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1. 发明申请

WO2003066162A3 METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：WO2003066162A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003678
申请日：2003-02-07
申请人： NORTHSTAR NEUROSCIENCE, INC. , FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
发明人： FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
IPC分类号： A61N1/18
摘要： The method (100) includes a diagnostic procedure (102) involving identifying a stimulation site at a location of the brain where an intended neural activity related to the neural-function is present. The method also includes an implanting procedure (104) involving positioning first and second electrodes at the identified stimulation site, and a stimulating procedure (106) involving applying an electrical current between the first and second electrodes.

2. 发明申请

WO2005002664A3 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：WO2005002664A3
公开(公告)日：2005-01-13
申请号：PCT/US2004/020398
申请日：2004-06-24
申请人： NORTHSTAR NEUROSCIENCE, INC. , FIRLIK, Andrew, D. , BALZER, Jeffrey , GLINER, Bradford, Evan , LEVY, Alan, J.
发明人： FIRLIK, Andrew, D. , BALZER, Jeffrey , GLINER, Bradford, Evan , LEVY, Alan, J.
IPC分类号： A61N1/08
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.

3. 发明申请

WO2003026736A2 METHODS AND IMPLANTABLE APPARATUS FOR ELECTRICAL THERAPY 审中-公开
标题翻译：电疗方法和可植入装置
公开(公告)号：WO2003026736A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/031170
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE, INC. , FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
发明人： FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/36017 , A61N1/36071
摘要： Some embodiments of the invention provide electrical therapy by delivering electrical pulses through at least one (and in some embodiments two or more) subcutaneously implanted electrode to stimulate one or more target nerves in a selected volume of tissue. Unlike conventional peripheral nerve stimulation or spinal column stimulation, there is no need to position the electrodes in direct contact with a specific nerve or the spinal column. Instead, the electrode can be implanted at an indeterminate distance from the target nerve. Other embodiments provide implantable neurostimulators with a pair of electrodes which can be connected to a common pulse system. Each electrode may include two or more contacts spaced 3 cm or more from one another and the electrodes are implantable at distances of 5 cm or more apart. The common pulse system may also be implantable.
摘要翻译：本发明的一些实施方案通过将电脉冲通过至少一个（在一些实施方案中为两个或更多个）皮下植入的电极提供电疗法，以刺激选定体积的组织中的一个或多个靶神经。与传统的周围神经刺激或脊柱刺激不同，不需要将电极定位成与特定神经或脊柱直接接触。相反，电极可以与目标神经以不确定的距离植入。其他实施例提供可植入的神经刺激器，其具有可以连接到公共脉冲系统的一对电极。每个电极可以包括彼此间隔3cm或更多的两个或更多个触点，并且电极可以在距离5cm或更长的距离处植入。普通脉冲系统也可以是可植入的。

4. 发明申请

WO2003066162A2 METHODS AND APPARATUS FOR EFFECTUATING A CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能改变的方法和装置
公开(公告)号：WO2003066162A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003678
申请日：2003-02-07
申请人： VERTIS NEUROSCIENCE, INC. , FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
发明人： FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
IPC分类号： A61N1/18
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/375 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as "neuroplasticity." The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase theresting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。根据本发明的方法的几个实施方案旨在增强或以其他方式诱导神经活动的持续变化以实现特定的神经功能。这种神经活动的持续变化被定义为“神经可塑性”。根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑疾病（例如阿尔茨海默氏症，皮克病，帕金森氏病等）和/或脑部疾病（例如癫痫，抑郁症等）。根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。根据本发明的方法的某些实施方案在发生神经可塑性的刺激部位电刺激脑。刺激部位可能不同于大脑中通常存在神经活动的区域，以根据脑的功能组织来执行特定的神经功能。在与神经功能相关的神经可塑性发生在脑中的一个实施方案中，该方法可以包括鉴定存在这种神经可塑性的位置。在脑中不发生神经可塑性的替代实施方案中，替代方面是在预期发生的刺激位点处诱导神经可塑性。预期对刺激部位的预期神经活动产生持久作用的这些方法的若干实施方案使用增加刺激部位的神经元的膜电位至亚阈值水平的电脉冲。

5. 发明申请

WO2003035163A2 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：WO2003035163A2
公开(公告)日：2003-05-01
申请号：PCT/US2002/031127
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE, INC. , GLINER, Bradford, Evan , FOWLER, Brad , FIRLIK, Andrew, D. , BALZER, Jeffrey , LEVY, Alan, J.
发明人： GLINER, Bradford, Evan , FOWLER, Brad , FIRLIK, Andrew, D. , BALZER, Jeffrey , LEVY, Alan, J.
IPC分类号： A61N1/00
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/3605 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。根据本发明的方法的某些实施方案在神经可塑性发生或预期发生的刺激部位电刺激脑。刺激部位可能不同于大脑中通常存在神经活动的区域，以根据脑的功能组织来执行特定的神经功能。在与神经功能相关的神经可塑性发生在脑中的一个实施方案中，该方法可以包括鉴定存在或预期发生这种神经可塑性的位置。在脑中不发生神经可塑性的替代实施方案中，替代方面是在预期发生的刺激位点处诱导神经可塑性。预期对刺激部位的预期神经活动产生持久影响的这些方法的若干实施方案使用增加刺激部位的神经元的静息膜电位至亚阈值水平的电脉冲。

