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1. 发明申请

WO2004091637A2 SYSTEM CAPABLE OF TREATING AND DEFINING VARIOUS DISEASES USING STEM CELLS 审中-公开
标题翻译：使用干细胞治疗和定义各种疾病的系统
公开(公告)号：WO2004091637A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010760
申请日：2004-04-07
申请人： NEOSTEM, INC. , RODGERSON, Denis , HIROSE, Thomas , PUNZALAN, Rubio
发明人： RODGERSON, Denis , HIROSE, Thomas , PUNZALAN, Rubio
IPC分类号： A61K35/00
CPC分类号： A61K35/28 , G01N33/5091 , G01N2800/52
摘要： A system provides individualized "baseline" or internal "control" for an individual by collecting cells from the individual at an earlier time point prior to the onset of disease, which can be used as a standard for normalcy and a benchmark or reference for measuring the progression or development of any process the cells undergo. This allows study of biophysical, biochemical, architectural, morphological, functional, or physiological differences between cells collected from an individual at one time to cells collected from the same individual at a later point in time. The comparison between cells collected at different times allows for the study of relative responses of these cells when treated with a variety of chemicals. With this system disease markers can be determined that can aid in diagnosis and discovery of therapeutics for the disease of interest. As a result, this system may provide a basis for the production of patient-specific, as opposed to disease-specific drugs.
摘要翻译：系统通过在疾病开始之前较早的时间点收集个体的细胞，为个体提供个性化的“基线”或内部“控制”，其可以用作正常的标准，以及用于测量细胞经历的任何过程的进展或发展。这允许研究从一个人一次收集的细胞在随后的时间点从相同个体收集的细胞之间的生物物理，生化，建筑，形态，功能或生理差异。在不同时间收集的细胞之间的比较允许研究当用多种化学物质处理时这些细胞的相对响应。利用该系统疾病，可以确定可以帮助诊断和发现感兴趣的疾病的治疗剂的标志物。因此，该系统可能为生产患者特异性而不是疾病特异性药物提供依据。

2. 发明申请

WO2010129495A1 METHOD AND COMPOSITION FOR RESTORATION OF AGE-RELATED TISSUE LOSS IN THE FACE OR SELECTED AREAS OF THE BODY 审中-公开
标题翻译：恢复年龄相关组织损失的方法和组合在身体或身体的选定领域
公开(公告)号：WO2010129495A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033463
申请日：2010-05-04
申请人： NEOSTEM, INC. , GIAMPAPA, Vincent , SMITH, Robin, L.
发明人： GIAMPAPA, Vincent , SMITH, Robin, L.
IPC分类号： A61K8/02
CPC分类号： A61K8/982 , A61K31/198 , A61K35/28 , A61K35/35 , A61K38/1825 , A61K38/28 , A61K2300/00 , A61Q19/08
摘要： This application relates to stem cell compositions and methods for restoring age-related tissue loss in the face and other selected areas of the body. In a first embodiment, a composition includes stem cells and hyaluronic acid as a carrier wherein the stem cells are peripheral blood stem cells, bone marrow-derived blood stem cells, or mesenchymal stem cells.
摘要翻译：本申请涉及用于恢复身体的面部和其他选定区域中与年龄有关的组织损失的干细胞组合物和方法。在第一个实施方案中，组合物包括作为载体的干细胞和透明质酸，其中干细胞是外周血干细胞，骨髓来源的血干细胞或间充质干细胞。

3. 发明申请

WO2007146432A2 PROCESSING PROCEDURE FOR PERIPHERAL BLOOD STEM CELLS 审中-公开
标题翻译：外周血干细胞的处理程序
公开(公告)号：WO2007146432A2
公开(公告)日：2007-12-21
申请号：PCT/US2007014108
申请日：2007-06-15
申请人： NEOSTEM INC , RODGERSON DENIS O , SMITH GEORGE S , ALLIN RONALD E , MARASCO WAYNE A
发明人： RODGERSON DENIS O , SMITH GEORGE S , ALLIN RONALD E , MARASCO WAYNE A
IPC分类号： C12N5/00 , C12N5/0789
CPC分类号： C12N5/0647 , A61K35/28 , A61K38/193
摘要： An elective healthcare insurance model using an individual's own peripheral blood stem cells for the individual's future healthcare uses. An individual can elect to have his or her own stem cells collected, processed and preserved, while he or she is in healthy or "pre-disease" state, for future distribution for his or her healthcare needs. The process includes methods of collection, processing, preservation and distribution of adult (including pediatric) peripheral blood stem cells during non-diseased state. The stem cells collected will contain adequate dosage amounts, for one or more transplantations immediately when needed by the individual for future healthcare treatments. The collected adult or non-neonate child peripheral blood stem cells can be aliquoted into defined dosage fractions before cryopreservation so that cells can be withdrawn from storage without the necessity of thawing all of the collected cells.
摘要翻译：使用个人自己的外周血干细胞作为个人未来医疗保健用途的选择性医疗保险模式。当他或她处于健康或“疾病前”状态时，个人可以选择收集，加工和保存自己的干细胞，以便将来分配他或她的医疗保健需求。该过程包括在非疾病状态下收集，处理，保存和分配成人（包括小儿）外周血干细胞的方法。收集的干细胞将含有足够的剂量，用于个体为将来的保健治疗需要时立即进行一次或多次移植。收集的成年或非新生儿儿童外周血干细胞可以在冷冻保存之前等分到确定的剂量组分中，使得细胞可以从储存中取出，而不需要解冻所有收集的细胞。

