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1. 发明申请

WO2008156732A3 PATTERNING WITH COMPOSITIONS COMPRISING LIPID 审中-公开
公开(公告)号：WO2008156732A3
公开(公告)日：2008-12-24
申请号：PCT/US2008/007498
申请日：2008-06-17
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , HUANG, Ling , LENHERT, Steven , VEGA, Rafael, A.
发明人： MIRKIN, Chad, A. , HUANG, Ling , LENHERT, Steven , VEGA, Rafael, A.
IPC分类号： B01J19/00 , C40B50/14
摘要： Better patterning methods, including for : better methods for forming biomolecular arrays, including a method comprising: -providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC (1, 2-di-oleoyl-sn-glycero-3-phosphocholine). The, patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM (atomic force microscope), and AFM (scanning probe microscope) tips can be used.

2. 发明申请

WO2008157550A2 MATRIX ASSISTED INK TRANSPORT 审中-公开
标题翻译： MATRIX辅助墨水运输
公开(公告)号：WO2008157550A2
公开(公告)日：2008-12-24
申请号：PCT/US2008/067231
申请日：2008-06-17
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , HUANG, Ling , HUO, Fengwei , HURST, Sarah, J. , QIN, Lidong , JANG, Jae-Won , KAKKASSERY, Joseph, J.
发明人： MIRKIN, Chad, A. , HUANG, Ling , HUO, Fengwei , HURST, Sarah, J. , QIN, Lidong , JANG, Jae-Won , KAKKASSERY, Joseph, J.
IPC分类号： B01J19/00 , C40B50/14
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Provided is a direct write patterning method utilizing a mixture comprising an ink of choice and an ink carrier matrix. The method involves disposing the mixture on a tip or stamp and transporting the mixture from the tip or stamp on a surface to form a pattern that contains the ink. The method does not require chemical or physical modification of either the tip or stamp or the surface prior to transporting the mixture to the surface. The method can be applied for patterning hard inks such as nanomaterials and crystallized polymers and soft inks such as biomaterials including peptides and proteins. Also provided are related biomaterial and hard ink arrays.
摘要翻译：提供了一种使用包括选择的墨水和墨水载体基质的混合物的直接写入图案化方法。该方法包括将混合物设置在尖端或印模上，并将混合物从尖端或印模输送到表面上以形成包含油墨的图案。在将混合物输送到表面之前，该方法不需要对尖端或印模或表面进行化学或物理改性。该方法可以应用于诸如纳米材料和结晶聚合物的硬油墨和软油墨如包括肽和蛋白质的生物材料的图形化。还提供了相关的生物材料和硬油墨阵列。

3. 发明申请

WO2008121137A2 FABRICATION OF MICROSTRUCTURES AND NANOSTRUCTURES USING ETCHING RESIST 审中-公开
标题翻译：使用蚀刻电阻制造微结构和纳米结构
公开(公告)号：WO2008121137A2
公开(公告)日：2008-10-09
申请号：PCT/US2007/025722
申请日：2007-12-17
申请人： NORTHWESTERN UNIVERSITY , MIRKIN, Chad, A. , HUANG, Ling , SANEDRIN, Raymond
发明人： MIRKIN, Chad, A. , HUANG, Ling , SANEDRIN, Raymond
IPC分类号： G03F7/00 , B82B3/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C23F1/02 , C23F1/14 , Y10T428/24355
摘要： Nanostructures and microstructures are formed by patterning methods such as Dip Pen Nanolithography (DPN) or microcontact printing of organic molecules functioning as a resist on a substrate followed by an etching step. The etch resist is a patterning composition and can contain on a substrate including polyethylene glycol (PEG). Positive and negative etch methods can be used.
摘要翻译：纳米结构和微结构通过诸如Dip Pen Nanoithography（DPN）的图案化方法或用作基底上的抗蚀剂的有机分子的微接触印刷形成，然后进行蚀刻步骤。抗蚀剂是图案化组合物，并且可以包含在包含聚乙二醇（PEG）的基材上。可以使用正和负蚀刻方法。

