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1. 发明申请

WO2007035474A2 TRANSDERMAL DELIVERY PEPTIDES AND METHOD OF USE THEREOF 审中-公开
标题翻译：超导递送肽及其使用方法
公开(公告)号：WO2007035474A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036012
申请日：2006-09-14
申请人： NOVOMED TECHNOLOGIES, INC. (Shanghai) , UNIVERSITY OF SCIENCE & TECHNOLOGY OF CHINA , WEN, Long-ping , CHEN, Yongping , SHEN, Yuanyuan , GUO, Xin , WANG, Weiping , ZHANG, Brian, M.
发明人： WEN, Long-ping , CHEN, Yongping , SHEN, Yuanyuan , GUO, Xin , WANG, Weiping , ZHANG, Brian, M.
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , A61K9/0014 , A61K9/06 , A61K38/27 , C07K1/20 , Y02A50/406
摘要： Transdermal delivery peptides for the treatment of skin diseases and/or facilitation or enhancement of transdermal delivery of pharmaceutically active agents are provided. Compositions comprising the transdermal delivery peptides and methods of therapeutic use, including the improvement of transdermal delivery of drugs or other pharmaceutically active agents, are also disclosed. Nucleic acids, expression vectors, and methods of their use, which encode the transdermal delivery peptides are disclosed. Methods are also provided for in vivo phage display for identifying further peptides with enhanced transdermal delivery capability.
摘要翻译：提供了用于治疗皮肤疾病和/或促进或增强药物活性剂透皮递送的透皮递送肽。还公开了包含透皮递送肽的组合物和治疗用途的方法，包括改善药物或其它药物活性剂的透皮递送。公开了编码透皮递送肽的核酸，表达载体及其使用方法。还提供了用于体内噬菌体展示以鉴定具有增强的透皮递送能力的其它肽的方法。

2. 发明申请

WO2007061875A1 LONGITUDINALLY REINFORCED CURED IN PLACE LINER AND REINFORCED COATING 审中-公开
标题翻译：长期加固固化在衬里和增强涂层
公开(公告)号：WO2007061875A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/044736
申请日：2006-11-17
申请人： INA ACQUISITION CORP. , DRIVER, Franklin, T. , WANG, Weiping
发明人： DRIVER, Franklin, T. , WANG, Weiping
IPC分类号： F16L55/165
CPC分类号： F16L55/1651 , B29C53/48 , B29C63/185 , B29C65/02 , B29C66/112 , B29C66/1122 , B29C66/1142 , B29C66/135 , B29C66/4322 , B29C66/49 , B29C66/5326 , B29C66/71 , B29C66/80 , B29D23/001 , B29L2023/006 , F16L55/1656 , B29K2077/10 , B29K2077/00 , B29K2075/00 , B29K2067/00 , B29K2027/06 , B29K2023/12 , B29K2023/06 , B29K2023/00
摘要： A longitudinally reinforced resin impregnated cured in place liner (21) with at least an outer impermeable layer of a coated reinforcing scrim (35) to limit longitudinal stretch is provided. A continuous length of resin impregnable liner is provided in lay flat condition and impregnated. The impregnated liner is then fed into a tubular former where a resin impermeable coated scrim in tubular form having greater strength in the warp direction than in the weft direction is fed into a tubular form, sealed and continuously inverted about the inner tubular member so that the inverted wrapping envelopes the tubular member. The reinforced liner may have an integral inner impermeable layer (22) that may also be longitudinally reinforced is installed in an existing pipeline.
摘要翻译：提供了浸渍固化的衬里（21）的纵向增强树脂，其中至少具有涂覆的加强稀松布（35）的外部不可渗透层以限制纵向拉伸。连续长度的树脂浸渍衬垫设置在平铺状态下并浸渍。然后将浸渍的衬垫进料到管状形成器中，其中管状形式的树脂不可渗透涂布稀松布在经纱方向上比沿纬向方向具有更大的强度被送入管状形式，密封并围绕内部管状构件连续倒置，使得倒置的包装包裹管状构件。增强衬里可以具有可以纵向增强的整体内部不可渗透层（22），其被安装在现有管道中。

