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1. 发明申请

WO2007127475A3 PYRIDAZINES FOR DEMYELINATING DISEASES AND NEUROPATHIC PAIN 审中-公开
标题翻译：用于消除疾病和神经痛疼痛的吡咯烷
公开(公告)号：WO2007127475A3
公开(公告)日：2008-11-06
申请号：PCT/US2007010464
申请日：2007-04-27
申请人： UNIV NORTHWESTERN , WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI PH D
发明人： WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI PH D
IPC分类号： A61K31/501 , A61K31/5025 , A61K31/506 , A61P9/10 , A61P25/00 , A61P29/02
CPC分类号： A61K31/5025 , A61K31/501 , A61K31/506
摘要： The invention relates to compositions and methods for treating patients with Demyelinating Diseases and Conditions including Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compositions and methods may also be used for Stroke Rehabilitation and the treatment of pain disorders including Neuropathic Pain and Chemokine-Induced Pain. The compositions comprise one or more pyridazine compounds having a pyridazinyl radical pendant with an aryl or substituted aryl, a heteroaryl or substituted heteroaryl.
摘要翻译：本发明涉及用于治疗患有脱髓鞘疾病和病症的组合物和方法，包括多发性硬化，脊髓损伤，创伤性脑损伤和中风。组合物和方法也可用于中风康复和治疗疼痛障碍，包括神经性疼痛和趋化因子诱导的疼痛。组合物包含一种或多种具有哒嗪基的哒嗪基化合物，其具有芳基或取代的芳基，杂芳基或取代的杂芳基。

2. 发明申请

WO2007127474A3 COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS 审中-公开
标题翻译：使用吡啶化合物和胆碱酯酶抑制剂的组合物和治疗
公开(公告)号：WO2007127474A3
公开(公告)日：2008-06-19
申请号：PCT/US2007010463
申请日：2007-04-27
申请人： UNIV NORTHWESTERN , WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
发明人： WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
IPC分类号： A61K31/501 , A61K31/435 , A61K31/50 , A61P25/28
CPC分类号： A61K31/50 , A61K31/435 , A61K31/501 , A61K45/06 , A61K2300/00
摘要： The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
摘要翻译：本发明涉及用于调节细胞途径（例如，信号转导途径）的哒嗪化合物和胆碱酯酶抑制剂，用于治疗或预防炎性疾病（例如阿尔茨海默病）的组合物，缀合物和方法，用于研究，药物筛选和治疗应用。

3. 发明申请

WO2007130383A3 COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND SECRETASES 审中-公开
标题翻译：使用吡咯烷酮化合物和组分的组合物和处理方法
公开(公告)号：WO2007130383A3
公开(公告)日：2008-06-19
申请号：PCT/US2007010510
申请日：2007-04-27
申请人： NEUROMEDIX INC , WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
发明人： WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
IPC分类号： A61K45/06 , A61K31/501 , A61P29/00
CPC分类号： A61K45/06 , A61K31/501 , A61K2300/00
摘要： The invention relates to compositions, conjugates and methods comprising pyridazine compounds and secretase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
摘要翻译：本发明涉及包含用于调节细胞途径（例如，信号转导途径）的哒嗪化合物和分泌酶抑制剂，用于治疗或预防炎性疾病（例如阿尔茨海默氏病）的组合物，缀合物和方法，用于研究，药物筛选和治疗应用。

4. 发明申请

WO2007127375A3 FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS FOR TREATING NEUROINFLAMMATORY DISEASES 审中-公开
标题翻译：含有吡咯烷酮化合物治疗神经炎症性疾病的配方
公开(公告)号：WO2007127375A3
公开(公告)日：2008-02-07
申请号：PCT/US2007010248
申请日：2007-04-27
申请人： UNIV NORTHWESTERN , WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
发明人： WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
IPC分类号： A61K31/501 , A61K31/506 , A61P25/28 , C07D403/04
CPC分类号： A61K31/506 , A61K31/501 , C07D237/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The invention relates to chemical compounds, compositions and methods of making and using the same. In particular, the invention provides selected pyridazine compounds of the formula (I) are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfenyl, sulfinyl, sulfonyl, sulfonate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, =0, =S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention additional relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulation of cellular pathways, for treatment or prevention of inflammatory diseases, for research, drug screening, and therapeutic applications.
摘要翻译：本发明涉及化合物，组合物和制备和使用它们的方法。特别地，本发明提供所选择的式（I）哒嗪化合物独立地是氢，羟基，烷基，烯基，炔基，亚烷基，亚烯基，烷氧基，烯氧基，环烷基，环烯基，环炔基，环烷氧基，芳基，芳氧基，芳基烷氧基，芳酰基杂芳基，杂环基，酰基，酰氧基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，卤素，硫酸酯，亚磺酰基，磺酰基，磺酸酯，亚砜，甲硅烷基，甲硅烷氧基，甲硅烷基烷基，甲硅烷硫基， 0，= S，膦酸酯，脲基，羧基，羰基，氨基甲酰基或甲酰胺; X是任选取代的嘧啶基或哒嗪基，异构体，药用盐或其衍生物。本发明另外涉及包含该化合物的组合物，以及使用该化合物和组合物调节细胞途径，用于治疗或预防炎性疾病，用于研究，药物筛选和治疗应用的方法。

