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1. 发明申请

WO2009057022A3 SEPARATOR COLUMN, SEPARATOR SYSTEM, METHOD OF FRACTIONATING MAGNETIC PARTICLES, METHOD OF MANUFACTURING A SEPARATOR COLUMN AND USE OF A SEPARATOR COLUMN 审中-公开
标题翻译：分离器柱，分离器系统，分离磁性颗粒的方法，制造分离器柱的方法和分离器柱的使用
公开(公告)号：WO2009057022A3
公开(公告)日：2009-08-06
申请号：PCT/IB2008054393
申请日：2008-10-24
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , MARKOV DENIS , BOEVE HANS M B , GLEICH BERNHARD , WEIZENECKER JUERGEN
发明人： MARKOV DENIS , BOEVE HANS M B , GLEICH BERNHARD , WEIZENECKER JUERGEN
IPC分类号： B03C1/28 , B03C1/01 , B03C1/033
CPC分类号： B03C1/286 , A61B5/0515 , B03C1/01 , B03C1/0335 , B03C2201/18
摘要： A separator system with a separator column and a method of fractionating magnetic particles, preferably using field-flow fractionation is proposed, which allows for more effective fractionation of magnetic particles with respect to their dynamic magnetic response in a wide frequency and amplitude range of an applied magnetic field, in particular relevant for magnetic particle imaging (MPI).
摘要翻译：提出了一种具有隔离柱的分离器系统和优选使用场流分级分离磁性颗粒的方法，其允许在所施加的宽频率和振幅范围内相对于其动态磁响应更有效地分级磁性颗粒磁场，特别是与磁性粒子成像（MPI）有关。

2. 发明申请

WO2008078275A3 METHOD AND ARRANGEMENT FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：在行动区域影响和/或检测磁性颗粒的方法和装置
公开(公告)号：WO2008078275A3
公开(公告)日：2008-08-21
申请号：PCT/IB2007055177
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515
摘要： A method and an arrangement for influencing and/or detecting magnetic particles in a region of action is disclosed, which method comprises the steps of: - generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action - changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles change locally, - acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein a magnetic drive vector of the magnetic drive field is rotated in at least one rotation plane.
摘要翻译：公开了一种用于影响和/或检测动作区域中的磁性颗粒的方法和装置，该方法包括以下步骤： - 产生具有其磁场强度的空间中的图案的磁选区，在动作区域形成具有低磁场强度的区域和具有较高磁场强度的第二子区域 - 通过磁驱动场来改变动作区域中两个子区域的空间位置使得磁性颗粒的磁化在局部变化， - 获取信号，该信号取决于作用区域中的磁化强度，该磁化受第一和第二子区域的空间位置的变化的影响，其中a 磁驱动场的磁驱动矢量在至少一个旋转平面中旋转。

3. 发明申请

WO2004091721A8 METHOD AND APPARATUS FOR INFLUENCING MAGNETIC PARTICLES 审中-公开
标题翻译：影响磁性颗粒的方法和装置
公开(公告)号：WO2004091721A8
公开(公告)日：2006-03-02
申请号：PCT/IB2004050442
申请日：2004-04-15
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN
IPC分类号： A61N1/40 , A61N2/02 , A61N2/06
CPC分类号： A61N2/06 , A61B5/0515 , A61N1/406 , A61N2/02
摘要： The invention relates to a method and an apparatus for influencing magnetic particles in a region of action. With the help of an arrangement that has means for generating magnetic fields, a spatially inhomogeneous magnetic field is generated that has at least one zone (301) in which the magnetization of the particles is in a state of non-saturation, whereas it is in a state of saturation in the remaining zone. By displacing the said zone within the region of action, a change in magnetization is produced that can be detected from outside and that gives information on the spatial distribution of the magnetic particles in the region of action. Alternatively, the displacement may also be repeated so frequently that the region of action heats up. To improve the accessibility of the region of action, the said region is situated outside the arrangement having means for generating magnetic fields.
摘要翻译：本发明涉及用于影响动作区域中的磁性颗粒的方法和装置。在具有产生磁场的装置的帮助下，产生空间不均匀的磁场，其具有至少一个区域（301），其中颗粒的磁化处于不饱和状态，而在剩余区域的饱和状态。通过在动作区域内移动所述区域，产生可以从外部检测到的磁化变化，并且提供关于磁性颗粒在作用区域中的空间分布的信息。或者，也可以如此频繁地重复位移，使得作用区域加热。为了提高作用区域的可达性，所述区域位于具有用于产生磁场的装置的布置之外。

