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1. 发明申请

WO2008023165A8 COMPOSITE MATERIAL 审中-公开
标题翻译：复合材料
公开(公告)号：WO2008023165A8
公开(公告)日：2009-04-09
申请号：PCT/GB2007003187
申请日：2007-08-21
申请人： NOVATHERA LTD , PHARMING GROUP NV , ROBERTS GARETH , DANIELS ROBERT , ZHAO XIAOBIN , THOMPSON IAN
发明人： ROBERTS GARETH , DANIELS ROBERT , ZHAO XIAOBIN , THOMPSON IAN
IPC分类号： A61L26/00 , A61L15/18 , A61L15/32 , A61L27/10 , A61L27/22 , A61L27/32 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/08 , A61L31/10
CPC分类号： A61L26/0004 , A61F2/0077 , A61F2/30767 , A61L15/18 , A61L15/32 , A61L26/0042 , A61L26/0047 , A61L26/0095 , A61L27/10 , A61L27/227 , A61L27/32 , A61L27/34 , A61L27/446 , A61L27/54 , A61L29/085 , A61L31/10 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/802
摘要： The present invention provides a composite material comprising lactoferrin and a bioactive glass. The invention also relates to pharmaceutical compositions containing the composite material. Further aspects of the invention relate to the use of the composite material of the for treating a wound, treating or preventing bacterial or viral infections in a wound, preventing viral transmission, regenerating bone, treating osteoporosis, preventing or alleviating bleeding in a wound, sterilising a wound and/or controlling haemorrhaging.
摘要翻译：本发明提供了包含乳铁蛋白和生物活性玻璃的复合材料。本发明还涉及含有该复合材料的药物组合物。本发明的其他方面涉及所述复合材料用于治疗伤口，治疗或预防伤口中的细菌或病毒感染，预防病毒传播，再生骨骼，治疗骨质疏松，预防或减轻伤口出血，杀菌伤口和/或控制出血。

2. 发明申请

WO2008023165A3 COMPOSITE MATERIAL 审中-公开
标题翻译：复合材料
公开(公告)号：WO2008023165A3
公开(公告)日：2009-02-26
申请号：PCT/GB2007003187
申请日：2007-08-21
申请人： NOVATHERA LTD , PHARMING GROUP NV , DANIELS ROBERT , ROBERTS GARETH , ZHAO XIAOBIN , THOMPSON IAN
发明人： ROBERTS GARETH , ZHAO XIAOBIN , THOMPSON IAN
IPC分类号： A61L26/00 , A61L15/18 , A61L15/32 , A61L27/10 , A61L27/22 , A61L27/32 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/08 , A61L31/10
CPC分类号： A61L26/0004 , A61F2/0077 , A61F2/30767 , A61L15/18 , A61L15/32 , A61L26/0042 , A61L26/0047 , A61L26/0095 , A61L27/10 , A61L27/227 , A61L27/32 , A61L27/34 , A61L27/446 , A61L27/54 , A61L29/085 , A61L31/10 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/802
摘要： The present invention provides a composite material comprising lactoferrin and a bioactive glass. The invention also relates to pharmaceutical compositions containing the composite material. Further aspects of the invention relate to the use of the composite material of the for treating a wound, treating or preventing bacterial or viral infections in a wound, preventing viral transmission, regenerating bone, treating osteoporosis, preventing or alleviating bleeding in a wound, sterilising a wound and/or controlling haemorrhaging.
摘要翻译：本发明提供了包含乳铁蛋白和生物活性玻璃的复合材料。本发明还涉及含有复合材料的药物组合物。本发明的其它方面涉及用于治疗伤口，治疗或预防伤口中细菌或病毒感染的复合材料的用途，防止病毒传播，再生骨，治疗骨质疏松症，预防或减轻伤口出血，灭菌伤口和/或控制性出血。

