SAMAYOA PHILIP , HOU JAY , HAMM LUKE , BERRY DAVID
IPC分类号： A61K9/00
CPC分类号： A61K38/05 , A23L33/18 , A23V2002/00 , A61K9/0053 , A61K31/198 , A61K38/02 , A61K38/03 , A61K38/16 , A61K38/1709 , A61K38/1738 , A23V2200/316 , A23V2250/55 , A61K2300/00
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including pharmaceutical formulations containing the nutritive polypeptides, nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions that comprise the polypeptides, and methods of using the polypeptides to treat or prevent diseases, disorders and conditions associated with muscle wasting, and of using the polypeptides to improve and maintain muscle health.
摘要翻译：本文提供营养多肽。还提供了各种其它实施方案，包括含有营养多肽的药物制剂，编码多肽的核酸，制备多肽的重组微生物，用于表达多肽的载体，使用重组微生物制备多肽的方法，包含多肽的组合物和方法使用多肽来治疗或预防与肌肉消瘦相关的疾病，病症和病症，以及使用多肽来改善和维持肌肉健康。

3. 发明申请

WO2014081884A1 ENGINEERED SECRETED PROTEINS AND METHODS 审中-公开
标题翻译：工程分泌蛋白质和方法
公开(公告)号：WO2014081884A1
公开(公告)日：2014-05-30
申请号：PCT/US2013071091
申请日：2013-11-20
申请人： PRONUTRIA INC
发明人： BASU SUBHAYU , GORA KATHERINE G , CHEN YING-JA , YOUNG DAVID M , SILVER NATHANIEL W , HAMILL MICHAEL , BERRY DAVID A
IPC分类号： A23L1/305 , A23L1/29
CPC分类号： C07K14/32 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K38/16 , A61K38/1709 , C07K14/195 , C07K14/37 , C12N9/00 , C12N9/2428 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12P21/02
摘要： Nutritive proteins are provided herein. Also provided are various other embodiments including nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins. Nutritive proteins include engineered proteins, wherein the engineered proteins comprise a sequence of at least 20 amino acids that comprise an altered amino acid sequence compared to the amino acid sequence of a reference secreted protein and a ratio of essential amino acids to total amino acids present in the engineered protein higher than the ratio of essential amino acids to total amino acids present in the reference secreted protein. In some embodiments, the engineered protein comprises at least one essential amino acid residue substitution of a non-essential amino acid residue in the reference secreted protein.
摘要翻译：营养蛋白质在本文中提供。还提供了各种其它实施方案，包括编码蛋白质的核酸，制备蛋白质的重组微生物，用于表达蛋白质的载体，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物以及使用蛋白质的方法。营养蛋白包括工程蛋白质，其中工程改造的蛋白质包含至少20个氨基酸的序列，其包含改变的氨基酸序列，与参考分泌蛋白质的氨基酸序列相比，必需氨基酸与总氨基酸的比例存在于工程蛋白质高于参考分泌蛋白质中存在的必需氨基酸与总氨基酸的比例。在一些实施方案中，工程改造的蛋白质包含参考分泌蛋白质中非必需氨基酸残基的至少一个必需氨基酸残基取代。

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