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1. 发明申请

WO2006079922A3 FAST-DISINTEGRATING MICROPOROUS BINDER AND PROCESS FOR MAKING IT 审中-公开
标题翻译：快速消毒微生物粘合剂及其制备方法
公开(公告)号：WO2006079922A3
公开(公告)日：2006-09-28
申请号：PCT/IB2006000189
申请日：2006-01-17
申请人： PFIZER PROD INC , CREW MARSHALL DAVID , FALK RICHARD FRANK , FRIESEN DWAYNE THOMAS , KONAGURTHU SANJAY , RAY RODERICK JACK
发明人： CREW MARSHALL DAVID , FALK RICHARD FRANK , FRIESEN DWAYNE THOMAS , KONAGURTHU SANJAY , RAY RODERICK JACK
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/1617 , A61K9/0056 , A61K9/1652 , A61K9/2054
摘要： A highly porous, fast-disintegrating binder suitable for pharmaceutical applications and methods of making the same are disclosed, the binder comprising microporous particles of an aqueous-soluble cellulosic polymer and a wicking agent. Pharmaceutical compositions and fast-disintegrating dosage forms containing the binder are also disclosed.
摘要翻译：公开了一种适用于药物应用的高度多孔，快速崩解的粘合剂及其制备方法，所述粘合剂包含水溶性纤维素聚合物的微孔颗粒和芯吸剂。还公开了含有粘合剂的药物组合物和快速崩解剂型。

2. 发明申请

WO2005053640A2 AZITHROMYCIN MULTIPARTICULATE DOSAGE FORMS BY LIQUID-BASED PROCESSES 审中-公开
标题翻译： AZITHROMYCIN基于液体过程的多重剂量形式
公开(公告)号：WO2005053640A2
公开(公告)日：2005-06-16
申请号：PCT/IB2004003911
申请日：2004-11-29
申请人： PFIZER PROD INC , APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , RAY RODERICK JACK , WEST JAMES BLAIR
发明人： APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , RAY RODERICK JACK , WEST JAMES BLAIR
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/52 , A61K31/7048 , B29B9/00
CPC分类号： A61K9/1652 , A61K9/1676 , A61K31/7048
摘要： Liquid-based processes are disclosed for forming azithromycin multiparticulates having minimal amounts of azithromycin esters.
摘要翻译：公开了用于形成具有最少量的阿奇霉素酯的阿奇霉素多颗粒的基于液体的方法。

3. 发明申请

WO2005053652A8 MULTIPARTICULATE CRYSTALLINE DRUG COMPOSITIONS CONTAINING A POLOXAMER AND A GLYCERIDE 审中-公开
标题翻译：含有泊洛沙姆和甘油酯的多颗粒结晶药物组合物
公开(公告)号：WO2005053652A8
公开(公告)日：2005-08-04
申请号：PCT/IB2004003808
申请日：2004-11-22
申请人： PFIZER PROD INC , APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , HERBIG SCOTT M , LO JULIAN BELKNAP , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , RAY RODERICK JACK , WEST JAMES BLAIR
发明人： APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , HERBIG SCOTT M , LO JULIAN BELKNAP , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , RAY RODERICK JACK , WEST JAMES BLAIR
IPC分类号： A61K9/16 , A61K31/00 , A61K31/4422 , A61K31/7032
CPC分类号： A61K31/7032 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K31/4422
摘要： A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt% of the drug in the multiparticulate is crystalline.
摘要翻译：用于药物受控释放的多颗粒包含结晶药物，具有至少一个至少16个碳原子的烷基化物取代基的甘油酯和泊洛沙姆，其中多颗粒中至少70wt％的药物是结晶的。

4. 发明申请

WO2005053639A3 CONTROLLED RELEASE MULTIPARTICULATES FORMED WITH DISSOLUTION ENHANCERS 审中-公开
标题翻译：控制释放与溶解增强剂形成的多重化合物
公开(公告)号：WO2005053639A3
公开(公告)日：2006-03-23
申请号：PCT/IB2004003857
申请日：2004-11-22
申请人： PFIZER PROD INC , APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LO JULIAN BELKNAP , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , NEWBOLD DAVID DIXON , RAY RODERICK JACK , WEST JAMES BLAIR
发明人： APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LO JULIAN BELKNAP , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , NEWBOLD DAVID DIXON , RAY RODERICK JACK , WEST JAMES BLAIR
IPC分类号： A61K9/14 , A61K9/16 , A61K9/22 , A61K31/7052
CPC分类号： A61K9/1617
摘要： Pharmaceutical compositions of crystalline azithromycin-containing multiparticulates having low concentrations of azithromycin ester degradants and exhibiting controlled release of the drug are achieved by inclusion of dissolution enhancers having low concentrations of acid and ester substituents.
摘要翻译：通过包含具有低浓度的酸和酯取代基的溶解增强剂来实现具有低浓度的阿奇霉素酯降解物并显示药物释放控制的含结晶阿奇霉素的多颗粒的药物组合物。

