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1. 发明申请

WO2007001744A2 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
标题翻译：用于增强血管通路的方法和组合物
公开(公告)号：WO2007001744A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/021755
申请日：2006-06-05
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , EDELMAN, Elazer , DALAL, Anupam , BOLLINGER, Steve , EPPERLY, Scott
发明人： NUGENT, Helen, Marie , EDELMAN, Elazer , DALAL, Anupam , BOLLINGER, Steve , EPPERLY, Scott
IPC分类号： A61F2/06 , A61K47/36 , A61K47/42 , C12N5/00 , A61K35/12 , A61L27/38 , A61L29/16
CPC分类号： C12N5/069 , A61L27/3808
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了一种可植入材料，其包含生物相容性基质和当提供给血管通路结构时可以通常促进功能的细胞。例如，本发明的可植入材料可以增强动静脉自然瘘的成熟以及延长适合于透析的成熟功能状态的瘘。此外，本发明可以促进适合于透析的功能性动静脉移植物的形成，并促进功能性外周旁路移植物的形成。可植入材料可以构造为柔性平面形式或具有适于植入在吻合或动静脉移植物附近或附近的形状保持性质的可流动组合物。根据本文公开的方法，可植入材料被提供到血管的外表面。柔性平面形式的某些实施例限定了狭槽。本发明的材料和方法包括细胞，优选内皮细胞或具有内皮样表型的细胞。

2. 发明申请

WO2006062909A2 METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS 审中-公开
标题翻译：用于增强血管通路的方法和组合物
公开(公告)号：WO2006062909A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/043967
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , EDELMAN, Elazer , DALAL, Anupam , BOLLINGER, Steve , EPPERLY, Scott
发明人： NUGENT, Helen, Marie , EDELMAN, Elazer , DALAL, Anupam , BOLLINGER, Steve , EPPERLY, Scott
CPC分类号： A61L27/3808 , A61L27/3839
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shaperetaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了一种可植入材料，其包含生物相容性基质和当提供给血管通路结构时可以通常促进功能的细胞。例如，本发明的可植入材料可以增强动静脉自然瘘的成熟以及延长适合于透析的成熟功能状态的瘘。此外，本发明可以促进适合于透析的功能性动静脉移植物的形成，并促进功能性外周旁路移植物的形成。可移植材料可以被配置为柔性平面形式或具有适于植入在吻合体或动静脉移植物附近或附近的具有成形特性的可流动组合物。根据本文公开的方法，可植入材料被提供到血管的外表面。柔性平面形式的某些实施例限定了狭槽。本发明的材料和方法包括细胞，优选内皮细胞或具有内皮样表型的细胞。

3. 发明申请

WO2006062962A2 MATERIALS AND METHODS FOR TREATING AND MANAGING PLAQUE DISEASE 审中-公开
标题翻译：治疗和治疗疾病的材料与方法
公开(公告)号：WO2006062962A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044090
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS, INC. , EDELMAN, Elazer , DALAL, Anupam , NUGENT, Helen, Marie , BOLLINGER, Steve
发明人： EDELMAN, Elazer , DALAL, Anupam , NUGENT, Helen, Marie , BOLLINGER, Steve
CPC分类号： A61L27/3808 , A61F2310/00365
摘要： Disclosed herein are materials and methods suitable for treating and managing plaque disease, including vulnerable plaque. An implantable material comprising cells, such as but not limited to endothelial cells, and a biocompatible matrix can reduce progression or deterioration of a plaque-associated lesion situated on the interior lumen of said blood vessel. The implantable material is implanted directly on an exterior surface of a blood vessel at or adjacent or in the vicinity of the site of a lesion on an interior lumen. Alternatively, the implantable material is deposited on an exterior surface at or adjacent or in the vicinity of the site of a lesion on an interior lumen by an intraluminal delivery device which traverses or penetrates the vessel wall or by a percutaneous delivery device which enters the perivascular space. Both modes of administration can be preceded by or coincident with an imaging step. The present invention can treat hemorrhage, erosion, fissure, plaque-associated thrombosis and occlusion, rupture, displacement and/or dislodgement of a plaque lesion.
摘要翻译：本文公开了适用于治疗和治疗斑块疾病的材料和方法，包括易损斑块。包括细胞，例如但不限于内皮细胞和生物相容性基质的可植入材料可以减少位于所述血管的内腔上的斑块相关病变的进展或恶化。将可植入材料直接注入在血管的外表面上，或者在内腔的病变部位附近或附近。或者，可植入材料通过腔内递送装置沉积在位于内腔上的病变部位处或附近的外表面上，该管腔内递送装置穿过或穿透血管壁，或通过经皮递送装置进入血管周围空间。两种模式的管理可以在成像步骤之前或与成像步骤重合。本发明可以治疗斑块病变的出血，侵蚀，裂隙，斑块相关的血栓形成和闭塞，破裂，移位和/或移位。