6. 发明申请

WO2003026738A1 METHODS AND APPARATUS FOR ELECTRICALLY STIMULATING CELLS IMPLANTED IN THE NERVOUS SYSTEM 审中-公开
标题翻译：用于电刺激神经系统中的电刺激的方法和装置
公开(公告)号：WO2003026738A1
公开(公告)日：2003-04-03
申请号：PCT/US2002/031112
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE, INC. , GLINER, Bradford, Evan , LEVY, Alan, J. , BALZER, Jeffrey , FIRLIK, Andrew, D. , SHEFFIELD, W., Douglas
发明人： GLINER, Bradford, Evan , LEVY, Alan, J. , BALZER, Jeffrey , FIRLIK, Andrew, D. , SHEFFIELD, W., Douglas
IPC分类号： A61N1/36
CPC分类号： A61N1/36103 , A61N1/36017 , A61N1/3756 , C12N13/00
摘要： The following disclosure describes several methods and apparatus for stimulating cells implanted in the regions of nervous system, such as the brain, spinal cord or peripheral nerves. Accordingly, the functionality of the cells can be improved, for example, by differentiating undifferentiated or partially undifferentiated cells into neurons or other cells having action potentials. The method can also include promoting directional growth and connectivity of fully differentiated neural cells implanted in a patient's nervous system through electrical enhancement, for example, electrical stimulation via an anode and cathode. Methods in accordance with the invention can be used to treat brain damage ( e.g. , stroke, trauma, etc.), brain disease ( e.g. , Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders ( e.g. , epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains ( e.g. , learning, memory, etc.), or to control sensory functions ( e.g. , pain).
摘要翻译：以下公开内容描述了用于刺激植入神经系统诸如脑，脊髓或周围神经的区域中的细胞的几种方法和装置。因此，可以通过例如将未分化或部分未分化的细胞分化成具有动作电位的神经元或其他细胞来改善细胞的功能。该方法还可以包括通过电增强（例如经由阳极和阴极的电刺激）促进植入患者神经系统中的完全分化的神经细胞的定向生长和连通性。根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑疾病（例如，阿尔茨海默氏症，皮克病，帕金森病等）和/或脑部疾病（例如，癫痫，抑郁症等）。根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。

7. 发明申请

WO2003026736A3 METHODS AND IMPLANTABLE APPARATUS FOR ELECTRICAL THERAPY 审中-公开
公开(公告)号：WO2003026736A3
公开(公告)日：2003-04-03
申请号：PCT/US2002/031170
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE, INC. , FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
发明人： FIRLIK, Andrew, D. , LEVY, Alan, J. , GLINER, Bradford, Evan
IPC分类号： A61N1/05
摘要： Some embodiments of the invention provide electrical therapy by delivering electrical pulses through at least one (and in some embodiments two or more) subcutaneously implanted electrode to stimulate one or more target nerves in a selected volume of tissue. Unlike conventional peripheral nerve stimulation or spinal column stimulation, there is no need to position the electrodes in direct contact with a specific nerve or the spinal column. Instead, the electrode can be implanted at an indeterminate distance from the target nerve. Other embodiments provide implantable neurostimulators with a pair of electrodes which can be connected to a common pulse system. Each electrode may include two or more contacts spaced 3 cm or more from one another and the electrodes are implantable at distances of 5 cm or more apart. The common pulse system may also be implantable.

8. 发明申请

WO2002072194A2 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：WO2002072194A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007077
申请日：2002-03-07
申请人： VERTIS NEUROSCIENCE, INC. , FIRLIK, Andrew, D. , BALZER, Jeffrey , GLINER, Bradford, E. , LEVY, Alan, J. , MORGAN, Carlton, B.
发明人： FIRLIK, Andrew, D. , BALZER, Jeffrey , GLINER, Bradford, E. , LEVY, Alan, J. , MORGAN, Carlton, B.
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as "neuroplasticity". The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the maethod can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。根据本发明的方法的几个实施方案旨在增强或以其他方式诱导神经活动的持续变化以实现特定的神经功能。这种神经活动的持续变化被定义为“神经可塑性”。根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑疾病（例如阿尔茨海默氏症，皮克病，帕金森氏病等）和/或脑部疾病（例如癫痫，抑郁症等）。根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。根据本发明的方法的某些实施方案在发生神经可塑性的刺激部位电刺激脑。刺激部位可能不同于大脑中通常存在神经活动的区域，以根据脑的功能组织来执行特定的神经功能。在与神经功能相关的神经可塑性发生在脑中的一个实施方案中，该方法可以包括鉴定存在这种神经可塑性的位置。在脑中不发生神经可塑性的替代实施方案中，替代方面是在预期发生的刺激位点处诱导神经可塑性。预期对刺激部位的预期神经活动产生持久影响的这些方法的若干实施方案使用增加刺激部位的神经元的静息膜电位至亚阈值水平的电脉冲。

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