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1. 发明申请

WO2015181747A1 NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS 审中-公开
标题翻译：新型吡咯并吡啶衍生物及其作为MALT1抑制剂的用途
公开(公告)号：WO2015181747A1
公开(公告)日：2015-12-03
申请号：PCT/IB2015/053975
申请日：2015-05-27
申请人： NOVARTIS AG , PISSOT SOLDERMANN, Carole , QUANCARD, Jean , SCHLAPBACH, Achim , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina , ZOLLER, Thomas
发明人： PISSOT SOLDERMANN, Carole , QUANCARD, Jean , SCHLAPBACH, Achim , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina , ZOLLER, Thomas
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： The present invention describes new pyrazolo-pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein, R1 is halogen, cyano, or C 1 -C 3 alkyl optionally substituted by halogen; R2 is C 1 -C 6 alkyl optionally substituted one or more times by C 1 -C 6 alkyl, C 2 -C 6 alkenyl, hydroxyl, N,N-di-C 1 -C 6 alkyl amino, N-mono-C 1 -C 6 alkyl amino, O-Rg, Rg, phenyl, or by C 1 -C 6 alkoxy wherein said alkoxy again may optionally be substituted by C 1 -C 6 alkoxy, N,N-di-C 1 -C 6 alkyl amino, Rg or phenyl; C 3 -C 6 cycloalkyl optionally substituted by C 1 -C 6 alkyl, N,N-di-C 1 -C 6 alkyl amino or C 1 -C 6 alkoxy-C 1 -C 6 alkyl, and/or two of said optional substituents together with the atoms to which they are bound may form an annulated or spirocyclic 4 - 6 membered saturated heterocyclic ring comprising 1 - 2 O atoms; phenyl optionally substituted by C 1 -C 6 alkoxy; a 5 - 6 membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O said ring being optionally substituted by C 1 -C 6 alkyl which may be optionally substituted by amino or hydroxy; Rg; or N,N-di-C 1 -C 6 alkyl amino carbonyl; and R is phenyl independently substituted two or more times by Ra, 2-pyridyl independently substituted one or more times by Rb, 3-pyridyl independently substituted one or more times by Rc, or 4-pyridyl independently substituted one or more times by Rd; which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.
摘要翻译：本发明描述了式（I）的新的吡唑并嘧啶衍生物或其药学上可接受的盐; （I）其中，R 1为卤素，氰基或任选被卤素取代的C 1 -C 3烷基; R2是任选被C 1 -C 6烷基，C 2 -C 6烯基，羟基，N，N-二-C 1 -C 6烷基氨基，N-单-C 1 -C 6烷基氨基，O-R g，R g，苯基，或C 1 -C 6烷氧基，其中所述烷氧基再次可任选被C 1 -C 6烷氧基，N，N-二-C 1烷基氨基，R g或苯基取代; 任选地被C 1 -C 6烷基，N，N-二-C 1 -C 6烷基氨基或C 1 -C 6烷氧基-C 1 -C 6烷基取代的C 3 -C 6环烷基和/或所述任选取代基中的两个与它们所键合的原子一起形成环状或包含1〜2个O原子的螺环4-6元饱和杂环; 任选被C 1 -C 6烷氧基取代的苯基; 具有1至3个选自N和O的杂原子的5-6元杂芳基环，所述环任选被可被氨基或羟基任选取代的C 1 -C 6烷基取代; RG; 或N，N-二-C 1 -C 6烷基氨基羰基; R为独立地被R a取代两次或更多次的苯基，R 2独立地取代一次或多次的2-吡啶基，R c独立地取代一次或多次的3-吡啶基，或被Rd独立地取代一次或多次的4-吡啶基; 其通常与MALT1蛋白水解和/或自发蛋白水解活性相互作用，特别是可能抑制所述活性。本发明还描述了所述新的吡唑并嘧啶衍生物的合成，它们作为药物的用途，特别是通过与MALT1蛋白水解和/或自身蛋白水解活性的相互作用。

