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1. 发明申请

WO0226034A3 APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：WO0226034A3
公开(公告)日：2003-03-20
申请号：PCT/US0126591
申请日：2001-08-27
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore vability of organs and preserver organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygeneted cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubuing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization preventing and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of th emedical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官和保存器官的存储和/或运输的可行性。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体（例如含氧交叉血红蛋白基碳酸氢盐医疗液体）灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地响应于设置在放置在器官中的管道末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压防止和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。防止过度加压防止或减少对血管内皮衬里和器官组织的损害。可以自动监测器官的生存能力，优选通过监测体液灌注液的特性。可以使用控制程序自动控制灌注过程。

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