3. 发明申请

WO2008023163A3 COMPOSITE MATERIAL COMPRISING FIBRINOGEN AND BIOACTIVE GLASS AS A WOUND DRESSING 审中-公开
标题翻译：包裹纤维素和生物玻璃的复合材料作为一个创新的连接
公开(公告)号：WO2008023163A3
公开(公告)日：2008-05-29
申请号：PCT/GB2007003184
申请日：2007-08-21
申请人： NOVATHERA LTD , PHARMING GROUP NV , ROBERTS GARETH , DANIELS ROBERT , ZHAO XIAOBIN , THOMPSON IAN
发明人： ROBERTS GARETH , DANIELS ROBERT , ZHAO XIAOBIN , THOMPSON IAN
IPC分类号： A61L26/00
CPC分类号： A61L26/0004 , A61L26/0042 , A61L26/0066 , A61L26/0085 , A61L26/0095 , A61L2300/21 , A61L2300/252 , A61L2300/418
摘要： The present invention provides a composite material comprising fibrinogen or fibrin, or a mixture thereof, and a bioactive glass. The invention also relates to wound dressings and pharmaceutical compositions containing the composite material. Further aspects of the invention relate to the use of the composite material of the for treating a wound, treating or preventing bacterial infections in a wound, preventing or alleviating bleeding in a wound, sterilising a wound, controlling haemorrhaging, increasing the rate of coagulation of blood and/or activating a coagulation system in a wound.
摘要翻译：本发明提供了包含纤维蛋白原或纤维蛋白或其混合物和生物活性玻璃的复合材料。本发明还涉及含有复合材料的伤口敷料和药物组合物。本发明的另外的方面涉及用于治疗伤口，治疗或预防伤口中的细菌感染的复合材料的用途，预防或减轻伤口出血，对伤口进行灭菌，控制出血，提高凝血速率血液和/或激活伤口中的凝血系统。

4. 发明申请

WO2007072065A3 SILICONE COMPOSITION 审中-公开
标题翻译：硅胶组合物
公开(公告)号：WO2007072065A3
公开(公告)日：2007-10-04
申请号：PCT/GB2006004936
申请日：2006-12-22
申请人： ADVANCED BIO TECHNOLOGIES INC , BRYANT DAVID , ROBERTS GARETH , THOMPSON IAN , DANIELS ROBERT
发明人： BRYANT DAVID , ROBERTS GARETH , THOMPSON IAN , DANIELS ROBERT
IPC分类号： C03C1/00 , A61K9/06 , A61K9/70 , A61K33/30 , A61K47/24 , A61L15/18 , A61L15/44 , A61L15/46 , A61L17/00 , A61L26/00 , C03B19/12 , C03C3/078 , C03C3/097 , C03C4/00 , C03C8/08
CPC分类号： A61K45/06 , A61K31/00 , A61K33/30 , A61K33/34 , A61K33/38 , A61L15/18 , A61L15/44 , A61L15/46 , A61L26/0004 , A61L26/0066 , A61L2300/102 , A61L2300/104 , A61L2300/404 , C03C1/006 , C03C3/097 , C03C4/0007 , C03C4/0035 , C03C11/005 , C03C11/007 , C03C12/00 , C03C2204/02 , A61K2300/00
摘要： Topical composition comprising bioactive glass particles and non-volatile silicone fluid.
摘要翻译：包含生物活性玻璃颗粒和非挥发性硅氧烷流体的局部组合物。

5. 发明申请

WO2012065025A2 PROSTATE CANCER POINT OF CARE DIAGNOSTICS 审中-公开
标题翻译：前列腺癌诊断的癌症点
公开(公告)号：WO2012065025A2
公开(公告)日：2012-05-18
申请号：PCT/US2011060307
申请日：2011-11-11
申请人： UNIV RICE WILLIAM M , UNIV TEXAS HEALTH SCIENCE CT , MCDEVITT JOHN T , CHRISTODOULIDES NICOLAOS , FLORIANO PIERRE N , THOMPSON IAN
发明人： MCDEVITT JOHN T , CHRISTODOULIDES NICOLAOS , FLORIANO PIERRE N , THOMPSON IAN
IPC分类号： G01N33/574
CPC分类号： G01N33/689 , C40B40/10 , G01N33/54386 , G01N33/57434
摘要： The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer. The present invention employs biomarker specific reagents in disposable cassettes or lab cards for use as analyzers, as well as software to evaluate and report test results. The system promises to improve point of care in vitro diagnostics.
摘要翻译：本发明涉及用于诊断或预测前列腺癌的护理点诊断一次性用品，装置，方法和系统。本发明在一次性盒子或实验室卡中使用生物标志物特异性试剂用作分析仪，以及评估和报告测试结果的软件。该系统有望改进体外诊断的护理点。