4. 发明申请

WO2006062871A2 MATERIALS AND METHODS FOR MINIMALLY-INVASIVE ADMINISTRATION OF A CELL-CONTAINING FLOWABLE COMPOSITION 审中-公开
标题翻译：含细胞流动性组合物的微量入侵管理的材料与方法
公开(公告)号：WO2006062871A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/043844
申请日：2005-12-06
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , EDELMAN, Elazer , BOLLINGER, Steve
发明人： NUGENT, Helen, Marie , EDELMAN, Elazer , BOLLINGER, Steve
IPC分类号： A61L24/10
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3808 , A61L27/3839 , A61L2400/06
摘要： The disclosed invention is based on the discovery that a cell-based therapy can be used to treat, ameliorate, manage and/or reduce the progression of clinical sequelae associated with vascular interventions or cardiovascular diseases, particularly occlusive thrombosis, restenosis, intimal hyperplasia, inflammation and vasodilation. The invention further benefits from the additional discovery that a heretofore undescribed implantable flowable composition is capable of sustaining a confluent population of sufficiently viable cells which can be effectively administered via a minimally-invasive surgical procedure without diminishing the clinical effectiveness or the viability of the cells. The disclosed invention can be used to treat vasculature as well as non-vascular tubular structures such as a fallopian tube.
摘要翻译：所公开的发明基于以下发现：基于细胞的治疗可用于治疗，改善，管理和/或减少与血管干预或心血管疾病特别是闭塞血栓形成，再狭窄，内膜增生，炎症相关的临床后遗症的进展和血管舒张。本发明进一步受益于另外的发现，即迄今为止未描述的可植入可流动组合物能够维持足够活细胞的汇合群体，其可以通过微创外科手术有效地施用，而不降低细胞的临床有效性或活力。所公开的发明可用于治疗脉管系统以及诸如输卵管的非血管管状结构。

5. 发明申请

WO2008057580A2 MATERIALS AND METHODS FOR TREATING AND MANAGING ANGIOGENESIS-MEDIATED DISEASES 审中-公开
标题翻译：材料和方法治疗和管理血管生成介导的疾病
公开(公告)号：WO2008057580A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/023535
申请日：2007-11-07
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , EDELMAN, Elazer, R. , TJIN THAM SJIN, Robert, M. , NG, Yin, Shan
发明人： NUGENT, Helen, Marie , EDELMAN, Elazer, R. , TJIN THAM SJIN, Robert, M. , NG, Yin, Shan
IPC分类号： A61F2/06 , A61K35/36 , A61K35/44
CPC分类号： A61K35/36 , A61K35/44 , A61L31/005
摘要： Disclosed herein are materials and methods suitable for treating sites of pathological angiogenesis and abnormal neovascularization. Sites of pathological angiogenesis or abnormal neovascularization can be treated by contacting a surface at or adjacent or in the vicinity of an area of pathological angiogenesis or abnormal neovascularization with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected site. The composition can be a flexible planar material or a flowable composition. Diseases susceptible to treatment with the present invention include, for example, macular degeneration, rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic inflammatory diseases, and treatment of tumors by surgical resection, radiation therapy or chemotherapy.
摘要翻译：本文所公开的是适用于治疗病理性血管生成和异常新血管形成部位的材料和方法。病理性血管生成或异常新血管形成的部位可以通过使病理性血管生成区域或异常新血管形成区域处或附近或其附近的表面与可植入材料接触来治疗。可植入材料包含生物相容性基质和细胞，并且其量可有效治疗患病部位。该组合物可以是柔性平面材料或可流动组合物。对本发明治疗敏感的疾病包括例如黄斑变性，类风湿性关节炎，牛皮癣，银屑病关节炎，全身性炎性疾病和通过手术切除，放射疗法或化学疗法治疗肿瘤。