2. 发明申请

WO2007140980A1 PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS 审中-公开
标题翻译：吡咯烷衍生物有效用作BACE抑制剂
公开(公告)号：WO2007140980A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/004959
申请日：2007-06-04
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , ROGEL, Olivier , RONDEAU, Jean-Michel , RUEEGER, Heinrich , SIMIC, Oliver , SIROCKIN, Finton , TINTELNOT-BLOMLEY, Marina
发明人： ROGEL, Olivier , RONDEAU, Jean-Michel , RUEEGER, Heinrich , SIMIC, Oliver , SIROCKIN, Finton , TINTELNOT-BLOMLEY, Marina
IPC分类号： C07D215/48 , A61K31/47 , A61P25/28
CPC分类号： C07D215/48
摘要： Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on the activity of beta-secretase and/or the generation of beta-amyloid and the subsequent aggregation into oligomers and fibrils; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on the activity of beta-secretase and/or the generation of beta-amyloid and the subsequent aggregation into oligomers and fibrils; the use of a compound of that class in the treatment of a disease that depends on the activity of beta- secretase and/or the generation of beta-amyloid and the subsequent aggregation into oligomers and fibrils; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound. The substituted pyrrolidine compounds are especially of the formula (I), wherein the substituents are as defined in the specification.
摘要翻译：新型3-单，3,4-二和3,4,4-三取代的吡咯烷化合物，用于诊断和治疗温血动物，特别是用于治疗疾病的化合物（=无序），其取决于β-分泌酶的活性和/或β-淀粉样蛋白的产生，并随后聚集成低聚物和原纤维; 使用该类化合物来制备用于治疗依赖于β-分泌酶的活性和/或产生β-淀粉样蛋白的疾病的药物制剂并随后聚集成低聚物和原纤维; 使用该类化合物治疗依赖于β-分泌酶活性和/或产生β-淀粉样蛋白的疾病，随后聚集成低聚物和原纤维; 包含所述取代的吡咯烷化合物的药物制剂和/或包括施用所述取代的吡咯烷化合物的治疗方法。取代的吡咯烷化合物特别是式（I），其中取代基如说明书中所定义。

3. 发明申请

WO2006074940A3 MACROCYCLIC COMPOUNDS AND COMPOSITIONS USEFUL AS BACE INHIBITORS 审中-公开
公开(公告)号：WO2006074940A3
公开(公告)日：2006-07-20
申请号：PCT/EP2006/000265
申请日：2006-01-13
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , LERCHNER, Andreas , MACHAUER, Rainer , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina
发明人： LERCHNER, Andreas , MACHAUER, Rainer , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina
IPC分类号： C07D245/06 , C07D281/00 , A61P25/28 , A61K31/395
摘要： The invention relates to novel macrocyclic compounds of the formula in which R 1 , R 3 , V 1 , V 2 , X 1 , X 2 , Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

4. 发明申请

WO2005035535A1 CERTAIN SUBSTITUTED SPIROCYCLIC LACTAMS AND USE THEREOF AS PHARMACEUTICALS 审中-公开
标题翻译：某些替代的螺旋藻和其作为药物的用途
公开(公告)号：WO2005035535A1
公开(公告)日：2005-04-21
申请号：PCT/EP2004/011054
申请日：2004-10-04
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , AUBERSON, Yves , GLATTHAR, Ralf , SALTER, RHYS , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina
发明人： AUBERSON, Yves , GLATTHAR, Ralf , SALTER, RHYS , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina
IPC分类号： C07D487/10
CPC分类号： C07D487/10
摘要： The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4-4]non-7-yl)-propionam ides of the formula wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及下式的新的2-（6-氧代-1,7-二氮杂 - 螺[4-4]壬-7-基） - 丙酰胺其中R1，R2，R3，R4，R5，R6， m和p如说明书中所定义，它们的制备，用作药物和含有它们的药物组合物。