5. 发明申请

WO2008065506A2 PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES COMPRISING ENTERIC POLYMERS AND CASEIN 审中-公开
标题翻译：包含肠溶聚合物和壳聚糖的纳米颗粒的药物组合物
公开(公告)号：WO2008065506A2
公开(公告)日：2008-06-05
申请号：PCT/IB2007003632
申请日：2007-11-16
申请人： PFIZER PROD INC , BEYERINCK RONALD ARTHUR , BLOOM COREY JAY , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
发明人： BEYERINCK RONALD ARTHUR , BLOOM COREY JAY , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
IPC分类号： A61K9/16 , A61K9/50 , A61K9/51 , A61K31/135
CPC分类号： A61K31/135 , A61K9/5161 , A61K9/5169 , A61K9/5192
摘要： A pharmaceutical composition comprises nanoparticles comprising the poorly water soluble lipophilic compound (2R)-3-[[3-(4-chloro-3-ethylphenoxy)phenyl][[3-(1,1,2,2- tetrafluoroethoxy)phenyl]methyl]amino]-1,1,1-trifluoro-2-propanol, and an enteric polymer.
摘要翻译：药物组合物包含包含难溶于水的亲脂性化合物（2R）-3 - [[3-（4-氯-3-乙基苯氧基）苯基] [[3-（1,1,2,2-四氟乙氧基）苯基] 甲基]氨基] -1,1,1-三氟-2-丙醇和肠溶性聚合物。

6. 发明申请

WO2005065656A3 STABILIZED PHARMACEUTICAL SOLID COMPOSITIONS OF LOW-SOLUBILITY DRUGS, POLOXAMERS, AND STABILIZING POLYMERS 审中-公开
标题翻译：低溶解性药物，POLOXAMERS和稳定聚合物稳定的药物固体组合物
公开(公告)号：WO2005065656A3
公开(公告)日：2006-07-13
申请号：PCT/IB2004004260
申请日：2004-12-20
申请人： PFIZER PROD INC , CREW MARSHALL DAVID , SHANKER RAVI MYSORE , SMITHEY DANIEL TOD , MILLER WARREN KENYON , FRIESEN DWAYNE THOMAS
发明人： CREW MARSHALL DAVID , SHANKER RAVI MYSORE , SMITHEY DANIEL TOD , MILLER WARREN KENYON , FRIESEN DWAYNE THOMAS
IPC分类号： A61K9/16
CPC分类号： A61K9/1652 , A61K9/1635 , A61K9/1641 , A61K31/47
摘要： Solid compositions with improved physical stability comprise an amorphous, low-solubility drug, a poloxamer, and a stabilizing polymer. The compositions provide good physical stability during storage and concentration enhancement of dissolved drug when administered to an aqueous environment of use.
摘要翻译：具有改善的物理稳定性的固体组合物包括无定形，低溶解度药物，泊洛沙姆和稳定聚合物。当给予使用的水性环境时，所述组合物在溶解药物的储存和浓缩增强期间提供良好的物理稳定性。

7. 发明申请

WO2008125940A3 NANOPARTICLES COMPRISING NON-CRYSTALLINE DRUG 审中-公开
标题翻译：包含非晶体药物的纳米颗粒
公开(公告)号：WO2008125940A3
公开(公告)日：2009-08-06
申请号：PCT/IB2008000844
申请日：2008-04-07
申请人： PFIZER PROD INC , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , SMITHEY DANIEL TOD , MORGEN MICHAEL MARK , TADDAY RALPH
发明人： CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , SMITHEY DANIEL TOD , MORGEN MICHAEL MARK , TADDAY RALPH
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , A61K9/1617 , A61K9/5146 , A61K9/5192
摘要： A pharmaceutical composition comprises nanoparticles comprising a core of non-crystalline drug and surface stabilizers consisting of a phospholipid and a bile salt.
摘要翻译：药物组合物包含包含非结晶药物核心和由磷脂和胆汁盐组成的表面稳定剂的纳米颗粒。

8. 发明申请

WO2009010842A3 NANOPARTICLES COMPRISING IONIZABLE, POORLY WATER SOLUBLE CELLULOSIC POLYMERS 审中-公开
标题翻译：包含可离子化，不溶于水的可溶性纤维素聚合物的纳米颗粒
公开(公告)号：WO2009010842A3
公开(公告)日：2009-03-12
申请号：PCT/IB2008001801
申请日：2008-06-30
申请人： PFIZER PROD INC , BLOOM COREY JAY , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , MILLER WARREN KENYON , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
发明人： BLOOM COREY JAY , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , MILLER WARREN KENYON , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
IPC分类号： A61K9/51 , A61K47/38
CPC分类号： A61K9/5161 , A61K9/5192 , A61K47/38
摘要： A pharmaceutical composition comprises nanoparticles comprising ionizable, poorly water soluble cellulosic polymers.
摘要翻译：药物组合物包含包含可离子化的，难溶于水的纤维素聚合物的纳米颗粒。

