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    • 6. 发明申请
    • MRI PROBES OF MEMBRANE POTENTIAL
    • 膜的潜能探测
    • WO2004041070A2
    • 2004-05-21
    • PCT/US2003/035013
    • 2003-11-03
    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIALOUIE, AngeliqueROSS, James
    • LOUIE, AngeliqueROSS, James
    • A61B
    • G01R33/5601A61K49/085A61K49/10A61K49/106A61K51/0446A61K51/0482A61K51/0497C07D491/10C07D491/107Y10T436/24
    • The Invention provides methods and compositions for molecular resonance imaging of membrane potential. The compositions comprise an indicator moiety attached through an optional linker to a macrocycle component that binds a lanthanide. The indicator moiety changes conformation in response to alterations in membrane potential and alters the interaction of the bound lanthanide with water. This alteration produces a detectable change in MRI Signal , notably the T 1 value. A preferred indicator moiety is spiropyran as it exhibits membrane-potential driven interconversions between the closed-ring spiropyran conformer and the extended merocyanine conformer. A preferred macrocycle is DO3A, known to bind gadolinium and an established MRI contrast agent. The methods of the invention comprise in vivo and in vitro uses of compositions of the invention to obtain MRI images that provide information about membrane potential.
    • 本发明提供了用于膜电位的分子共振成像的方法和组合物。 组合物包含通过任选的接头连接到结合镧系元素的大环组分的指示剂部分。 指示剂部分响应于膜电位的变化而改变构象,并改变结合的镧系元素与水的相互作用。 这种改变在MRI信号中产生可检测的变化,特别是T1值。 优选的指示剂部分是螺吡喃,因为它表现出闭环螺吡喃构象异构体与延伸的部花青同系异构体之间的膜电位驱动的相互转换。 已知的优选的大环是DO3A,已知结合钆和已建立的MRI造影剂。 本发明的方法包括体内和体外使用本发明的组合物以获得提供关于膜电位的信息的MRI图像。
    • 8. 发明申请
    • COMPUTER SYSTEM PERFORMANCE IMPROVEMENTS BY RELOCATION OF FILES ON DEVICES
    • 计算机系统性能通过设备文件转移改进
    • WO2002082277A1
    • 2002-10-17
    • PCT/AU2002/000434
    • 2002-04-05
    • PLATYPUS TECHNOLOGY HOLDINGS, INC.SHEEDY, AdrianLILLYWHITE, ColinTRIGG, AndrewROSS, JamesO'REILLY, James
    • SHEEDY, AdrianLILLYWHITE, ColinTRIGG, AndrewROSS, JamesO'REILLY, James
    • G06F12/08
    • G06F3/0653G06F3/061G06F3/0647G06F3/0683G06F11/3476G06F11/3485
    • The present invention can be used to improve the performance of a computer system. Monitoring software is introduced into computer system so that the monitoring software can identify or assist to identify files on a drive which place a substantial load on the computer system. Identification of files can be performed automatically by software, manually, or by data being sent to a web-site. By monitoring factors for a file such as seek times, read times, write times, etc. the monitoring software can build a list of information which contains data on each file on the drive accessed by the computer system's operating system. Files are then identified that may provide an improvement in system performance if these files were relocated to a faster or improved performance drive. Calculations or estimations may also be made to quantify the expected improvements should files (or a file) be moved to a faster drive. Files loading the computer system are moved to a faster drive. The files may be manually moved, or automatically moved by software provided to perform such a task.
    • 本发明可以用于提高计算机系统的性能。 监控软件被引入到计算机系统中,使得监控软件可以识别或协助识别驱动器上的文件,这些驱动器对计算机系统造成重大负担。 可以通过软件,手动或通过数据发送到网站来自动执行文件的识别。 通过监视诸如查找时间,读取时间,写入时间等文件的因素,监视软件可以构建包含由计算机系统的操作系统访问的驱动器上的每个文件的数据的信息列表。 然后识别文件,如果这些文件被重新定位到更快或更改性能的驱动器,可以提高系统性能。 还可以进行计算或估计,以量化文件(或文件)移动到更快的驱动器时的预期改进。 加载计算机系统的文件被移动到更快的驱动器。 这些文件可以由提供的软件手动移动或自动移动,以执行此类任务。