专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011017691A2 ENHANCED MOLECULAR DETECTION OF TARGETED INTRACELLULAR MRNA TRANSCRIPTION USING POLYNUCLEOTIDE FUNCTIONALIZED NANOPARTICLES 审中-公开
标题翻译：用多核苷酸功能化纳米粒子增强靶细胞MRNA转录的分子检测
公开(公告)号：WO2011017691A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/044847
申请日：2010-08-09
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , MCMAHON, Kaylin , THAXTON, C., Shad , PRIGODICH, Andrew, E.
发明人： MIRKIN, Chad, A. , MCMAHON, Kaylin , THAXTON, C., Shad , PRIGODICH, Andrew, E.
IPC分类号： C12N15/63 , C12N15/113 , C12Q1/68 , G01N33/52
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/136 , C12Q2600/158 , C12Q2565/626 , C12Q2565/107 , C12Q2563/155
摘要： The present invention is directed to compositions and methods for enhanced molecular detection of targeted intracellular mRNA transcription using a polynucleotide functionalized nanoparticle (PN-NP).
摘要翻译：本发明涉及用于使用多核苷酸功能化纳米颗粒（PN-NP）增强靶向细胞内mRNA转录的分子检测的组合物和方法。

2. 发明申请

WO2011017456A2 LOCALIZED DELIVERY OF NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于治疗和诊断应用的纳米颗粒的本地化递送
公开(公告)号：WO2011017456A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/044453
申请日：2010-08-04
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , OMARY, Reed, A. , THAXTON, C., Shad , EIFLER, Aaron , MOULI, Samdeep, K. , MCMAHON, Kaylin , LARSON, Andrew
发明人： MIRKIN, Chad, A. , OMARY, Reed, A. , THAXTON, C., Shad , EIFLER, Aaron , MOULI, Samdeep, K. , MCMAHON, Kaylin , LARSON, Andrew
IPC分类号： A61K31/713 , A61K48/00 , A61K51/00 , B82B3/00 , A61P35/00
CPC分类号： A61K48/0025 , A61K9/0019 , A61K9/5115 , A61K31/713 , A61K47/6923 , C12N15/111 , C12N2310/113 , C12N2320/32
摘要： The present invention is directed to compositions and methods of localized delivery of a functionalized nanoparticle.
摘要翻译：本发明涉及官能化纳米颗粒的局部递送的组合物和方法。

3. 发明申请

WO2009131704A2 NANOSTRUCTURES SUITABLE FOR SEQUESTERING CHOLESTEROL AND OTHER MOLECULES 审中-公开
标题翻译：适用于测定胆固醇和其他分子的纳米结构
公开(公告)号：WO2009131704A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/002540
申请日：2009-04-24
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , THAXTON, C., Shad , GILJOHANN, David, A. , DANIEL, Weston
发明人： MIRKIN, Chad, A. , THAXTON, C., Shad , GILJOHANN, David, A. , DANIEL, Weston
IPC分类号： A61K9/127 , A61K31/7088 , A61P9/10
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1275 , A61K9/5115 , A61K9/5123 , A61K31/7088
摘要： Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.
摘要翻译：提供了与纳米结构相关的制品，组合物，试剂盒和方法，包括可以螯合分子如胆固醇的那些。本文描述的某些实施例包括具有核 - 壳型布置的结构; 例如，纳米颗粒核心可以被包含可与胆固醇和/或其它脂质相互作用的材料（例如脂质双层）包围。在一些实施方案中，当引入受试者时，结构可以螯合胆固醇和/或其它脂质并将其从循环中除去。因此，本文所述的结构可用于诊断，预防，治疗或管理某些疾病或身体状况，特别是与异常脂质水平相关的疾病或身体状况。

4. 发明申请

WO2010060110A1 POLYVALENT RNA-NANOPARTICLE COMPOSITIONS 审中-公开
标题翻译：多价RNA-纳米材料组合物
公开(公告)号：WO2010060110A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065822
申请日：2009-11-24
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , GILJOHANN, David, A. , SEFEROS, Dwight , PRIGODICH, Andrew, E. , PATEL, Pinal, C.
发明人： MIRKIN, Chad, A. , GILJOHANN, David, A. , SEFEROS, Dwight , PRIGODICH, Andrew, E. , PATEL, Pinal, C.
IPC分类号： A61K9/51 , A61K47/48
CPC分类号： A61K31/713 , A61K9/51 , A61K47/6923 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/351 , C12N2310/531 , C12N2320/32
摘要： The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.
摘要翻译：本发明涉及用于多种用途（包括但不限于基因调控）的用双功能RNA功能化的纳米颗粒。更具体地，本公开提供了将RNA与纳米颗粒缀合以实现增加的稳定性和活性的新策略。