6. 发明申请

WO2006116357A1 MATERIALS AND METHODS FOR ALTERING AN IMMUNE RESPONSE TO EXOGENOUS AND ENDOGENOUS IMMUNOGENS, INCLUDING SYNGENEIC AND NON-SYNGENEIC CELLS, TISSUES OR ORGANS 审中-公开
标题翻译：用于改变对异源和内源性免疫球蛋白的免疫应答的材料和方法，包括合成和非合成细胞，组织或器官
公开(公告)号：WO2006116357A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015555
申请日：2006-04-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PERVASIS THERAPEUTICS, INC. , EDELMAN, Elazer, R. , NUGENT, Helen, Marie , METHE, Heiko
发明人： EDELMAN, Elazer, R. , NUGENT, Helen, Marie , METHE, Heiko
IPC分类号： C12N5/06 , A61K35/12
CPC分类号： A61K35/44 , A61K9/00 , A61K39/001 , A61K45/06 , A61K2035/122 , C12N5/069 , C12N2533/54
摘要： Disclosed herein are materials and methods for modulating an immunologically adverse response to an exogenous or endogenous immunogen, including a cell, tissue, or organ associated immunogen. An implantable material comprising cells, such as but not limited to endothelial cells, anchored or embedded in a biocompatible matrix can modulate an adverse immune or inflammatory reaction to exogenous or endogenous immunogens, including response to non-syngeneic or syngeneic cells, tissues or organs, exogenous immunogens or stimuli, as well as ameliorate an autoimmune condition. The implantable material can be provided prior to, coincident with, or subsequent to occurrence of the immune response or inflammatory reaction. The implantable material can induce immunological acceptance in a transplant patient, reduce graft rejection and reduce donor antigen immunogenicity.
摘要翻译：本文公开了调节对外源或内源性免疫原（包括细胞，组织或器官相关免疫原）的免疫学不良反应的材料和方法。锚定或嵌入在生物相容性基质中的包含细胞，例如但不限于内皮细胞的可植入材料可以调节对外源或内源性免疫原的不良免疫或炎性反应，包括对非同基因或同基因细胞，组织或器官的反应，外源性免疫原或刺激物，以及改善自身免疫病症。可植入材料可以在发生免疫应答或炎性反应之前，同时或之后提供。可移植材料可以诱导移植患者的免疫接受，减少移植排斥反应并降低供体抗原免疫原性。

7. 发明申请

WO2009020650A2 MATERIALS AND METHODS FOR TREATING AND MANAGING WOUNDS AND THE EFFECTS OF TRAUMA 审中-公开
标题翻译：治疗和处理创伤的材料和方法以及创伤的影响
公开(公告)号：WO2009020650A2
公开(公告)日：2009-02-12
申请号：PCT/US2008/009540
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , BOLLINGER, Stephen, A. , EDELMAN, Elazer, R. , SCHUBERT, Shai , NG, Yin, Shan , TJIN THAM SJIN, Robert
发明人： NUGENT, Helen, Marie , BOLLINGER, Stephen, A. , EDELMAN, Elazer, R. , SCHUBERT, Shai , NG, Yin, Shan , TJIN THAM SJIN, Robert
IPC分类号： A61K35/12 , A61L27/38 , A61L29/16 , A61F2/06 , A61P17/02
CPC分类号： A61K35/44 , A61K35/36 , A61L24/0005 , A61L24/0015 , A61L27/3808 , A61L27/3813 , A61L27/3886 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2400/06
摘要： Disclosed herein are materials and methods suitable for treating traumatic injury sites resulting from wounds, surgery or other tissue disruption. Traumatic injury sites can be treated by contacting a surface of a traumatic injury at or adjacent or in the vicinity of an area of injury or damage with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the traumatic injury site. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the traumatic injury site. The composition can be a flexible planar material or a flowable composition.
摘要翻译：本文公开的是适用于治疗由伤口，手术或其他组织破坏引起的创伤性损伤部位的材料和方法。创伤性损伤部位可以通过使用可植入材料在损伤或损伤区域处或其附近或附近接触创伤性损伤的表面来治疗。可植入材料包含生物相容性基质和细胞，并且其量可有效治疗创伤性损伤部位。包含生物相容性基质和植入其中或其上的细胞的组合物可用于治疗创伤性损伤部位。该组合物可以是柔性平面材料或可流动组合物。

