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1. 发明申请

WO2005105744A1 HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：组胺-3受体拮抗剂
公开(公告)号：WO2005105744A1
公开(公告)日：2005-11-10
申请号：PCT/IB2005/001038
申请日：2005-04-18
申请人： PFIZER PRODUCTS INC. , HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
发明人： HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
IPC分类号： C07D213/38
CPC分类号： C07D213/38 , A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/506 , A61K45/06 , C07C215/30 , C07C233/43 , C07C237/30 , C07C255/58 , C07C311/37 , C07C317/32 , C07C323/32 , C07D207/09 , C07D209/08 , C07D211/26 , C07D213/61 , C07D217/02 , C07D231/12 , C07D239/26 , C07D239/30 , C07D239/34 , C07D239/36 , C07D239/42 , C07D239/52 , C07D261/08 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/58 , A61K2300/00
摘要： This invention is directed to a compound of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy- induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro- intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
摘要翻译：本发明涉及本文定义的式（I）化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用如上所述的式I化合物，以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神障碍，睡眠中的障碍或病症的方法过敏反应，过敏性鼻炎，鼻塞，过敏性充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动性和酸性分泌胃肠道，该方法包括向需要这种治疗的哺乳动物施用f 如上所述。

2. 发明申请

WO2006011042A1 1, 3 SUBSTITUTED CYCLOAMINO DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 1,3代替环孢霉素衍生物及其作为组胺3受体拮抗剂的用途
公开(公告)号：WO2006011042A1
公开(公告)日：2006-02-02
申请号：PCT/IB2005/002185
申请日：2005-07-07
申请人： PFIZER PRODUCTS INC. , HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
发明人： HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
IPC分类号： C07D401/10
CPC分类号： C07D207/14 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： This invention is directed to compounds of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above.
摘要翻译：本发明涉及本文定义的式（I）化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，该方法包括向需要这种治疗的哺乳动物施用如上所述的式（I）化合物以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神病性障碍，睡眠障碍，肥胖，眩晕，癫痫，运动病，呼吸系统疾病，过敏，过敏引起的气道反应，过敏性鼻炎，鼻充血，过敏充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动和胃肠道的酸性分泌，所述方法包括向需要这种治疗的哺乳动物施用f （I）。

3. 发明申请

WO2006000914A1 DIAZABICYCLIC HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： DIAZABICYCLIC HISTAMINE-3受体拮抗剂
公开(公告)号：WO2006000914A1
公开(公告)日：2006-01-05
申请号：PCT/IB2005/002089
申请日：2005-06-10
申请人： PFIZER PRODUCTS INC. , HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
发明人： HOWARD, Harry, Ralph, Jr. , WLODECKI, Bishop
IPC分类号： A61K31/4985
CPC分类号： C07D471/04
摘要： This invention is directed to compounds of the formula (I) and (II) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula (I) or (II), a method of treatment of a disorder or condition that may be treated by antagonizing histamine H 3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) or (II) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) or (II) as described above.
摘要翻译：本发明涉及本文定义的式（I）和（II）化合物或其药学上可接受的盐; 含有式（I）或（II）化合物的药物组合物，治疗可以通过拮抗组胺H

4. 发明申请

WO2006024955A1 AZABICYCLIC AMINE HISTAMINE-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： AZABICYCLIC HISTAMINE-3受体拮抗剂
公开(公告)号：WO2006024955A1
公开(公告)日：2006-03-09
申请号：PCT/IB2005/003014
申请日：2005-08-22
申请人： PFIZER PRODUCTS INC. , WLODECKI, Bishop
发明人： WLODECKI, Bishop
IPC分类号： C07D209/52 , A61K31/40 , A61P1/04 , A61P17/00
CPC分类号： C07D209/02 , C07D209/52
摘要： This invention is directed to compounds of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
摘要翻译：本发明涉及本文定义的式（I）化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用如上所述的式I化合物，以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神障碍，睡眠中的障碍或病症的方法疾病，肥胖，头晕，癫痫，晕车，呼吸系统疾病，过敏，过敏引起的气道反应，过敏性鼻炎，鼻充血，过敏充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动性和酸性分泌胃肠道，该方法包括向需要这种治疗的哺乳动物施用化合物我如上所述。

