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1. 发明申请

WO2013143839A1 EARLY BIOMARKERS OF AGE-RELATED LOW-GRADE INFLAMMATION 审中-公开
标题翻译：与年龄相关的低等级炎症的早期生物标志物
公开(公告)号：WO2013143839A1
公开(公告)日：2013-10-03
申请号：PCT/EP2013/054987
申请日：2013-03-12
申请人： NESTEC S.A. , INRA
发明人： BRAHMBHATT, Viral , BREUILLE, Denis , GUY, Philippe Alexandre , MONTOLIU ROURA, Ivan , PAPET, Isabelle , VIDAL, Karine
IPC分类号： G01N33/68
CPC分类号： G01N33/492 , G01N33/6893 , G01N2800/7042 , G01N2800/7095
摘要： The present invention relates to a method for predicting the risk of acquiring an age-related low-grade inflammation for a subject, said method comprising a) providing a biological sample from a subject, b) determining in said sample the level of at least one biomarker selected from the group consisting of a compound of molecular weight between 859-863 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 861-86 g/mol and which is a diacylphosphatidylcholine, a compound of molecular weight between 791-794 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 522-525 g/mol and which is a monoacylphosphatidylcholine, octadecanoylcarnitine (C18), and tryptophan, c) comparing the level of the at least one biomarker to a reference level, and d) determining whether said subject is likely to be at risk of acquiring an age-related low-grade inflammation, when the level of biomarker(s) deviate significantly from the respective reference level.
摘要翻译：本发明涉及一种用于预测获得受试者年龄相关的低度炎症的风险的方法，所述方法包括：a）从受试者提供生物样品，b）在所述样品中确定至少一种选自分子量在859-863g / mol之间的化合物，其为烷基酰基磷脂酰胆碱，分子量在861-86g / mol之间的化合物，其为二酰基磷脂酰胆碱，分子量为791的化合物 -794g / mol，其为烷基酰基磷脂酰胆碱，分子量为522-525g / mol的化合物，其为单酰基磷脂酰胆碱，十八烷酰基肉碱（C18）和色氨酸，c）将至少一种生物标志物的水平与参考水平，以及d）当生物标志物的水平显着偏离呼吸时，确定所述受试者是否可能处于获得年龄相关的低度炎症的风险中实际参考水平。

2. 发明申请

WO2013144085A1 4-OXO-2-PENTENOIC ACID AND LIVER DISORDERS 审中-公开
标题翻译： 4-OXO-2-PENTENOIC酸和肝脏疾病
公开(公告)号：WO2013144085A1
公开(公告)日：2013-10-03
申请号：PCT/EP2013/056272
申请日：2013-03-25
申请人： NESTEC S.A.
发明人： ARCE VERA, Francia Jacqueline , BOURQUI, Bertrand , BUETLER, Timo , DUBOUX, Stéphane , FOATA, Francis , GUY, Philippe Alexandre , PAGE, Nicolas , REZZI, Serge André Dominique
IPC分类号： A61K31/19 , A23L1/00 , A61P1/16 , A61K35/00 , C12R1/00
CPC分类号： A61K31/19 , A23L33/10 , A23V2002/00 , A23Y2300/29 , A61K35/74 , A23V2200/32 , A23V2250/206
摘要： The present invention relates generally to compositions with a health benefit. In particular, the invention relates to treatment or prevention of liver disorders.A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of liver disorders. A further subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of liver disorders linked to an insufficient activity of phase II enzymes in the liver.
摘要翻译：本发明一般涉及具有健康益处的组合物。特别地，本发明涉及治疗或预防肝脏疾病。本发明的主题是包含用于治疗或预防肝脏疾病的4-氧代-2-戊烯酸的组合物。本发明的另一个主题是包含4-氧代-2-戊烯酸的组合物，其用于治疗或预防与肝脏中II期酶活性不足相关的肝脏疾病。

3. 发明申请

WO2013144080A1 4-OXO-2-PENTENOIC ACID AND CARDIOVASCULAR HEALTH 审中-公开
公开(公告)号：WO2013144080A1
公开(公告)日：2013-10-03
申请号：PCT/EP2013/056262
申请日：2013-03-25
申请人： NESTEC S.A.
发明人： ARCE VERA, Francia Jacqueline , BOURQUI, Bertrand , BUETLER, Timo , DUBOUX, Stéphane , FOATA, Francis , GUY, Philippe Alexandre , PAGE, Nicolas , REZZI, Serge André Dominique
IPC分类号： A61K31/19 , A23L1/00 , C12R1/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61K35/00
CPC分类号： A61K31/19 , A23L33/10 , A23L33/135 , A23V2002/00 , A61K35/745 , C12N1/20 , C12P7/40 , A23V2200/30 , A23V2200/326 , A23V2250/02
摘要： The present invention relates generally to compositions with a health benefit. In particular, the invention relates to the field of cardiovascular disorders, for example, atherosclerosis,high blood pressure, coronary heart disease, myocardial infarction, angina pectoris, stroke, and heart failure. A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of cardiovascular disorders.
摘要翻译：本发明一般涉及具有健康益处的组合物。特别地，本发明涉及心血管疾病领域，例如动脉粥样硬化，高血压，冠心病，心肌梗塞，心绞痛，中风和心力衰竭。本发明的主题是包含用于治疗或预防心血管疾病的4-氧代-2-戊烯酸的组合物。

