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1. 发明申请

WO2014004409A2 STEM CELL TREATMENT FOR RADIATION EXPOSURE 审中-公开
标题翻译：用于辐射暴露的干细胞治疗
公开(公告)号：WO2014004409A2
公开(公告)日：2014-01-03
申请号：PCT/US2013/047435
申请日：2013-06-24
申请人： NEOSTEM, INC , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , RATAJCZAK, Mariusz , RATAJCZAK, Janina , KUCIA, Magdalena
发明人： RATAJCZAK, Mariusz , RATAJCZAK, Janina , KUCIA, Magdalena , RODGERSON, Denis
IPC分类号： A61K35/12
CPC分类号： A61K35/48 , A61K35/28 , C12N5/0607 , C12N5/0669
摘要： The invention provides adult pluripotent stem cells (PSC) for treatment or prophylaxis for radiological exposure. In an embodiment of the invention, the cells are very small embryonic like stem cells (VSELs). The VSELs can be used to rescue the hematopoietic and immune systems of individuals suffering from the delayed effects of acute radiation syndrome (ARS).
摘要翻译：本发明提供用于治疗或预防放射性暴露的成人多能干细胞（PSC）。在本发明的一个实施方案中，细胞是非常小的胚胎样干细胞（VSEL）。 VSEL可用于拯救患有急性放射综合征（ARS）延迟作用的个体的造血和免疫系统。

2. 发明申请

WO2009059032A2 USES AND ISOLATION OF VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS 审中-公开
标题翻译：使用和分离非常小的类似（VSEL）干细胞
公开(公告)号：WO2009059032A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/081832
申请日：2008-10-30
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , RATAJCZAK, Mariusz , KUCIA, Magdalena , RATAJCZAK, Janina , RODGERSON, Denis , SMITH, George , ALLEN, Ronald , MARASCO, Wayne , BOLLI, Roberto
发明人： RATAJCZAK, Mariusz , KUCIA, Magdalena , RATAJCZAK, Janina , RODGERSON, Denis , SMITH, George , ALLEN, Ronald , MARASCO, Wayne , BOLLI, Roberto
IPC分类号： A61K35/12 , C12N5/00 , A61P17/02 , A61P9/00
CPC分类号： C12N5/0607 , A61K35/12 , A61K38/193
摘要： The presently disclosed subject matter provides populations of stem cells that are purified from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供从骨髓，外周血和/或其它来源纯化的干细胞群体。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

3. 发明申请

WO2004091637A2 SYSTEM CAPABLE OF TREATING AND DEFINING VARIOUS DISEASES USING STEM CELLS 审中-公开
标题翻译：使用干细胞治疗和定义各种疾病的系统
公开(公告)号：WO2004091637A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010760
申请日：2004-04-07
申请人： NEOSTEM, INC. , RODGERSON, Denis , HIROSE, Thomas , PUNZALAN, Rubio
发明人： RODGERSON, Denis , HIROSE, Thomas , PUNZALAN, Rubio
IPC分类号： A61K35/00
CPC分类号： A61K35/28 , G01N33/5091 , G01N2800/52
摘要： A system provides individualized "baseline" or internal "control" for an individual by collecting cells from the individual at an earlier time point prior to the onset of disease, which can be used as a standard for normalcy and a benchmark or reference for measuring the progression or development of any process the cells undergo. This allows study of biophysical, biochemical, architectural, morphological, functional, or physiological differences between cells collected from an individual at one time to cells collected from the same individual at a later point in time. The comparison between cells collected at different times allows for the study of relative responses of these cells when treated with a variety of chemicals. With this system disease markers can be determined that can aid in diagnosis and discovery of therapeutics for the disease of interest. As a result, this system may provide a basis for the production of patient-specific, as opposed to disease-specific drugs.
摘要翻译：系统通过在疾病开始之前较早的时间点收集个体的细胞，为个体提供个性化的“基线”或内部“控制”，其可以用作正常的标准，以及用于测量细胞经历的任何过程的进展或发展。这允许研究从一个人一次收集的细胞在随后的时间点从相同个体收集的细胞之间的生物物理，生化，建筑，形态，功能或生理差异。在不同时间收集的细胞之间的比较允许研究当用多种化学物质处理时这些细胞的相对响应。利用该系统疾病，可以确定可以帮助诊断和发现感兴趣的疾病的治疗剂的标志物。因此，该系统可能为生产患者特异性而不是疾病特异性药物提供依据。

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