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1. 发明申请

WO2008009435A1 AMINO-PIPERIDINE DERIVATIVES AS CETP INHIBITORS 审中-公开
标题翻译：氨基哌啶衍生物作为CETP抑制剂
公开(公告)号：WO2008009435A1
公开(公告)日：2008-01-24
申请号：PCT/EP2007/006384
申请日：2007-07-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , IMASE, Hidetomo , IWAKI, Yuki , KAWANAMI, Toshio , MIYAKE, Takahiro , MOGI, Muneto , OHMORI, Osamu , QIN, Hongbo , UMEMURA, Ichiro , YAMADA, Ken , YASOSHIMA, Kayo
发明人： IMASE, Hidetomo , IWAKI, Yuki , KAWANAMI, Toshio , MIYAKE, Takahiro , MOGI, Muneto , OHMORI, Osamu , QIN, Hongbo , UMEMURA, Ichiro , YAMADA, Ken , YASOSHIMA, Kayo
IPC分类号： C07D401/12 , C07D311/30 , A61K31/455 , A61P9/00 , C07D211/58 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D211/58 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula (I), wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译：本发明提供式（I）化合物，其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。

2. 发明申请

WO2009059943A1 4-BENZYLAMINO-1-CARBOXYACYL-PIPERIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLIPIDEMIA OR ARTERIOSCLEROSIS 审中-公开
标题翻译： 4-苄氧基-1-羧氧基 - 哌啶衍生物作为CETP抑制剂用于治疗疾病如高脂血症或类风湿性心脏病
公开(公告)号：WO2009059943A1
公开(公告)日：2009-05-14
申请号：PCT/EP2008/064859
申请日：2008-11-03
申请人： NOVARTIS AG , MOGI, Muneto , YAMADA, Ken , YASOSHIMA, Kayo , KAWANAMI, Toshio , UMEMURA, Ichiro , IWAKI, Yuki , QIN, Hongbo , IMASE, Hidetomo
发明人： MOGI, Muneto , YAMADA, Ken , YASOSHIMA, Kayo , KAWANAMI, Toshio , UMEMURA, Ichiro , IWAKI, Yuki , QIN, Hongbo , IMASE, Hidetomo
IPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , A61K31/5377 , A61P3/06
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译：本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。

3. 发明申请

WO2009071509A1 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS 审中-公开
标题翻译：作为CETP抑制剂的1,2-取代-4-苄氧基 - 吡咯烷衍生物用于治疗疾病如HYPERLI PIDEMIA或ARTERIOSCLEROSIS
公开(公告)号：WO2009071509A1
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066537
申请日：2008-12-01
申请人： NOVARTIS AG , MOGI, Muneto , KAWANAMI, Toshio , YAMADA, Ken , YASOSHIMA, Kayo , IMASE, Hidetomo , MIYAKE, Takahiro , OHMORI, Osamu
发明人： MOGI, Muneto , KAWANAMI, Toshio , YAMADA, Ken , YASOSHIMA, Kayo , IMASE, Hidetomo , MIYAKE, Takahiro , OHMORI, Osamu
IPC分类号： C07D207/14 , C07D403/12 , C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/40 , A61P3/06
CPC分类号： C07D207/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译：本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的疾病或疾病或响应于CETP的抑制。

4. 发明申请

WO2007073934A1 PYRIDINYL AMINE DERIVATIVES AS INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) 审中-公开
标题翻译：作为胆固醇转运蛋白（CETP）的抑制剂的吡啶胺衍生物
公开(公告)号：WO2007073934A1
公开(公告)日：2007-07-05
申请号：PCT/EP2006/012540
申请日：2006-12-27
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , SAKAKI, Junichi , KISHIDA, Masashi , MATSUURA, Naoko , UMEMURA, Ichiro , KAWAHARA, Eiji , YAMADA, Ken , KONISHI, Kazuhide , IWAKI, Yuki , IMASE, Hidetomo , MIYAKE, Takahiro
发明人： SAKAKI, Junichi , KISHIDA, Masashi , MATSUURA, Naoko , UMEMURA, Ichiro , KAWAHARA, Eiji , YAMADA, Ken , KONISHI, Kazuhide , IWAKI, Yuki , IMASE, Hidetomo , MIYAKE, Takahiro
IPC分类号： C07D213/38 , C07D213/40 , C07D401/12 , A61K31/44 , A61K31/4439 , A61P3/00 , A61P9/00
CPC分类号： C07D401/12 , C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables are as defined, useful as inhibitors of chlosteryl ester transfer protein.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中变量如上所定义，可用作chlosteryl ester transfer protein的抑制剂。

