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1. 发明申请

WO2010149688A3 ANTITUMORAL COMPOUNDS 审中-公开
标题翻译：抗肿瘤化合物
公开(公告)号：WO2010149688A3
公开(公告)日：2011-08-25
申请号：PCT/EP2010058879
申请日：2010-06-23
申请人： PHARMA MAR SA , GARRANZO GARCIA-IBARROLA MARIA , MURCIA PEREZ CARMEN , RODRIGUEZ VICENTE ALBERTO , MATEO URBANO MARIA CRISTINA , SANCHEZ SANCHO FRANCISCO , FRANCESCH SOLLOSO ANDRES , CUEVAS MARCHANTE MARIA DEL CARMEN
发明人： GARRANZO GARCIA-IBARROLA MARIA , MURCIA PEREZ CARMEN , RODRIGUEZ VICENTE ALBERTO , MATEO URBANO MARIA CRISTINA , SANCHEZ SANCHO FRANCISCO , FRANCESCH SOLLOSO ANDRES , CUEVAS MARCHANTE MARIA DEL CARMEN
IPC分类号： C07C235/76 , A61K31/16 , A61K31/27 , A61P35/00 , C07C237/22 , C07C271/12 , C07F7/18
CPC分类号： C07C271/12 , C07C237/22 , C07F7/1852
摘要： A compound of general formula (I), wherein Y, W, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and the dashed lines take various meanings, for use in the treatment of cancer.
摘要翻译：通式（I）的化合物，其中Y，W，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11和虚线具有各种含义，用于治疗癌症。

2. 发明申请

WO2004014917A3 ANTITUMORAL ANALOGS OF LAMELLARINS 审中-公开
标题翻译：层状蛋白的抗肿瘤类似物
公开(公告)号：WO2004014917A3
公开(公告)日：2004-05-13
申请号：PCT/GB0303541
申请日：2003-08-13
申请人： PHARMA MAR SAU , BAILLY CHRISTIAN , FRANCESCH SOLLOSO ANDRES , MATEO URBANO MARIA CRISTINA , JIMENEZ GUERRERO JOSE ANTONIO , PASTOR DEL CASTILLO ALFREDO , CUEVAS MARCHANTE CARMEN , RUFFLES GRAHAM KEITH
发明人： BAILLY CHRISTIAN , FRANCESCH SOLLOSO ANDRES , MATEO URBANO MARIA CRISTINA , JIMENEZ GUERRERO JOSE ANTONIO , PASTOR DEL CASTILLO ALFREDO , CUEVAS MARCHANTE CARMEN
IPC分类号： C07D491/147 , A61K31/437 , A61K31/4745 , A61P35/00 , A61P43/00 , C07D471/14 , C07D491/00 , C07D491/14 , A61K31/435 , C07D471/04
CPC分类号： C07D471/14 , C07D491/14
摘要： New lamellarins are provided of the general formula III wherein X is selected from the group consisting of N, O and S; wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from the group consisting of H, OH, OR', SH, SR', SO2R', NHR', N(R')2, N=R', NHCOR', N(COR')2, NHS02R', N02, PO(R'2, P02R', C(=0)H, C(=0)R', C02H, C02R', OPO(R')2, OP02R', OC(=0)H, OC(=0)R', N=C(R')2, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C1-C12 haloalkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R' groups is independently selected from the group consisting of H, OH, N02, NH2, SH, CN, halogen, =0, C(=0)H, C(=O)CH3, C02H, C(=0)R', substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted C1-C18 alkoxyl, substituted or unsubstituted C1-C18 aminoalkyl, substituted or unsubstituted C1-C18 aminoacid, substituted or unsubstituted C1-C18 thioalkyl, substituted or unsubstituted C1-C18 alkylsulfinyl, substituted or unsubstituted C1-C18 alkylsulfonyl; wherein the pairs of groups R1 and R2, R2 and R3, R3 and R4, R3 and R9, R4 and R9, R9 and R5, R9 and R6, or R6 and R7, R7 and R8 may be joined into a carbocyclic or heterocyclic ring system; and the dotted line represents an single or double bond; or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof.
摘要翻译：提供了通式III的新片晶蛋白，其中X选自N，O和S; 其中R1，R2，R3，R4，R5，R6，R7，R8和R9各自独立地选自H，OH，OR'，SH，SR'，SO2R'，NHR'，N 2，N = R'，NHCOR'，N（COR'）2，NHSO 2 R'，NO 2，PO（R'2，PO 2 R'，C（= O）H，C（= O）R'，CO 2 H，（= O）H，OC（= O）R'，N = C（R'）2，取代或未取代的C 1 -C 12烷基，取代或未取代的C 1 -C 12卤代烷基取代或未取代的C 2 -C 12烯基，取代或未取代的C 2 -C 12炔基，取代或未取代的芳基，取代或未取代的芳烷基和取代或未取代的杂芳族基团;其中每个R'基团独立地选自H，OH （= O）CH 3，CO 2 H，C（= O）R'，取代或未取代的C 1 -C 18烷基，取代或未取代的C 2 -C 6烷基，取代或未取代的C 1 -C 18烷基， -C 18烯基，取代或未取代的C 2 -C 18炔基，取代或未取代的芳基，取代或未取代的C 1 -C 18烷氧基，取代或未取代的C 1 -C 18氨基烷基，取代或未取代的C 1 -C 18硫代烷基，取代或未取代的C 1 -C 18烷基亚磺酰基，取代或未取代的C 1 -C 18烷基磺酰基; 其中基团对R1和R2，R2和R3，R3和R4，R3和R9，R4和R9，R9和R5，R9和R6或R6和R7，R7和R8可以连接成碳环或杂环系统; 虚线表示单键或双键; 或其药学上可接受的盐，衍生物，前药或立体异构体。

