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1. 发明申请

WO2009056631A3 MOLECULES AND METHODS FOR MODULATING COMPLEMENT COMPONENT 审中-公开
公开(公告)号：WO2009056631A3
公开(公告)日：2009-05-07
申请号：PCT/EP2008/064809
申请日：2008-10-31
申请人： NOVARTIS AG , ETEMAD-GILBERTSON, Bijan , GUILD, Braydon Charles , KEATING, Mark Taylor , KIM, Yong-In , KLICKSTEIN, Lloyd B. , MIKHAILOV, Dmitri , MILIK, Mariusz , ROGUSKA, Michael , SPLAWSKI, Igor , ZHAO, Kehao
发明人： ETEMAD-GILBERTSON, Bijan , GUILD, Braydon Charles , KEATING, Mark Taylor , KIM, Yong-In , KLICKSTEIN, Lloyd B. , MIKHAILOV, Dmitri , MILIK, Mariusz , ROGUSKA, Michael , SPLAWSKI, Igor , ZHAO, Kehao
IPC分类号： C07K16/18 , A61K39/395 , C07K7/00
摘要： Compositions that bind to C3b epitopes and methods of using the compositions are described herein.

2. 发明申请

WO2008113834A2 C5 ANTIGENS AND USES THEREOF 审中-公开
标题翻译： C5抗原及其用途
公开(公告)号：WO2008113834A2
公开(公告)日：2008-09-25
申请号：PCT/EP2008/053321
申请日：2008-03-19
申请人： NOVARTIS AG , GUILD, Braydon Charles , KEATING, Mark Taylor , MILIK, Mariusz , MIKHAILOV, Dmitri , ROGUSKA, Michael , SPLAWSKI, Igor , ZHAO, Kehao
发明人： GUILD, Braydon Charles , KEATING, Mark Taylor , MILIK, Mariusz , MIKHAILOV, Dmitri , ROGUSKA, Michael , SPLAWSKI, Igor , ZHAO, Kehao
IPC分类号： C07K7/00
CPC分类号： G01N33/6893 , G01N2333/4716 , G01N2800/16
摘要： The present invention pertains to the use of a complement inhibitor in methods of treatment of ocular disorders and the use of a complement inhibitor in the manufacture of a medicament in the treatment of an ocular disorder.
摘要翻译：本发明涉及补体抑制剂在治疗眼部疾病的方法中的用途以及补体抑制剂在制备用于治疗眼部疾病的药物中的用途。

3. 发明申请

WO2010136311A2 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING COMPLEMENT PROTEIN C3B 审中-公开
标题翻译：抗体补体蛋白C3B的组合物和方法
公开(公告)号：WO2010136311A2
公开(公告)日：2010-12-02
申请号：PCT/EP2010/056129
申请日：2010-05-05
申请人： NOVARTIS AG , ETEMAD-GILBERTSON, Bijan , GUILD, Braydon, Charles , KIM, Yong-In , KLAGGE, Ingo , KRAUS, Alexandra , ROGUSKA, Michael , SPLAWSKI, Igor , ZHAO, Kehao
发明人： ETEMAD-GILBERTSON, Bijan , GUILD, Braydon, Charles , KIM, Yong-In , KLAGGE, Ingo , KRAUS, Alexandra , ROGUSKA, Michael , SPLAWSKI, Igor , ZHAO, Kehao
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and antigen binding fragments thereof that bind to both human and cynomolgus complement protein C3b, as well as compositions and methods of use thereof.
摘要翻译：本发明涉及结合人和食蟹猴补体蛋白C3b的抗体及其抗原结合片段，以及其组合物和使用方法。

4. 发明申请

WO2010015608A1 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING COMPLEMENT PROTEIN C5 审中-公开
标题翻译：抗体补体蛋白C5的组合物和方法
公开(公告)号：WO2010015608A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060052
申请日：2009-08-03
申请人： NOVARTIS AG , DIEFENBACH-STREIBER, Beate , EBERTH, Adina , GUILD, Braydon Charles , KIM, Yong-In , ROGUSKA, Michael , SPLAWSKI, Igor
发明人： DIEFENBACH-STREIBER, Beate , EBERTH, Adina , GUILD, Braydon Charles , KIM, Yong-In , ROGUSKA, Michael , SPLAWSKI, Igor
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
摘要翻译：本发明涉及靶向补体蛋白C5的抗体及其使用方法。

