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1. 发明申请

WO2008011175A3 BIOABSORBABLE POLYMERIC MEDICAL DEVICE 审中-公开
标题翻译：生物可溶性聚合物医疗器械
公开(公告)号：WO2008011175A3
公开(公告)日：2008-06-26
申请号：PCT/US2007016514
申请日：2007-07-20
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
发明人： COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/9155 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/91591 , A61F2210/0076 , A61F2230/0013 , A61F2230/0054 , A61F2250/001 , A61F2250/0068 , A61F2250/0071 , A61F2250/0098
摘要： In embodiments there is described a scaffold that may be bioabsorbable and comprised of crystallizable polymer and/or comprise hoop ring structures for stability.
摘要翻译：在实施方案中，描述了可以是生物可吸收的并且由可结晶聚合物组成的支架和/或包括用于稳定性的箍环结构。

2. 发明申请

WO2008011612A3 BIOABSORBABLE POLYMERIC MEDICAL DEVICE 审中-公开
标题翻译：生物可吸收聚合物医疗设备
公开(公告)号：WO2008011612A3
公开(公告)日：2008-11-13
申请号：PCT/US2007074050
申请日：2007-07-20
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
发明人： COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/9155 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/91591 , A61F2210/0076 , A61F2230/0013 , A61F2230/0054 , A61F2250/001 , A61F2250/0068 , A61F2250/0071 , A61F2250/0098
摘要： In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
摘要翻译：在实施方案中，描述了由可结晶生物可吸收聚合物组合物或共混物制造的具有低免疫原性的心血管管形可锁定和可扩张生物可吸收支架。

3. 发明申请

WO2008011614A3 BIOABSORBABLE POLYMERIC MEDICAL DEVICE 审中-公开
公开(公告)号：WO2008011614A3
公开(公告)日：2008-10-30
申请号：PCT/US2007074052
申请日：2007-07-20
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
发明人： COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/9155 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/91591 , A61F2210/0076 , A61F2230/0013 , A61F2230/0054 , A61F2250/001 , A61F2250/0068 , A61F2250/0071 , A61F2250/0098
摘要： In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.

4. 发明申请

WO2008011613A2 BIOABSORBABLE POLYMERIC MEDICAL DEVICE 审中-公开
标题翻译：生物可溶性聚合物医疗器械
公开(公告)号：WO2008011613A2
公开(公告)日：2008-01-24
申请号：PCT/US2007074051
申请日：2007-07-20
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
发明人： COTTONE ROBERT J , YE SHUSHENG , PAZIENZA JOHN
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/9155 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/91591 , A61F2210/0076 , A61F2230/0013 , A61F2230/0054 , A61F2250/001 , A61F2250/0068 , A61F2250/0071 , A61F2250/0098
摘要： In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
摘要翻译：在实施方案中，描述了由可结晶生物可吸收聚合物组合物或共混物制造的具有低免疫原性的心血管管状可锁定和可膨胀的生物可吸收支架。

5. 发明申请

WO2009140214A1 SLEEVES FOR POSITIONING A STENT ON A DELIVERY BALLOON CATHETHER SYSTEM 审中-公开
标题翻译：用于在交付气球导管系统上定位的步骤
公开(公告)号：WO2009140214A1
公开(公告)日：2009-11-19
申请号：PCT/US2009043504
申请日：2009-05-11
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J , YE SHUSHENG
发明人： COTTONE ROBERT J , YE SHUSHENG
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9583
摘要： The present invention provides one or more sleeves for positioning a stent on a stent delivery system, such as a balloon catheter. The sleeve wraps around the catheter. One or two sleeves are positioned adjacent to one or both ends of the stent without overlapping with the stent. One end of the sleeve may be attached to the catheter or the balloon. The outer diameter of the end of the sleeve adjacent to the stent may be no greater than the outer diameter of the unexpanded stent. As a result, the profile of the stent delivery system is not increased by the sleeves of the present invention. If the stent dislodges during delivery to the target site, the stent can come to rest on the wall of the sleeve. Because the sleeves are positioned adjacent to the stent without overlapping with the stent, the stent is able to expand without being restrained by the sleeves. In addition, except for the stent, no other component of the stent delivery system, including the sleeves, comes into contact with the vessel wall when the balloon is expanded. This minimizes damages caused by the stent delivery system to the vessel.
摘要翻译：本发明提供一种或多种用于将支架定位在支架输送系统（例如球囊导管）上的套筒。套管环绕导管。一个或两个套筒邻近支架的一端或两端定位而不与支架重叠。套筒的一端可以附接到导管或气囊。邻近支架的套筒的端部的外径可以不大于未膨胀的支架的外径。结果，本发明的套筒不会增加支架输送系统的轮廓。如果在输送到目标部位期间支架移开，则支架可以停留在套管的壁上。因为套管定位成与支架相邻而不与支架重叠，所以支架能够膨胀而不受袖子约束。另外，除了支架之外，当气囊膨胀时，包括套管在内的支架输送系统的其它部件不会与血管壁接触。这最大限度地减少了支架输送系统对血管造成的损害。

