专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO02074776A3 HIGHLY PURIFIED AND CRYSTALLINE FORM OF HARRINGTONINE 审中-公开
标题翻译：哈丁顿高纯度和结晶形式
公开(公告)号：WO02074776A3
公开(公告)日：2002-12-27
申请号：PCT/IB0202054
申请日：2002-03-21
申请人： ONCOPHARM CORP , ROBIN JEAN-PIERRE , BLANCHARD JULIE , DHAL ROBERT , MARIE JEAN-PIERRE , RADOSEVIC NINA
发明人： ROBIN JEAN-PIERRE , BLANCHARD JULIE , DHAL ROBERT , MARIE JEAN-PIERRE , RADOSEVIC NINA
IPC分类号： C07D491/153 , A61K31/55 , A61P35/00 , A61P35/02 , A61P37/06 , C07D491/20
CPC分类号： C07D491/20
摘要： The invention concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula (I): wherein n = 2 (i.e. harringtonine) or n = 3(i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97,5%.
摘要翻译：本发明涉及天然的，合成的或半合成的哈林顿（harringtonine），包括其互变异构形式及其下式（I）的盐：其中n = 2（即，哈林顿）或n = 3（即高粱素），其中可能包括对映体形式的杂质低于1％，和/或主要杂质的含量低于0.9％，和/或色谱测定显示哈林顿含量高于97.5％。

2. 发明申请

WO2010103405A3 PROCESS FOR PREPARING CEPHALOTAXINE ESTERS 审中-公开
标题翻译：制备头孢噻肟酯的方法
公开(公告)号：WO2010103405A3
公开(公告)日：2010-11-04
申请号：PCT/IB2010000835
申请日：2010-03-11
申请人： ROBIN JEAN-PIERRE , RADOSEVIC NINA , BLANCHARD JULIE
发明人： ROBIN JEAN-PIERRE , RADOSEVIC NINA , BLANCHARD JULIE
IPC分类号： A61P35/00 , C07D491/147
CPC分类号： C07D491/056 , C07D263/44 , C07D307/58 , C07D307/60 , C07D491/147 , C07D498/08 , C07D498/22
摘要： A process for preparing cephalotaxine esters corresponding to the following general formula I which comprises the cephalotaxine backbone: C(R1) (R2) (XH)COO[CTX] wherein CTX represents the cephalotaxine backbone, being optionally substituted and/or dehydrogenated, in which formula I, X is a heteroatom, preferably an oxygen, a sulfur or a nitrogen, R1 and R2, taken separately, may be alkyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, heterocycloalkyl or aralkyl groups, said groups being optionally interrupted by ester functions, or groups that can form one or more rings or a heterocycle together, consisting in bringing the corresponding cephalotaxine compound, or salts, isomers or tautomeric forms thereof, which is free or which is in the form of a metal alkoxide corresponding to the following general formula CTXOM, wherein CTX represents the cephalotaxine backbone, being optionally substituted and/or dehydrogenated, in which M is a hydrogen atom or a metal atom, into contact with a heterocyclic side chain precursor having both a bifunctional protected (bidentate) and activated (acylating) form of an acid bearing a hydrogenated heteroatom, in the alpha (a) position with respect to the carboxyl group, and corresponding to the following general formula: in which case W is a carbon, sulfur, silicon or bore atom, X, R1 and R2 have respectively the same meaning as above, it being possible for R1 and R2 to form a ring or a heterocycle together, and Y and Z are alkyl or heteroalkyl radicals, or monovalent heteroatoms, which may be identical or different, in an independent manner, or may fuse so as to give a divalent heteroatom, it being possible for the X-W bond to be covalent or ionic.
摘要翻译：一种制备对应于下列通式I的三尖杉碱酯的方法，该酯包括三尖杉碱主链：C（R1）（R2）（XH）COO [CTX]其中CTX代表任意取代和/或脱氢的三尖杉碱骨架，其中式I，X为杂原子，优选为氧，硫或氮，R 1和R 2分别为烷基，环烷基，杂烷基，芳基，杂芳基，杂环烷基或芳烷基，所述基团任选被酯官能，或可以一起形成一个或多个环或杂环的基团，其中包括使相应的三尖杉碱碱化合物或其盐，异构体或互变异构体形式，其不含游离形式或其形式为对应于以下通用术语的金属醇盐式CTXOM，其中CTX表示三尖杉碱骨架，其任选地被取代和/或脱氢，其中M为氢原子或金属原子，与hete 在相对于羧基的α（a）位置上具有带有氢化杂原子的酸的双官能保护（二齿）和活化（酰化）形式的双环侧链前体，并且对应于以下通式：其中情况W是碳，硫，硅或钻孔原子，X，R1和R2分别具有与上述相同的含义，R1和R2可能一起形成环或杂环，并且Y和Z是烷基或杂烷基基团或单价杂原子，其可以是相同或不同的，可以独立的方式或可以融合以产生二价杂原子，其中XW键可以是共价键或离子键。

