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1. 发明申请

WO2005054294A3 INHIBITORS OF GLYCOPROTEIN VI BASED ON MONOCLONAL ANTIBODY HGP 5C4 审中-公开
公开(公告)号：WO2005054294A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004/013779
申请日：2004-12-03
申请人： PROCORDE GMBH , GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH , GAWAZ, Meinrad , KREMMER, Elisabeth , MÜNCH, Götz
发明人： GAWAZ, Meinrad , KREMMER, Elisabeth , MÜNCH, Götz
IPC分类号： C07K16/28
摘要： The present invention relates to a specific inhibitor of human platelet glycoprotein VI. The inhibitor may be an optionally humanized antibody or function-conservative fragments or variants thereof, a specific fusion protein or conjugate. Moreover, the present invention relates to pharmaceutical compositions containing the specific inhibitor of the invention. The present invention also relates to hybridomas expressing the antibody of the present invention. Furthermore, the present invention relates to the use of the specific inhibitor of glycoprotein VI for the preparation of a medicament for the prevention of acute and chronic vascular diseases associated with arterial and/or intravenous thrombosis, such as acute coronary syndrome, acute carotid artery syndrome, acute myocardial infarction, acute cerebral stroke and chronic coronary or peripheral vessel disease. Finally, the present invention relates to a process for preparing the antibody of the invention and to a process for preparing a specific fragment of the antibody of the present invention.

2. 发明申请

WO2003104282A3 GLYCOPROTEIN VI - FC FUSION PROTEIN FOR TREATING VASCULAR DISORDERS 审中-公开
公开(公告)号：WO2003104282A3
公开(公告)日：2003-12-18
申请号：PCT/EP2003/005929
申请日：2003-06-05
申请人： PROCORDE GMBH , MASSBERG, Steffen , GAWAZ, Meinrad , BÜLTMANN, Andreas , MÜNCH, Götz , UNGERER, Martin , PELUSO, Mario
发明人： MASSBERG, Steffen , GAWAZ, Meinrad , BÜLTMANN, Andreas , MÜNCH, Götz , UNGERER, Martin , PELUSO, Mario
IPC分类号： C07K19/00
摘要： The present invention provides a fusion protein comprising (a) the extracellular domain of glycoprotein VI or a variant thereof that is functional for binding to collagen and (b) the Fc domain of an immunoglobulin or a function-conservative part thereof, characterised by a polypeptide chain having an amino acid sequence as shown in Figure 7 and whereby the fusion protein is obtainable by a process which provides the fusion protein in the form of a specific dimer.

3. 发明申请

WO2003103662A3 INHIBITORS OF GLYCOPROTEIN VI 审中-公开
公开(公告)号：WO2003103662A3
公开(公告)日：2003-12-18
申请号：PCT/EP2003/005919
申请日：2003-06-05
申请人： PROCORDE GMBH , MASSBERG, Steffen , GAWAZ, Meinrad , NIESWANDT, Bernhard , BÜLTMANN, Andreas , MÜNCH, Götz , UNGERER, Martin , PELUSO, Mario , GRÜNER, Sabine
发明人： MASSBERG, Steffen , GAWAZ, Meinrad , NIESWANDT, Bernhard , BÜLTMANN, Andreas , MÜNCH, Götz , UNGERER, Martin , PELUSO, Mario , GRÜNER, Sabine
IPC分类号： C07K16/28
摘要： The Invention provides use of an antibody against platelet glycoprotein VI (GPVI) for the preparation of a medicament for the prevention of intraarterial thrombosis in a Patient characterized by (i) having suffered from an acute coronary or carotid syndrome and (ü)having active intraarterial lesions. The present Invention also provides an antibody against platelet glycoprotein VI (GPVI) for the preparation of a medicament for the manufacture of a medicament for the treatment of diabetes. Further, in vivo and in vivo screening methods for inhibitors or GP VI are provided and inhibitors identified thereby.