6. 发明申请

WO2008070304A3 BIOABSORBABLE POLYMERIC COMPOSITION AND MEDICAL DEVICE BACKGROUND 审中-公开
标题翻译：生物可吸收性聚合物组合物和医疗装置背景技术
公开(公告)号：WO2008070304A3
公开(公告)日：2008-09-18
申请号：PCT/US2007082034
申请日：2007-10-20
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J
发明人： COTTONE ROBERT J
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： B29C47/0026 , A61F2/915 , A61F2002/91591 , A61F2230/0054 , A61L31/041 , A61L31/048 , A61L31/148 , B29C47/0004 , B29K2067/046 , B29K2995/006 , B29K2995/0088 , B29L2031/7532 , C08L67/04
摘要： A method for fabricating an embodiment of a medical device comprising the steps of: preparing a biodegradable polymeric structure; coating the biodegradable polymeric structure with a polymeric coat including a pharmacological or biological agent; cutting the structure into patterns configured to allow for crimping of the cut structure and expansion of the cut structure after crimping into a deployed configuration.
摘要翻译：一种用于制造医疗装置的实施例的方法，包括以下步骤：制备可生物降解的聚合物结构; 用包含药理学或生物学试剂的聚合物涂层涂覆生物可降解聚合物结构; 将所述结构切割成图案，所述图案被配置成允许所述切割结构卷曲并在所述切割结构卷曲成展开配置后扩展所述切割结构。

7. 发明申请

WO2008070304A9 BIOABSORBABLE POLYMERIC COMPOSITION AND MEDICAL DEVICE BACKGROUND 审中-公开
标题翻译：可生物聚合的聚合物组合物和医疗装置
公开(公告)号：WO2008070304A9
公开(公告)日：2008-07-31
申请号：PCT/US2007082034
申请日：2007-10-20
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J
发明人： COTTONE ROBERT J
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： B29C47/0026 , A61F2/915 , A61F2002/91591 , A61F2230/0054 , A61L31/041 , A61L31/048 , A61L31/148 , B29C47/0004 , B29K2067/046 , B29K2995/006 , B29K2995/0088 , B29L2031/7532 , C08L67/04
摘要： A method for fabricating an embodiment of a medical device comprising the steps of: preparing a biodegradable polymeric structure; coating the biodegradable polymeric structure with a polymeric coat including a pharmacological or biological agent; cutting the structure into patterns configured to allow for crimping of the cut structure and expansion of the cut structure after crimping into a deployed configuration.
摘要翻译：一种用于制造医疗装置的实施方案的方法，包括以下步骤：制备可生物降解的聚合物结构; 用包括药理学或生物学试剂的聚合物涂层涂覆可生物降解的聚合物结构; 将结构切割成图案，其被构造成允许在压接成展开构造之后切割结构的卷曲和切割结构的膨胀。