6. 发明申请

WO2008001058A3 APPARATUS FOR DETECTING INFECTED TISSUE 审中-公开
标题翻译：检测感染组织的装置
公开(公告)号：WO2008001058A3
公开(公告)日：2008-09-04
申请号：PCT/GB2007002364
申请日：2007-06-25
申请人： OSSPRAY LTD , THOMPSON IAN , WATSON TIM , COOK RICHARD
发明人： THOMPSON IAN , WATSON TIM , COOK RICHARD
IPC分类号： A61B5/00
CPC分类号： A61B5/0088 , A61B5/0068
摘要： An apparatus and method for detecting infected tissue are disclosed. The apparatus comprises a light source for producing a light beam and an optical element having an input end optically coupled to the light source and an output end arranged to direct the light beam as a confocal beam into tissue. The apparatus also comprise a detector optically coupled to the optical element to receive a return beam back from the tissue stimulated by the confocal beam and to generate an output dependent upon the return beam. An analyser is arranged to analyse the output of the detector to determine whether the return beam is indicative of infected tissue. The use of a confocal beam allows it to be directed to a specific predetermined point or depth in tissue, such as a tooth, thus eliminating the 'swamping effect' of the bulk background tissue. Thus an embodiment of the apparatus is more sensitive at detecting infected tissue.
摘要翻译：公开了一种用于检测感染组织的装置和方法。该装置包括用于产生光束的光源和具有光耦合到光源的输入端的光学元件和布置成将光束作为共焦束引导到组织中的输出端。该装置还包括光学耦合到光学元件的检测器，以从由共聚焦束刺激的组织接收返回光束并产生取决于返回光束的输出。分析器被布置成分析检测器的输出以确定返回光束是否指示感染的组织。使用共焦束允许其被引导到组织（例如牙齿）中的特定预定点或深度，从而消除了散装背景组织的“淹没效应”。因此，该装置的一个实施例在检测感染的组织时更为敏感。

7. 发明申请

WO2006013337A3 TISSUE-ADHESIVE MATERIALS 审中-公开
标题翻译：组织粘合材料
公开(公告)号：WO2006013337A3
公开(公告)日：2006-09-14
申请号：PCT/GB2005002981
申请日：2005-07-29
申请人： TISSUEMED LTD , KETTLEWELL GRAEME , MANDLEY DAVID JOHN , FORTUNE DAVID HARRY , THOMPSON IAN , MORRIS DIANE
发明人： KETTLEWELL GRAEME , MANDLEY DAVID JOHN , FORTUNE DAVID HARRY , THOMPSON IAN , MORRIS DIANE
IPC分类号： A61L15/58
CPC分类号： A61L15/58
摘要： This invention related to a tissue-adhesive sheet comprising a homogeneous, preformed and cross-linked matrix formed from one or more polymers, and having at least one surface that, in use, is exposed, at least one of said one or more polymers being a synthetic polymer and having appendant functional groups of a first form, cross-linking of said matrix being via a proportion of said functional groups of the first form, and the remainder of said functional groups of the first form being free. The sheet is particularly useful as a tissue adhesive and sealant, and is intended for topical application to internal and external surfaces of the body for therapeutic reasons. The invention further relates to sheets comprising a scaffold material, three-dimensional articles formed from similar material to that of the sheet and to implantable medical devices coated with such material.
摘要翻译：本发明涉及一种组织粘附片，其包含由一种或多种聚合物形成的均质的，预成形的和交联的基质，并且具有至少一个在使用中暴露的表面，所述一种或多种聚合物中的至少一种是合成聚合物并具有第一种形式的附带官能团，所述基质的交联是通过一部分所述第一种形式的官能团，而第一种形式的其余所述官能团是游离的。该片材作为组织粘合剂和密封剂特别有用，并且出于治疗原因用于局部施用于身体的内部和外部表面。本发明还涉及包含支架材料，由与所述片材相似的材料形成的三维制品的片材以及涂覆有这种材料的可植入医疗器械。

8. 发明申请

WO2009019516A3 TISSUE-ADHESIVE MATERIALS 审中-公开
标题翻译：组织胶粘材料
公开(公告)号：WO2009019516A3
公开(公告)日：2010-03-11
申请号：PCT/GB2008050669
申请日：2008-08-06
申请人： TISSUEMED LTD , MANDLEY DAVID JOHN , FORTUNE DAVID , THOMPSON IAN , MORRIS DIANE , AMBRIDGE APRIL
发明人： MANDLEY DAVID JOHN , FORTUNE DAVID , THOMPSON IAN , MORRIS DIANE , AMBRIDGE APRIL
IPC分类号： A61L24/04
CPC分类号： A61L24/0015 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606
摘要： A multi-lamellar tissue-adhesive sheet comprises a first, tissue-contacting, layer (1) of material containing tissue-reactive functional groups. A second layer (2) comprising a synthetic polymer is conjoined to the first layer (1). The second layer (2) additionally comprises one or more therapeutic agents.
摘要翻译：多层薄纸粘合片包括第一组织接触层（1）的含有组织反应性官能团的材料层。包含合成聚合物的第二层（2）与第一层（1）结合。第二层（2）另外包含一种或多种治疗剂。