4. 发明申请

WO2003103662A2 INHIBITORS OF GLYCOPROTEIN VI 审中-公开
标题翻译：葡萄糖苷VI的抑制剂
公开(公告)号：WO2003103662A2
公开(公告)日：2003-12-18
申请号：PCT/EP2003/005919
申请日：2003-06-05
申请人： PROCORDE GMBH , MASSBERG, Steffen , GAWAZ, Meinrad , NIESWANDT, Bernhard , BÜLTMANN, Andreas , MÜNCH, Götz , UNGERER, Martin , PELUSO, Mario , GRÜNER, Sabine
发明人： MASSBERG, Steffen , GAWAZ, Meinrad , NIESWANDT, Bernhard , BÜLTMANN, Andreas , MÜNCH, Götz , UNGERER, Martin , PELUSO, Mario , GRÜNER, Sabine
IPC分类号： A61K31/4035
CPC分类号： C07K14/745 , A61K38/00 , A61K47/6811 , A61K2039/505 , C07K14/70503 , C07K16/2803 , C07K19/00 , C07K2319/00 , C07K2319/30 , C12N2799/021 , G01N33/5088 , G01N33/86 , Y02A50/407
摘要： The Invention provides use of an antibody against platelet glycoprotein VI (GPVI) for the preparation of a medicament for the prevention of intraarterial thrombosis in a Patient characterized by (i) having suffered from an acute coronary or carotid syndrome and (ü)having active intraarterial lesions. The present Invention also provides an antibody against platelet glycoprotein VI (GPVI) for the preparation of a medicament for the manufacture of a medicament for the treatment of diabetes. Further, in vivo and in vivo screening methods for inhibitors or GP VI are provided and inhibitors identified thereby.
摘要翻译：本发明提供抗血小板糖蛋白VI（GPVI）的抗体用于制备用于预防患者动脉内血栓形成的药物，其特征在于：（i）患有急性冠状动脉或颈动脉综合征，和（ü）具有活动动脉内病变。本发明还提供了抗血小板糖蛋白VI（GPVI）的抗体，用于制备用于制备用于治疗糖尿病的药物的药物。此外，提供了用于抑制剂或GP VI的体内和体内筛选方法，由此鉴定出抑制剂。

5. 发明申请

WO2012130651A1 DIAGNOSTISCHE DIFFERENZIERUNG ZWISCHEN EINEM AKUTEN KORONARSYNDROM UND EINER STABILEN ANGINA PECTORIS 审中-公开
标题翻译：急性冠状动脉和稳定型心绞痛的诊断之间的差异
公开(公告)号：WO2012130651A1
公开(公告)日：2012-10-04
申请号：PCT/EP2012/054767
申请日：2012-03-19
申请人： EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKLINIKUM , BIGALKE, Boris , GAWAZ, Meinrad , POETZ, Oliver , JOOS, Thomas , KREMMER, Elisabeth
发明人： BIGALKE, Boris , GAWAZ, Meinrad , POETZ, Oliver , JOOS, Thomas , KREMMER, Elisabeth
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N2800/324
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur diagnostischen Differenzierung zwischen einem akuten Koronarsyndrom (ACS) und einer stabilen Angina pectoris (SAP) bei einem Lebewesen.
摘要翻译：本发明涉及诊断分化的受试者中的急性冠状动脉综合征（ACS）和稳定型心绞痛（SAP）之间的方法。