5. 发明申请

WO2011113054A3 CROSSLINKED POLYNUCLEOTIDE STRUCTURE 审中-公开
公开(公告)号：WO2011113054A3
公开(公告)日：2011-09-15
申请号：PCT/US2011/028380
申请日：2011-03-14
申请人： AURASENSE LLC , MIRKIN, Chad, A. , THAXTON, C., Shad , GILJOHANN, David, A. , CUTLER, Joshua, I.
发明人： MIRKIN, Chad, A. , THAXTON, C., Shad , GILJOHANN, David, A. , CUTLER, Joshua, I.
IPC分类号： C12Q1/70 , B82Y15/00 , B82Y30/00 , B82Y5/00
摘要： The present invention provides structures formed from crosslinked polynucleotides, where a subset of the polynucleotides binds to a target under physiological conditions, where the signal group detectably changes upon binding.

6. 发明申请

WO2012125986A1 METHOD OF ANALYZING AN ANALYTE USING COMBINATORIAL ARRAYS AND UNIFORM PATTERNS 审中-公开
标题翻译：使用组合阵列和均匀图案分析分析的方法
公开(公告)号：WO2012125986A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029569
申请日：2012-03-17
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , GIAM, Louise, R. , MASSICH, Matthew, D.
发明人： MIRKIN, Chad, A. , GIAM, Louise, R. , MASSICH, Matthew, D.
IPC分类号： B01J19/00 , G03F7/00
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00743 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： The disclosure relates to a method of analyzing an analyte that includes forming a combinatorial pattern comprising pattern elements with a plurality of sizes and/or structures on a substrate surface with a tilted pen array, applying an analyte to the combinatorial pattern, and identifying a pattern element size and/or structure having a desired effect on an analyte parameter using the combinatorial pattern. The method further includes forming a uniform pattern comprising pattern elements each having substantially the same size and/or structure corresponding to the identified pattern element size and/or structure, and analyzing the effect of pattern element size and/or structure on the analyte parameter using the uniform pattern.
摘要翻译：本公开涉及一种分析分析物的方法，其包括用倾斜的笔阵列在基底表面上形成包括多个尺寸和/或结构的图案元素的组合图案，将分析物施加到组合图案，以及识别图案使用组合图案对分析物参数具有期望效果的元件尺寸和/或结构。该方法还包括形成包含图案元素的均匀图案，每个图案元素具有与所识别的图案元素尺寸和/或结构相对应的基本相同的尺寸和/或结构，并且使用以下方式分析图案元素尺寸和/或结构对分析物参数的影响均匀图案。

7. 发明申请

WO2009015381A1 PLASMONIC-DRIVEN SYNTHESIS OF NANOPRISMS FROM ISOTROPIC AND ANISOTROPIC GOLD CORES 审中-公开
标题翻译：等离子体和多相金黄色金属纳米粒子的合成驱动合成
公开(公告)号：WO2009015381A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/071296
申请日：2008-07-28
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , XUE, Can , MILLSTONE, Jill, E.
发明人： MIRKIN, Chad, A. , XUE, Can , MILLSTONE, Jill, E.
IPC分类号： B22F1/00 , B22F1/02 , B22F9/02 , B22F9/24
CPC分类号： B22F1/025 , B22F1/0018 , B22F2001/0037 , B22F2998/00 , B22F2999/00 , B82Y30/00 , Y10T428/12181 , B22F9/24 , B22F2201/11
摘要： A nanoprism having a prismatic silver shell formed about a gold core and a process of forming the same are disclosed. The process includes irradiating a mixture of gold and silver nanoparticles with a narrow band of wavelengths capable of exciting the surface plasmon resonance of the gold.
摘要翻译：公开了一种具有围绕金芯形成的方形银壳的纳米棱镜及其形成方法。该方法包括用能够激发金的表面等离子体共振的窄波长波段照射金和银纳米颗粒的混合物。