3. 发明申请

WO2005047758A1 RESIN IMPREGNATION TOWER FOR CURED IN PLACE LINER 审中-公开
标题翻译：树脂浸渍塔固化在地板内衬
公开(公告)号：WO2005047758A1
公开(公告)日：2005-05-26
申请号：PCT/US2004/036629
申请日：2004-11-03
申请人： INSITUFORM (NETHERLANDS) B.V. , INSITUFORM HOLDINGS (UK) LIMITED , INA ACQUISITION CORP. , DRIVER, Franklin, Thomas , WANG, Weiping
发明人： DRIVER, Franklin, Thomas , WANG, Weiping
IPC分类号： F16L55/165
CPC分类号： B29C63/065 , B29C53/382 , B29C63/0021 , B29L2023/006 , F16L55/1654 , F16L55/1656 , Y10T156/1013
摘要： A non-pressurized resin impregnation tower (54) for continuously impregnating the resin impregnable layer of a tubular cured in place liner (55) is provided. The tower (54) is at a height to provide sufficient resin pressure head to impregnate the resin impregnable layer fully. The resin impregnated tube (55) is fed into the top of the tower (54), drawn down about a roller at the bottom, removed from the top of the tower (54) and then wrapped with an outer impermeable coating. The impregnated liner (55) is suitable for pull-in-and-inflate method of installation or may be everted. For liners formed with an inner impermeable layer, the Linner is suitable for curing with steam.
摘要翻译：提供了用于连续浸渍管状固化的衬垫（55）的树脂浸渍层的非加压树脂浸渍塔（54）。塔（54）处于高度以提供足够的树脂压头以完全浸渍树脂浸渍层。将树脂浸渍管（55）送入塔（54）的顶部，围绕底部的辊被拉出，从塔（54）的顶部移除，然后用外部不可渗透的涂层包裹。浸渍的衬垫（55）适合于安装或者可以旋转的拉入和膨胀方法。对于形成有内部不可渗透层的衬垫，Linner适用于用蒸汽固化。

4. 发明申请

WO2005047755A1 CURED IN PLACE LINER WITH EVERTED OUTER IMPERMEABLE LAYER AND METHOD OF MANUFACTURE 审中-公开
标题翻译：固定在具有外部不可重复层的地板衬里和制造方法中
公开(公告)号：WO2005047755A1
公开(公告)日：2005-05-26
申请号：PCT/US2004/036633
申请日：2004-11-03
申请人： INSITUFORM (NETHERLANDS) B.V. , INSITUFORM HOLDINGS (UK) LIMITED , INA ACQUISITION CORP. , DRIVER, Franklin, Thomas , WANG, Weiping
发明人： DRIVER, Franklin, Thomas , WANG, Weiping
IPC分类号： F16L55/16
CPC分类号： B29D23/001 , B29C53/50 , B29C65/5042 , B29C65/5092 , B29C65/62 , B29C66/1142 , B29C66/133 , B29C66/4322 , B29C66/71 , B29C66/7234 , B29C66/836 , B29C67/0018 , B29L2023/006 , F16L55/1654 , F16L55/1656 , Y10T156/1013 , B29K2075/00 , B29K2067/00 , B29K2033/12 , B29K2033/08 , B29K2027/06 , B29K2023/12 , B29K2023/06
摘要： A resin impregnated cured in place liner having an everted outer impermeable coating is provided. A roll of a continuous length of resin impregnable material is formed into a tube. An impermeable film or wrapping is formed into a tube about a tubular former, sealed and continuously everted about the inner tubular member travelling in an opposite direction so that the everted wrapping envelopes the inner tubular member. Alternatively, the inner tubular member may be passed into a stuffer tube having an impermeable tube thereon that is everted onto the moving tubular member to encapsulate the inner tubular member. The inner tubular member may be passed through an open resin impregnation tank to impregnate the impregnable material prior to everting the outer layer thereon. The inner tubular member may have an inner layer of impermeable material bonded thereto. It may be formed into a tube with the impermeable layer on the outside and continuously everted to place the impermeable layer on the inside of the tube.
摘要翻译：提供了浸渍固化的树脂，其具有外翻的外部不可渗透涂层。将一卷连续长度的树脂浸渍材料形成为管。不透膜或包裹物围绕管形成形体形成管子，密封并且围绕围绕相反方向行进的内部管状构件连续地旋转，使得转动的包裹物包裹内部管状构件。或者，内部管状构件可以进入其上具有不可渗透管的填塞管，该填塞管绕过移动的管状构件以封装内部管状构件。内部管状构件可以穿过开放的树脂浸渍槽，以在其外部层之前浸渍可浸渍材料。内部管状构件可以具有与其结合的不透水材料的内层。它可以形成为具有在外部的不渗透层的管并且连续地转动以将不可渗透层放置在管的内部。

