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1. 发明申请

WO1995025482A1 THREE-DIMENSIONAL BIOREMODELABLE COLLAGEN FABRICS 审中-公开
标题翻译：三维生物可调胶原蛋白
公开(公告)号：WO1995025482A1
公开(公告)日：1995-09-28
申请号：PCT/US1995003455
申请日：1995-03-20
申请人： ORGANOGENESIS, INC.
发明人： ORGANOGENESIS, INC. , KEMP, Paul, D. , CAVALLARO, John, F.
IPC分类号： A61F02/02
CPC分类号： D04B21/20 , A61B17/68 , A61F2/0063 , A61F2/28 , A61F2/30942 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F13/00063 , A61F2002/041 , A61F2002/043 , A61F2002/044 , A61F2002/046 , A61F2002/047 , A61F2002/30011 , A61F2002/30062 , A61F2002/30199 , A61F2002/30235 , A61F2002/30677 , A61F2013/00093 , A61F2013/00221 , A61F2013/00238 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61F2210/0004 , A61F2230/0063 , A61F2230/0069 , A61F2250/0023 , A61F2250/0067 , A61F2310/00365 , A61L27/24 , D10B2509/00
摘要： The invention is in the field of tissue engineering implantable medical devices and is directed to three-dimensional bioremodelable fabrics made from collagen threads which are used to replace or repair tissue organs. The fabrics are tailor-made to suit a wide variety of applications with varied porosity, elongation, and strength requirements based on the knowledge gained from biomimetic studies.
摘要翻译：本发明在组织工程可植入医疗装置的领域中，并且涉及用于替代或修复组织器官的由胶原线制成的三维生物可重构织物。面料是量身定制的，以适应各种应用，具有不同的孔隙率，伸长率和强度要求，基于从仿生研究获得的知识。

2. 发明申请

WO1996031157A1 PERACETIC ACID CROSSLINKED NON-ANTIGENIC ICL GRAFTS 审中-公开
标题翻译： PERACTIC ACID CROSSLINKED NAN-ANGGICIC ICL GRAFTS
公开(公告)号：WO1996031157A1
公开(公告)日：1996-10-10
申请号：PCT/US1996003336
申请日：1996-03-12
申请人： ORGANOGENESIS, INC. , CARR, Robert, M., Jr. , TERMIN, Paul, L. , CONDON, Kimberlie, D. , YOUNG, Janet, Hardin
发明人： ORGANOGENESIS, INC.
IPC分类号： A61B17/00
CPC分类号： A61L27/3691 , A61F2/0077 , A61L2/18 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/58
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译：本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并将经受受控的生物降解，伴随患者活细胞的生物模型发生。治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。因此，在其各种实施方案中，本发明的假体具有双重性质。首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。

3. 发明申请

WO1994010940A1 IN VITRO CORNEA EQUIVALENT MODEL 审中-公开
标题翻译：在体外CORNEA等效模型
公开(公告)号：WO1994010940A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010727
申请日：1993-11-15
申请人： ORGANOGENESIS, INC. , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ORGANOGENESIS, INC. , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , PARENTEAU, Nancy, L. , MASON, Valerie, S. , OLSEN, Bjorn, R.
IPC分类号： A61F02/14
CPC分类号： A61L27/3891 , A61F2/142 , A61K35/12 , A61L27/24 , A61L27/38 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0062 , C12N5/0621 , C12N5/0697 , C12N2500/25 , C12N2501/39 , C12N2501/395 , C12N2502/085 , C12N2502/094 , C12N2502/1323 , C12N2510/04 , C12N2533/54
摘要： This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro.
摘要翻译：本发明涉及使用组织培养系统制造的眼睛的角膜部分的器官当量。构建角膜等价物的方法产生类似于眼内角膜的结构。角膜等效物是眼的体外模型，其可用于体内移植或植入或用于体外筛选化合物。

