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1. 发明申请

WO0247732A2 METHOD OF MAKING DEMINERALIZED BONE PARTICLES 审中-公开
标题翻译：制造脱矿骨粒子的方法
公开(公告)号：WO0247732A2
公开(公告)日：2002-06-20
申请号：PCT/US0148384
申请日：2001-12-14
申请人： OSTEOTECH INC , MORRIS JOHN , SHIMP LAWRENCE A , PETERSEN KENNETH C , MANRIQUE ALBERT , KAES DAVID , SCARBOROUGH NELSON L , DOWD MICHAEL
发明人： MORRIS JOHN , SHIMP LAWRENCE A , PETERSEN KENNETH C , MANRIQUE ALBERT , KAES DAVID , SCARBOROUGH NELSON L , DOWD MICHAEL
IPC分类号： A61L27/00 , A61L27/36 , A61L
CPC分类号： A61L27/3847 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L2430/02 , A61L2430/40
摘要： Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译：脱矿骨颗粒通过将全骨去矿物质并随后细分脱矿骨以提供去矿物质骨颗粒而获得。

2. 发明申请

WO0207654A3 INTERVERTEBRAL SPACER AND IMPLANT INSERTION INSTRUMENTATION 审中-公开
标题翻译：横向间隙和植入插入仪
公开(公告)号：WO0207654A3
公开(公告)日：2002-06-06
申请号：PCT/US0123481
申请日：2001-07-26
申请人： OSTEOTECH INC
发明人： LIN JO-WEN , SCARBOROUGH NELSON L
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/40
CPC分类号： A61F2/4684 , A61F2/28 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2002/2825 , A61F2002/2853 , A61F2002/2892 , A61F2002/30057 , A61F2002/30131 , A61F2002/30492 , A61F2002/30616 , A61F2002/4622 , A61F2002/4628 , A61F2220/0025 , A61F2230/0013 , A61F2310/00017
摘要： An intervertebral spacer (400) formed of dense cancellous human or animal bone is provided. In one preferred embodiment, the intervertebral spacer (400) includes at least one bore (414) which is dimensioned to receive a plug (412) formed from cortical bone tissue. The cortical bone plug (412) provides increased mechanical strength to the intervertebral spacer (400). Instrumentation for gauging the size of an intervertebral receiving bed and for grasping and inserting an intervertebral spacer or implant into an intervertebral receiving bed are also provided. These instruments include a spacer trial or set of spacer trials for determining the appropriate size spacer required for a particular surgical procedure, a spacer introducer for grasping and positioning a spacer at least partially within a receiving bed formed in the intervertebral space, and a bone tamp for driving a spacer into the receiving bed. Any one or all these instruments may be provided in a kit for inserting an implant into the intervertebral space. The kit may also include one or more intervertebral spacers or implants.
摘要翻译：提供由致密的松质骨或动物骨形成的椎间间隔物（400）。在一个优选实施例中，椎间间隔物（400）包括至少一个孔（414），其尺寸适于接收由皮层骨组织形成的塞子（412）。皮质骨塞（412）为脊椎间隔物（400）提供增强的机械强度。还提供了用于测量椎间接受床的尺寸并用于将椎间间隔物或植入物夹持并插入椎间接受床的仪器。这些仪器包括用于确定特定手术过程所需的适当尺寸的隔离器试验或间隔试验的套件，用于将至少部分地至少部分地置于形成于椎间空间的接收床内的间隔件的间隔导引器和骨夯用于将间隔件驱动到接收床中。任何一个或所有这些器械可以设置在用于将植入物插入椎间空间的工具箱中。该套件还可以包括一个或多个椎间间隔物或植入物。

3. 发明申请

WO0205750A2 OSTEOIMPLANT AND METHOD OF MAKING SAME 审中-公开
标题翻译： OSTEOIMPLANT及其制造方法
公开(公告)号：WO0205750A2
公开(公告)日：2002-01-24
申请号：PCT/US0122853
申请日：2001-07-19
申请人： OSTEOTECH INC , EDWARDS JEAN T , SCARBOROUGH NELSON L , MANRIQUE ALBERT , BODEN SCOTT D
发明人： EDWARDS JEAN T , SCARBOROUGH NELSON L , MANRIQUE ALBERT , BODEN SCOTT D
IPC分类号： A61B17/86 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/36 , A61L31/00 , A61K
CPC分类号： A61L27/3683 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2/446 , A61F2002/2817 , A61F2002/30059 , A61F2002/30113 , A61F2002/30153 , A61F2002/30156 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30261 , A61F2002/3085 , A61F2002/30957 , A61F2002/4649 , A61F2230/0006 , A61F2230/0019 , A61F2230/0023 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61L27/3608 , A61L27/365 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is provided which comprises a shaped, coherent, three-dimensional porous matrix of elongate demineralized bone particles, wherein said matrix possesses a bulk density of lower than about 0.3 g/cm . The osteoimplant of the invention is highly absorbent and sponge/like in nature. Also provided herein are a method of fabricating the osteoimplant herein and a method of repairing and/or treating bone utilizing the osteoimplant.
摘要翻译：提供了一种骨植入物，其包含细长的脱矿骨颗粒的成形的，粘附的三维多孔基质，其中所述基质具有低于约0.3g / cm 3的堆积密度。本发明的骨植入物本质上具有高吸收性和海绵状。本文还提供了本文制造骨移植物的方法以及利用骨移植物修复和/或治疗骨的方法。