4. 发明申请

WO2013139582A1 1-O-ALKYL-2-ACYLGLYCEROPHOSPHOCHOLINE (PC-O) 40:1 AS BIOMARKER FOR HEALTHY AGEING 审中-公开
标题翻译： 1-O-烷基-2-乙酰胆碱醚（PC-O）40：1作为生物标记用于健康衰老
公开(公告)号：WO2013139582A1
公开(公告)日：2013-09-26
申请号：PCT/EP2013/054332
申请日：2013-03-05
申请人： NESTEC S.A.
发明人： COLLINO, Sebastiano , MONTOLIU ROURA, Ivan , MARTIN, François-Pierre , GUY, Philippe Alexandre , REZZI, Serge André Dominique
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/49 , G01N33/492 , G01N33/493 , G01N33/6848 , G01N33/6893 , G01N33/92 , G01N2405/06 , G01N2570/00 , G01N2800/04 , G01N2800/50 , G01N2800/7042 , G01N2800/7095 , G09B19/00 , G09B19/0092
摘要： Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using PC-O 40:1 as biomarker.
摘要翻译：使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经探索了老年人和年轻成年人的老龄化和长寿的代谢表型。本发明人已经鉴定出降低发展与衰老有关的慢性炎症性疾病的风险的生物标志物，并且提出了一种诊断生活方式的方法，该方法允许使用PC-O 40：1作为生物标志物延迟和/或避免与衰老有关的慢性炎症性疾病。

5. 发明申请

WO2013186151A1 PC-O 44:4 - A BIOMARKER FOR VISCERAL ADIPOSITY 审中-公开
标题翻译： PC-O 44：4 - 用于VISCERAL ADIPOSITY的生物标记
公开(公告)号：WO2013186151A1
公开(公告)日：2013-12-19
申请号：PCT/EP2013/061876
申请日：2013-06-10
申请人： NESTEC S.A.
发明人： MARTIN, François-Pierre , MONTOLIU ROURA, Ivan , GUY, Philippe Alexandre , REZZI, Serge André Dominique
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , C07F9/09 , G01N33/48 , G01N2405/04 , G01N2800/044
摘要： The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-0 44:4 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.
摘要翻译：本发明一般涉及生物标志物领域。特别地，本发明涉及可用于例如检测和/或定量内脏肥胖和/或内脏肥胖变化的生物标志物例如PC-0 44：4。该生物标志物也可用于诊断生物体改变对受试者内脏肥胖的影响。

6. 发明申请

WO2013144079A1 4-OXO-2-PENTENOIC ACID AND SKIN PIGMENTATION 审中-公开
标题翻译： 4-OXO-2-PENTENOIC酸和皮肤色素
公开(公告)号：WO2013144079A1
公开(公告)日：2013-10-03
申请号：PCT/EP2013/056257
申请日：2013-03-25
申请人： NESTEC S.A.
发明人： ARCE VERA, Francia Jacqueline , BOURQUI, Bertrand , BUETLER, Timo , DUBOUX, Stéphane , FOATA, Francis , GUITARD, Marjorie , GUY, Philippe Alexandre , PAGE, Nicolas , REZZI, Serge André Dominique
IPC分类号： A61K31/19 , A23L1/00 , A61K8/00 , C12R1/00 , A61P17/00 , A61K8/368 , A61Q19/02
CPC分类号： A61K8/365 , A23K20/105 , A23L2/52 , A23L33/10 , A23L33/135 , A23V2002/00 , A23Y2300/29 , A61K8/99 , A61K31/19 , A61K2800/40 , A61K2800/92 , A61Q19/02 , A23V2200/318 , A23V2250/206
摘要： The present invention relates generally to the field of enhancing skin appearance. One aspect of the invention aims to provide a composition comprising 4-oxo-2-pentenoic acid for use in the reduction or prevention of regions of the skin with darker pigmentation. The present invention also relates to cosmetic use of a composition comprising 4-oxo-2-pentenoic acid for the reduction or prevention of regions of the skin with darker pigmentation.
摘要翻译：本发明一般涉及增强皮肤外观的领域。本发明的一个方面旨在提供一种包含4-氧代-2-戊烯酸的组合物，用于减少或预防皮肤的较暗色素沉着区域。本发明还涉及包含4-氧代-2-戊烯酸的组合物的化妆品用途，用于减少或预防具有较暗色素沉着的皮肤区域。