5. 发明申请

WO2005014517A2 NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译：新二苯并[B，F] OXEPINE-10-羧酰胺及其药物用途
公开(公告)号：WO2005014517A2
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008283
申请日：2004-07-23
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , AUBERSON, Yves , BETSCHART, Claudia , FLOHR, Stefanie , GLATTHAR, Ralf , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina , TROXLER, Thomas, J. , VANGREVELINGHE, Eric , VEENSTRA, Siem, Jacob
发明人： AUBERSON, Yves , BETSCHART, Claudia , FLOHR, Stefanie , GLATTHAR, Ralf , SIMIC, Oliver , TINTELNOT-BLOMLEY, Marina , TROXLER, Thomas, J. , VANGREVELINGHE, Eric , VEENSTRA, Siem, Jacob
IPC分类号： C07C61/00
CPC分类号： C07D405/12 , C07C235/82 , C07C2603/32 , C07D313/14 , C07D407/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The present invention pertains to compounds of formula (I) wherein X is O, NH, N(C 1-4 )alkyl, CO or CHOH, Y is CH or N, A and B are each hydrogen or together form a second bond between the carbon atoms to which they are attached, R 1 is hydrogen or (C 1-4 )alkyl, R 2 is optionally substituted (C 1-8 )alkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, aryl or heteroaryl, R 3 is CH(R e )CONR a R b or (CH 2 ) n NR c ,R d , n is 0, 1 or 2, R a , R b , R c and R d , independently, are hydrogen or optionally substituted (C 1-8 )alkyl, (C 3-7 )cycloalkyl, (C 3-7 )cycloalkyl(C 1-4 )alkyl, (C 7-9 )bicycloalkyl, 1-aza-(C 7-9 )bicycloalkyl, aryl, aryl(C 1-4 )alkyl, heteroaryl, heteroaryl(C 1-4 )alkyl or heterocyclyl, or R a , R b , R c and R d , together with the nitrogen to which they are attached, form an optionally substituted pyrrolidinyl, piperidino, morpholino or piperazinyl group, R e is (C 1-8 )alkyl, (C 1-4 )alkoxy(C 1-4 )alkyl, (C 3-7 )cycloalkyl or (C 3-7 )cycloalkyl(C 1-4 )alkyl, and R 4 , R 5 , R 6 , R 7 , R 8 and R 9 , independently, are hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 1-4 )alkyl-SO 2 , cyano, nitro or halogen; to a process for the preparation of such compounds of formula (I), their use as a pharmaceuticals, especially in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation, and to pharmaceutical compositions and combinations comprising such compounds of formula (I).
摘要翻译：本发明涉及式（I）化合物，其中X是O，NH，N（C 1-4）烷基，CO或CHOH，Y是CH或N，A和B各自是氢或一起形成第二键碳原子，R 1是氢或（C 1-4）烷基，R 2是任选取代的（C 1-8）烷基，（C 3-7）环烷基，（C 3-7）环烷基（C 1-4）烷基，芳基或杂芳基，R3是CH（Re）CONRaRb或（CH2）nNRc，Rd，n是0,1或2，Ra，Rb，Rc和Rd独立地是氢或任选取代的（C 1-8）烷基，（ C3-7）环烷基，（C3-7）环烷基（C1-4）烷基，（C7-9）双环烷基，1-氮杂 - （C7-9）双环烷基，芳基，芳基（C1-4）烷基，杂芳基，杂芳基（C 1-4）烷基或杂环基，或R a，R b，R c和R d与它们所连接的氮一起形成任选取代的吡咯烷基，哌啶子基，吗啉代或哌嗪基，Re是（C 1-8）烷基，（C 1-4）烷氧基（C 1-4）烷基，（C 3-7）环烷基或（C 3-7）环烷基（C 1-4）烷基，R 4，R 5，R 6，R 7，R 8和R 9独立地为氢，（C1-4 ）烷基，（C 1-4）烷氧基，（C 1-4）烷基-SO 2，氰基，硝基或卤素; 制备这种式（I）化合物的方法，它们作为药物的用途，特别是用于治疗与β-淀粉样蛋白生成和/或聚集相关的神经和血管疾病，以及包含这些化合物的药物组合物和组合的式（I）化合物。