5. 发明申请

WO2004081007A1 PYRIDYLOXYMETHYL AND BENZISOXAZOLE AZABICYCLIC DERIVATIVES 审中-公开
标题翻译：吡咯烷基甲基和苯并恶唑偶氮衍生物
公开(公告)号：WO2004081007A1
公开(公告)日：2004-09-23
申请号：PCT/IB2004/000499
申请日：2004-02-23
申请人： PFIZER PRODUCTS INC. , BRIGHT, Gene, Michael , BRODNEY, Michael, Aaron , WLODECKI, Bishop
发明人： BRIGHT, Gene, Michael , BRODNEY, Michael, Aaron , WLODECKI, Bishop
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： An aminomethylpyridyloxymethyl/benzisoxazole substituted azabicyclic compound according to formula (I) a pharmaceutical composition comprising same, and a method of treating one or more CNS or other disorders, including concurrent treatment of disorders such as chizophrenia and depression. Or the (R) or (S) enantiomer thereof, or the cis or trans isomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, or of any of the foregoing, wherein m is 0 or 1, Z is wherein R 7 is hydrogen or (C 1 -C 3 )alkoxy; R 8 is hydrogen, hydroxy, or (C 1 -C 3 )alkoxy; and R 9 is (C 1 -C 3 )alkoxy; X is oxygen or NR, wherein R is hydrogen or (C 1 -C 6 )alkyl; Y is methylene, wherein n is 0, 1 or 2; or oxygen, nitrogen or sulfur, wherein n is 2, 3 or 4; R 1 and R 2 are each independently hydrogen, halogen, or a (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy or a (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl group, any one of which groups may be unsbustituted or substituted with one or more halogens.
摘要翻译：根据式（I）的氨基甲基吡啶氧基甲基/苯并异恶唑取代的氮杂双环化合物，包含其的药物组合物，以及治疗一种或多种CNS或其它病症的方法，包括同时治疗诸如精神分裂症和抑郁症等疾病。或其（R）或（S）对映异构体或其顺式或反式异构体或其药学上可接受的盐，溶剂化物或前药，或任何上述物质，其中m为0或1，Z为其中R 7>是氢或（C 1 -C 3）烷氧基; R 8是氢，羟基或（C 1 -C 3）烷氧基; 并且R 9为（C 1 -C 3）烷氧基; X是氧或NR，其中R是氢或（C1-C6）烷基; Y是亚甲基，其中n是0,1或2; 或氧，氮或硫，其中n为2,3或4; R 1和R 2各自独立地为氢，卤素或（C 1 -C 6）烷基，（C 1 -C 6）烷氧基或（C 1 -C 6）烷氧基（C 1 -C 6）烷基，哪些基团可以是未被取代的或被一个或多个卤素取代。

6. 发明申请

WO2004043929A1 QUINOLINE DERIVATIVES 审中-公开
标题翻译：喹啉衍生物
公开(公告)号：WO2004043929A1
公开(公告)日：2004-05-27
申请号：PCT/IB2003/004903
申请日：2003-10-31
申请人： PFIZER PRODUCTS INC. , WLODECKI, Bishop , BRIGHT, Gene, Michael
发明人： WLODECKI, Bishop , BRIGHT, Gene, Michael
IPC分类号： C07D215/12
CPC分类号： C07D401/04
摘要： The present invention relates to compounds of Formula I, wherein R 1 , R 2 , R 3 , R 4 , and n are as defined, and to pharmaceutically acceptable salts of said compounds. Compounds of Formula I have activity in agonizing 5HT7 receptors and are useful in treating, for example, disorders that can be treated by modulating circadian rhythms.
摘要翻译：本发明涉及式I化合物，其中R 1，R 2，R 3，R 4和n如上定义，以及所述化合物的药学上可接受的盐。式I化合物在激动5HT7受体中具有活性，并且可用于治疗例如可通过调节昼夜节律治疗的病症。

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