4. 发明申请

WO2004089439A2 ELECTIVE COLLECTION AND BANKING OF AUTOLOGOUS PERIPHERAL BLOOD STEM CELLS 审中-公开
标题翻译：选择性采集和储存自体外周血干细胞
公开(公告)号：WO2004089439A2
公开(公告)日：2004-10-21
申请号：PCT/US2004/010500
申请日：2004-04-05
申请人： NEOSTEM, INC. , HIROSE, Thomas, Gordon , LAM, Simon, Sun-man , PUNZALAN, Rubio, R. , RODGERSON, Denis, O.
发明人： HIROSE, Thomas, Gordon , LAM, Simon, Sun-man , PUNZALAN, Rubio, R. , RODGERSON, Denis, O.
IPC分类号： A61M1/00
CPC分类号： C12N5/0607 , A61K35/12 , A61K2035/124 , C12N5/0647

5. 发明申请

WO2014004409A2 STEM CELL TREATMENT FOR RADIATION EXPOSURE 审中-公开
标题翻译：用于辐射暴露的干细胞治疗
公开(公告)号：WO2014004409A2
公开(公告)日：2014-01-03
申请号：PCT/US2013/047435
申请日：2013-06-24
申请人： NEOSTEM, INC , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , RATAJCZAK, Mariusz , RATAJCZAK, Janina , KUCIA, Magdalena
发明人： RATAJCZAK, Mariusz , RATAJCZAK, Janina , KUCIA, Magdalena , RODGERSON, Denis
IPC分类号： A61K35/12
CPC分类号： A61K35/48 , A61K35/28 , C12N5/0607 , C12N5/0669
摘要： The invention provides adult pluripotent stem cells (PSC) for treatment or prophylaxis for radiological exposure. In an embodiment of the invention, the cells are very small embryonic like stem cells (VSELs). The VSELs can be used to rescue the hematopoietic and immune systems of individuals suffering from the delayed effects of acute radiation syndrome (ARS).
摘要翻译：本发明提供用于治疗或预防放射性暴露的成人多能干细胞（PSC）。在本发明的一个实施方案中，细胞是非常小的胚胎样干细胞（VSEL）。 VSEL可用于拯救患有急性放射综合征（ARS）延迟作用的个体的造血和免疫系统。

6. 发明申请

WO2007146432A3 PROCESSING PROCEDURE FOR PERIPHERAL BLOOD STEM CELLS 审中-公开
公开(公告)号：WO2007146432A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/014108
申请日：2007-06-15
申请人： NEOSTEM, INC. , RODGERSON, Denis, O. , SMITH, George, S. , ALLIN, Ronald, E. , MARASCO, Wayne, A.
发明人： RODGERSON, Denis, O. , SMITH, George, S. , ALLIN, Ronald, E. , MARASCO, Wayne, A.
IPC分类号： C12N5/06 , A61K35/14
摘要： An elective healthcare insurance model using an individual's own peripheral blood stem cells for the individual's future healthcare uses. An individual can elect to have his or her own stem cells collected, processed and preserved, while he or she is in healthy or "pre-disease" state, for future distribution for his or her healthcare needs. The process includes methods of collection, processing, preservation and distribution of adult (including pediatric) peripheral blood stem cells during non-diseased state. The stem cells collected will contain adequate dosage amounts, for one or more transplantations immediately when needed by the individual for future healthcare treatments. The collected adult or non-neonate child peripheral blood stem cells can be aliquoted into defined dosage fractions before cryopreservation so that cells can be withdrawn from storage without the necessity of thawing all of the collected cells.