9. 发明申请

WO2008122360A3 METHOD FOR ADMINISTERING A FLUID ACTIVE SUBSTANCE FROM A MULTI-CHAMBER AMPOULE 审中-公开
标题翻译：装置用于流体的活性物质从更CHAMBER安瓿管理
公开(公告)号：WO2008122360A3
公开(公告)日：2009-02-05
申请号：PCT/EP2008002341
申请日：2008-03-25
申请人： TECPHARMA LICENSING AG , GALBRAITH SOFIA , MOSER ULRICH , HIRSCHEL JUERG , THOMPSON IAN
发明人： GALBRAITH SOFIA , MOSER ULRICH , HIRSCHEL JUERG , THOMPSON IAN
IPC分类号： A61M5/24
CPC分类号： A61M5/24 , A61M5/2448 , A61M5/3146 , A61M5/31505 , A61M5/31535 , A61M5/31551 , A61M5/31591 , A61M5/50 , A61M2005/3125 , A61M2005/31508 , A61M2205/583
摘要： The invention relates to a device for administering an active substance from a multi-chamber carpule comprising at least one first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance. Said device also comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device. The invention is characterized by at least one first indication (15; 21) for marking or indicating a position of the multi-chamber carpule (4) relative to the housing (1) upon completion of the mixing step and a second indication (16; 22) for marking or indicating a position of the carpule (4) relative to the housing (1) upon completion of a venting step of the carpule (4).
摘要翻译：一种用于从Mehrkammerkarpule与至少一个第一腔室与固体活性物质和第二室用溶液液体用于活性物质施用活性化合物设备具有用于将活性物质和溶液液体和用于接收所述混合装置的外壳混合的混合装置。它至少提供一个第一显示器（15; 21）的显示装置用于标记或混合的完成和第二显示（16; 22）之后，指示对于所述壳体（1）的Mehrkammerkarpule（4）相对的位置标记或指示包括安瓿（4）相对于壳体（1）的安瓿（4）的排气操作完成之后的位置。

10. 发明申请

WO2010063998A2 ANTIBIOTIC NANOMATERIAL 审中-公开
标题翻译：抗生素NANOMATERIAL
公开(公告)号：WO2010063998A2
公开(公告)日：2010-06-10
申请号：PCT/GB2009002795
申请日：2009-12-01
申请人： ISIS INNOVATION , THOMPSON IAN , MOLINA FRANCISCO RODRIGO , DOBSON PETER
发明人： THOMPSON IAN , MOLINA FRANCISCO RODRIGO , DOBSON PETER
IPC分类号： A61K47/48 , A01N25/08 , A01N25/34 , A01N41/08 , A01N65/42 , A01P1/00 , A01P3/00 , A61K9/00 , A61K9/20
CPC分类号： B82Y5/00 , A01N41/08 , A61K9/0019 , A61K9/0095 , A61K9/2059 , A61K47/6923 , A61K47/6949 , A01N25/08 , A01N25/10 , A01N25/34 , A01N59/16
摘要： The invention provides a composition comprising nanoparticles, which nanoparticles comprise Allicin and an inorganic carrier. Further provided is a process for producing the composition of the invention, the process comprising treating precursor nanoparticles, comprising said inorganic carrier, with Allicin. The composition of the invention may be used as an antimicrobial agent or for treating a bacterial infection, a fungal infection, a viral infection, an infection by a pathogenic protozoan, a tumour, cancer or thrombosis, or to stimulate or enhance the immune system. The invention further provides antimicrobial films, coatings, coated products, packaging materials, and polymer compositions, all of which comprise said nanoparticles, and processes for producing the films, coatings and coated products.
摘要翻译：本发明提供包含纳米颗粒的组合物，该纳米颗粒包含大蒜素和无机载体。进一步提供的是制备本发明组合物的方法，该方法包括用大蒜素处理包含所述无机载体的前体纳米颗粒。本发明的组合物可用作抗微生物剂或用于治疗细菌感染，真菌感染，病毒感染，致病性原生动物感染，肿瘤，癌症或血栓形成，或刺激或增强免疫系统。本发明还提供了抗微生物膜，涂层，涂层产品，包装材料和聚合物组合物，所有这些都包括所述纳米颗粒，以及用于生产膜，涂层和涂层产品的方法。

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