5. 发明申请

WO2007127474A2 COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS 审中-公开
标题翻译：使用吡啶化合物和胆碱酯酶抑制剂的组合物和治疗
公开(公告)号：WO2007127474A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010463
申请日：2007-04-27
申请人： NORTHWESTERN UNIVERSITY , WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui
发明人： WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui
IPC分类号： A61K31/501 , A61K31/50 , A61P25/28 , A61K31/435
CPC分类号： A61K31/50 , A61K31/435 , A61K31/501 , A61K45/06 , A61K2300/00
摘要： The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
摘要翻译：本发明涉及用于调节细胞途径（例如，信号转导途径）的哒嗪化合物和胆碱酯酶抑制剂，用于治疗或预防炎性疾病（例如阿尔茨海默病）的组合物，缀合物和方法，用于研究，药物筛选和治疗应用。

6. 发明申请

WO2007127375A2 FORMULATIONS CONTAINING PYRID AZINE COMPOUND FIELD OF INVENTION 审中-公开
标题翻译：含有吡嗪化合物的制剂技术领域
公开(公告)号：WO2007127375A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010248
申请日：2007-04-27
申请人： NEUROMEDIX, INC. , WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui, Ph.D.
发明人： WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui, Ph.D.
CPC分类号： A61K31/506 , A61K31/501 , C07D237/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The invention relates to chemical compounds, compositions and methods of making and using the same. In particular, the invention provides selected pyridazine compounds of the formula I wherein R1, R4, R5, R6, R7, R8, R9, R12, R13 ET R14 are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfenyl, sulfinyl, sulfonyl, sulfonate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, =0, =S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention additional relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulation of cellular pathways, for treatment or prevention of inflammatory diseases, for research, drug screening, and therapeutic applications.
摘要翻译：本发明涉及化合物，组合物和制备和使用它们的方法。特别地，本发明提供了选择的式I的哒嗪化合物，其中R 1，R 4，R 5，R 6，R 7，R 8，R 9，R 12，R 13，ET R 14独立地为氢，羟基，烷基，烯基，炔基，亚烷基，亚烯基，，烯氧基，环烷基，环烯基，环炔基，环烷氧基，芳基，芳氧基，芳基烷氧基，芳酰基，芳基，杂环，酰基，酰氧基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，磺酰基，磺酰基，亚砜，甲硅烷基，甲硅烷氧基，甲硅烷基烷基，甲硅烷硫基，= O，= S，膦酸酯，脲基，羧基，羰基，氨基甲酰基或甲酰胺; X是任选取代的嘧啶基或哒嗪基，异构体，药用盐或其衍生物。本发明另外涉及包含该化合物的组合物，以及使用该化合物和组合物调节细胞途径，用于治疗或预防炎性疾病，用于研究，药物筛选和治疗应用的方法。

7. 发明申请

WO2007127448A3 SALTS OF PYRIDAZINE COMPOUNDS 审中-公开
标题翻译：吡啶化合物的盐
公开(公告)号：WO2007127448A3
公开(公告)日：2008-01-31
申请号：PCT/US2007010368
申请日：2007-04-27
申请人： UNIV NORTHWESTERN , WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
发明人： WATTERSON MARTIN , VAN ELDIK LINDA , HU WENHUI
IPC分类号： A61K31/506 , A61P25/00 , A61P25/28 , C07D403/12
CPC分类号： A61K31/506 , C07D403/12
摘要： The invention relates to stable and substantially purified synthetic pharmaceutically acceptable acid addition salts of pyridazine compounds of the formula I wherein R10 is hydrogen, hydroxyl, alkyl, alkoxy, alkenyl, alkynyl, alkylene, aryl, heteroaryl, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, carboxyl, carbonyl, carbamoyl, carboxamide, or phosphonate, and R11 is alkyl, alkoxy, alkenyl, alkynyl, alkylene, alkenylene, alkenyloxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, phosphonate, carboxyl, carbonyl, carbamoyl, carboxamide, or ureido. The invention also relates to formulations, dosage forms and compositions comprising the salts, and methods of using the salts, formulations, dosage forms and compositions.
摘要翻译：本发明涉及式I的哒嗪化合物的稳定且基本纯化的合成药学上可接受的酸加成盐，其中R 10是氢，羟基，烷基，烷氧基，烯基，炔基，亚烷基，芳基，杂芳基，磺酰基，亚磺酰基，亚硫酰基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，卤素，= S，羧基，羰基，氨基甲酰基，羧酰胺或膦酸酯，R11是烷基，烷氧基，烯基，炔基，亚烷基，亚烯基，链烯氧基，芳基，芳氧基，芳基烷氧基，芳酰基，杂芳基，杂环基，酰基，酰氧基，磺酰基，亚磺酰基，亚磺酰基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，卤素，膦酸酯，羧基，羰基，氨基甲酰基，羧酰胺或脲基。本发明还涉及制剂，剂型和包含盐的组合物，以及使用盐，制剂，剂型和组合物的方法。

