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1. 发明申请

WO2008024137A2 NOVEL METHOD AND APPARATUS FOR DETERMINING OPTIMAL NEUROMUSCULAR DETECTION SITES, NOVEL DIAGNOSTIC BIOSENSOR ARRAY FORMED IN ACCORDANCE WITH THE SAME, AND NOVEL METHOD FOR TESTING A PATIENT USING THE NOVEL DIAGNOSTIC BIOSENSOR ARRAY 审中-公开
标题翻译：用于确定最佳神经肌肉检测位置的新颖方法和设备，与其形成一致的新的诊断生物传感器阵列以及使用新型诊断生物传感器阵列测试患者的新方法
公开(公告)号：WO2008024137A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/007088
申请日：2007-03-21
申请人： NEUROMETRIX, INC. , GOZANI, Shai, N. , NEVEROV, Marie , FENDROCK, Charles , WILLIAMS, Michael
发明人： GOZANI, Shai, N. , NEVEROV, Marie , FENDROCK, Charles , WILLIAMS, Michael
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/4893 , A61B2562/0209 , A61B2562/046
摘要： This invention relates to the detection of bioelectric signals indicative of neuromuscular function. A mapping biosensor array is first used to identify, relative to reliable anatomical landmarks, the optimal myoelectrical detection site for the majority of the population. Then a diagnostic biosensor array is fabricated using this information so that when the diagnostic biosensor array is positioned on an individual using the reliable anatomical landmarks, the detection electrode is automatically positioned over the optimal detection site.
摘要翻译：本发明涉及检测指示神经肌肉功能的生物电信号。映射生物传感器阵列首先用于相对于可靠的解剖标志识别大部分群体的最佳肌电检测位点。然后使用该信息制造诊断性生物传感器阵列，以便当使用可靠的解剖标志将诊断性生物传感器阵列定位在个体上时，检测电极自动定位在最佳检测位点上。

2. 发明申请

WO2012037527A2 APPARATUS AND METHOD FOR THE AUTOMATED MEASUREMENT OF SURAL NERVE CONDUCTION VELOCITY AND AMPLITUDE 审中-公开
标题翻译：自动测量神经传导速度和振幅的装置和方法
公开(公告)号：WO2012037527A2
公开(公告)日：2012-03-22
申请号：PCT/US2011/052042
申请日：2011-09-16
申请人： NEUROMETRIX, INC. , BOETTCHER, Bonniejean , CRYAN, Marc , GOZANI, Shai, N. , HERB, Glenn , KONG, Xuan , WILLIAMS, Michael , FENDROCK, Charles
发明人： BOETTCHER, Bonniejean , CRYAN, Marc , GOZANI, Shai, N. , HERB, Glenn , KONG, Xuan , WILLIAMS, Michael , FENDROCK, Charles
IPC分类号： A61B5/05 , G06F17/00
CPC分类号： A61B5/04001 , A61B5/01 , A61B5/05 , A61B5/4041 , A61B2560/0266 , A61B2560/028 , A61B2560/0425 , A61B2560/0468 , A61B2562/0209 , A61B2562/046
摘要： Apparatus for measuring sural nerve conduction velocity and amplitude, the apparatus comprising: a housing; stimulation means mounted to the housing for electrically stimulating a human sural nerve; a biosensor releasably mounted to the housing, the biosensor comprising a plurality of electrodes for detecting a sural nerve response evoked by the stimulation means; acquisition means mounted to the housing and electrically connected to the biosensor for electrically acquiring the sural nerve response detected by the biosensor; processing means mounted to the housing and electrically connected to the acquisition means for digitizing, processing and storing the acquired sural nerve response; calculation means mounted to the housing and electrically connected to the processing means for calculating the conduction velocity and amplitude of the processed sural nerve response; and display means mounted to the housing for displaying the sural nerve conduction velocity and amplitude; wherein the stimulation means and the biosensor are designed to be placed on a patient's anatomy, in the vicinity of a sural nerve, by manipulating the housing.
摘要翻译：用于测量腓肠神经传导速度和振幅的装置，该装置包括：壳体; 刺激装置安装到壳体上以电刺激人的腓肠神经; 所述生物传感器包括多个用于检测由所述刺激装置引起的腓肠神经反应的电极; 获取装置，其安装到所述壳体并电连接到所述生物传感器，用于电采集由所述生物传感器检测到的所述腓肠神经反应; 处理装置安装到壳体并电连接到采集装置，用于数字化，处理和存储所获取的腓肠神经反应; 计算装置安装到壳体并电连接到处理装置，用于计算处理的腓肠神经反应的传导速度和幅度; 以及显示装置，安装到所述壳体以显示所述腓肠神经传导速度和振幅; 其中所述刺激装置和所述生物传感器被设计成通过操纵所述壳体而放置在腓肠神经附近的患者解剖结构上。