4. 发明申请

WO1996024018A1 METHOD AND PACKAGE DESIGN FOR CRYOPRESERVATION AND STORAGE OF CULTURED TISSE EQUIVALENTS 审中-公开
标题翻译：方法和包装设计用于培养的组织等效物的储存和储存
公开(公告)号：WO1996024018A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001217
申请日：1996-01-30
申请人： ORGANOGENESIS, INC. , WATSON, Stephen, R. , TONER, Mehmet , TSCHUMAKOW, Alexander, G.
发明人： ORGANOGENESIS, INC.
IPC分类号： F25D17/02
CPC分类号： A01N1/02 , A01N1/0221 , A01N1/0263 , A01N1/0284 , B65D55/06 , B65D77/0486 , B65D85/50
摘要： This invention is directed to an efficient cryopreservation package desgin of harvested mammalian tissues and living cultured tissue equivalents made by in vitro technology. The invention involves immersing a mammalian tissue or cultured tissue equivalent in a cryoprotectant solution, agitating the cryoprotectant solution and the immersed tissue to achieve effective penetration of the cryoprotectant solution into the tissue, and then freezing the tissue at a very slow freezing rate. In the freezing step, extracellular ice formation is initiated by seeding. The cryopreserved tissue may be stored for indefinite periods of time prior to use. The cultured tissue equivalent is an in vitro model of the equivalent human tissue, such as skin or cornea, which, when retrieved from storage can be used for transplantation or implantation in vivo or for screening compounds in vitro.
摘要翻译：本发明涉及对收获的哺乳动物组织的有效的冷冻保存包装，以及通过体外技术制造的活体培养的组织等同物。本发明涉及将哺乳动物组织或培养的组织当量浸入冷冻保护剂溶液中，搅拌冷冻保护剂溶液和浸入的组织以实现冷冻保护剂溶液有效穿透到组织中，然后以非常慢的冷冻速率冷冻组织。在冷冻步骤中，通过播种开始细胞外冰的形成。冷冻保存的组织可以在使用前储存无限期。培养的组织等价物是等效人体组织的体外模型，例如皮肤或角膜，当从储存中取出时可以用于体内移植或植入或用于体外筛选化合物。

5. 发明申请

WO1995007611A1 CRYOPRESERVATION OF CULTURED TISSUE EQUIVALENTS 审中-公开
标题翻译：培养的组织等效物的CRYOPRESERATION
公开(公告)号：WO1995007611A1
公开(公告)日：1995-03-23
申请号：PCT/US1994010042
申请日：1994-09-14
申请人： ORGANOGENESIS, INC.
发明人： ORGANOGENESIS, INC. , WILKINS, Leon, M. , WATSON, Stephen, R.
IPC分类号： A01N01/02
CPC分类号： A01N1/02 , A01N1/0221
摘要： This invention is directed to cryopreservation of cultured tissue equivalents made by in vitro technology. The invention involves immersing a cultured tissue equivalent in a cooled cryoprotectant solution, agitating the cryoprotectant solution and the immersed cultured tissue to achieve effective penetration of the cryoprotectant solution into the cultured tissue equivalent, and then freezing the cultured tissue at a high freezing rate. The cryopreserved cultured tissue equivalent may be stored for indefinite periods of time prior to use. The cultured tissue equivalent is an in vitro model of the equivalent human tissue, which, when retrieved from storage, can be used for transplantation or implantation in vivo or for screening compounds in vitro.
摘要翻译：本发明涉及通过体外技术制备的培养组织等同物的低温保存。本发明涉及将冷冻冷冻保护剂溶液中的培养组织当量浸入，搅拌冷冻保护剂溶液和浸没的培养组织以实现冷冻保护剂溶液有效渗透到培养组织当量中，然后以高冷冻速率冷冻培养的组织。冷冻保存的培养组织等同物可以在使用前储存无限期。培养的组织当量是等效人体组织的体外模型，当从储存中取出时，其可以用于体内移植或植入或用于体外筛选化合物。