3. 发明申请

WO2007068776B1 ANTITUMOUR COMPOUNDS 审中-公开
标题翻译：抗肿瘤化合物
公开(公告)号：WO2007068776B1
公开(公告)日：2007-08-02
申请号：PCT/ES2006000687
申请日：2006-12-14
申请人： PHARMA MAR SA , MARTIN LOPEZ MA JESUS , REYES BENITEZ JOSE FERNANDO , FERNANDEZ RODRIGUEZ ROGELIO , FRANCESCH SOLLOSO ANDRES , CUEVAS MARCHANTE MARIA DEL CAR , COELLO MOLINERO LAURA
发明人： MARTIN LOPEZ MA JESUS , REYES BENITEZ JOSE FERNANDO , FERNANDEZ RODRIGUEZ ROGELIO , FRANCESCH SOLLOSO ANDRES , CUEVAS MARCHANTE MARIA DEL CAR , COELLO MOLINERO LAURA
IPC分类号： C07D493/18 , A61K31/357 , A61P35/00 , C07D311/00 , C07D323/00 , C07D493/22
CPC分类号： C07D493/18
摘要： The invention relates to novel antitumour compounds having general formula (I) and to the corresponding pharmaceutically-acceptable salts, derivatives, pro-drugs and stereoisomers thereof. The inventive compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. Said compounds have a cytotoxic activity and can be used for the treatment of cancer.
摘要翻译：本发明涉及具有通式（I）的新型抗肿瘤化合物及其相应的药学上可接受的盐，衍生物，前药和立体异构体。本发明的化合物可以通过从海鸥科，海桐属和物种swinhoei分离海绵并由分离的化合物形成衍生物而获得。所述化合物具有细胞毒活性并可用于治疗癌症。

4. 发明申请

WO2005103072A8 CONVERGENT SYNTHESIS FOR KAHALALIDE COMPOUNDS 审中-公开
标题翻译：卡拉沙利特化合物的合成合成
公开(公告)号：WO2005103072A8
公开(公告)日：2006-05-18
申请号：PCT/GB2005001537
申请日：2005-04-22
申请人： PHARMA MAR SAU , TUBBY DAVID GEORGE , FRANCESCH SOLLOSO ANDRES , LOPEZ MACIA ANGEL , CUEVAS MARCHANTE CARMEN , ALBERICIO PALOMERA FERNANDO , ACOSTA CRESPO GERARDO , CRUZ RICONDO LUIS JAVIER , GIRALT LLEDO ERNEST , GRACIA CANTADOR CAROLINA , ISIDRO LOBET ALBERT
发明人： FRANCESCH SOLLOSO ANDRES , LOPEZ MACIA ANGEL , CUEVAS MARCHANTE CARMEN , ALBERICIO PALOMERA FERNANDO , ACOSTA CRESPO GERARDO , CRUZ RICONDO LUIS JAVIER , GIRALT LLEDO ERNEST , GRACIA CANTADOR CAROLINA , ISIDRO LOBET ALBERT
IPC分类号： C07K1/107 , C07K7/08
CPC分类号： C07K7/08
摘要： New synthetic routes to kahalalide compounds are provided. These are based on convergent approaches using orthogonal protecting schemes, where a better control of the intermediates is taken. Kahalalide F or a mimic of kahalalide F is synthesised by coupling a cyclic part with a side chain fragment, e.g. according to the reaction (1)
摘要翻译：提供了新的合成kahalalide化合物的途径。这些基于使用正交保护方案的收敛方法，其中采用更好的控制中间体。卡哈拉肽F或卡拉沙利汀F的模拟物通过将环状部分与侧链片段偶联而合成。根据反应（1）

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