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1. 发明申请

WO2011139344A3 NANOSCALE APERTURES HAVING ISLANDS OF FUNCTIONALITY 审中-公开
标题翻译：具有功能岛屿的纳粹门户
公开(公告)号：WO2011139344A3
公开(公告)日：2012-04-05
申请号：PCT/US2011000747
申请日：2011-04-27
申请人： PACIFIC BIOSCIENCES CALIFORNIA , TURNER STEPHEN , KUSE RON , KEARNS GREGORY , MONADGEMI PEZHMAN , FOQUET MATHIEU , MARTINEZ DREW
发明人： TURNER STEPHEN , KUSE RON , KEARNS GREGORY , MONADGEMI PEZHMAN , FOQUET MATHIEU , MARTINEZ DREW
IPC分类号： G01N33/48 , B82Y30/00 , G01N33/50 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00509 , B01J2219/00637 , B01J2219/00725 , B01J2219/0074 , B01L3/5085 , B01L2200/0668 , B01L2200/12 , B01L2300/0819 , B01L2300/0896
摘要： Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided. Arrays of confined regions are produced wherein each confined region comprises a single island within the confined region. The island can be selectively functionalized with a coupling agent to couple a single molecule of interest within the confined region.
摘要翻译：提供了将单一分析物分子非随机加载到阵列结构中的方法，组合物和阵列。产生限制区域的阵列，其中每个限制区域包括在限制区域内的单个岛。岛可以用偶联剂选择性地官能化，以将约束区域内的单个感兴趣的分子耦合。

2. 发明申请

WO2011112260A3 MICROMIRROR ARRAYS HAVING SELF ALIGNED FEATURES 审中-公开
标题翻译：具有自对准特征的MICROMIRROR ARRAYS
公开(公告)号：WO2011112260A3
公开(公告)日：2012-01-19
申请号：PCT/US2011000452
申请日：2011-03-10
申请人： PACIFIC BIOSCIENCES CALIFORNIA , MONADGEMI PEZHMAN
发明人： MONADGEMI PEZHMAN
IPC分类号： G02B26/00 , G01N21/00
CPC分类号： B82Y20/00 , B29D11/00596 , G02B1/118 , G02B5/09 , G02B5/26 , G02B6/3512 , G02B6/3556 , G02B6/3584 , G02B2207/101
摘要： Methods, arrays, and systems for the optical analysis of multiple chemical, biological, or biochemical reactions are provided. The invention includes methods for producing arrays of micromirrors on transparent substrates, each micromirror comprising a nanostructure or optical confinement on its top. The arrays are produced by a process in which lateral dimensions of both the nanostructures and micromirrors are defined in a single step, allowing for control of the relative placement of the features on the substrate, minimizing the process-related defects, allowing for improved optical performance and consistency. In some aspects, the invention provides methods of selectively etching large features on a substrate while not concurrently etching small features. In some aspects, the invention provides methods of etching large features on a substrate using hard mask materials.
摘要翻译：提供了用于多种化学，生物或生化反应的光学分析的方法，阵列和系统。本发明包括在透明衬底上产生微镜阵列的方法，每个微反射镜在其顶部包括纳米结构或光学限制。阵列是通过一个方法制造的，其中纳米结构和微反射镜的横向尺寸在单个步骤中被限定，允许控制特征在基底上的相对放置，最小化与工艺相关的缺陷，允许改进的光学性能和一致性。在一些方面，本发明提供了选择性地蚀刻衬底上的大特征而不同时蚀刻小特征的方法。在一些方面，本发明提供了使用硬掩模材料在基底上蚀刻大特征的方法。

3. 发明申请

WO2010039199A3 ULTRA-HIGH MULTIPLEX ANALYTICAL SYSTEMS AND METHODS 审中-公开
标题翻译：超高度多重分析系统和方法
公开(公告)号：WO2010039199A3
公开(公告)日：2010-09-23
申请号：PCT/US2009005319
申请日：2009-09-25
申请人： PACIFIC BIOCIENCES OF CALIFORN , ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
发明人： ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
IPC分类号： G02B6/12 , G01N21/00
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析超高多路复用中的离散反应并减少光噪声的设备，系统和方法，以及增加的系统灵活性。装置包括具有集成光学部件的基板，所述集成光学部件通过增加反应区域的密度，改善从分立反应区域向光的传输或收集光的一个或多个来增加多路复用能力。集成光学元件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

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