5. 发明申请

WO2014089111A1 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING EPO 审中-公开
标题翻译：针对EPO抗体的组合物和方法
公开(公告)号：WO2014089111A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/072915
申请日：2013-12-03
申请人： NOVARTIS AG , GHOSH, Joy , RUTZ, Mark Anthony , TISSOT-DAGUETTE, Katrin Ulrike , SPLAWSKI, Igor , ROGUSKA, Michael
发明人： GHOSH, Joy , RUTZ, Mark Anthony , TISSOT-DAGUETTE, Katrin Ulrike , SPLAWSKI, Igor , ROGUSKA, Michael
IPC分类号： C07K16/22 , A61K39/00
CPC分类号： C07K16/26 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to compositions and methods for the inhibition of EPO. The invention provides antibodies and antigen binding fragments thereof that bind to EPO and are able to inhibit EPO-dependent cell proliferation and/or EPO-dependent cell signaling.
摘要翻译：本发明涉及抑制EPO的组合物和方法。本发明提供了结合EPO并能够抑制EPO依赖性细胞增殖和/或EPO依赖性细胞信号传导的抗体及其抗原结合片段。

6. 发明申请

WO2015198243A3 COMPOSITIONS AND METHODS FOR LONG ACTING PROTEINS 审中-公开
公开(公告)号：WO2015198243A3
公开(公告)日：2015-12-30
申请号：PCT/IB2015/054745
申请日：2015-06-24
申请人： NOVARTIS AG , GHOSH, Joy , ROGUSKA, Michael , NGUYEN, Andrew Anh , PIETZONKA, Thomas , POOR, Stephen , MACHACEK, Matthias , BIGELOW, Chad Eric
发明人： GHOSH, Joy , ROGUSKA, Michael , NGUYEN, Andrew Anh , PIETZONKA, Thomas , POOR, Stephen , MACHACEK, Matthias , BIGELOW, Chad Eric
IPC分类号： C07K14/47
摘要： The present invention is based, in part, on the discovery of peptide tags that increase the half-life and/or mean residence time of proteins or nucleic acids in the eye. In certain aspects the invention peptide tags increase the half-life and/or mean residence time of antibodies and antigen binding fragments, therapeutic proteins, protein receptors, DARPins and/or aptamers in the eye.

7. 发明申请

WO2014099997A1 COMPOSITIONS AND METHODS THAT UTILIZE A PEPTIDE TAG THAT BINDS TO HYALURONAN 审中-公开
标题翻译：组合物和方法，使用一种肽标签，用于HYALURONAN
公开(公告)号：WO2014099997A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/075795
申请日：2013-12-17
申请人： NOVARTIS AG , GHOSH, Joy , ROGUSKA, Michael , NGUYEN, Andrew Anh , PIETZONKA, Thomas , POOR, Stephen , MACHACEK, Matthais , BIGELOW, Chad
发明人： GHOSH, Joy , ROGUSKA, Michael , NGUYEN, Andrew Anh , PIETZONKA, Thomas , POOR, Stephen , MACHACEK, Matthais , BIGELOW, Chad
IPC分类号： C12N15/62 , C07K14/47
CPC分类号： C07K14/00 , A61K31/713 , A61K38/00 , A61K39/3955 , A61K47/42 , A61K47/48246 , A61K47/64 , C07K14/4718 , C07K16/22 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/20 , C07K2319/31 , C07K2319/33 , C12N15/115 , C12N2310/16 , C12N2310/3513 , C12N2320/32
摘要： The invention relates, in part, to compositions and methods that utilize a peptide tag that binds to hyaluronan (HA). The HA tag can be linked to a molecule such as a protein or nucleic acid which, when administered to the eye, results in an increase in ocular half-life and/ or mean residence time, and or a decrease in ocular clearance of the protein or nucleic acid. The invention also encompasses methods for treating ocular disease, including retinal vascular disease, by administering a protein or nucleic acid linked to an HA peptide tag.
摘要翻译：本发明部分涉及利用结合透明质酸（HA）的肽标签的组合物和方法。 HA标签可以连接到分子，例如蛋白质或核酸，当被施用于眼睛时，导致眼部半衰期和/或平均停留时间增加，和/或蛋白质的眼清除率降低或核酸。本发明还包括通过施用与HA肽标签连接的蛋白质或核酸来治疗眼部疾病（包括视网膜血管疾病）的方法。