6. 发明申请

WO2011124370A1 FUSION PROTEIN 审中-公开
标题翻译：融合蛋白
公开(公告)号：WO2011124370A1
公开(公告)日：2011-10-13
申请号：PCT/EP2011/001711
申请日：2011-04-06
申请人： CORIMMUN GMBH , GAWAZ, Meinrad , SCHÖNBERGER, Tanja , DEGEN, Heidrun , MÜNCH, Götz , HOLTHOFF, Hans-Peter , BÜLTMANN, Andreas , BÜHRING, Hans-Jörg , LEDER, Christoph
发明人： GAWAZ, Meinrad , SCHÖNBERGER, Tanja , DEGEN, Heidrun , MÜNCH, Götz , HOLTHOFF, Hans-Peter , BÜLTMANN, Andreas , BÜHRING, Hans-Jörg , LEDER, Christoph
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K14/705 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/70
摘要： An isolated nucleic acid molecule selected from the group consisting of: vi. a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to the nucleotide sequence of SEQ ID NO:1 or a complement thereof; vii. a nucleic acid molecule comprising a fragment of at least 1500 consecutive nucleotides of the nucleotide sequence of SEQ ID NO:1, or a complement thereof; viii. a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least 85% identical to SEQ ID NO:2; ix. a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 500 contiguous amino acids of SEQ ID NO: 2; and x. a nucleic acid molecule encoding a polypeptide containing a humanized immunoglobulin or parts of an immunoglubulin having binding specificity for CD133 a nucleic acid molecule which encodes a variant of a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising the entire SEQ ID NO: 1, or complement thereof under conditions of incubation at 45 °C in 6.0xSSC followed by washing in 0.2xSSC/0.1% SDS at 65 °C.
摘要翻译：选自以下的分离的核酸分子：vi。核酸分子，其包含与SEQ ID NO：1的核苷酸序列至少85％的核苷酸序列或其互补序列; 七。包含SEQ ID NO：1的核苷酸序列的至少1500个连续核苷酸的片段的核酸分子或其互补物; 八。编码包含与SEQ ID NO：2至少85％相同的氨基酸序列的多肽的核酸分子; 九。编码包含SEQ ID NO：2的氨基酸序列的多肽的片段的核酸分子，其中所述片段包含SEQ ID NO：2的至少500个连续氨基酸; 和x。编码含有人源化免疫球蛋白的多肽的核酸分子或对CD133具有结合特异性的免疫球蛋白的部分的编码包含SEQ ID NO：2的氨基酸序列的多肽的变体的核酸分子的核酸分子，其中所述核酸分子与涉及包含整个SEQ ID NO：1或其互补序列的核酸分子，其在45℃下在6.0×SSC中孵育，然后在65℃下在0.2×SSC / 0.1％SDS中洗涤。

7. 发明申请

WO2006061650A2 METHODS, PRODUCTS AND USES INVOLVING PLATELETS AND/OR THE VASCULATURE 审中-公开
标题翻译：涉及平板电脑和/或血管的方法，产品和用途
公开(公告)号：WO2006061650A2
公开(公告)日：2006-06-15
申请号：PCT/GB2005/004764
申请日：2005-12-12
申请人： TRIGEN GMBH , TRIGEN LIMITED , MÜNCH, Götz , BÜLTMANN, Andreas , BOUCHER, Oliver, Vimpany, Arnold , CHAHWALA, Suresh, Babubhai , GAWAZ, Meinrad , UNGERER, Martin
发明人： MÜNCH, Götz , BÜLTMANN, Andreas , BOUCHER, Oliver, Vimpany, Arnold , CHAHWALA, Suresh, Babubhai , GAWAZ, Meinrad , UNGERER, Martin
IPC分类号： C12N15/62 , C07K14/705 , C07K16/28 , C07K19/00 , A61K47/48 , A61K38/17 , G01N33/50 , A61P9/10
CPC分类号： C07K14/745 , A61K38/00 , A61K47/6811 , C07K14/70503 , C07K16/2803 , C07K2319/00 , C07K2319/30
摘要： The present disclosure relates to agents which interfere with the binding of GPVI to various components. Agents which interfere with GPVI Interaction with one or both of fibronectin and vironectin or sequences thereof are also disclosed. Methods of treating disorders or diseases which involve pathological, dysfunctional or non-pathological interaction of GPVI with fibronectin and/or vitronectin are included in the present disclosure. The invention also relates to uses of agents for the prevention or treatment of disorders arising from blood platelet adhesion and aggregation.
摘要翻译：本公开涉及干扰GPVI与各种组分的结合的试剂。还公开了干扰GPVI与纤连蛋白和维生素或其序列中的一者或两者的相互作用的试剂。涉及GPVI与纤连蛋白和/或玻连蛋白的病理，功能障碍或非病理相互作用的疾病或疾病的方法包括在本公开中。本发明还涉及用于预防或治疗由血小板粘附和聚集引起的疾病的药剂的用途。