5. 发明申请

WO2013008164A2 METHOD OF TREATING ATHEROSCLEROSIS IN HIGH TRIGLYCERIDE SUBJECTS 审中-公开
标题翻译：治疗高胆固醇血症的方法
公开(公告)号：WO2013008164A2
公开(公告)日：2013-01-17
申请号：PCT/IB2012/053479
申请日：2012-07-06
申请人： NOVARTIS AG , ARAI, Yoshie , BROUSSEAU, Margaret Elizabeth , GU, Jessie , HAYASHI, Tomoko , MITANI, Hironobu , MOGI, Muneto , NONOMURA, Kazuhiko , YAMADA, Ken
发明人： ARAI, Yoshie , BROUSSEAU, Margaret Elizabeth , GU, Jessie , HAYASHI, Tomoko , MITANI, Hironobu , MOGI, Muneto , NONOMURA, Kazuhiko , YAMADA, Ken
IPC分类号： A61K31/4025 , A61K31/4709 , A61K31/506 , A61K31/55 , A61P9/10 , A61P3/06
CPC分类号： A61K31/421 , A61K31/41 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06
摘要： The present invention provides a compound of Formula I for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride level; wherein R 1 , X 1 , R 7 , R 5 , C, L and p are defined herein. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride levels.
摘要翻译：本发明提供了用于治疗，改善和/或预防与甘油三酯水平高的受试者中CETP活性如动脉粥样硬化和血脂异常相关的疾病和病症的式I化合物; 其中R1，X1，R7，R5，C，L和p在本文中定义。本发明还提供了用于治疗，改善和/或预防与甘油三酯水平高的受试者中CETP活性如动脉粥样硬化和血脂异常相关的疾病和病症的药理活性剂的组合。

6. 发明申请

WO2015200078A8 FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES 审中-公开
公开(公告)号：WO2015200078A8
公开(公告)日：2015-12-30
申请号：PCT/US2015/036328
申请日：2015-06-18
申请人： NOVARTIS AG , BARNES, David Weninger , YAMADA, Ken , IBEBUNJO, Chikwendu , DUTTAROY, Alokesh , KIRMAN, Louise Clare , BRUCE, Alexandra Marshall , USERA, Aimee Richardson , ZECRI, Frederic , YUAN, Jun , LOU, Changgang , KANTER, Aaron , BOSE, Avirup
发明人： BARNES, David Weninger , YAMADA, Ken , IBEBUNJO, Chikwendu , DUTTAROY, Alokesh , KIRMAN, Louise Clare , BRUCE, Alexandra Marshall , USERA, Aimee Richardson , ZECRI, Frederic , YUAN, Jun , LOU, Changgang , KANTER, Aaron , BOSE, Avirup
IPC分类号： A61K47/48 , A61P3/00 , C07K14/475
摘要： The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R 1 , R 2 , R 3 , R 4 , Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

7. 发明申请

WO2005068814A1 CYLINDER BLOCK 审中-公开
标题翻译：气缸块
公开(公告)号：WO2005068814A1
公开(公告)日：2005-07-28
申请号：PCT/JP2005/000557
申请日：2005-01-12
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , YASUKI, Akira , YAMADA, Ken
发明人： YASUKI, Akira , YAMADA, Ken
IPC分类号： F02F1/16
CPC分类号： F02F1/16 , F02F1/102 , F02F1/108 , F02F7/0007 , F02F7/007 , F02F7/008 , F02F2001/106
摘要： An inner block member and an outer block member are separately formed from one another and assembled with one another to define a water jacket therebetween. The inner block member has a cylinder bore defined therein for a reciprocating motion of a piston. At least one elastic member is supported between the inner block member and the outer block member to absorb vibration generated between the inner and outer block members.
摘要翻译：内部块构件和外部块构件彼此分开地形成并且彼此组装以在其间限定水套。内部块件具有限定在其中的气缸孔，用于活塞的往复运动。至少一个弹性构件被支撑在内部块构件和外部块构件之间以吸收在内部和外部块构件之间产生的振动。