5. 发明申请

WO2005046973A1 LONGITUDINALLY REINFORCED CURED IN PLACE LINER 审中-公开
标题翻译：长时间加固固定在地板内
公开(公告)号：WO2005046973A1
公开(公告)日：2005-05-26
申请号：PCT/US2004/036621
申请日：2004-11-03
申请人： INSITUFORM (NETHERLANDS) B.V. , INSITUFORM HOLDINGS (UK) LIMITED , INA ACQUISITION CORP. , DRIVER, Franklin, Thomas , WANG, Weiping
发明人： DRIVER, Franklin, Thomas , WANG, Weiping
IPC分类号： B29C63/06
CPC分类号： F16L55/1654 , B29C53/382 , B29C63/0021 , B29C63/065 , B29L2023/006
摘要： A longitudinally reinforced resin impregnated cured in place liner (21) with a reinforcing scrim (33) to limit longitudinal stretch is provided. A continuous length of resin impregnable tube is provided in lay flat condition and impregnated and a scrim (33) having greater strength in the warp direction than in the weft direction is placed on a portion of the bottom of the tube that is then feed into a tubular former where an impermeable film (31) is formed into a tube sealed and continuously everted about the inner tubular member and scrim travelling in an opposite direction so that the everted wrapping envelopes the tubular member. The reinforced tube may have an integral inner impermeable layer that is installed in an existing pipeline by the pull-in-and inflate method.
摘要翻译：提供浸渍固化的衬里（21）的纵向增强树脂与加强稀松布（33）以限制纵向拉伸。将连续长度的树脂浸渍管设置在平铺状态并浸渍，并且在经纱方向上比纬向方向具有更大强度的稀松布（33）放置在管的底部的一部分上，然后将其进料到管状成形器，其中不透水膜（31）形成为密封并且围绕内部管状构件和连续地绕着内部管状构件并且沿相反方向行进的缝合线的管子，使得所述直肠包裹物包封所述管状构件。加强管可以具有一体的内部不可渗透层，其通过拉入和膨胀方法安装在现有管道中。