3. 发明申请

WO2015162217A3 CRYSTALLINE SALTS OF CEPHALOTAXINE AND THEIR USE FOR ITS PURIFICATION INCLUDING ENANTIOMERS 审中-公开
标题翻译：西酞红质的晶体盐及其用于纯化的用途，包括纯化剂
公开(公告)号：WO2015162217A3
公开(公告)日：2016-01-21
申请号：PCT/EP2015058833
申请日：2015-04-23
申请人： ROBIN JEAN-PIERRE , BLANCHARD JULIE , RADOSEVIC NINA
发明人： ROBIN JEAN-PIERRE , BLANCHARD JULIE , RADOSEVIC NINA , ROISNEL THIERRY , BATAILLE THIERRY
IPC分类号： C07D491/04 , A61K31/55 , A61P35/02
CPC分类号： C07D491/04 , C07B2200/13
摘要： The present invention concerns crystalline salts of (2S,3S,4R)-cephalotaxine and of (2R,3R,4S)-cephalotaxine defined by their solid state analysis patterns, their process of preparation allowing their use for crude cephalotaxine purification including for resolution of racemic or partially racemized cephalotaxine.
摘要翻译：本发明涉及（2S，3S，4R） - 头孢噻肟和由其固态分析模式定义的（2R，3R，4S） - 头孢噻肟的结晶盐，其制备方法允许其用于粗头孢噻肟纯化，包括用于外消旋或部分消旋化的头孢噻肟。

4. 发明申请

WO02074314A9 THERAPEUTICAL METHOD INVOLVING SUBCUTANEOUS ADMINISTRATION OF DRUGS CONTAINING CEPHALOTAXINE DERIVATIVES 审中-公开
标题翻译：涉及含有CEPHALOTAXINE衍生物的药物的副作用的治疗方法
公开(公告)号：WO02074314A9
公开(公告)日：2003-12-04
申请号：PCT/IB0201979
申请日：2002-03-11
申请人： ONCOPHARM CORP
发明人： ROBIN JEAN-PIERRE , MARIE JEAN-PIERRE , RADOSEVIC NINA , VEKHOFF ANNE , BLANCHARD JULIE
IPC分类号： A61K31/55 , A61K45/06 , A61P33/00 , A61P35/00 , A61P35/02
CPC分类号： A61K45/06 , A61K31/55 , A61K2300/00
摘要： A new method of therapy using the subcutaneous mode of administration of formulations based upon harringtonines including their salts and tautomeric forms having the formula (I) where: R is H, OH; Ome, O-(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-aryl-(C1-C30)-alkenyl, O-(C3-C30)-cycloalkyl or null and R is H or OH; or R , R form together O-, R = R Ome or R and R form together OCH2O- n is 0 to 8, R is H, OH, Ome, 0-(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30)-cycloalkyl or O-aryl, Z = O, S, or NH, and Formula (II) or Z-R is NR R , R and R representing respectively R and R , R , R , R are independently H, C1-C30 alkyl, C3-C30 cycloalkyl, aryl, aryl-(C1-C30)-alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C1-C30 trihalogenoalkyl, C1-C30 alkylamino-(C1-C30)alkyl, C1-C30 dialkylamino(C1-C30)-alkyl, or amino-(C1-C30)-alkyl, or Formula (III) where R , R , R are independently H, halogen, C1-C30 alkyl, C3-C30 cycloalkyl, aryl, aryl-(C1-C30)-alkyl, C2-C30 alkenyl or C2-C30 alkynyl, C1-C30trihalogenoalkyl, m is 0 to 4, each of these groups including or not heteroatom(s) or their combination with another antitumor agent or a mixture of antitumor agents useful for the treatment of a disease in humans or animals, particularly cancers, leukemias, lymphomas, parasite diseases or chemotherapeutic resistance to other agents, in using a formulation specifically adapted for subcutaneous administration.
摘要翻译：使用基于哈林顿素（包括其盐和互变异构形式）的制剂的皮下给药方法的新的治疗方法，其具有式（I）其中：R 1是H，OH; O-（C 1 -C 30） - 烷基，O-芳基 - （C 1 -C 30） - 烷基，O-芳基 - （C 1 -C 30） - 烯基，O-（C 3 -C 30） - 环烷基或无 2>是H或OH; 或R 1，R 2一起形成O-，R 3 = R 4或R 3和R 4一起形成OCH 2 O-n为0至8，R 5为 H，OH，O，O-（C 1 -C 30） - 烷基，O-芳基 - （C 1 -C 30） - 烷基，O-（C 2 -C 30） - 烯基，O-（C 3 -C 30） - 环烷基或O- 芳基，Z = O，S或NH，式（II）或ZR 8为NR 12 R 13，R 12和R 13分别表示R 9和R 10 R 9，R 10，R 11独立地为H，C 1 -C 30烷基，C 3 -C 30环烷基，芳基，芳基 - （C 1 -C 30） - 烷基，C 2 -C 30烯基，C 2 -C 30 炔基，C 1 -C 30三卤代烷基，C 1 -C 30烷基氨基 - （C 1 -C 30）烷基，C 1 -C 30二烷基氨基（C 1 -C 30） - 烷基或氨基 - （C 1 -C 30） - 烷基或式（III） R 15，R 16独立地为H，卤素，C 1 -C 30烷基，C 3 -C 30环烷基，芳基，芳基 - （C 1 -C 30） - 烷基，C 2 -C 30烯基或C 2 -C 30炔基， C1-C30三卤代烷基，m为0至4，这些基团中的每一个包括或不包括杂原子或它们与另一种抗肿瘤剂的组合或用于治疗人或动物，特别是癌症中的疾病的抗肿瘤剂的混合物 s，白血病，淋巴瘤，寄生虫病或对其他药物的化学抗性，使用特别适合于皮下给药的制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式