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1. 发明申请

WO2012033537A8 BENCHMARKS FOR NORMAL CELL IDENTIFICATION 审中-公开
公开(公告)号：WO2012033537A8
公开(公告)日：2012-03-15
申请号：PCT/US2011/001565
申请日：2011-09-08
申请人： NODALITY, INC. , LONGO, Diane , COVEY, Todd , SOPER, David , NOLAN, Garry, P. , CESANO, Alessandra
发明人： LONGO, Diane , COVEY, Todd , SOPER, David , NOLAN, Garry, P. , CESANO, Alessandra
IPC分类号： C40B30/06
摘要： Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample.

2. 发明申请

WO2010006291A1 METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法
公开(公告)号：WO2010006291A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/050295
申请日：2009-07-10
申请人： NODALITY, INC. , FANTL, Wendy, J. , ROSEN, David, B. , CESANO, Alessandra , PUTTA, Santosh, K. , NOLAN, Garry, P. , COHEN, Aileen, C. , EVENSON, Erik
发明人： FANTL, Wendy, J. , ROSEN, David, B. , CESANO, Alessandra , PUTTA, Santosh, K. , NOLAN, Garry, P. , COHEN, Aileen, C. , EVENSON, Erik
IPC分类号： G01N33/50
CPC分类号： G01N33/57426 , G01N33/5041 , G01N33/5044 , G01N33/5055 , G01N33/5073 , G01N33/6893 , G01N2333/70589 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要翻译：本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。此外，这种方法允许细胞活动或性质的相关性。此外，使用细胞激活的调节剂允许表征途径和细胞群体。可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。

3. 发明申请

WO2011031803A1 ANALYSIS OF CELL NETWORKS 审中-公开
标题翻译：细胞网络分析
公开(公告)号：WO2011031803A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048181
申请日：2010-09-08
申请人： NODALITY, INC. , NOLAN, Garry, P. , CESANO, Alessandra
发明人： NOLAN, Garry, P. , CESANO, Alessandra
IPC分类号： G06F7/00
CPC分类号： G01N33/5041 , G01N33/5091 , G06F19/12 , G06F19/24
摘要： The present invention provides an approach for the determination of activation state of a plurality of discrete cell populations and/or the state of one or more cellular networks in an individual. The status of a plurality of discrete cell populations and/or the state of one or more cellular networks can be correlated with the diagnosis, prognosis, choice or modification of treatment, and/or monitoring of a condition
摘要翻译：本发明提供了一种用于确定多个离散小区群体的激活状态和/或个体中一个或多个蜂窝网络的状态的方法。多个离散细胞群体的状态和/或一个或多个细胞网络的状态可以与治疗的诊断，预后，选择或修改相关联，和/或监测病症

4. 发明申请

WO2009134944A2 METHODS OF DETERMINING THE HEALTH STATUS OF AN INDIVIDUAL 审中-公开
标题翻译：确定个体健康状况的方法
公开(公告)号：WO2009134944A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/042187
申请日：2009-04-29
申请人： NODALITY, INC. , FANTL, Wendy, J. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C. , NOLAN, Garry, P.
发明人： FANTL, Wendy, J. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C. , NOLAN, Garry, P.
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/56966 , G01N33/5091 , G01N33/57426
摘要： Methods of determining health status based on analysis of single cells in a sample or set of samples from an individual are described.
摘要翻译：描述了基于来自个体的样本或一组样本中的单个细胞的分析来确定健康状况的方法。

5. 发明申请

WO2011106558A1 METHODS FOR AUTOIMMUNE DISEASE DIAGNOSIS, PROGNOSIS, AND TREATMENT 审中-公开
标题翻译：自发性疾病诊断，预防和治疗方法
公开(公告)号：WO2011106558A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/026117
申请日：2011-02-24
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , HALE, Matthew, B. , PTACEK, Jason , NOLAN, Garry, P.
发明人： HALE, Matthew, B. , PTACEK, Jason , NOLAN, Garry, P.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/564 , C12Q1/6883 , C12Q2600/118 , G01N33/5047 , G01N2800/102 , G01N2800/104 , G01N2800/52 , G01N2800/56
摘要： In one aspect, the present invention provides methods for the classification, diagnosis, prognosis, theranosis, and/or prediction of an outcome of an autoimmune disease in a subject.
摘要翻译：一方面，本发明提供了用于分类，诊断，预后，评估和/或预测受试者自身免疫性疾病的结果的方法。