9. 发明申请

WO2005053650A8 AZITHROMYCIN DOSAGE FORMS WITH REDUCED SIDE EFFECTS 审中-公开
标题翻译： AZITHROMYCIN剂型减少副作用
公开(公告)号：WO2005053650A8
公开(公告)日：2005-12-01
申请号：PCT/IB2004001654
申请日：2004-05-14
申请人： PFIZER PROD INC , HAGEN TIMOTHY ARTHUR , HERBIG SCOTT MAX , LO JULIAN BELKNAP , THOMBRE AVINASH GOVIND , APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , WEST JAMES BLAIR
发明人： HAGEN TIMOTHY ARTHUR , HERBIG SCOTT MAX , LO JULIAN BELKNAP , THOMBRE AVINASH GOVIND , APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , WEST JAMES BLAIR
IPC分类号： C07H17/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K31/7052 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04
CPC分类号： A61K9/1611 , A61K9/143 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K31/7052
摘要： An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule.Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate,and a poloxamer. Also disclosed is a method for reducing gastrointestinal side effects, associated with administering azithromycin to a mammal, comprising contiguously administering azithromycin and an effective amount of alkalizing agent to said mammal wherein the frequency of gastrointestinal side effects is lower than that experienced by administering an equal dose of azithromycin without said alkalizing agent.Further disclosed is a method of treating a bacterial or protozoal infection in a mammal in need thereof comprising contiguously administering to said mammal a single dose of an oral dosage form wherein said oral dosage form comprises azithromycin and an effective amount of an alkalizing agent.Additionally disclosed are azithromycin multiparticulates comprising azithromycin, a surfactant; and a pharmaceutically acceptable carrier.
摘要翻译：包含阿奇霉素和有效量的碱化剂的口服剂型。优选地，所述口服剂型包含有效量的碱化剂和阿奇霉素多颗粒，其中所述多颗粒包含阿奇霉素，单山嵛酸甘油酯，二苯乙酸甘油酯和枸橼酸甘油酯和泊洛沙姆的混合物。通常，口服剂型包括任何合适的口服给药方式，例如用于口服悬浮液的粉末，单位剂量包或小药囊，片剂或胶囊。另外公开的是包含阿奇霉素，有效量的碱化剂和一辆车。优选地，阿奇霉素是多颗粒形式，其中所述多颗粒包括阿奇霉素，甘油单山嵛酸甘油酯，二苯甲酸甘油酯和枸橼酸甘油酯和泊洛沙姆的混合物。还公开了一种减少与向哺乳动物施用阿奇霉素相关的胃肠道副作用的方法，包括向所述哺乳动物连续施用阿奇霉素和有效量的碱化剂，其中胃肠道副作用的频率低于施用相等剂量的阿奇霉素。没有所述碱化剂的阿奇霉素的进一步公开是一种在有需要的哺乳动物中治疗细菌或原生动物感染的方法，其包括向所述哺乳动物连续施用单剂量的口服剂型，其中所述口服剂型包含阿奇霉素和有效量的碱性试剂。另外公开了包含阿奇霉素，表面活性剂的阿奇霉素多颗粒; 和药学上可接受的载体。

10. 发明申请

WO03063831A2 IMMEDIATE RELEASE DOSAGE FORMS CONTAINING SOLID DRUG DISPERSIONS 审中-公开
标题翻译：立即释放含有固体药物分散剂的剂型
公开(公告)号：WO03063831A2
公开(公告)日：2003-08-07
申请号：PCT/IB0300276
申请日：2003-01-28
申请人： PFIZER PROD INC , HANCOCK BRUNO CASPAR , SCHADTLE STEPHEN JOSEPH , APPEL LEAH ELISABETH , BYERS JOHN E , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS
发明人： HANCOCK BRUNO CASPAR , SCHADTLE STEPHEN JOSEPH , APPEL LEAH ELISABETH , BYERS JOHN E , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K31/47 , A61K47/32 , A61K47/38 , A61P43/00
CPC分类号： A61K9/146 , A61K9/1652 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2081 , A61K31/47 , A61K31/7028
摘要： High loading immediate release dosage forms containing at least 30wt% of a solid drug dispersion, at least 5wt% of a disintegrant and a porosigen are disclosed that exhibit excellent strength and aqueous solubility.
摘要翻译：公开了含有至少30wt％的固体药物分散体，至少5wt％的崩解剂和porosigen的高负荷速释剂型，其表现出优异的强度和水溶性。

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