7. 发明申请

WO2013144077A1 4-OXO-2-PENTENOIC ACID AND BRAIN HEALTH 审中-公开
公开(公告)号：WO2013144077A1
公开(公告)日：2013-10-03
申请号：PCT/EP2013/056253
申请日：2013-03-25
申请人： NESTEC S.A.
发明人： ARCE VERA, Francia Jacqueline , BOURQUI, Bertrand , BUETLER, Timo , DUBOUX, Stéphane , DURGA, Jane , FOATA, Francis , GUY, Philippe Alexandre , PAGE, Nicolas , REZZI, Serge André Dominique
IPC分类号： A61K31/19 , A23L1/00 , A61K35/00 , C12R1/00 , A61P25/00 , A61P25/28
CPC分类号： A61K31/19 , A23L33/10 , A23V2002/00 , A23Y2300/29 , A61K35/74 , C12N1/20 , C12P7/40 , A23V2200/322 , A23V2250/206
摘要： The present invention relates generally to compositions with a health benefit. In particular, the invention relates to the field of brain health, for example brain protection, maintenance of cognitive function, prevention of cognitive decline and prevention of cognitive disorders. A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of cognitive decline.
摘要翻译：本发明一般涉及具有健康益处的组合物。特别地，本发明涉及脑健康领域，例如脑保护，认知功能的维持，预防认知衰退和预防认知障碍。本发明的主题是包含用于治疗或预防认知衰退的4-氧代-2-戊烯酸的组合物。

8. 发明申请

WO2013186149A1 PC-O 44:6 - A BIOMARKER FOR VISCERAL ADIPOSITY 审中-公开
标题翻译： PC-O 44：6 - 用于VISCERAL ADIPOSITY的生物标记
公开(公告)号：WO2013186149A1
公开(公告)日：2013-12-19
申请号：PCT/EP2013/061874
申请日：2013-06-10
申请人： NESTEC S.A.
发明人： MARTIN, François-Pierre , MONTOLIU ROURA, Ivan , GUY, Philippe Alexandre , REZZI, Serge André Dominique
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N33/48 , G01N2405/04 , G01N2800/044 , Y10T436/24
摘要： The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-O 44:6 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.
摘要翻译：本发明一般涉及生物标志物领域。特别地，本发明涉及可用于例如检测和/或定量内脏肥胖和/或内脏肥胖变化的生物标志物例如PC-O 44：6。该生物标志物也可用于诊断生物体改变对受试者内脏肥胖的影响。

9. 发明申请

WO2013139580A1 PHENYLACETYLGLUTAMINE AS BIOMARKER FOR HEALTHY AGEING 审中-公开
标题翻译：苯乙烯胺作为生物标志物进行健康衰老
公开(公告)号：WO2013139580A1
公开(公告)日：2013-09-26
申请号：PCT/EP2013/054327
申请日：2013-03-05
申请人： NESTEC S.A.
发明人： COLLINO, Sebastiano , MONTOLIU ROURA, Ivan , MARTIN, François-Pierre , GUY, Philippe Alexandre , REZZI, Serge André Dominique
IPC分类号： G01N33/68
CPC分类号： G01N33/54306 , G01N33/6842 , G01N33/6848 , G01N33/6893 , G01N2800/50 , G01N2800/60 , G01N2800/7042 , G01N2800/7095 , Y10T436/173845 , Y10T436/182 , Y10T436/200833 , Y10T436/203332 , Y10T436/24
摘要： Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose an in vitro method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using phenylacetylglutamine (PAG) as biomarker.
摘要翻译：使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经探索了老年人和年轻成年人的老龄化和长寿的代谢表型。本发明人已经鉴定了降低发展与衰老有关的慢性炎症性疾病的风险的生物标志物，并提出了使用苯乙酰谷氨酰胺（PAG）作为生物标志物来延缓和/或避免老化相关的慢性炎性疾病的生活方式的体外诊断方法。

10. 发明申请

WO2010029076A9 METHOD OF PROMOTING AND SELLING COFFEE 审中-公开
公开(公告)号：WO2010029076A9
公开(公告)日：2010-03-18
申请号：PCT/EP2009/061637
申请日：2009-09-08
申请人： NESTEC S.A. , RENOUF, Mathieu , GUY, Philippe Alexandre , MARMET, Cynthia Colette Olga , STEILING, Heike , CAVIN, Christophe , WILLIAMSON, Gary
发明人： RENOUF, Mathieu , GUY, Philippe Alexandre , MARMET, Cynthia Colette Olga , STEILING, Heike , CAVIN, Christophe , WILLIAMSON, Gary
IPC分类号： G06Q30/00

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