8. 发明申请

WO2008151049A2 NUCLEIC ACID FUNCTIONALIZED NANOPARTICLES FOR THERAPEUTIC APPLICATIONS 审中-公开
标题翻译：用于治疗应用的核酸功能纳米颗粒
公开(公告)号：WO2008151049A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065366
申请日：2008-05-30
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , GILJOHANN, David, A. , SEFEROS, Dwight , PATEL, Pinal, C.
发明人： MIRKIN, Chad, A. , GILJOHANN, David, A. , SEFEROS, Dwight , PATEL, Pinal, C.
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K9/51 , A61K31/7088 , C12N15/111 , C12N15/87 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle.
摘要翻译：提供了用于调节功能化纳米颗粒的细胞摄取的材料和方法。还提供了用于调节具有官能化纳米颗粒的治疗剂的有效性的材料和方法。

9. 发明申请

WO2008127789A2 MOLECULE ATTACHMENT TO NANOPARTICLES 审中-公开
标题翻译：分子与纳米颗粒的连接
公开(公告)号：WO2008127789A2
公开(公告)日：2008-10-23
申请号：PCT/US2008/055133
申请日：2008-02-27
申请人： NORTHWESTERN UNIVERSITY , ELGHANIAN, Robert , MIRKIN, Chad, A.
发明人： ELGHANIAN, Robert , MIRKIN, Chad, A.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6876 , G01N33/5432
摘要： Disclosed herein are molecule-modified nanoparticles and methods of making and using the same. More specifically, disclosed herein are molecule-modified nanoparticles wherein the molecule is attached to the surface of the nanoparticle via an oligonucleotide. Also disclosed are methods of preparing nanoparticles having oligonucleotides and molecules (e.g., biomolecules, such as proteins, peptides, antibodies, lipids, and/or carbohydrates) attached to the nanoparticle surface, wherein the oligonucleotide and molecule are covalently attached. Further disclosed are methods of detecting an analyte of interest using these disclosed molecule-modified nanoparticles.
摘要翻译：本文公开了分子修饰的纳米颗粒及其制备和使用方法。更具体地，本文公开了分子修饰的纳米颗粒，其中分子经由寡核苷酸连接到纳米颗粒的表面。还公开了制备与寡核苷酸和分子（例如生物分子，如蛋白质，肽，抗体，脂质和/或碳水化合物）连接在纳米颗粒表面上的纳米颗粒的方法，其中寡核苷酸和分子是共价连接的。进一步公开的是使用这些公开的分子修饰的纳米颗粒检测感兴趣分析物的方法。

10. 发明申请

WO2008020851A2 NANOARRAYS OF SINGLE VIRUS PARTICLES, METHODS AND INSTRUMENTS FOR THE FABRICATION AND USE THEREOF 审中-公开
标题翻译：纳米阵列病毒粒子，方法和仪器的制造和使用
公开(公告)号：WO2008020851A2
公开(公告)日：2008-02-21
申请号：PCT/US2006/032316
申请日：2006-08-18
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , VEGA, Rafael, A. , MASPOCH, Daniel , SALAITA, Khalid
发明人： MIRKIN, Chad, A. , VEGA, Rafael, A. , MASPOCH, Daniel , SALAITA, Khalid
IPC分类号： G01N33/50
CPC分类号： A61K31/70 , B82Y5/00 , B82Y30/00 , C12N7/00 , C12N2770/00011 , G01N33/56983 , Y10S977/802
摘要： A novel coordination chemistry or metal ion binding approach to controlling the site- isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.
摘要翻译：一种新颖的配位化学或金属离子结合方法，用于控制纳米阵列模板上的病毒颗粒（例如TMV）的位点分离和取向，所述纳米阵列模板通过包括浸笔纳米光刻术的光刻产生。通过使用许多病毒中固有的表面化学，金属离子基或无机配位化学被用于固定各个病毒颗粒而不需要它们的基因修饰。由于病毒架构与组成这些阵列的功能之间的尺寸不匹配，单粒子控制将使得涉及病毒的各种研究成为微阵列不可能实现的。这些包括：单粒子，单细胞传染性研究，材料合成和分子电子学模板等结构的探索，以及旨在了解表面表达如何影响其生物活性的研究。这是单粒子水平上这种控制的开创性例子，因此纳米阵列在生物系统中的商业应用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式