4. 发明申请

WO2010080538A1 COVALENT DIABODIES AND USES THEREOF 审中-公开
标题翻译：同性双胞胎及其用途
公开(公告)号：WO2010080538A1
公开(公告)日：2010-07-15
申请号：PCT/US2009/068577
申请日：2009-12-17
申请人： MACROGENICS, INC. , JOHNSON, Leslie, S. , HUANG, Ling
发明人： JOHNSON, Leslie, S. , HUANG, Ling
IPC分类号： A61K39/00
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/32 , C07K16/44 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2319/00
摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody- like functionality to engineered into the molecule.
摘要翻译：本发明涉及双抗体分子及其在治疗各种疾病和病症（包括免疫学疾病，感染性疾病，中毒和癌症）中的用途。本发明的双抗体分子包含两个缔合以形成至少两个表位结合位点的多肽链，其可识别相同或不同抗原上相同或不同的表位。另外，抗原可以来自相同或不同的分子。双抗体分子的单个多肽链可以通过非肽键共价键共价结合，例如但不限于位于每个多肽链内的半胱氨酸残基的二硫键。在具体实施方案中，本发明的双抗体分子还包含Fc区，其允许类似抗体的功能改造成分子。

5. 发明申请

WO2008105886A2 HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：人类FC？RIIB特异性抗体及其使用方法
公开(公告)号：WO2008105886A2
公开(公告)日：2008-09-04
申请号：PCT/US2007/069767
申请日：2007-05-25
申请人： MACROGENICS, INC. , JOHNSON, Leslie S. , HUANG, Ling
发明人： JOHNSON, Leslie S. , HUANG, Ling
IPC分类号： A61K39/395 , A61P43/00 , C07H21/04 , C07K16/18 , C12N15/00 , C12N5/06 , C12P21/04 , G01N33/564
CPC分类号： A61K39/39 , A61K2039/505 , A61K2039/55516 , C07K16/283 , C07K2317/24 , C07K2317/34 , C07K2317/52 , G01N33/564 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention encompasses the use of the humanized antibodies of the invention for the treatment of any disease related to loss of balance of Fc receptor mediated signaling, such as cancer, autoimmune and inflammatory disease. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the humanized antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing the efficacy of a vaccine composition by administering the humanized antibodies of the invention. The invention encompasses methods for treating an autoimmune disease and methods for elimination of cancer cells that express FcγRIIB.
摘要翻译：本发明涉及以比所述抗体更大的亲和力结合FcγRIIA的结合人FcγRIIB的人源化FcγRIIB抗体，其片段和变体。本发明包括本发明的人源化抗体用于治疗与Fc受体介导的信号传导的平衡丧失有关的任何疾病（例如癌症，自身免疫性和炎症性疾病）的用途。本发明提供了通过施用本发明的人源化抗体来增强治疗性抗体的治疗效果以增强治疗性抗体的效应子功能的方法。本发明还提供了通过施用本发明的人源化抗体来增强疫苗组合物的功效的方法。本发明包括治疗自身免疫疾病的方法和消除表达FcγRIIB的癌细胞的方法。

6. 发明申请

WO2006088494A9 IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT FC REGIONS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2006088494A9
公开(公告)日：2006-08-24
申请号：PCT/US2005/024645
申请日：2005-07-12
申请人： MACROGENICS, INC. , STAVENHAGEN, Jeffrey , VIJH, Sujata , RANKIN, Christopher , GORLATOV, Sergey , HUANG, Ling
发明人： STAVENHAGEN, Jeffrey , VIJH, Sujata , RANKIN, Christopher , GORLATOV, Sergey , HUANG, Ling
IPC分类号： A61K39/395 , C07K16/28
摘要： The present invention relates to molecules, particularly polypeptides, more particularly immunoglobins ( e.g ., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function ( e.g ., ADCC) mediated by FcγR is desired, e.g ., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