7. 发明申请

WO2004091637A3 SYSTEM CAPABLE OF TREATING AND DEFINING VARIOUS DISEASES USING STEM CELLS 审中-公开
标题翻译：系统能够使用干细胞处理和定义各种疾病
公开(公告)号：WO2004091637A3
公开(公告)日：2004-11-25
申请号：PCT/US2004010760
申请日：2004-04-07
申请人： NEOSTEM INC , RODGERSON DENIS , HIROSE THOMAS , PUNZALAN RUBIO
发明人： RODGERSON DENIS , HIROSE THOMAS , PUNZALAN RUBIO
IPC分类号： A61K35/14 , A61K35/28 , A61P31/00 , A61P35/00 , C12N5/08 , G01N33/50 , C12N5/06 , A61K35/12
CPC分类号： A61K35/28 , G01N33/5091 , G01N2800/52
摘要： A system provides individualized "baseline" or internal "control" for an individual by collecting cells from the individual at an earlier time point prior to the onset of disease, which can be used as a standard for normalcy and a benchmark or reference for measuring the progression or development of any process the cells undergo. This allows study of biophysical, biochemical, architectural, morphological, functional, or physiological differences between cells collected from an individual at one time to cells collected from the same individual at a later point in time. The comparison between cells collected at different times allows for the study of relative responses of these cells when treated with a variety of chemicals. With this system disease markers can be determined that can aid in diagnosis and discovery of therapeutics for the disease of interest. As a result, this system may provide a basis for the production of patient-specific, as opposed to disease-specific drugs.
摘要翻译：系统通过在疾病发作之前的较早时间点从个体收集细胞来为个体提供个体化的“基线”或内部“对照”，其可以用作正常的标准以及用于测量细胞进行的任何过程的进展或发展。这允许研究在一个时间从个体收集的细胞之间的生物物理，生物化学，构造，形态，功能或生理差异，以及在稍后的时间点从同一个体收集的细胞。在不同时间收集的细胞之间的比较允许研究用各种化学物质处理时这些细胞的相对反应。有了这个系统，可以确定疾病标志物，可以帮助诊断和发现感兴趣的疾病的治疗。因此，该系统可以为特定患者的生产提供基础，而不是疾病特异性药物。

8. 发明申请

WO2013181642A1 HUMAN VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS FOR TREATMENT OF OCULAR DISEASE 审中-公开
标题翻译：人类非常小的胚胎样（VSEL）干细胞用于治疗眼部疾病
公开(公告)号：WO2013181642A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/043797
申请日：2013-05-31
申请人： NEOSTEM, INC. , LASHKARI, Kameran , YOUNG, Michael , EMINLI, Sarah , MARASCO, Wayne , PRETI, Robert
发明人： LASHKARI, Kameran , YOUNG, Michael , EMINLI, Sarah , MARASCO, Wayne , PRETI, Robert
IPC分类号： A61K35/28 , A61K35/48 , A61K35/12
CPC分类号： A61K35/545 , A61K9/0048 , A61K45/06
摘要： The present invention relates to use of very small embryonic-like (VSEL) stem cells in therapies for ocular disease involving retinal degeneration or dysfunction. The invention also included pharmaceutical compositions made with VSELs which may be used to restore lost vision or reduce or halt vision loss due to diseases or disorders of the retina, or other diseases or retinal injuries that would benefit from stem cell replacement therapy.
摘要翻译：本发明涉及非常小的胚胎样（VSEL）干细胞在涉及视网膜变性或功能障碍的眼部疾病的治疗中的用途。本发明还包括用VSEL制备的药物组合物，其可用于恢复视力丧失或由于视网膜的疾病或病症引起的视力丧失或其它可能受益于干细胞替代疗法的视网膜损伤。

9. 发明申请

WO2010039241A1 METHODS FOR ISOLATING VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS 审中-公开
标题翻译：分离非常小的胚胎样（VSEL）干细胞的方法
公开(公告)号：WO2010039241A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/005414
申请日：2009-09-30
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , NEOSTEM, INC. , ZUBA-SURMA, Ewa, K. , RATAJCZAK, Mariusz , RATAJCZAK, Janina , KUCIA, Magdalena
发明人： ZUBA-SURMA, Ewa, K. , RATAJCZAK, Mariusz , RATAJCZAK, Janina , KUCIA, Magdalena
IPC分类号： C12N5/071
CPC分类号： C12N5/0607
摘要： The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供了从骨髓，外周血和/或其他来源分离干细胞群体的方法。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

10. 发明申请

WO2014138710A1 STEM CELL COMPOSITIONS AND METHODS FOR WOUND HEALING 审中-公开
标题翻译：干细胞组合物和治疗方法
公开(公告)号：WO2014138710A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/022159
申请日：2014-03-07
申请人： NEOSTEM, INC.
发明人： FALANGA, Vincent
IPC分类号： A61P17/02 , A61K35/28
CPC分类号： A61L26/0057 , A61K35/28 , A61K35/51 , A61K35/545 , A61K38/363 , A61K38/4833 , A61L24/0005 , A61L24/0015 , A61L24/106 , A61L26/0004 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0076 , A61L2300/418 , A61L2300/64 , A61L2430/34 , C12Y304/21005 , A61K2300/00
摘要： This application provides compositions for wound repair comprising VSEL stem cells and methods for treating acute and chronic cutaneous wounds, including burns and ulcers.
摘要翻译：本申请提供了包含VSEL干细胞的伤口修复组合物和用于治疗急性和慢性皮肤伤口（包括烧伤和溃疡）的方法。

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