6. 发明申请

WO2016100976A2 METHODS FOR IDENTIFYING MULTIPLE EPITOPES IN SELECTED SUB-POPULATIONS OF CELLS 审中-公开
标题翻译：在细胞的某些亚群体中鉴定多种表位的方法
公开(公告)号：WO2016100976A2
公开(公告)日：2016-06-23
申请号：PCT/US2015/067147
申请日：2015-12-21
申请人： APPRISE BIO, INC. , NOLAN, Garry, P.
发明人： NOLAN, Garry, P.
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/686 , C12Q1/703 , G01N33/56966 , G01N2458/10 , C12Q2537/143 , C12Q2563/179
摘要： A method for identifying a sub-population within a mixed population of cells is disclosed. The method involves contacting the mixed population of cells with at least one unique binding agent, wherein the at least one unique binding agent is designed to bind to a target molecule present in the sub-population, and wherein the at least one unique binding agent is attached to an epitope specific barcode that represents the identity of the target molecule. The method further involves sequentially attaching two or more assayable polymer subunits to the epitope specific barcode to create unique cell origination barcodes that represent the identities of individual cells to which the at least one unique binding agent has bound; and decoding the epitope specific barcode and cell origination barcodes, thereby identifying the sub-population within the mixed population of cells.
摘要翻译：公开了用于鉴定混合细胞群体内的亚群体的方法。该方法包括使混合的细胞群与至少一种独特的结合剂接触，其中至少一种独特的结合剂被设计成结合存在于亚群中的靶分子，并且其中至少一种独特的结合剂是连接到表示靶分子身份的表位特异性条形码。该方法进一步涉及将两种或更多种可测定聚合物亚基依次附着至表位特异性条形码以产生独特的细胞起源条形码，所述条形码表示至少一种独特结合剂所结合的单个细胞的身份; 并解码表位特异性条形码和细胞起源条形码，从而鉴定混合细胞群体内的亚群。

7. 发明申请

WO2003067210A3 METHODS AND COMPOSITIONS FOR DETECTING THE ACTIVATION STATE OF THE MULTIPLE PROTEINS IN SINGLE CELLS 审中-公开
公开(公告)号：WO2003067210A3
公开(公告)日：2003-08-14
申请号：PCT/US2002/022328
申请日：2002-07-10
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , PEREZ, Omar, D. , NOLAN, Garry, P.
发明人： PEREZ, Omar, D. , NOLAN, Garry, P.
IPC分类号： G01N33/53
摘要： The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of the screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.

8. 发明申请

WO2010011774A1 COLLECTION DEVICE AND METHOD FOR STIMULATING AND STABILIZING A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于刺激和稳定生物样品的收集装置和方法
公开(公告)号：WO2010011774A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051439
申请日：2009-07-22
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , NOLAN, Garry, P. , HALE, Matthew
发明人： NOLAN, Garry, P. , HALE, Matthew
IPC分类号： G01N1/00
CPC分类号： F16K99/003 , A61B5/15003 , A61B5/150221 , A61B5/150251 , A61B5/150755 , A61B5/154 , B01L3/502 , B01L3/5082 , B01L7/00 , B01L2400/0475 , B01L2400/0478 , B01L2400/0677 , F16K31/025 , F16K99/0001 , F16K99/0044 , F16K2099/0084
摘要： A collection device and methods for stimulating and stabilizing a biological sample are provided. Aspects of the device include an evacuated sample collection container having stimulating and stabilizing additives contained in separate internal chambers of the container. The internal chambers are arranged to facilitate stimulation upon collection of a sample, followed by stabilization of the sample after a desired period of time in the same sealed container. Also provided are methods for use of the subject device. The device and methods find use in a variety of different applications, including the collection and analysis of clinically relevant samples, such as whole blood and other body fluids, obtained directly from a patient.
摘要翻译：提供了用于刺激和稳定生物样品的收集装置和方法。装置的方面包括具有刺激和稳定的添加剂的抽空样品收集容器，其容纳在容器的分开的内部室中。内室被设置为便于在收集样品时刺激，随后在相同的密封容器中在所需的时间段之后使样品稳定。还提供了使用本发明装置的方法。该装置和方法可用于各种不同的应用，包括收集和分析直接从患者获得的临床相关样品，如全血和其他体液。

9. 发明申请

WO2014026032A2 INCREASING DYNAMIC RANGE FOR IDENTIFYING MULTIPLE EPITOPES IN CELLS 审中-公开
标题翻译：增加细胞中鉴定多种抗原决定簇的动态范围
公开(公告)号：WO2014026032A2
公开(公告)日：2014-02-13
申请号：PCT/US2013/054190
申请日：2013-08-08
申请人： APPRISE BIO, INC. , NOLAN, Garry, P.
发明人： NOLAN, Garry, P.
IPC分类号： C12Q1/68
CPC分类号： C12N15/1065 , C12Q1/6813 , C12Q2525/155 , C12Q2525/161 , C12Q2563/107
摘要： The invention provides methods, compositions, kits and devices for the detection of target molecules. In some embodiments, the invention allows for multiplexed target molecule detection.
摘要翻译：本发明提供了用于检测靶分子的方法，组合物，试剂盒和装置。在一些实施方案中，本发明允许复用的靶分子检测。

10. 发明申请

WO2012097070A1 MASS DOTS: NANOPARTICLE ISOTOPE TAGS 审中-公开
标题翻译： MASS DOTS：NANOPARTICLE同位素标签
公开(公告)号：WO2012097070A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/020950
申请日：2012-01-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , NOLAN, Garry, P. , SIMONDS, Erin, F. , BENDALL, Sean, C.
发明人： NOLAN, Garry, P. , SIMONDS, Erin, F. , BENDALL, Sean, C.
IPC分类号： C12Q1/25
CPC分类号： G01N33/566 , B82Y5/00 , G01N33/587 , G01N2458/20
摘要： Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.
摘要翻译：提供了使用纳米颗粒的组合物，其可以在本文中称为质点，作为具有ICP-MS检测的多重生物测定中的探针如抗体，适体，核酸等的质量标签。

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