4. 发明申请

WO2008078257A3 ARRANGEMENT FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION AND METHOD OF PRODUCING A DISK SHAPED COIL 审中-公开
标题翻译：影响和/或检测区域内磁性颗粒的装置和磁盘形状线圈的制造方法
公开(公告)号：WO2008078257A3
公开(公告)日：2008-11-27
申请号：PCT/IB2007055152
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN , KANZENBACH JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN , KANZENBACH JUERGEN
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515 , G01R33/1269
摘要： An arrangement for influencing and/or detecting magnetic particles in a region of action and a method of producing a disk shaped coil is disclosed, which arrangement comprises: selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the selection means and/or the drive means and/or the receiving means comprises an at least partially disk shaped coil.
摘要翻译：公开了一种用于影响和/或检测作用区域中的磁性粒子的装置和一种制造盘形线圈的方法，该装置包括：选择装置，用于产生具有磁场强度空间模式的磁选择场，例如在作用区域中形成具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域的驱动装置，用于改变在区域中的两个子区域的空间位置的驱动装置，通过磁驱动场作用以使磁性粒子的磁化局部改变;用于获取信号的接收装置，该信号取决于作用区域中的磁化，该磁化受空间位置变化第一和第二分区，其中选择装置和/或驱动装置和/或接收装置包括至少部分盘形的线圈。

5. 发明申请

WO2008078267A3 INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION OF AN EXAMINATION OBJECT 审中-公开
标题翻译：在检查对象的行为区域中影响和/或检测磁性颗粒
公开(公告)号：WO2008078267A3
公开(公告)日：2008-09-25
申请号：PCT/IB2007055163
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN
IPC分类号： A61B5/00
CPC分类号： A61B5/05 , A61B5/0515 , A61B5/415 , A61B5/418
摘要： A method and an arrangement for influencing and/or detecting magnetic particles in a region of action of an examination object is disclosed, which method comprises the steps of: generating a magnetic selection field by means of selection means, the magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field generated by drive means so that the magnetization of the magnetic particles change locally, acquiring signals by means of receiving means, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the selection means and/or the drive means and/or the receiving means are provided at least partly movable relative to the examination object during the acquisition and/or the change in the position in space of the two sub-zones in the region of action.
摘要翻译：公开了一种用于影响和/或检测检查对象的动作区域中的磁性颗粒的方法和装置，该方法包括以下步骤：通过选择装置产生磁选区，该磁选区具有图案在其磁场强度的空间中，使得具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域在作用区域中形成，改变两个子场的空间位置，通过由驱动装置产生的磁驱动场的动作区域，使得磁性颗粒的磁化在局部变化，通过接收装置获取信号，这些信号取决于作用区域中的磁化，该磁化受到第一和第二子区域的空间位置变化的影响，其中选择装置和/或驱动装置和/或接收装置是在获取过程中至少部分地相对于检查对象移动，和/或在动作区域中两个子区域的空间位置的改变。

6. 发明申请

WO2008078272A3 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：影响和/或检测行动区域中的磁性颗粒的装置和方法
公开(公告)号：WO2008078272A3
公开(公告)日：2008-08-21
申请号：PCT/IB2007055174
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515
摘要： An arrangement for influencing and/or detecting magnetic particles, a method for adjusting such an arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the receiving means comprises a first compensation means and a second compensation means the first and second compensation means comprising each a compensation coil.
摘要翻译：公开了一种用于影响和/或检测磁性粒子的装置，一种用于调整这种装置的方法以及一种用于影响和/或检测作用区域中的磁性粒子的方法，该装置包括用于产生磁选择场的选择装置，在其磁场强度的空间中形成图案，使得在该作用区域中形成具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域;用于改变空间位置的驱动装置在作用区域中的两个子区域借助磁场驱动磁性粒子的磁化局部改变，用于获取信号的接收装置，该信号取决于作用区域中的磁化，该磁化受到影响通过改变第一和第二分区的空间位置，其中接收装置包括第一补偿装置和秒补偿意味着第一和第二补偿装置包括每个补偿线圈。

7. 发明申请

WO2006067664A3 MARKER FOR POSITION DETERMINATION WITH A MAGNETIC METHOD 审中-公开
标题翻译：用磁性方法进行位置确定的标记
公开(公告)号：WO2006067664A3
公开(公告)日：2006-11-02
申请号：PCT/IB2005054171
申请日：2005-12-12
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN
IPC分类号： A61B5/06 , A61B19/00
CPC分类号： G01V15/00 , A61B5/05 , A61B5/0515 , A61B5/06 , A61B2090/3933 , A61B2090/3954
摘要： The application relates to a marker whose position in an examination region can be determined by a magnetic method. This method is used to determine the spatial distribution of magnetic particles in an examination region. A spatially inhomogeneous gradient magnetic field is generated, having at least one low field strength region in which the magnetization of the particles is in an unsaturated state, while they are in a saturated state in the rest of the region. Displacing the low field strength region by variation means insid the examination region leads to a change in the magnetization of the magnetic particles, which can be detected externally and contains information about th spatial distribution of the magnetic particles in the examination region. Wit the aid of the markers according to the invention it is also possible to determine the position of objects, or parts of the examination subject in the examination region.
摘要翻译：本申请涉及一种可以通过磁性方法确定检查区域的位置的标记物。该方法用于确定检测区域磁性颗粒的空间分布。产生空间不均匀的梯度磁场，具有至少一个低场强区域，其中颗粒的磁化处于不饱和状态，而在该区域的其余部分处于饱和状态。通过变化的方式使低场强度区域发生变化，因为检查区域导致磁性粒子的磁化变化，这可以从外部检测到，并且包含有关磁性粒子在检查区域中的空间分布的信息。在根据本发明的标记物的帮助下，也可以确定检查对象或检查对象的部分在检查区域中的位置。