7. 发明申请

WO2005110474A2 HUMANIZED FcγRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：人类FcγRIIB特异性抗体及其使用方法
公开(公告)号：WO2005110474A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/016260
申请日：2005-05-10
申请人： MACROGENICS, INC. , JOHNSON, Leslie, S. , HUANG, Ling
发明人： JOHNSON, Leslie, S. , HUANG, Ling
IPC分类号： A61K39/395
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/24 , C07K2317/34
摘要： The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention encompasses the use of the humanized antibodies of the invention for the treatment of any disease related to loss of balance of Fc receptor mediated signaling, such as cancer, autoimmune and inflammatory disease. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the humanized antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing the efficacy of a vaccine composition by administering the humanized antibodies of the invention. The invention encompasses methods for treating an autoimmune disease and methods for elimination of cancer cells that express FcγRIIB.
摘要翻译：本发明涉及以与抗体结合FcγRIIA更大的亲和力结合人FcγRIIB的人源化FcγRIIB抗体，其片段和变体。本发明包括本发明的人源化抗体用于治疗与Fc受体介导的信号传导的平衡失去相关的任何疾病（例如癌症，自身免疫性和炎性疾病）的用途。本发明提供了通过施用本发明的人源化抗体来增强治疗性抗体的治疗效果以增强治疗性抗体的效应子功能的方法。本发明还提供了通过施用本发明的人源化抗体来增强疫苗组合物的功效的方法。本发明包括治疗自身免疫疾病的方法和用于消除表达FcγRIIB的癌细胞的方法。

8. 发明申请

WO2003060520A3 SAMPLE PREPARATION FOR THE DETECTION OF INFECTIOUS AGENTS 审中-公开
公开(公告)号：WO2003060520A3
公开(公告)日：2003-07-24
申请号：PCT/GB2002/005923
申请日：2002-12-24
申请人： LEE, Helen , HUANG, Ling , NADALA, Elpidio, Cesar, Jr. , BUTTRESS, Nigel, Derek
发明人： LEE, Helen , HUANG, Ling , NADALA, Elpidio, Cesar, Jr. , BUTTRESS, Nigel, Derek
IPC分类号： G01N33/571
摘要： Methods for improving the quality of sub-optimal patient samples for dectection of infectious agents are described. In particular, endocervical fluid samples or vaginal fluid samples are treated with DNase to improve the reliability of detection of infectious agents. Kits for carrying out the methods are also described.

9. 发明申请

WO2012018687A1 COVALENT DIABODIES AND USES THEREOF 审中-公开
标题翻译：同性双胞胎及其用途
公开(公告)号：WO2012018687A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/045922
申请日：2011-07-29
申请人： MACROGENICS, INC. , JOHNSON, Leslie, S. , HUANG, Ling , RAINEY, Godfrey Jonah Anderson
发明人： JOHNSON, Leslie, S. , HUANG, Ling , RAINEY, Godfrey Jonah Anderson
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： A61K39/39558 , A61K38/164 , C07K14/315 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2851 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70
摘要： Diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers are disclosed. The diabody molecules comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as disulfide bonding of cysteine residues located within each polypeptide chain. The diabody molecules may further comprise an Fc region, which allows antibody-like functionality to be engineered into the molecule.
摘要翻译：公开了抗体分子及其用于治疗各种疾病和病症（包括免疫学疾病，感染性疾病，中毒和癌症）的用途。双抗体分子包含两个缔合以形成至少两个表位结合位点的多肽链，其可识别相同或不同抗原上相同或不同的表位。另外，抗原可以来自相同或不同的分子。双抗体分子的单个多肽链可以通过非肽键共价键共价结合，例如位于每个多肽链内的半胱氨酸残基的二硫键。双抗体分子可以进一步包含Fc区，其允许抗体样功能被改造成分子。

10. 发明申请

WO2009151717A2 BCR-COMPLEX-SPECIFIC ANTIBODIES AND METHODS OF USING SAME 审中-公开
标题翻译： BCR复合特异性抗体及其使用方法
公开(公告)号：WO2009151717A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/038171
申请日：2009-03-25
申请人： MACROGENICS, INC. , JOHNSON, Leslie, S. , HUANG, Ling
发明人： JOHNSON, Leslie, S. , HUANG, Ling
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , C07K16/2803 , C07K2317/24 , C07K2317/56
摘要： This invention relates to chimeric and humanized antibodies that specifically bind the BCR complex, and particularly chimeric and humanized antibodies to the BCR complex. The invention also relates to methods of using the antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
摘要翻译：本发明涉及特异性结合BCR复合物的嵌合和人源化抗体，特别是涉及BCR复合物的嵌合和人源化抗体。本发明还涉及将抗体及其组合物用于诊断，预后和治疗诸如癌症，自身免疫性疾病，炎症性疾病和感染性疾病的疾病的方法。

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