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1. 发明申请

WO2006016525A3 GENES AND POLYPEPTIDES RELATING TO BREAST CANCERS 审中-公开
标题翻译：与乳腺癌相关的基因和多肽
公开(公告)号：WO2006016525A3
公开(公告)日：2006-07-06
申请号：PCT/JP2005014369
申请日：2005-07-29
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68 , C07K14/47 , C12N15/12
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present application provides novel human genes B1194, A2282V1, A2282V2, and A2282V3 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer.
摘要翻译：本申请提供了在乳腺癌中表达显着升高的新型人基因B1194，A2282V1，A2282V2和A2282V3。由此编码的这些基因和多肽可用于例如乳腺癌的诊断，以及用于开发针对乳腺癌的药物的靶分子。

2. 发明申请

WO2008018642A3 GENES AND POLYPEPTIDES RELATING TO BREAST CANCERS 审中-公开
标题翻译：与乳腺癌相关的基因和多肽
公开(公告)号：WO2008018642A3
公开(公告)日：2008-04-03
申请号：PCT/JP2007065992
申请日：2007-08-10
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C07K14/43 , C12N15/12 , G01N33/00
CPC分类号： C07K16/18 , A61K31/7088 , C07K14/47 , C07K14/4748 , C12N2310/14 , C12Q1/485 , G01N33/5011 , G01N33/5035 , G01N33/57415 , G01N2333/9121 , G01N2510/00
摘要： The present application provides novel human genes A7322,
摘要翻译：本申请提供了新的人类基因A7322，

3. 发明申请

WO2007013575A3 METHOD FOR DIAGNOSING AND TREATING RENAL CELL CARCINOMA 审中-公开
标题翻译：诊断和治疗肾细胞癌的方法
公开(公告)号：WO2007013575A3
公开(公告)日：2007-10-25
申请号：PCT/JP2006314946
申请日：2006-07-21
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Objective methods for detecting and diagnosing renal cell carcinoma (RCC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of RCC-associated gene that discriminates between RCC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of renal cell carcinoma, methods of treating renal cell carcinoma and method of vaccinating a subject against renal cell carcinoma.
摘要翻译：本文描述了用于检测和诊断肾细胞癌（RCC）的客观方法。在一个实施方案中，诊断方法包括确定区分RCC细胞和正常细胞的RCC相关基因的表达水平。本发明进一步提供筛选用于治疗肾细胞癌的治疗剂的方法，治疗肾细胞癌的方法以及针对肾细胞癌接种受试者的方法。

4. 发明申请

WO2006085684A9 METHOD OF DIAGNOSING BLADDER CANCER 审中-公开
标题翻译：诊断膀胱癌的方法
公开(公告)号：WO2006085684A9
公开(公告)日：2006-10-19
申请号：PCT/JP2006302684
申请日：2006-02-09
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2500/00
摘要： Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.
摘要翻译：本文描述了用于检测和诊断膀胱癌（BLC）的客观方法。在一个实施方案中，诊断方法包括确定区分BLC细胞和正常细胞的BLC相关基因的表达水平。本发明进一步提供了使用在具有淋巴结转移的膀胱癌细胞中具有独特改变的表达模式的BLC相关基因来预测和预防膀胱癌转移的手段。最后，本发明提供了筛选可用于治疗膀胱癌的治疗剂的方法，治疗膀胱癌的方法以及针对膀胱癌接种受试者的方法。具体而言，本申请提供了在膀胱癌中表达显着升高的新型人基因C2093，B5860N和C6055。由基因编码的基因和多肽可以用于例如膀胱癌的诊断，作为开发针对该疾病的药物的靶分子，以及用于减弱膀胱癌的细胞生长。

5. 发明申请

WO2005029067A3 METHOD OF DIAGNOSING BREAST CANCER 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：WO2005029067A3
公开(公告)日：2005-08-18
申请号：PCT/JP2004011741
申请日：2004-08-10
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C07K14/47 , C12N9/10 , C12Q1/68 , G01N33/574 , G01N33/48
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Compositions and objective methods for detecting, diagnosing, and treating breast cancer (BRC) are described herein. In particular, the present invention describes three BRC-associated genes, referred to herein as A5657, B9769, and C7965, up-regulated in BRC cells as compared to normal cells. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells; in an alternate embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS cells and IDC cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and methods for vaccinating a subject against breast cancer.
摘要翻译：本文描述了用于检测，诊断和治疗乳腺癌（BRC）的组合物和客观方法。特别地，本发明描述了与正常细胞相比，在BRC细胞中上调的三种BRC相关基因（本文称为A5657，B9769和C7965）。在一个实施方案中，诊断方法包括确定区分BRC细胞和正常细胞的BRC相关基因的表达水平; 在替代实施方案中，诊断方法包括确定区分BRC细胞，DCIS细胞和IDC细胞之间的BRC相关基因的表达水平。本发明进一步提供了筛选用于治疗乳腺癌的治疗剂的方法，以及用于治疗乳腺癌的方法以及接种受试者抵抗乳腺癌的方法。