6. 发明申请

WO2008027973A2 REUSABLE INVERSION SLEEVE ASSEMBLY FOR INVERSION OF CURED IN PLACE LINERS 审中-公开
标题翻译：可反转的反转组件用于在地板衬里中固化
公开(公告)号：WO2008027973A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/077123
申请日：2007-08-29
申请人： INA ACQUISITION CORP. , DRIVER, Franklin, Thomas , BIRCHLER, Neil, T. , COSTA, Kyle, M. , POLIVKA, Richard, C. , WANG, Weiping
发明人： DRIVER, Franklin, Thomas , BIRCHLER, Neil, T. , COSTA, Kyle, M. , POLIVKA, Richard, C. , WANG, Weiping
CPC分类号： F16L55/1651 , B29C63/36 , F16L55/1654
摘要： Installation of a flexible cured in place liner by inverting the liner utilizing an inversion sleeve assembly with an installation apparatus having at least one selectively operable rigid gland. The sleeve assembly includes a sleeve portion of an absorbable material secured in an apparatus with an inversion boot fitted at the distal end with an inlet port for inversion and/or curing fluid. The sleeve assembly and apparatus are particularly well suited for inverting with air and curing the liner with steam introduced through a perforated lay flat hose using an apparatus with two glands. The installation sleeve is the same dimension as the liner to be installed and is reusable thereby substantially reducing the set up time to install using the dual gland apparatus. Preferably, the flexible sleeve is a length of dry cured in place liner inverted on to itself to expose two impregnable surfaces. The sleeve may have a built in fluid inlet port for use with a dual gland apparatus.
摘要翻译：通过使用具有至少一个选择性操作的刚性压盖的安装装置的倒置套筒组件来翻转衬套来安装柔性固化的衬里。套筒组件包括固定在装置中的可吸收材料的套筒部分，该装置具有安装在远端的反转靴，其具有用于反转和/或固化流体的入口。套筒组件和装置特别适用于使用具有两个压盖的装置通过空气翻转和固化通过穿孔平铺软管引入的蒸汽的衬套。安装套筒的尺寸与待安装的衬垫相同，可重复使用，从而大大减少了使用双压盖装置进行安装的安装时间。优选地，柔性套管是一定长度的干燥固化衬垫，其倒置在其自身上以暴露两个浸渍表面。套筒可以具有用于双压盖装置的内置流体入口。

7. 发明申请

WO2006052539A2 INSTALLATION OF CURED IN PLACE LINERS WITH AIR AND FLOW-THROUGH STEAM TO CURE 审中-公开
标题翻译：安装在具有空气和流量的蒸汽的地板衬里固化
公开(公告)号：WO2006052539A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/039470
申请日：2005-11-02
申请人： INSITUFORM (NETHERLANDS) B.V. , INSITUFORM HOLDINGS (UK) LIMITED , INA ACQUISITION CORP. , DRIVER, Franklin, Thomas , WANG, Weiping , COYNE, Joseph, M.
发明人： DRIVER, Franklin, Thomas , WANG, Weiping , COYNE, Joseph, M.
CPC分类号： F16L55/1651 , Y10T156/1084
摘要： A process for lining an existing pipeline or conduit with a flexible resin impregnated cured in place liner by pulling in the liner and inflating a resin impregnated inflation bladder with air and curing the liner with flow-through steam without loss of pressure is provided. The liner includes a resin absorbent material in tubular form with an impermeable membrane forming an outer layer. The inflation bladder also includes a resin absorbent material in tubular form with an impermeable membrane forming an outer layer and an exhaust assembly at the trailing end and is passed through a pressurized inversion apparatus into the collapsed liner. As the bladder reaches the distal end, the exhaust assembly exits the everting bladder and is coupled to an exhaust hose. Steam is then introduced the inversion apparatus to cure the resin and is exhausted through the exhaust tube. After cure, steam is replaced with air to cool the liner and the ends are cut to restore service through the host pipe.
摘要翻译：提供了一种利用柔性树脂浸渍的已固化的固定衬垫来拉动内衬并用空气使树脂浸渍的充气囊膨胀并且在不损失压力的情况下固化衬管的过程。衬垫包括管状形式的树脂吸收材料，其中形成外层的不渗透膜。膨胀囊还包括管状形式的树脂吸收材料，其中形成外层的不可渗透膜和在尾端处的排气组件，并且通过加压的反转装置进入塌缩的衬里。当膀胱到达远端时，排气组件离开退缩气囊并且联接到排气软管。然后将蒸汽引入反转装置以固化树脂，并通过排气管排出。固化后，用空气代替蒸汽以冷却衬管，并且端部被切割以通过主管恢复使用。

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