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1. 发明申请

WO2004014917A3 ANTITUMORAL ANALOGS OF LAMELLARINS 审中-公开
标题翻译：层状蛋白的抗肿瘤类似物
公开(公告)号：WO2004014917A3
公开(公告)日：2004-05-13
申请号：PCT/GB0303541
申请日：2003-08-13
申请人： PHARMA MAR SAU , BAILLY CHRISTIAN , FRANCESCH SOLLOSO ANDRES , MATEO URBANO MARIA CRISTINA , JIMENEZ GUERRERO JOSE ANTONIO , PASTOR DEL CASTILLO ALFREDO , CUEVAS MARCHANTE CARMEN , RUFFLES GRAHAM KEITH
发明人： BAILLY CHRISTIAN , FRANCESCH SOLLOSO ANDRES , MATEO URBANO MARIA CRISTINA , JIMENEZ GUERRERO JOSE ANTONIO , PASTOR DEL CASTILLO ALFREDO , CUEVAS MARCHANTE CARMEN
IPC分类号： C07D491/147 , A61K31/437 , A61K31/4745 , A61P35/00 , A61P43/00 , C07D471/14 , C07D491/00 , C07D491/14 , A61K31/435 , C07D471/04
CPC分类号： C07D471/14 , C07D491/14
摘要： New lamellarins are provided of the general formula III wherein X is selected from the group consisting of N, O and S; wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from the group consisting of H, OH, OR', SH, SR', SO2R', NHR', N(R')2, N=R', NHCOR', N(COR')2, NHS02R', N02, PO(R'2, P02R', C(=0)H, C(=0)R', C02H, C02R', OPO(R')2, OP02R', OC(=0)H, OC(=0)R', N=C(R')2, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C1-C12 haloalkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R' groups is independently selected from the group consisting of H, OH, N02, NH2, SH, CN, halogen, =0, C(=0)H, C(=O)CH3, C02H, C(=0)R', substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted C1-C18 alkoxyl, substituted or unsubstituted C1-C18 aminoalkyl, substituted or unsubstituted C1-C18 aminoacid, substituted or unsubstituted C1-C18 thioalkyl, substituted or unsubstituted C1-C18 alkylsulfinyl, substituted or unsubstituted C1-C18 alkylsulfonyl; wherein the pairs of groups R1 and R2, R2 and R3, R3 and R4, R3 and R9, R4 and R9, R9 and R5, R9 and R6, or R6 and R7, R7 and R8 may be joined into a carbocyclic or heterocyclic ring system; and the dotted line represents an single or double bond; or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof.
摘要翻译：提供了通式III的新片晶蛋白，其中X选自N，O和S; 其中R1，R2，R3，R4，R5，R6，R7，R8和R9各自独立地选自H，OH，OR'，SH，SR'，SO2R'，NHR'，N 2，N = R'，NHCOR'，N（COR'）2，NHSO 2 R'，NO 2，PO（R'2，PO 2 R'，C（= O）H，C（= O）R'，CO 2 H，（= O）H，OC（= O）R'，N = C（R'）2，取代或未取代的C 1 -C 12烷基，取代或未取代的C 1 -C 12卤代烷基取代或未取代的C 2 -C 12烯基，取代或未取代的C 2 -C 12炔基，取代或未取代的芳基，取代或未取代的芳烷基和取代或未取代的杂芳族基团;其中每个R'基团独立地选自H，OH （= O）CH 3，CO 2 H，C（= O）R'，取代或未取代的C 1 -C 18烷基，取代或未取代的C 2 -C 6烷基，取代或未取代的C 1 -C 18烷基， -C 18烯基，取代或未取代的C 2 -C 18炔基，取代或未取代的芳基，取代或未取代的C 1 -C 18烷氧基，取代或未取代的C 1 -C 18氨基烷基，取代或未取代的C 1 -C 18硫代烷基，取代或未取代的C 1 -C 18烷基亚磺酰基，取代或未取代的C 1 -C 18烷基磺酰基; 其中基团对R1和R2，R2和R3，R3和R4，R3和R9，R4和R9，R9和R5，R9和R6或R6和R7，R7和R8可以连接成碳环或杂环系统; 虚线表示单键或双键; 或其药学上可接受的盐，衍生物，前药或立体异构体。

2. 发明申请

WO2004083365A9 COMPOUNDS AND THEIR USE FOR SPECIFIC AND SIMULTANEOUS INHIBITION OF GENES INVOLVED IN DISEASES AND RELATED DRUGS 审中-公开
标题翻译：化合物及其用于特异性和同时抑制疾病和相关药物参与的基因的使用
公开(公告)号：WO2004083365A9
公开(公告)日：2008-07-10
申请号：PCT/EP2004004022
申请日：2004-03-18
申请人： INST NAT SANTE RECH MED , CENTRE NAT RECH SCIENT , MUSEUM NAT D HISTOIRE NATURELL , ARIMONDO PAOLA BARBARA , BOUTORINE ALEXANDRE , SUN JIAN-SHENG , BAILLY CHRISTIAN , HELENE CLAUDE , GARESTIER THERESE
发明人： ARIMONDO PAOLA BARBARA , BOUTORINE ALEXANDRE , SUN JIAN-SHENG , BAILLY CHRISTIAN , HELENE CLAUDE , GARESTIER THERESE
IPC分类号： A61K38/00 , A61P35/00 , C12N15/113
CPC分类号： C12N15/1132 , A61K38/00 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N2310/15 , C12N2310/314 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/3511 , C12N2310/53
摘要： The invention relate to the use of a compound of formula A-B-C Wherein A is a DNA sequence-specific ligand capable of simultaneously and specifically recognizing a sequence common to genes of pathological interest; B is a linker arm, said linker arm being bound to the 3' end of A; C is a topoisomerase I posion; for the preparation of a drug for the treatment of a disease brought about by the expression of a gene and said gene is inhibited by the stabilized topoisomerase I-mediated DNA cleavage. Application, particularly, for the treatment of infective microorganism or virus, dismetabolic disease and autoimmune disease.
摘要翻译：本发明涉及式A-B-C化合物的用途，其中A是能够同时且特异性识别病理学基因共有序列的DNA序列特异性配体; B是连接臂，所述连接臂与A的3'末端结合; C是拓扑异构酶I posion; 用于制备用于治疗由基因表达引起的疾病的药物，并且所述基因被稳定化的拓扑异构酶I介导的DNA切割抑制。尤其适用于治疗感染性微生物或病毒，代谢疾病和自身免疫性疾病。