8. 发明申请

WO2007130383A2 COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND SECRETASES 审中-公开
标题翻译：使用吡咯烷酮化合物和组分的组合物和处理方法
公开(公告)号：WO2007130383A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010510
申请日：2007-04-27
申请人： NEUROMEDIX , INC. , WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui
发明人： WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui
IPC分类号： A61K45/06 , A61K31/501 , A61P29/00
CPC分类号： A61K45/06 , A61K31/501 , A61K2300/00
摘要： The invention relates to compositions, conjugates and methods comprising pyridazine compounds and secretase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
摘要翻译：本发明涉及包含哒嗪化合物和分泌酶抑制剂的组合物，缀合物和方法，用于调节细胞途径（例如，信号转导途径），用于治疗或预防炎性疾病（例如阿尔茨海默病），用于研究，药物筛选和治疗应用。

9. 发明申请

WO2007127475A2 COMPOSITIONS AND TREATMENTS FOR DEMYELINATING DISEASES AND PAIN DISORDERS 审中-公开
标题翻译：化合物和疼痛症状的组合物和治疗
公开(公告)号：WO2007127475A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010464
申请日：2007-04-27
申请人： NORTHWESTERN UNIVERSITY , WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui, Ph.D.
发明人： WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui, Ph.D.
IPC分类号： A61K31/501 , A61K31/5025 , A61K31/506 , A61P29/02 , A61P25/00 , A61P9/10
CPC分类号： A61K31/5025 , A61K31/501 , A61K31/506
摘要： The invention relates to compositions and methods for treating patients with Demyelinating Diseases and Conditions including Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compositions and methods may also be used for Stroke Rehabilitation and the treatment of pain disorders including Neuropathic Pain and Chemokine-Induced Pain. The compositions comprise one or more pyridazine compounds having a pyridazinyl radical pendant with an aryl or substituted aryl, a heteroaryl or substituted heteroaryl.
摘要翻译：本发明涉及用于治疗患有脱髓鞘疾病和病症的组合物和方法，包括多发性硬化，脊髓损伤，创伤性脑损伤和中风。组合物和方法也可用于中风康复和治疗疼痛障碍，包括神经性疼痛和趋化因子诱导的疼痛。组合物包含一种或多种具有哒嗪基的哒嗪基化合物，其具有芳基或取代的芳基，杂芳基或取代的杂芳基。

10. 发明申请

WO2007127448A2 SALTS OF PYRIDAZINE COMPOUNDS 审中-公开
标题翻译：吡啶化合物的盐
公开(公告)号：WO2007127448A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010368
申请日：2007-04-27
申请人： NEUROMEDIX, INC. , WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui
发明人： WATTERSON, Martin , VAN ELDIK, Linda , HU, Wenhui
IPC分类号： C07D403/12
CPC分类号： A61K31/506 , C07D403/12
摘要： The invention relates to stable and substantially purified synthetic pharmaceutically acceptable acid addition salts of pyridazine compounds of the formula I wherein R10 is hydrogen, hydroxyl, alkyl, alkoxy, alkenyl, alkynyl, alkylene, aryl, heteroaryl, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, carboxyl, carbonyl, carbamoyl, carboxamide, or phosphonate, and R11 is alkyl, alkoxy, alkenyl, alkynyl, alkylene, alkenylene, alkenyloxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, phosphonate, carboxyl, carbonyl, carbamoyl, carboxamide, or ureido. The invention also relates to formulations, dosage forms and compositions comprising the salts, and methods of using the salts, formulations, dosage forms and compositions.
摘要翻译：本发明涉及式I的哒嗪化合物的稳定且基本纯化的合成药学上可接受的酸加成盐，其中R 10是氢，羟基，烷基，烷氧基，烯基，炔基，亚烷基，芳基，杂芳基，磺酰基，亚磺酰基，亚硫酰基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，卤素，= S，羧基，羰基，氨基甲酰基，羧酰胺或膦酸酯，R11是烷基，烷氧基，烯基，炔基，亚烷基，亚烯基，链烯氧基，芳基，芳氧基，芳基烷氧基，芳酰基，杂芳基，杂环基，酰基，酰氧基，磺酰基，亚磺酰基，亚磺酰基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，卤素，膦酸酯，羧基，羰基，氨基甲酰基，羧酰胺或脲基。本发明还涉及制剂，剂型和包含盐的组合物，以及使用盐，制剂，剂型和组合物的方法。

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