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1. 发明申请

WO2016100411A2 COLLAGENOUS TISSUE REPAIR DEVICE 审中-公开
标题翻译：胶原组织修复装置
公开(公告)号：WO2016100411A2
公开(公告)日：2016-06-23
申请号：PCT/US2015/065919
申请日：2015-12-15
申请人： NORTHEASTERN UNIVERSITY
发明人： PATEN, Jeffrey, A. , RUBERTI, Jeffrey, W.
IPC分类号： A61K38/39 , A61M5/142
CPC分类号： A61L27/24 , A61H1/008 , A61H1/02 , A61K9/0019 , A61K38/39 , A61K38/47 , A61K38/4873 , A61K38/4886 , A61K47/183 , A61L27/50 , A61L27/54 , A61L2300/41 , A61L2300/426 , A61L2400/06 , A61L2430/10 , A61M5/14 , A61M5/142 , A61M5/14248 , A61M2202/095 , A61M2205/50 , A61N1/0456 , C12Y302/01035 , C12Y304/22001 , C12Y304/24 , C12Y304/24007 , D01D5/00 , D01F4/00 , D10B2509/00 , A61K2300/00
摘要： Methods and devices for tissue remodeling and repair of collagenous tissues, including tendons, ligaments, and bone, as well as scalable connective tissue manufacturing, are provided. Collagen fibers are assembled by extensional strain-induced flow crystallization of collagen monomers. Extensional strain also drives the fusion of already formed short collagen fibrils to produce long-range, continuous fibers. Wearable devices for controlled tissue remodeling and wound healing deliver a tissue remodeling solution to a tissue repair site. The remodeling solution, together with appropriate application of strain to the tissue remodeling site, accelerate healing, prevent injury, and reduce scar formation.
摘要翻译：提供了用于组织重塑和胶原组织修复的方法和装置，包括肌腱，韧带和骨以及可伸缩的结缔组织制造。胶原纤维通过胶原单体的拉伸应变引发的流动结晶来组装。拉伸应变也驱动已经形成的短胶原纤维的融合以产生长距离连续纤维。用于受控组织重塑和伤口愈合的可穿戴设备将组织重塑溶液递送至组织修复部位。重塑解决方案，连同对组织重塑部位的适当应变，加速愈合，防止损伤和减少疤痕形成。

2. 发明申请

WO2007038601A2 NANOLOOM FOR CONTROLLING POLYMER ASSEMBLY 审中-公开
标题翻译：用于控制聚合物组件的纳米组装
公开(公告)号：WO2007038601A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037681
申请日：2006-09-27
申请人： NORTHEASTERN UNIVERSITY , RUBERTI, Jeffrey, W. , KOWALSKI, Gregory, J. , BURKEY, Daniel
发明人： RUBERTI, Jeffrey, W. , KOWALSKI, Gregory, J. , BURKEY, Daniel
IPC分类号： B05C7/06
CPC分类号： A61L33/00 , B82Y30/00 , C08L89/06
摘要： Systems, devices, and methods are provided for assembling polymer-forming molecular components such that highly-structured arrays of polymer strands, such as collagen fibrils, are formed without the need for cells. A polymer nanoloom is designed to control the self-assembly of monomers into fibrils and related tissue constructs including ligament, tendon, cartilage, and bone. A nanoloom system comprises a polymer printhead, a temperature controller, and a movable substrate for polymer printing. A polymer printhead contains one or more nanoreactors that can control the assembly of collagen fibrils or other polymers on a nanoscale. Methods are provided for temperature-driven, enzyme-driven, and cholesteric assembly of collagen or other polymers into two- or three-dimensional tissue constructs.
摘要翻译：提供用于组装聚合物形成分子组分的系统，装置和方法，使得不需要细胞就形成高度结构化的聚合物链如胶原纤维的阵列。聚合物纳米室设计用于控制单体自组装成原纤维和相关的组织结构，包括韧带，肌腱，软骨和骨。纳米室系统包括聚合物印刷头，温度控制器和用于聚合物印刷的可移动基板。聚合物印刷头包含一个或多个纳米反应器，其可以控制纳米级上的胶原纤维或其他聚合物的组装。提供了将胶原蛋白或其他聚合物温度驱动，酶促和胆固醇装配成二维或三维组织构建体的方法。

3. 发明申请

WO2012078769A1 MICROVASCULAR ANASTOMOTIC COUPLER AND METHODS OF USING THE SAME 审中-公开
标题翻译：微血管分析仪及其使用方法
公开(公告)号：WO2012078769A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063759
申请日：2011-12-07
申请人： NORTHEASTERN UNIVERSITY , RUBERTI, Jeffrey, W. , SCHECTER, David , COTE, Nicholas , MYERS, Ryan , PATEL, Jessica , OUELLETTE, Matthew , GUO, Lifei
发明人： RUBERTI, Jeffrey, W. , SCHECTER, David , COTE, Nicholas , MYERS, Ryan , PATEL, Jessica , OUELLETTE, Matthew , GUO, Lifei
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1107 , A61B2017/1132 , A61F2/064 , A61F2/07 , A61F2/915 , A61F2/962 , A61F2210/0004 , B29C70/688
摘要： Disclosed herein are devices and methods for fast and simple generation of an anastomosis. In certain embodiments, the devices and methods involve the deployment of self- expanding stents without the use of a catheter. The devices and methods disclosed herein further utilize a sheath that allows an operator to deploy the stent without the use of an inter-lumen device.
摘要翻译：本文公开了用于快速和简单地产生吻合的装置和方法。在某些实施方案中，所述装置和方法涉及在不使用导管的情况下部署自扩张支架。本文公开的装置和方法进一步利用允许操作者在不使用管腔内装置的情况下部署支架的护套。

4. 发明申请

WO2010124010A1 MICROPARTICLE ORGANIZATION 审中-公开
标题翻译：微生物组织
公开(公告)号：WO2010124010A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031922
申请日：2010-04-21
申请人： NORTHEASTERN UNIVERSITY , RUBERTI, Jeffrey, W. , SAEIDI, Nima
发明人： RUBERTI, Jeffrey, W. , SAEIDI, Nima
IPC分类号： C07K14/00 , B82B3/00
CPC分类号： C01B31/0253 , B82B3/00 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B2202/02 , C01B2202/06 , C07K14/75
摘要： Methods and compositions are described for organizing nanoparticles or microparticles into nanostructures or microstructures using collagen as a template.
摘要翻译：描述了使用胶原作为模板将纳米颗粒或微粒组织成纳米结构或微结构的方法和组合物。

5. 发明申请

WO2009126958A1 COLLAGEN FIBRILLAR CONSTRUCTION 审中-公开
标题翻译：胶原纤维结构
公开(公告)号：WO2009126958A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/040364
申请日：2009-04-13
申请人： NORTHEASTERN UNIVERSITY , SAEIDI, Nima , RUBERTI, Jeffrey, W.
发明人： SAEIDI, Nima , RUBERTI, Jeffrey, W.
IPC分类号： C08H1/06 , C08L89/06
CPC分类号： C07K14/78 , C08H1/06 , C08L89/06
摘要： Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.
摘要翻译：描述了用于将胶原蛋白组织成纤维网络的方法和组合物，例如短距离和远程组织。通过公开的方法生产的胶原蛋白可用于组织工程。

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