4. 发明申请

WO0042954A3 INTERVERTEBRAL IMPLANT 审中-公开
公开(公告)号：WO0042954A3
公开(公告)日：2000-11-30
申请号：PCT/US0001766
申请日：2000-01-24
申请人： OSTEOTECH INC
发明人： SCARBOROUGH NELSON L , BOYLE JOHN W
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/30771 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30153 , A61F2002/30158 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/3023 , A61F2002/30266 , A61F2002/30772 , A61F2002/30774 , A61F2002/30785 , A61F2002/30789 , A61F2002/3079 , A61F2002/30879 , A61F2002/30884 , A61F2002/30892 , A61F2002/30902 , A61F2002/30904 , A61F2002/30971 , A61F2002/448 , A61F2002/4649 , A61F2230/0019 , A61F2230/0026 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2240/001 , A61F2310/00017 , A61F2310/00131 , A61F2310/00293 , A61F2310/00359 , Y10S623/901
摘要： An intervertebral implant having a composite wedge/dowel configuration is provided. The intervertebral implant includes a central body portion and a pair of radially extending wings. The radially extending wings can be tapered from a first end of the implant to the second end of the implant along an axis parallel to the longitudinal axis of the central body portion. Alternately, the radially extending wings can be tapered along an axis transverse to the longitudinal axis of the cylindrical body portion or along any other axis between parallel and transverse to the longitudinal axis. A throughbore or plurality of throughbores extend from a top surface of the implant through the implant to a bottom surface of the implant. The implant may be formed from a cortical ring cut from the diaphysis of a long bone by milling the top and bottom surfaces of the cortical ring to form the substantially central body portion and the tapered radially extending wings. The cortical ring is milled such that the intramedullary canal of the cortical ring defines a throughbore in the central body portion of the implant. The sidewalls of the implant may be machined to form a substantially rectangular shape or the implant can be left to have a substantially circular configuration. Alternately, the implant may be formed of any biocompatible material having the requisite strength requirements via any known process, i.e., molding.
摘要翻译：提供具有复合楔形/定位销构造的椎间植入物。椎间植入物包括中心主体部分和一对径向延伸的翼部。径向延伸的翼可以沿着平行于中心主体部分的纵向轴线的轴线从植入物的第一端到植入物的第二端渐缩。或者，径向延伸的翼可以沿着与圆柱形主体部分的纵向轴线相垂直的轴线或沿着与纵向轴线平行和横向的任何其它轴线成锥形。通孔或多个通孔从植入物的顶表面通过植入物延伸到植入物的底表面。植入物可以由通过研磨皮质环的顶部和底部表面的长骨骨干切割的皮质环形成，以形成基本中心的主体部分和锥形径向延伸的翼。皮质环被研磨成使得皮质环的髓内管在植入物的中心体部分中形成通孔。植入物的侧壁可以被机加工以形成基本上矩形的形状，或者植入物可以留下具有大致圆形的构型。或者，植入物可以通过任何已知的方法即成型具有必要的强度要求的任何生物相容性材料形成。

5. 发明申请

WO0187369A3 OSTEOIMPLANT AND METHOD FOR MAKING SAME 审中-公开
标题翻译： OSTEOIMPLANT及其制备方法
公开(公告)号：WO0187369A3
公开(公告)日：2002-07-04
申请号：PCT/US0115599
申请日：2001-05-14
申请人： OSTEOTECH INC , EDWARDS JEAN T , SHIMP LAWRENCE A , DIEGMANN MICHELE , BOYCE TODD M , SCARBOROUGH NELSON L , RUSSELL JAMES L
发明人： EDWARDS JEAN T , SHIMP LAWRENCE A , DIEGMANN MICHELE , BOYCE TODD M , SCARBOROUGH NELSON L , RUSSELL JAMES L
IPC分类号： A61L27/36
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
摘要翻译：提供了一种制造骨诱导性骨样植入物的方法，其包括以下步骤：将皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。

6. 发明申请

WO0202156A3 OSTEOGENIC IMPLANTS DERIVED FROM BONE 审中-公开
标题翻译：来自骨骼的成骨植入物
公开(公告)号：WO0202156A3
公开(公告)日：2002-05-23
申请号：PCT/US0120220
申请日：2001-06-27
申请人： OSTEOTECH INC
发明人： BOYCE TODD M , KAES DAVID , SCARBOROUGH NELSON L
IPC分类号： A61L27/00 , A61F2/00 , A61F2/28 , A61L27/36
CPC分类号： A61F2/28 , A61F2002/30535 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L2430/02
摘要： An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32 % and a method of making an osteogenic osteoimplant having not greater than about 32 % void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.
摘要翻译：一种柔性片形式的成骨性骨植入物，其包含粘附团块的骨衍生颗粒，所述骨植入物具有不大于约32％的空隙体积，以及制备具有不大于约32％空隙体积的成骨骨植入物的方法，该方法包括：提供粘附团块的骨衍生颗粒; 并且机械地成形所述粘附团块的骨衍生颗粒以形成柔性片形式的成骨性骨移植物。

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