8. 发明申请

WO2005068813A1 FASTENING STRUCTURE FOR CYLINDER HEAD AND DIVIDED TYPE CYLINDER BLOCK OF ENGINE 审中-公开
标题翻译：发动机气缸盖和分体式气缸块的紧固结构
公开(公告)号：WO2005068813A1
公开(公告)日：2005-07-28
申请号：PCT/JP2005/000631
申请日：2005-01-13
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , OMURA, Seiji , YAMADA, Ken
发明人： OMURA, Seiji , YAMADA, Ken
IPC分类号： F02F1/10
CPC分类号： F02F1/102 , F02F1/10 , F02F1/16 , F02F2007/0063
摘要： A cylinder block 3 of an engine 1 is formed by assembling an inner block member 10 and an outer block member 15. The inner block member 10 includes an upper deck portion 7 integrated with a cylinder liner portion 8. The outer block member 15 includes a cylinder outer wall portion 12. The cylinder head 2 is fastened to an upper deck portion 7 with head bolts 31. The cylinder outer wall portion 12 is fastened to the upper deck portion 7 with block fastening bolts 32 at an opposite side of the upper deck portion 7 with respect to the cylinder head 2. The head bolts 31 and the block fastening bolts 32 are threaded with the upper deck portion 7 from the opposite sides with respect to each other. As a result, deformation of the upper deck portion 7 and inclination of the cylinder liner portion 8 due to fastening of the bolts 31, 32 are reliably prevented.
摘要翻译：发动机1的气缸体3通过组装内部块构件10和外部块构件15而形成。内部块构件10包括与气缸套部分8一体化的上部甲板部分7.外部构件15包括气缸盖2用头螺栓31固定在上甲板部分7上。气缸外壁部分12在上甲板的相对侧用块紧固螺栓32紧固到上甲板部分7 相对于气缸盖2的头部螺栓31和块紧固螺栓32从上甲板部分7相对于彼此的相对侧螺纹连接。结果，能够可靠地防止上部甲板部7的变形和由于螺栓31,32的紧固引起的气缸套部8的倾斜。

9. 发明申请

WO2012026108A1 POWER MANAGEMENT SYSTEM 审中-公开
标题翻译：电源管理系统
公开(公告)号：WO2012026108A1
公开(公告)日：2012-03-01
申请号：PCT/JP2011/004667
申请日：2011-08-23
申请人： SANYO ELECTRIC CO., LTD. , YAMADA, Ken , NAKASHIMA, Takeshi , IKEBE, Hayato , SAKAI, Souich , OKUDA, Yasuo , SUGATA, Takuji , IWASAKI, Toshiya , NISHIKAWA, Youichiro
发明人： YAMADA, Ken , NAKASHIMA, Takeshi , IKEBE, Hayato , SAKAI, Souich , OKUDA, Yasuo , SUGATA, Takuji , IWASAKI, Toshiya , NISHIKAWA, Youichiro
IPC分类号： H02J3/32 , H02J3/38 , H02J7/00 , H02J7/34
CPC分类号： H02J3/32 , H02J3/38 , H02J7/0022 , H02J7/007 , H02J7/35 , Y02P90/50 , Y10T307/527
摘要： Provided is a power management system capable of controlling charge and discharge of storage batteries according to power requirement of load even when handling electric power of large scale. A system controller receives load-related information data including the power requirement of load and storage battery-related information data including a state of a storage battery assembly including multiple storage batteries and creates an overall charge-discharge control instruction for the entire power management system based on the load-related information data and the storage battery-related information data. A hierarchical charge-discharge control apparatus receives the overall charge-discharge control instruction from the system controller and performs charge-discharge control of the multiple storage batteries, classified into hierarchical levels, on a hierarchical level basis.
摘要翻译：提供一种电力管理系统，即使处理大规模的电力，也能够根据负载的电力需要来控制蓄电池的充放电。系统控制器接收负载相关的信息数据，包括负载和与蓄电池有关的信息数据的电力需求，包括包括多个蓄电池的蓄电池组的状态，并且为整个电力管理系统创建总体充放电控制指令关于负载相关信息数据和与蓄电池相关的信息数据。分级充放电控制装置从系统控制器接收总的充放电控制指令，并且以分级为基础对分级为分级的多个蓄电池执行充放电控制。

10. 发明申请

WO2018073788A1 NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA 审中-公开
标题翻译：萘啶酮衍生物及其在治疗心律失常中的用途
公开(公告)号：WO2018073788A1
公开(公告)日：2018-04-26
申请号：PCT/IB2017/056515
申请日：2017-10-19
申请人： NOVARTIS AG
发明人： BARBE, Guillaume , BEBERNITZ, Gregory Raymond , GENG, Sicong , GULGEZE EFTHYMIOU, Hatice Belgin , LIAO, Lv , MA, Fupeng , MO, Ruowei , PARKER, David Thomas , PENG, Yunshan , PEUKERT, Stefan , YAMADA, Ken , YASOSHIMA, Kayo
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/06
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) Wherein R 1 , R 3 -R 6 , X 2 and X 3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供了式（I）的化合物或其药学上可接受的盐; （I）其中R 1，R 3，-R 6，X 2和X 3各自独立地表示氢，如本文所定义，制备本发明化合物的方法及其治疗用途。本发明进一步提供了药理活性剂和药物组合物的组合。

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