8. 发明申请

WO2015198245A1 COMPOSITIONS AND METHODS FOR VISUALIZATION OF THE VITREOUS 审中-公开
标题翻译：组合物和方法可视化的VITREOUS
公开(公告)号：WO2015198245A1
公开(公告)日：2015-12-30
申请号：PCT/IB2015/054747
申请日：2015-06-24
申请人： NOVARTIS AG , GHOSH, Joy , DRYJA, Thaddeus Peter , ROGUSKA, Michael , CARLSON, Eric
发明人： GHOSH, Joy , DRYJA, Thaddeus Peter , ROGUSKA, Michael , CARLSON, Eric
IPC分类号： A61K47/42 , C07K14/47 , A61K49/00 , A61P41/00
CPC分类号： A61K49/0056 , A61K9/0051 , A61K49/0021 , A61K49/0043 , C07K14/4718
摘要： The invention provides compositions for rendering a vitreous cavity visible during a surgical procedure to alleviate a structural disorder caused by the vitreous in an eye, and methods of using the compositions. The compositions are vitreous delineating agents that comprise a hyaluronan binding peptide linked to an optically detectable moiety. Such compositions can be in a formulation that may be a solution, a suspension, or an emulsion, and would be injected into the vitreous shortly prior to use. The composition may additionally contain a therapeutic agent, a diagnostic agent, or a chemosensirig material, in use, the composition marks or delineates the vitreous by binding preferentially to the hyaluronan that permeates the vitreous humor and binding little or not at ail to surrounding tissues such as the retina. The interface between the labelled vitreous humor and the non-labelled surrounding vital tissues produces a visible signal, thereby allowing a surgeon to clearly visualize the entire vitreous cavity and distinguish it from vital ocular structures. Use of the method improves the accuracy and safety of a vitrectomy and thus prevents suboptimal outcomes or the need for repeated procedures. The compositions comprising chemosensing material are useful as long- lasting biosensors, which when used in the vitreous enable repetitive, non-invasive, in vivo measurements of metabolites or pharmacologic agents in the vitreous of animals or humans.
摘要翻译：本发明提供用于在外科手术过程中使玻璃体腔可见的组合物，以减轻由眼睛中的玻璃体引起的结构障碍，以及使用该组合物的方法。组合物是包含与可光学检测部分连接的透明质酸结合肽的玻璃体描绘剂。这样的组合物可以是可以是溶液，悬浮液或乳液的制剂，并且在使用前不久将被注入玻璃体。该组合物可以在使用中另外含有治疗剂，诊断剂或化学感光材料，组合物通过优先结合渗透玻璃体液的透明质酸并且很少或不与周围组织结合而标记或描绘玻璃体，如作为视网膜。标记的玻璃体液和未标记的周围重要组织之间的界面产生可见信号，从而允许外科医生清楚地观察整个玻璃体腔并将其与重要的眼部结构区分开。使用该方法可提高玻璃体切割术的准确性和安全性，从而防止次优结局或重复手术的需要。包含化学感应材料的组合物可用作持久的生物传感器，当用于玻璃体时，能够重复，非侵入性地体内测量动物或人体玻璃体中的代谢物或药理学试剂。

9. 发明申请

WO2008082651A3 DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES 审中-公开
公开(公告)号：WO2008082651A3
公开(公告)日：2008-07-10
申请号：PCT/US2007/026482
申请日：2007-12-28
申请人： ABBOTT LABORATORIES , HSIEH, Chung-ming , MCRAE, Bradford, L. , KUTSKOVA, Yuliya , MEMMOTT, John, E. , ROGUSKA, Michael , TOMLINSON, Ian , TUNA, Mihriban , GRANT, Steven , ENEVER, Carrie
发明人： HSIEH, Chung-ming , MCRAE, Bradford, L. , KUTSKOVA, Yuliya , MEMMOTT, John, E. , ROGUSKA, Michael , TOMLINSON, Ian , TUNA, Mihriban , GRANT, Steven , ENEVER, Carrie
IPC分类号： A61K39/00
摘要： The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-l α and human IL-I β. The dual specific antibodies of the invention also neutralize both human IL-I α and human IC-I β. The invention also provides domain antibodies (dAbs) specific for human IL-l α and human IL-l β.

10. 发明申请

WO2005100403A2 ANTIBODIES TO ERYTHROPOIETIN RECEPTOR AND USES THEREOF 审中-公开
标题翻译：抗精神病药物受体的抗体及其用途
公开(公告)号：WO2005100403A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/011956
申请日：2005-04-08
申请人： ABBOTT LABORATORIES , REILLY, Edward, B. , LACY, Susan, E. , FUNG, Emma , BELK, Jonathan, P. , ROGUSKA, Michael
发明人： REILLY, Edward, B. , LACY, Susan, E. , FUNG, Emma , BELK, Jonathan, P. , ROGUSKA, Michael
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/74 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions.
摘要翻译：本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。本发明还涉及编码这种抗体和抗原结合部分的核酸序列。本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。

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