6. 发明申请

WO2014005150A1 CRYSTALLINE FORMS OF L-(2-((LR,3S,5R)-3-( (2 -FLUORO-3 - (TRIFLUOROMETHOXY) PHENYL) CARBAMOYL) - 2 -AZABICYCL O [3.1.0] HEXAN- 2 -YL) - 2 -OXOETHYL) - 5 -METHYL - 1H - PYRAZOLO [3, 4 -C] PYRIDINE - 3 - CARBOXAMI DE AND SALTS THEREOF 审中-公开
标题翻译： L-（2 - （（LR，3S，5R）-3-（（2-氟-3-（三氟甲酰基）苯基）羰基）-2-氨基] O [3.1.0]庚烷-2-基） -2-乙氧基）-5-甲基-1H-吡唑并[3,4-C]吡啶-3-羧酸酯及其盐
公开(公告)号：WO2014005150A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/048960
申请日：2013-07-01
申请人： NOVARTIS AG , TOWLER, Christopher , ALTMANN, Eva , HOMMEL, Ulrich , LORTHIOIS, Edwige Liliane Jeanne , MAIBAUM, Juergen Klaus , OSTERMANN, Nils , QUANCARD, Jean , RANDL, Stefan Andreas , SIMIC, Oliver , VULPETTI, Anna
发明人： TOWLER, Christopher , ALTMANN, Eva , HOMMEL, Ulrich , LORTHIOIS, Edwige Liliane Jeanne , MAIBAUM, Juergen Klaus , OSTERMANN, Nils , QUANCARD, Jean , RANDL, Stefan Andreas , SIMIC, Oliver , VULPETTI, Anna
IPC分类号： C07D471/04 , A61K31/437 , A61P27/02
CPC分类号： C07D471/04
摘要： Crystalline forms and pharmaceutically acceptable salts of l-(2- ((1 R,3S,5R)-3-((2-fluoro- 3-(trifluoromethoxy)phenyl)carbamoyl)-2- azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-5- methyl-1 H-pyrazolo[3,4- c]pyridine-3-carboxamide. l-(2-((l R,3S,5R)3-((2-fluoro-3- (trifluoromethoxy)phenyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl) -2-oxoethyl)-5- methyl-1 H-pyrazolo[3,4-c]pyridine-3-carboxamide is useful in treating Age-related Macular Degeneration (AMD).
摘要翻译： 1-（2-（（1R，3S，5R）-3 - （（2-氟-3-（三氟甲氧基）苯基）氨基甲酰基）-2-氮杂双环[3.1.0]己烷 - -2-氧代乙基）-5-甲基-1H-吡唑并[3,4-c]吡啶-3-甲酰胺。 1-（2 - （（1R，3S，5R）3 - （（2-氟-3-（三氟甲氧基）苯基）氨基甲酰基）-2-氮杂双环[3.1.0]己-2-基）-2-氧代乙基）-5-甲基-1H-吡唑并[3,4-c]吡啶-3-甲酰胺可用于治疗年龄相关性黄斑变性（AMD）。

7. 发明申请

WO2014002059A1 CRYSTALLINE FORMS OF 1-(2-((1R,3S,5R)-3-(((R)-1-(3-chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1Hpyrazolo[3,4-c]pyridine-3-carboxamide 审中-公开
标题翻译： 1-（2 - （（1R，3S，5R）-3 - （（（R）-1-（3-氯-2-氟苯基）乙基）氨基甲酰基）-2-氮杂双环[3.1.0]己烷的晶体形式吡啶-2-基）-2-氧代乙基）-1H-吡唑并[3,4-c]吡啶-3-甲酰胺
公开(公告)号：WO2014002059A1
公开(公告)日：2014-01-03
申请号：PCT/IB2013/055301
申请日：2013-06-27
申请人： NOVARTIS AG , TOWLER, Christopher , ALTMANN, Eva , HOMMEL, Ulrich , LORTHIOIS, Edwige Liliane Jeanne , MAIBAUM, Juergen Klaus , OSTERMANN, Nils , QUANCARD, Jean , RANDL, Stefan Andreas , SIMIC, Oliver , VULPETTI, Anna
发明人： TOWLER, Christopher , ALTMANN, Eva , HOMMEL, Ulrich , LORTHIOIS, Edwige Liliane Jeanne , MAIBAUM, Juergen Klaus , OSTERMANN, Nils , QUANCARD, Jean , RANDL, Stefan Andreas , SIMIC, Oliver , VULPETTI, Anna
IPC分类号： C07D471/04 , A61K31/437 , A61P27/02
CPC分类号： C07D471/04
摘要： Crystalline forms of 11-(2-((1R,3S,5R)-3-(((R)-1-(3-chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H- pyrazolo[3,4-c]pyridine-3-carboxamide. 1-(2-((1R,3S,5R)-3-(((R)-1-(3-chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H- pyrazolo[3,4-c]pyridine-3-carboxamide is useful in treating a disorder or a disease in a subject mediated by complement activation, in particular mediated by activation of the complement alternative pathway.
摘要翻译： 11-（（1R，3S，5R）-3 - （（（R）-1-（3-氯-2-氟苯基）乙基）氨基甲酰基）-2-氮杂双环[3.1.0]己烷 -2-氧代乙基）-1H-吡唑并[3,4-c]吡啶-3-甲酰胺。 1-（2 - （（1R，3S，5R）-3 - （（（R）-1-（3-氯-2-氟苯基）乙基）氨基甲酰基）-2-氮杂二环[3.1.0] -2- 吡啶-3-甲酰胺可用于治疗由补体活化介导的受试者中的病症或疾病，特别是通过补体替代途径的活化来介导。