3. 发明申请

WO2009067592A1 DISPOSABLE NEEDLE ELECTRODE WITH IDENTIFICATION, AND ALTERABLE, CONNECTOR INTERFACE 审中-公开
标题翻译：具有识别性和可更换的连接器接口的可拆卸针头电极
公开(公告)号：WO2009067592A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/084183
申请日：2008-11-20
申请人： NEUROMETRIX, INC. , FENDROCK, Charles , BARBATO, Louis, J. , WU, Charlie
发明人： FENDROCK, Charles , BARBATO, Louis, J. , WU, Charlie
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61N1/0502 , A61N1/0551 , Y10S439/955
摘要： An interconnect for connecting a needle electrode to a neurological testing device, the interconnect comprising a needle-side connector and a device-side connector, wherein the needle-side connector and the device-side connector have complementary aspects so as to ensure that the correct needle electrode is used with a given neurological testing device A method for connecting a needle electrode to a neurological testing device, the method comprising providing an interconnect comprising a needle-side connector and a device-side connector, wherein the needle-side connector and the device-side connector have complementary aspects so as to ensure that the correct needle electrode is used with a given neurological testing device, and connecting the needle-side connector to the device-side connector.
摘要翻译：用于将针电极连接到神经检查装置的互连件，所述互连件包括针侧连接器和器件侧连接器，其中针侧连接器和器件侧连接器具有互补的方面，以便确保正确的针状电极与给定的神经检查装置一起使用将针电极连接到神经检查装置的方法，该方法包括提供包括针侧连接器和器件侧连接器的互连件，其中针侧连接器和器件侧连接器具有互补的方面，以确保使用正确的针电极与给定的神经学测试装置，并将针侧连接器连接到装置侧连接器。

4. 发明申请

WO2007030541A2 DISPOSABLE, MULTI-PURPOSE CARDIOVASCULAR AUTONOMIC NEUROPATHY TESTING DEVICE 审中-公开
标题翻译：多用途多用途心脏自动神经病理测试装置
公开(公告)号：WO2007030541A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/034717
申请日：2006-09-06
申请人： NEUROMETRIX, INC.
发明人： FENDROCK, Charles
IPC分类号： A61B5/04
CPC分类号： A61B5/0408 , A61B5/02405 , A61B5/0245 , A61B5/038 , A61B5/0404 , A61B5/087 , A61B5/0878 , A61B5/4035
摘要： A novel disposable, multi-purpose cardiovascular autonomic neuropathy testing device which comprises: a tubular body having a distal end, a proximal end and a passageway extending therebetween; at least one ECG electrode disposed on the exterior surface of the tubular body for monitoring ECG signals of a patient holding the tubular body; a breathing sensor attached to the tubular body for monitoring breathing through the passageway; a closure mechanism attached to the tubular body for selectively restricting the passageway; and a pressure monitor attached to the tubular body for confirming when a pre-determined pressure has been established in the passageway; whereby (i) when the closure mechanism is in a first configuration such that the passageway is unrestricted, the testing device can be used to conduct metronomic breathing tests by having the patient breath through the passageway while the patient's ECG is monitored by the at least one ECG electrode, (ii) when the closure mechanism is in a second configuration such that the passageway is restricted, the testing device can be used to conduct Valsalva maneuver tests by having the patient breath into the passageway until the pressure monitor confirms that the pre-determined pressure has been established in the passageway while the patient's ECG is monitored by the at least one ECG electrode, and (iii) when the closure mechanism is in either the first configuration, the testing device can be used to conduct HRV standing tests by having the patient stand and having the patient's ECG monitored by the a least one ECG electrode.
摘要翻译：一种新颖的一次性多用途心血管自主神经病变测试装置，其包括：管状体，其具有远端，近端和在其间延伸的通路; 设置在所述管状体的外表面上的至少一个ECG电极，用于监测保持所述管状体的患者的ECG信号; 呼吸传感器附接到管状体，用于通过通道监测呼吸; 闭合机构，其附接到所述管状体，用于选择性地限制所述通道; 以及压力监视器，其附接到所述管状体，用于确认在所述通道中何时建立了预定的压力; 由此（i）当所述闭合机构处于第一构造使得所述通道不受限制时，所述测试装置可用于通过使患者呼吸通过所述通道进行节律性呼吸测试，同时所述患者的ECG由所述至少一个 ECG电极，（ii）当闭合机构处于第二结构以使得通道受到限制时，测试装置可用于通过使患者呼吸进入通道直到压力监测器确认预先测定的方式进行Valsalva机动测试，当患者的ECG由至少一个ECG电极监测时，在通道中建立了确定的压力，以及（iii）当闭合机构处于第一配置中时，可以使用测试装置进行HRV站立测试，患者站立并且由至少一个ECG电极监测患者的ECG。

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