6. 发明申请

WO2007013670A3 GENE GALNT6 AS BREAST CANCER MARKER AND SMALL INTERFERING RNAS DIRECTED AGAINST GENE GALNT6 审中-公开
标题翻译：基因GALNT6作为乳腺癌标记和针对基因GALNT6的小干扰RNA
公开(公告)号：WO2007013670A3
公开(公告)日：2007-08-16
申请号：PCT/JP2006315341
申请日：2006-07-26
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68 , C07K16/32 , C12N15/113
CPC分类号： C12N15/1137 , C12N15/1135 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present application provides novel human gene GALNT6 whose expression is markedly elevated in breast cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of breast cancers, as target molecules for developing drugs against the disease, such as siRNAS, and for attenuating cell growth of breast cancer.
摘要翻译：本申请提供了在乳腺癌中表达显着升高的新型人基因GALNT6。由该基因编码的基因和多肽可用于例如乳腺癌的诊断，作为用于开发针对该疾病的药物的靶分子，例如siRNAS，以及用于减弱乳腺癌的细胞生长。

7. 发明申请

WO2006085684A3 METHOD OF DIAGNOSING BLADDER CANCER 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：WO2006085684A3
公开(公告)日：2007-03-29
申请号：PCT/JP2006302684
申请日：2006-02-09
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2500/00
摘要： Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.
摘要翻译：本文描述了膀胱癌（BLC）检测和诊断的客观方法。在一个实施方案中，诊断方法涉及确定鉴别BLC细胞和正常细胞的BLC相关基因的表达水平。本发明还提供了使用具有淋巴结转移的膀胱癌细胞中具有独特改变的表达模式的BLC相关基因来预测和预防膀胱癌转移的手段。最后，本发明提供筛选可用于治疗膀胱癌的治疗剂，治疗膀胱癌的方法和接种疫苗接种膀胱癌的方法。特别地，本申请提供了新的人基因C2093，B5860Ns和C6055，其表达在膀胱癌中显着升高。由该基因编码的基因和多肽可用于例如膀胱癌的诊断，作为用于开发针对该疾病的药物的靶分子，以及用于减轻膀胱癌的细胞生长。

8. 发明申请

WO2005028676A3 METHOD OF DIAGNOSING BREAST CANCER 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：WO2005028676A3
公开(公告)日：2005-09-15
申请号：PCT/JP2004014438
申请日：2004-09-24
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC分类号： C07K14/47 , C12N9/10 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
摘要翻译：本文描述了用于检测和诊断乳腺癌（BRC）的客观方法。在一个实施方案中，诊断方法包括确定区分BRC细胞和正常细胞的BRC相关基因的表达水平。在另一个实施方案中，诊断方法包括确定在DCIS和IDC细胞之间区分BRC细胞的BRC相关基因的表达水平。本发明进一步提供了用于在具有淋巴结转移的乳腺癌细胞中使用具有独特改变的表达模式的BRC相关基因来预测和预防乳腺癌转移的手段。最后，本发明提供筛选可用于治疗乳腺癌的治疗剂的方法，治疗乳腺癌的方法和用于针对乳腺癌接种受试者的方法。

9. 发明申请

WO2004031231A3 GENES AND POLYPEPTIDES RELATING TO PROSTATE CANCERS 审中-公开
标题翻译：与前列腺癌相关的基因和多肽
公开(公告)号：WO2004031231A3
公开(公告)日：2004-07-08
申请号：PCT/JP0312074
申请日：2003-09-22
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
IPC分类号： C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
摘要翻译：本申请提供了新型人基因MICAL2-PV，其表达在前列腺癌中显着升高。此外，它提供由该基因编码的多肽以及由PCOTH编码的多肽，其表达也被发现在前列腺癌中升高。由该基因编码的基因和多肽可以用于例如前列腺癌的诊断中，作为用于开发针对该疾病的药物的靶分子，以及用于减轻前列腺癌的细胞生长。

10. 发明申请

WO2004031414A3 METHOD FOR DIAGNOSING PROSTATE CANCER 审中-公开
标题翻译：诊断前列腺癌的方法
公开(公告)号：WO2004031414A3
公开(公告)日：2004-07-08
申请号：PCT/JP0312073
申请日：2003-09-22
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
IPC分类号： C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
摘要翻译：本文描述了用于检测和诊断前列腺癌（PRC）或前列腺上皮内瘤变（PIN）的客观方法。在一个实施方案中，诊断方法涉及确定区分PRC或PIN和正常细胞的PRC相关基因的表达水平。本发明还提供筛选用于治疗PRC和PIN中的任一者或两者的治疗剂的方法，治疗PRC和PIN中的任一者或两者的方法以及针对PRC和PIN中的任一者或两者接种受试者的方法。

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