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    • 2. 发明申请
    • SALTS OF PYRIDAZINE COMPOUNDS
    • 吡啶化合物的盐
    • WO2007127448A2
    • 2007-11-08
    • PCT/US2007/010368
    • 2007-04-27
    • NEUROMEDIX, INC.WATTERSON, MartinVAN ELDIK, LindaHU, Wenhui
    • WATTERSON, MartinVAN ELDIK, LindaHU, Wenhui
    • C07D403/12
    • A61K31/506C07D403/12
    • The invention relates to stable and substantially purified synthetic pharmaceutically acceptable acid addition salts of pyridazine compounds of the formula I wherein R10 is hydrogen, hydroxyl, alkyl, alkoxy, alkenyl, alkynyl, alkylene, aryl, heteroaryl, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, carboxyl, carbonyl, carbamoyl, carboxamide, or phosphonate, and R11 is alkyl, alkoxy, alkenyl, alkynyl, alkylene, alkenylene, alkenyloxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, phosphonate, carboxyl, carbonyl, carbamoyl, carboxamide, or ureido. The invention also relates to formulations, dosage forms and compositions comprising the salts, and methods of using the salts, formulations, dosage forms and compositions.
    • 本发明涉及式I的哒嗪化合物的稳定且基本纯化的合成药学上可接受的酸加成盐,其中R 10是氢,羟基,烷基,烷氧基,烯基,炔基,亚烷基,芳基,杂芳基,磺酰基,亚磺酰基,亚硫酰基,氨基, 亚氨基,叠氮基,硫醇,硫代烷基,硫代烷氧基,硫代芳基,硝基,氰基,卤素,= S,羧基,羰基,氨基甲酰基,羧酰胺或膦酸酯,R11是烷基,烷氧基,烯基,炔基,亚烷基,亚烯基, 链烯氧基,芳基,芳氧基,芳基烷氧基,芳酰基,杂芳基,杂环基,酰基,酰氧基,磺酰基,亚磺酰基,亚磺酰基,氨基,亚氨基,叠氮基,硫醇,硫代烷基,硫代烷氧基,硫代芳基,硝基,氰基,卤素, 膦酸酯,羧基,羰基,氨基甲酰基,羧酰胺或脲基。 本发明还涉及制剂,剂型和包含盐的组合物,以及使用盐,制剂,剂型和组合物的方法。