8. 发明申请

WO2003069339A1 METHOD FOR GENERATING RECOMBINANT HUMAN PLATELETS FOR IDENTIFYING THERAPEUTIC TARGET PROTEINS 审中-公开
标题翻译：用于产生用于鉴定治疗目标蛋白的重组人板的方法
公开(公告)号：WO2003069339A1
公开(公告)日：2003-08-21
申请号：PCT/EP2003/001450
申请日：2003-02-13
申请人： PROCORDE GMBH , PELUSO, Mario , UNGERER, Martin , GAWAZ, Meinrad , MASSBERG, Steffen , LAUGWITZ, Karl-Ludwig , GILLITZER, Angelika
发明人： PELUSO, Mario , UNGERER, Martin , GAWAZ, Meinrad , MASSBERG, Steffen , LAUGWITZ, Karl-Ludwig , GILLITZER, Angelika
IPC分类号： G01N33/50
CPC分类号： G01N33/5005 , C12N5/0644 , C12N2500/24 , C12N2501/125 , C12N2501/145 , C12N2501/23 , C12N2503/00 , C12N2503/02 , C12N2510/02 , G01N2500/10
摘要： A composition is provided comprising patelets having a combination of the following modifications: a) a modification of the protein constituents of the platelets which is obtained or obtainable by genetic modification of platelet precursor cells; b) incorporation of a detectable label into said platelet; whereby the functions of modification a) and b) are mutually independent. Further, methods of determining platelet functions, notably aggregation and adhesion to endothelial cells are provided. Further, a novel method of preparing transgenic or modified platelets is provided.
摘要翻译：提供了一种组合物，其包含具有以下修饰的组合的皮脂组织：a通过血小板前体细胞的遗传修饰获得或可获得的血小板的蛋白质成分的修饰b将可检测标记结合到所述血小板中，由此修饰a的功能和b是相互独立的。此外，提供了确定血小板功能的方法，特别是聚集和粘附到内皮细胞。此外，提供了制备转基因或改良血小板的新方法。

9. 发明申请

WO2002076482A3 VERWENDUNG VON INHIBITOREN VON IKK-β UND VERFAHREN ZUM AUFFINDEN SOLCHER INHIBITOREN 审中-公开
公开(公告)号：WO2002076482A3
公开(公告)日：2002-10-03
申请号：PCT/EP2002/003382
申请日：2002-03-26
申请人： PROCORDE GMBH , UNGERER, Martin , BRAND, Korbinian , GAWAZ, Meinrad
发明人： UNGERER, Martin , BRAND, Korbinian , GAWAZ, Meinrad
IPC分类号： A61K38/00
摘要： Diese Erfindung beschreibt die Verwendung eines Inhibitors von IKK-ß zur Herstellung eines Medikaments zur Behandlung oder Vorbeugung von Atherosklerose. Ferner wird ein Screeningverfahren zum Auffinden von Inhibitoren von IKK-ß in Endothelzellen beschrieben, wobei das Verfahren ein Kontaktieren eines potentiellen Inhibitors mit aktivierten Endothelzellen und eine Bestimmung einer Sekretion von MCP-1 aus den Endothelzellen umfasst.

10. 发明申请

WO2002076482A2 VERWENDUNG VON INHIBITOREN VON IKK-β UND VERFAHREN ZUM AUFFINDEN SOLCHER INHIBITOREN 审中-公开
标题翻译： IKKβ和方法抑制剂用于搜索这种抑制剂的使用
公开(公告)号：WO2002076482A2
公开(公告)日：2002-10-03
申请号：PCT/EP2002/003382
申请日：2002-03-26
申请人： PROCORDE GMBH , UNGERER, Martin , BRAND, Korbinian , GAWAZ, Meinrad
发明人： UNGERER, Martin , BRAND, Korbinian , GAWAZ, Meinrad
IPC分类号： A61K38/00
CPC分类号： C07K14/4703 , A61K38/00 , G01N33/5064 , G01N2333/521
摘要： Diese Erfindung beschreibt die Verwendung eines Inhibitors von IKK-ß zur Herstellung eines Medikaments zur Behandlung oder Vorbeugung von Atherosklerose. Ferner wird ein Screeningverfahren zum Auffinden von Inhibitoren von IKK-ß in Endothelzellen beschrieben, wobei das Verfahren ein Kontaktieren eines potentiellen Inhibitors mit aktivierten Endothelzellen und eine Bestimmung einer Sekretion von MCP-1 aus den Endothelzellen umfasst.
摘要翻译：本发明描述了用于治疗或预防动脉粥样硬化的药物中的用途使用IKK-β的抑制剂。此外，用于发现IKK-β的抑制剂的筛选方法在内皮细胞中，该方法包括潜在的抑制剂与活化的内皮细胞接触，并从所述内皮细胞确定MCP-1分泌说明。

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