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1. 发明申请

WO2004089235A3 METHODS AND APPARATUS FOR PERFUSION, DIAGNOSIS, STORAGE AND/OR TRANSPORT OF AN ORGAN OR TISSUE 审中-公开
标题翻译：用于组织或组织的灌注，诊断，储存和/或运输的方法和装置
公开(公告)号：WO2004089235A3
公开(公告)日：2005-06-23
申请号：PCT/US2004010182
申请日：2004-04-02
申请人： ORGAN RECOVERY SYSTEMS INC , WRIGHT DAVID WALTER , BRASSIL JOHN , SCHEIN DOUGLAS , GARLAND JEFFREY C , TRAVIS LEE WILLIAMS
发明人： WRIGHT DAVID WALTER , BRASSIL JOHN , SCHEIN DOUGLAS , GARLAND JEFFREY C , TRAVIS LEE WILLIAMS
IPC分类号： A01N1/02 , B65D81/18 , B65D85/02
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247 , Y10S435/809
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied. The apparatus and methods further include the cassette with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces. The apparatus and methods further include a tube frame removably connected to the cassette and configured to hold a plurality of tubes in a position to be connected to tubes in the portable housing.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该装置和方法包括具有一个或多个开口的器官盒，其被配置为允许管道穿过开口并连接到盒内的器官或组织，并且包括压力控制装置，以允许便携式外壳内的压力变化。该装置和方法还包括具有传热表面的盒，其布置成在所述运送器中的冷却源和传热表面之间传递热量。该装置和方法还包括可移除地连接到盒子并被配置为将多个管子保持在与便携式外壳中的管连接的位置的管框架。

2. 发明申请

WO0226034A3 APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：WO0226034A3
公开(公告)日：2003-03-20
申请号：PCT/US0126591
申请日：2001-08-27
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore vability of organs and preserver organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygeneted cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubuing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization preventing and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of th emedical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官和保存器官的存储和/或运输的可行性。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体（例如含氧交叉血红蛋白基碳酸氢盐医疗液体）灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地响应于设置在放置在器官中的管道末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压防止和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。防止过度加压防止或减少对血管内皮衬里和器官组织的损害。可以自动监测器官的生存能力，优选通过监测体液灌注液的特性。可以使用控制程序自动控制灌注过程。

3. 发明申请

WO2005074681A2 APPARATUS AND METHOD FOR DETERMINING EFFECTS OF A SUBSTANCE ON AN ORGAN 审中-公开
标题翻译：用于确定物质对器官的影响的装置和方法
公开(公告)号：WO2005074681A2
公开(公告)日：2005-08-18
申请号：PCT/US2005003008
申请日：2005-01-27
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： BRASSIL JOHN , SCHEIN DOUGLAS , CURTIS CHRISTOPHER G
IPC分类号： A01N1/02 , G01N33/50 , A01N1/00
CPC分类号： G01N33/5082 , A01N1/02 , A01N1/0247
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. During the period in which the organ is preserved and/or maintained, various drug research and development may be performed on and/or with the organ. The organ may be perfused with a fluid containing a substance such as a test substance to obtain data regarding the organ, the substance and an interaction of the substance and the organ. The data may then be used to ultimately provide information regarding the drugs efficacy in support of regulatory filings for new drugs.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的生存力并保存器官用于储存和/或运输。其他装置包括器官运输器，器官盒和器官诊断装置。该方法包括在低温和/或常温温度下灌注器官，优选在低温器官冲洗后用于器官运输和/或储存。该方法可以在器官的先前或随后的静态或灌注低温暴露下实施。通过在正常温度下用医用流体（例如含氧的交联的基于血红蛋白的碳酸氢盐医用流体）灌注器官来恢复高能核苷酸（例如ATP）水平来恢复器官活力。在器官保存和/或维持期间，可以在器官上和/或器官上进行各种药物研究和开发。可以用含有诸如测试物质的物质的流体灌注器官以获得关于器官，物质以及物质和器官的相互作用的数据。这些数据可以用于最终提供有关药物功效的信息，以支持新药的监管申报。

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