8. 发明申请

WO2006067692A3 ARRANGEMENT AND METHOD FOR DETERMINING THE SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES 审中-公开
标题翻译：确定磁性粒子空间分布的布置和方法
公开(公告)号：WO2006067692A3
公开(公告)日：2006-09-08
申请号：PCT/IB2005054248
申请日：2005-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN , NIELSEN TIM
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN , NIELSEN TIM
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515
摘要： The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non- saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument.
摘要翻译：本发明涉及用于确定检查区域中的磁性颗粒的空间分布的布置和方法。磁场装置用于产生具有低场强的至少一个区域的空间不均匀梯度磁场，其中，粒子的磁化处于非饱和状态，而它们处于饱和状态剩余区域。通过使用改变装置在检查区域内以低场强移动区域，引起磁性粒子的磁化变化，其可以由检测装置从外部检测到，并且包含关于磁性粒子的空间分布的信息在考试区域。磁场装置或改变装置或检测装置或这些装置的组合至少部分地布置在医疗器械上。

9. 发明申请

WO2008078244A3 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：影响和/或检测行动区域中的磁性颗粒的装置和方法
公开(公告)号：WO2008078244A3
公开(公告)日：2008-09-25
申请号：PCT/IB2007055131
申请日：2007-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN
IPC分类号： A61B5/00 , G01R33/00
CPC分类号： A61B5/05 , A61B5/0515
摘要： An arrangement for influencing and/or detecting magnetic particles, a method for calibrating such an arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, the arrangement comprising a drive signal chain, receiving means for acquiring detection signals, which detection signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, the arrangement comprising a detection signal chain, wherein the arrangement comprises a compensation controller providing a compensation signal to the drive signal chain and/or to the detection signal chain by means of a coupling means.
摘要翻译：公开了一种用于影响和/或检测磁性颗粒的装置，一种用于校准这种装置的方法以及一种用于影响和/或检测作用区域中的磁性颗粒的方法，所述装置包括用于产生磁选择场的选择装置，在其磁场强度的空间中形成图案，使得在该作用区域中形成具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域;用于改变空间位置的驱动装置在作用区域中的两个子区域借助磁场驱动，使得磁性粒子的磁化局部改变，该装置包括驱动信号链，用于获取检测信号的接收装置，该检测信号取决于磁化在磁化受第一和第二子区的空间位置变化影响的作用区中，包括检测信号链的装置，其中该装置包括补偿控制器，该补偿控制器借助于耦合装置向驱动信号链和/或检测信号链提供补偿信号。

10. 发明申请

WO2008078242A3 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：在行动区域影响和/或检测磁性颗粒的布置方法
公开(公告)号：WO2008078242A3
公开(公告)日：2008-09-25
申请号：PCT/IB2007055126
申请日：2007-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , GLEICH BERNHARD , WEIZENECKER JUERGEN , KANZENBACH JUERGEN
发明人： GLEICH BERNHARD , WEIZENECKER JUERGEN , KANZENBACH JUERGEN
IPC分类号： A61B5/00 , H01B7/00
CPC分类号： A61B5/05 , A61B5/0515 , H01B7/30
摘要： An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises: - selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, - drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, - receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the selection means and/or the drive means and/or the receiving means comprises at least partially a litz wire/stranded wire.
摘要翻译：公开了一种用于影响和/或检测动作区域中的磁性颗粒的装置和方法，该装置包括： - 选择装置，用于产生具有其磁场强度的空间中的图案的磁选区，在动作区域中形成具有低磁场强度的区域和具有较高磁场强度的第二子区域; - 驱动装置，用于通过以下方式改变作用区域中两个子区域的空间位置：磁性磁场，使得磁性颗粒的磁化在局部变化; - 接收装置，用于获取信号，该信号取决于作用区域中的磁化强度，该磁化受第一和第二空间位置的变化的影响; 第二子区，其中所述选择装置和/或所述驱动装置和/或所述接收装置至少部分地包括绞合线/绞线。

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