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2. 发明申请

WO2002070703A2 CELL VISUAL CHARACTERISTIC-MODIFYING SEQUENCES 审中-公开
标题翻译：细胞视觉特征修改序列
公开(公告)号：WO2002070703A2
公开(公告)日：2002-09-12
申请号：PCT/GB2002/000928
申请日：2002-03-01
申请人： NUFARM LIMITED , THE UNIVERSITY OF QUEENSLAND , JONES, Elizabeth, Louise , KARAN, Mirko , BRUGLIERA, Filippa , MASON, John , DOVE, Sophie, Gwendoline , HOEGH-GULDBERG, Ian, Ove , PRESCOTT, Mark
发明人： JONES, Elizabeth, Louise , KARAN, Mirko , BRUGLIERA, Filippa , MASON, John , DOVE, Sophie, Gwendoline , HOEGH-GULDBERG, Ian, Ove , PRESCOTT, Mark
IPC分类号： C12N15/12
CPC分类号： C12Q1/6897 , A61K8/64 , A61K2800/86 , A61Q17/04 , C07K14/43595
摘要： The present invention relates generally to peptides, polypeptides or proteins having one or more amino acids or one or more amino acid sequences which exhibit color-facilitating properties, either on their own or following interaction with one or more other amino acids and to nucleic acid molecules encoding same. Such peptides, polypeptides and proteins are referred to herein as "color-facilitating molecules" or "CFMs". The present invention further provides genetic constructs for use in genetically modifying eukaryotic or prokaryotic cells and more particularly eukaryotic tissue so as to alter their visual characteristics or capacity for exhibiting same to a human eye in the absence of excitation by an extraneous non-white light or particle emission. The present invention, therefore, extends to eukaryotic or prokaryotic cells and more particularly eukaryotic tissue, which are genetically modified to produce CFMs and which thereby exhibit altered visual characteristics in the absence of excitation by an extraneous non-white light or particle emission. In one particular embodiment, the CFMs are used to alter the visual characteristics of plants and even more particularly flower color. In another embodiment, the present invention provides gels or coatings or similar biomaterials in the form of a biomatrix comprising the CFMs such as for use as a UV sink, in a sun screen, in cosmetics, as an expression marker or other reporter molecule or for use as a photon trap to increase light intensity.
摘要翻译：本发明一般涉及具有一个或多个氨基酸或一个或多个氨基酸序列的肽，多肽或蛋白质，其表现出颜色促进性质，其本身或之后与一种或多种其它氨基酸和核酸分子的相互作用编码相同。这样的肽，多肽和蛋白质在本文中称为“促色分子”或“CFM”。本发明还提供用于遗传修饰真核细胞或原核细胞，更特别是真核组织的遗传构建体，以便在没有外来非白光的激发的情况下改变其在人眼中显示相同的视觉特征或能力颗粒发射。因此，本发明延伸到真核细胞或原核细胞，更特别是真核组织，其被遗传修饰以产生CFM，并且由此在没有通过外来的非白光或颗粒发射的激发的情况下表现出改变的视觉特征。在一个具体实施方案中，CFM用于改变植物的视觉特征，甚至更特别地是花色。在另一个实施方案中，本发明提供了生物基质形式的凝胶或涂层或类似的生物材料，其包括CFM，例如用作UV吸收池，在日光屏中，在化妆品中，作为表达标记物或其他报告分子，或用于用作光子阱以增加光强度。

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