6. 发明申请

WO1995022301A1 BIOREMODELABLE COLLAGEN GRAFT PROSTHESIS 审中-公开
标题翻译：生物修复胶原蛋白
公开(公告)号：WO1995022301A1
公开(公告)日：1995-08-24
申请号：PCT/US1995002025
申请日：1995-02-17
申请人： ORGANOGENESIS, INC.
发明人： ORGANOGENESIS, INC. , TERMIN, Paul, L. , CARR, Robert, M., Jr. , CONDON, Kimberlie, D.
IPC分类号： A61F02/06
CPC分类号： A61L27/58 , A61F2/06 , A61F2/3094 , A61F2002/30062 , A61F2002/3024 , A61F2002/30535 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61F2250/0058 , A61F2310/00365 , A61L27/24 , A61L27/34 , A61L27/3629 , A61L27/3641 , A61L27/3687 , C08L89/06
摘要： This invention is directed to prostheses, which, when implanted into a mammalian host, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the host's living cells. The prosthesis of this invention, in its various embodiments, thus has dual properties: first, it functions as a substitute body part and second, it functions as a bioremodeling template for the ingrowth of host cells.
摘要翻译：本发明涉及假体，其当植入哺乳动物宿主时，用作身体部位或组织结构的功能替代物，并将经受受控的生物降解，伴随宿主活细胞的生物模拟发生。因此，在其各种实施方案中，本发明的假体具有双重特性：首先，其用作替代体部分，其次用作用于宿主细胞向内生长的生物模拟模板。

7. 发明申请

WO1995018529A1 PERACETIC ACID STERILIZATION 审中-公开
标题翻译：营养性灭菌
公开(公告)号：WO1995018529A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000126
申请日：1995-01-04
申请人： ORGANOGENESIS, INC.
发明人： ORGANOGENESIS, INC. , KEMP, Paul, D.
IPC分类号： A01N01/02
CPC分类号： A61L2/0088 , A01N1/0215 , A01N37/16 , A01N1/02 , A01N2300/00
摘要： This invention is directed to the sterilization of collagen and collagenous tissue which is to be used for implantation, repair, or use in a mammalian host in the emerging field of tissue engineering. The sterilants are low concentration peracetic acid solutions in either neutral or high ionic strength that prevent or minimize the swelling of collagen or collagenous tissue so that the sterilized tissue retains its structural integrity and bioremodelable properties.
摘要翻译：本发明涉及在组织工程新兴领域的哺乳动物宿主中用于植入，修复或使用的胶原和胶原组织的灭菌。灭菌剂是中性或高离子强度的低浓度过乙酸溶液，其防止或最小化胶原或胶原组织的溶胀，使得灭菌组织保持其结构完整性和生物可重构性质。

8. 发明申请

WO1993006791A1 COLLAGEN CONSTRUCTS 审中-公开
标题翻译： COLLAGEN结构
公开(公告)号：WO1993006791A1
公开(公告)日：1993-04-15
申请号：PCT/US1992008520
申请日：1992-10-07
申请人： ORGANOGENESIS, INC.
发明人： ORGANOGENESIS, INC. , KEMP, Paul, D. , CARR, Robert, M., Jr. , MARESH, John, G. , CAVALLARO, John , GROSS, Jerome
IPC分类号： A61F02/02
CPC分类号： A61L27/507 , A61F2/06 , A61F2/08 , A61F2310/00365 , A61L27/24 , A61L27/3808 , A61L27/3813 , A61L27/60 , D01F4/00 , Y10S623/901
摘要： The present invention provides improved collagen threads (14). In the production of collagen threads (14) means (1) for extruding a collagen solution include a syringe pump (2), a syringe (3), leader tubing (4) and a blunt needle (5). The dehydrating bath (10) includes dehydrating trough (11), dehydrating agent (12) and recirculating pump (13), the rinsing bath (20) includes a rinsing trough (21) and rince liquid (22). The drying means includes a drying cabinet (31) pulleys (43, 44, 45 and 47) and a heated blower (32). The collagen threads (14) are carried to uptake spool (40).
摘要翻译：本发明提供了改进的胶原线（14）。在生产胶原丝（14）时，意味着用于挤出胶原溶液的（1）包括注射泵（2），注射器（3），引导管（4）和钝针（5）。脱水槽（10）包括脱水槽（11），脱水剂（12）和再循环泵（13），漂洗槽（20）包括清洗槽（21）和液体（22）。干燥装置包括干燥箱（31），滑轮（43,44,45和47）和加热的鼓风机（32）。胶原线（14）被携带到摄影卷轴（40）。

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