8. 发明申请

WO2012093101A1 INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) 审中-公开
标题翻译：用于治疗老年相关性恶化的化合物或其类似物（AMD）
公开(公告)号：WO2012093101A1
公开(公告)日：2012-07-12
申请号：PCT/EP2012/050005
申请日：2012-01-02
申请人： NOVARTIS AG , ALTMANN, Eva , HOMMEL, Ulrich , LORTHIOIS, Edwige Liliane Jeanne , MAIBAUM, Juergen Klaus , OSTERMANN, Nils , QUANCARD, Jean , RANDL, Stefan Andreas , SIMIC, Oliver , VULPETTI, Anna , ROGEL, Olivier
发明人： ALTMANN, Eva , HOMMEL, Ulrich , LORTHIOIS, Edwige Liliane Jeanne , MAIBAUM, Juergen Klaus , OSTERMANN, Nils , QUANCARD, Jean , RANDL, Stefan Andreas , SIMIC, Oliver , VULPETTI, Anna , ROGEL, Olivier
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/403 , A61K31/407 , A61K31/416 , A61P27/02
CPC分类号： C07D403/12 , A61K31/404 , A61K31/437 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I）化合物：本发明化合物的制备方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

9. 发明申请

WO2008033389A3 MACROCYCLIC HCV INHIBITORS AND THEIR USES 审中-公开
公开(公告)号：WO2008033389A3
公开(公告)日：2008-03-20
申请号：PCT/US2007/019801
申请日：2007-09-11
申请人： NOVARTIS AG , BRANDL, Trixi , COTTENS, Sylvain , EHRHARDT, Claus , FU, Jiping , KARUR, Subramanian , PARKER, David, Thomas , PATANE, Michael, A. , RAMAN, Prakash , RANDL, Stefan, Andreas , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver
发明人： BRANDL, Trixi , COTTENS, Sylvain , EHRHARDT, Claus , FU, Jiping , KARUR, Subramanian , PARKER, David, Thomas , PATANE, Michael, A. , RAMAN, Prakash , RANDL, Stefan, Andreas , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver
IPC分类号： C07K5/06 , C07K5/08 , A61P31/00 , A61P31/12 , A61P31/18 , C07D413/14
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

10. 发明申请

WO2008101665A1 MACROCYCLIC COMPOUNDS AS HCV NS3 PROTEASE INHIBITORS 审中-公开
标题翻译：作为HCV NS3蛋白酶抑制剂的大环化合物
公开(公告)号：WO2008101665A1
公开(公告)日：2008-08-28
申请号：PCT/EP2008/001281
申请日：2008-02-19
申请人： NOVARTIS AG , BRITT, Shawn, D. , FU, Jiping , PARKER, David, Thomas , PATANE, Michael A. , RAMAN, Prakash , RADETICH, Branko , SEEPERSAUD, Mohindra , YIFRU, Aregahegn , ZHENG, Rui , BRANDL, Trixi , COTTENS, Sylvain , EHRHARDT, Claus , RANDL, Stefan, Andreas , RIGOLLIER, Pascal , SCHIERING, Nikolaus , SIMIC, Oliver
发明人： BRITT, Shawn, D. , FU, Jiping , PARKER, David, Thomas , PATANE, Michael A. , RAMAN, Prakash , RADETICH, Branko , SEEPERSAUD, Mohindra , YIFRU, Aregahegn , ZHENG, Rui , BRANDL, Trixi , COTTENS, Sylvain , EHRHARDT, Claus , RANDL, Stefan, Andreas , RIGOLLIER, Pascal , SCHIERING, Nikolaus , SIMIC, Oliver
IPC分类号： C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D513/04 , C07D515/04 , C07D519/00 , A61K31/395 , A61P31/14 , C07K5/02
CPC分类号： C07D513/04 , C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D515/04 , C07D519/00 , C07K5/0202 , C07K5/0207 , C07K5/0804 , C07K5/0827 , C07K5/1008 , C07K5/1024
摘要： The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection.
摘要翻译：本申请描述了式（I）的大环化合物与用于治疗丙型肝炎病毒感染的NS3蛋白酶抑制活性。

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