8. 发明申请

WO2008057590A2 METHODS AND COMPOSITIONS FOR MODULATING TISSUE MODELING 审中-公开
标题翻译：调节组织建模的方法和组合物
公开(公告)号：WO2008057590A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/023566
申请日：2007-11-07
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , EDELMAN, Elazer, R. , TJIN THAM SJIN, Robert, M.
发明人： NUGENT, Helen, Marie , EDELMAN, Elazer, R. , TJIN THAM SJIN, Robert, M.
IPC分类号： A61K35/44
CPC分类号： A61K35/44 , A61L31/005
摘要： Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a tubular or non-tubular tissue, structure or organ, can promote functionality and positive tissue modeling generally. For example, implantable material of the present invention can reduce fibrosis, fibroblast proliferation and migration, tissue thickening and/or MMP expression and/or activation. According to the methods disclosed herein, the implantable material is provided adjacent to a surface of a tubular or non-tubular tissue, structure or organ. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
摘要翻译：公开了包含生物相容性基质和细胞的可植入材料，当提供给管状或非管状组织，结构或器官时，其通常可促进功能性和正面组织造型。例如，本发明的可植入材料可减少纤维化，成纤维细胞增殖和迁移，组织增厚和/或MMP表达和/或活化。根据本文公开的方法，可植入材料被提供为邻近管状或非管状组织，结构或器官的表面。本发明的材料和方法包含细胞，优选内皮细胞或具有内皮样表型的细胞。

9. 发明申请

WO2010091206A1 COMPOSITIONS AND USES TO GOVERN CANCER CELL GROWTH 审中-公开
标题翻译：组合物和用于治癌细胞生长的用途
公开(公告)号：WO2010091206A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023237
申请日：2010-02-04
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FRANSES, Joseph, W. , EDELMAN, Elazer, R. , CARDOSO, Angelo, Manuel De Almeida , NUGENT, Helen, Marie
发明人： FRANSES, Joseph, W. , EDELMAN, Elazer, R. , CARDOSO, Angelo, Manuel De Almeida , NUGENT, Helen, Marie
IPC分类号： A61K47/42 , A61K9/00 , A61K35/00
CPC分类号： A61L27/3808 , A61K9/0024 , A61K35/12 , A61K39/0011 , A61K47/42 , A61K2039/5152 , A61L27/3804 , A61L27/40 , A61L27/50 , A61L2400/18
摘要： The invention relates to composition and a method of using the composition for modulating proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of a patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor- associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. The composition comprises a biocompatible matrix and cells engrafted thereon.
摘要翻译：本发明涉及组合物和使用该组合物调节增殖，侵袭性，异常细胞生物标志物表达，降低患者细胞变得异常风险或调节癌相关成纤维细胞增殖的方法的肿瘤相关巨噬细胞。本发明还涉及培养组合物以产生调节异常细胞增殖，侵袭或转移的分子的方法。组合物包含生物相容性基质和植入其上的细胞。

10. 发明申请

WO2009020651A4 MATERIALS AND METHODS FOR TREATING SKELETAL SYSTEM DAMAGE AND PROMOTING SKELETAL SYSTEM REPAIR AND REGENERATION 审中-公开
公开(公告)号：WO2009020651A4
公开(公告)日：2009-02-12
申请号：PCT/US2008/009543
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , NG, Yin, Shan , TJIN THAM SJIN, Robert , SCHUBERT, Shai , BIRKHEAD, James, Richard
发明人： NUGENT, Helen, Marie , NG, Yin, Shan , TJIN THAM SJIN, Robert , SCHUBERT, Shai , BIRKHEAD, James, Richard
IPC分类号： A61L27/38
摘要： Disclosed herein are materials and methods suitable for treating injured, damaged or diseased mineralized and non-mineralized skeletal tissues, including bones, joints, tendons, ligaments, cartilage and/or other non-mineralized skeletal tissues. The affected structure can be treated by contacting a surface of the skeletal element at or adjacent to or in the vicinity of an area of injury, damage or disease with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected structure. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the affected structure. The composition can be a flexible planar material or a flowable composition.

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