3. 发明申请

WO2008068042A3 POLYMER COMPOSITE MATERIAL STRUCTURES COMPRISING CARBON BASED CONDUCTIVE LOADS 审中-公开
标题翻译：聚合物复合材料结构包含基于碳的导电负载
公开(公告)号：WO2008068042A3
公开(公告)日：2008-08-07
申请号：PCT/EP2007010786
申请日：2007-12-04
申请人： UNIV LOUVAIN , UNIV LIEGE , JEROME ROBERT , PAGNOULLE CHRISTOPHE , DETREMBLEUR CHRISTOPHE , THOMASSIN JEAN-MICHEL , HUYNEN ISABELLE , BAILLY CHRISTIAN , BEDNARZ LUKASZ , DAUSSIN RAPHAEL , SAIB AIMAD , BAUDOUIN ANNE-CHRISTINE , LALOYAUX XAVIER
发明人： JEROME ROBERT , PAGNOULLE CHRISTOPHE , DETREMBLEUR CHRISTOPHE , THOMASSIN JEAN-MICHEL , HUYNEN ISABELLE , BAILLY CHRISTIAN , BEDNARZ LUKASZ , DAUSSIN RAPHAEL , SAIB AIMAD , BAUDOUIN ANNE-CHRISTINE , LALOYAUX XAVIER
IPC分类号： C08J9/00 , H05K9/00
CPC分类号： C08J9/0066 , H05K9/0083 , Y10T428/249986
摘要： The present invention provides a polymer composite material structure comprising at least one layer of a foamed polymer composite material comprising a foamed polymer matrix and 0.1 wt% to 6 wt% carbon based conductive loads, such as e.g. carbon nanotubes, dispersed in the foamed polymer matrix. The polymer composite material structure according to embodiments of the present invention shows good shielding and absorbing properties notwithstanding the low amount of carbon based conductive loads. The present invention furthermore provides a method for forming a polymer composite material structure comprising carbon based conductive loads.
摘要翻译：本发明提供一种聚合物复合材料结构，其包含至少一层泡沫聚合物复合材料层，其包含发泡聚合物基质和0.1重量％至6重量％的碳基导电载荷，分散在发泡聚合物基质中的碳纳米管。根据本发明的实施方案的聚合物复合材料结构虽然具有低的碳基导电载量，但显示出良好的屏蔽和吸收性能。本发明还提供了一种形成包含碳基导电负载的聚合物复合材料结构的方法。

4. 发明申请

WO2004083365A2 COMPOUNDS AND THEIR USE FOR SPECIFIC AND SIMULTANEOUS INHIBITION OF GENES INVOLVED IN DISEASES AND RELATED DRUGS 审中-公开
标题翻译：化合物及其用于特异性和同时抑制疾病和相关药物参与的基因的使用
公开(公告)号：WO2004083365A2
公开(公告)日：2004-09-30
申请号：PCT/EP2004004022
申请日：2004-03-18
申请人： INST NAT SANTE RECH MED , CENTRE NAT RECH SCIENT , MUSEUM NAT D HISTOIRE NATURELL , ARIMONDO PAOLA BARBARA , BOUTORINE ALEXANDRE , SUN JIAN-SHENG , BAILLY CHRISTIAN , HELENE CLAUDE , GARESTIER THERESE
发明人： ARIMONDO PAOLA BARBARA , BOUTORINE ALEXANDRE , SUN JIAN-SHENG , BAILLY CHRISTIAN , HELENE CLAUDE , GARESTIER THERESE
IPC分类号： A61K38/00 , A61P35/00 , C12N15/113 , C12N
CPC分类号： C12N15/1132 , A61K38/00 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N2310/15 , C12N2310/314 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/3511 , C12N2310/53
摘要： The invention relate to the use of a compound of formula A-B-C Wherein A is a DNA sequence-specific ligand capable of simultaneously and specifically recognizing a sequence common to genes of pathological interest; B is a linker arm, said linker arm being bound to the 3' end of A; C is a topoisomerase I posion; for the preparation of a drug for the treatment of a disease brought about by the expression of a gene and said gene is inhibited by the stabilized topoisomerase I-mediated DNA cleavage. Application, particularly, for the treatment of infective microorganism or virus, dismetabolic disease and autoimmune disease.
摘要翻译：本发明涉及式A-B-C化合物的用途，其中A是能够同时且特异性识别病理学基因共有序列的DNA序列特异性配体; B是连接臂，所述连接臂与A的3'末端结合; C是拓扑异构酶I posion; 用于制备用于治疗由基因表达引起的疾病的药物，并且所述基因被稳定化的拓扑异构酶I介导的DNA切割抑制。尤其适用于治疗感染性微生物或病毒，代谢疾病和自身免疫性疾病。

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