8. 发明申请

WO2008051881A3 BIOABSORBABLE MEDICAL DEVICE WITH COATING 审中-公开
标题翻译：带涂层的生物可吸收医疗设备
公开(公告)号：WO2008051881A3
公开(公告)日：2008-06-26
申请号：PCT/US2007082033
申请日：2007-10-20
申请人： ORBUSNEICH MEDICAL INC , COTTONE ROBERT J
发明人： COTTONE ROBERT J
IPC分类号： A61L27/28
CPC分类号： A61L27/58 , A61L27/18 , A61L27/34 , A61L27/507 , A61L27/54 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/80 , C08L67/04
摘要： A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a bioabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent.
摘要翻译：一种可生物降解的生物可吸收医疗设备，带有一层涂层，用于体内捕获祖细胞内皮细胞，并在植入部位递送治疗剂。医疗装置上的涂层提供有生物可吸收聚合物组合物，例如生物可吸收性聚合物，共聚物或三元共聚物，以及用于控制治疗剂递送速率的共聚物或三元共聚物添加剂。

9. 发明申请

WO2008011615A2 BIOABSORBABLE POLYMERIC COMPOSITION FOR A MEDICAL DEVICE 审中-公开
标题翻译：用于医疗器械的生物可降解聚合物组合物
公开(公告)号：WO2008011615A2
公开(公告)日：2008-01-24
申请号：PCT/US2007074054
申请日：2007-07-20
申请人： ORBUSNEICH MEDICAL INC , THATCHER G LAWRENCE , COTTONE ROBERT J
发明人： THATCHER G LAWRENCE , COTTONE ROBERT J
IPC分类号： A61F2/82
CPC分类号： A61L27/26 , A61F2/82 , A61F2/915 , A61F2210/0004 , A61K9/10 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/14 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/412 , A61L2300/606 , B29C45/0053 , B29C47/0066 , B29C71/0063 , B29C2793/0018 , B29C2793/009 , B29K2067/046 , B29K2105/0085 , B29K2995/0041 , B29K2995/006 , B29L2031/7534 , C08G63/91 , C08L67/00 , C08L2203/02 , C08L2205/02 , Y10T428/1352 , Y10T428/139 , C08L67/04
摘要： A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.
摘要翻译：提供了可生物降解和生物相容性无毒的聚合物组合物，其包括诸如可结晶聚合物，共聚物或三元共聚物的基础材料，以及共聚物或三元共聚物添加剂。还提供了由该组合物制造的医疗装置。

10. 发明申请

WO2014066356A3 MEDICAL DEVICE FOR IMPLANTATION INTO LUMINAL STRUCTURES 审中-公开
标题翻译：用于植入到LUMINAL结构的医疗设备
公开(公告)号：WO2014066356A3
公开(公告)日：2014-06-19
申请号：PCT/US2013066128
申请日：2013-10-22
申请人： ORBUSNEICH MEDICAL INC
发明人： COTTONE ROBERT J , JUMAN MUHAMMAD IKE , PAZIENZA JOHN , IPPOLITO JENNIFER
IPC分类号： A61F2/06 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/915 , A61F2/92
CPC分类号： A61F2/04 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2210/0004 , A61F2230/0091
摘要： The present invention relates to expandable scaffolds which may be stents. The stents of the present invention comprise a generally cylindrically shaped main body having a plurality of expandable first and second circumferential elements. The body of the vascular scaffold comprises a plurality of circumferential elements. At least two circumferential elements may be connected to form a pair of circumferential elements. There may be one or more connections between the circumferential elements forming the pair comprising connection elements which may be found in a variety of different geometric shapes. Each pair of circumferential elements is connected to an adjacent pair of circumferential elements by at least one connection element. When expanded, a contiguous spiral pattern as a helix is formed.
摘要翻译：本发明涉及可以是支架的可扩展支架。本发明的支架包括具有多个可扩张的第一和第二周向元件的大致圆柱形的主体。血管支架的主体包括多个圆周元件。可以连接至少两个周向元件以形成一对周向元件。形成包括可以以各种不同几何形状形成的连接元件的圆周元件之间可以存在一个或多个连接。每对周向元件通过至少一个连接元件连接到相邻的一对圆周元件。当膨胀时，形成作为螺旋的连续螺旋图案。

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