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1. 发明申请

WO2011123239A1 MULTI-WAVELENGTH PHOTON DENSITY WAVE SYSTEM USING AN OPTICAL SWITCH 审中-公开
标题翻译：使用光开关的多波长光子密度波系统
公开(公告)号：WO2011123239A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/028437
申请日：2011-03-15
申请人： NELLCOR PURITAN BENNETT LLC , LI, Youzhi , LIN, Andy , MCKENNA, Edward
发明人： LI, Youzhi , LIN, Andy , MCKENNA, Edward
IPC分类号： A61B5/1455 , A61B5/024 , G01N21/25 , G01N21/31 , G01N21/41 , G01N21/47
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/1455 , A61B2562/0242 , A61B2562/223 , G01N21/3151 , G01N21/49
摘要： Multi-wavelength photon density wave (PDW) medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter and a detector configured to pass a multi-wavelength PDW input signal into a patient and receive a resulting multi-wavelength PDW output signal. The sensor cable may couple to the sensor and include two optical cables for transmitting and receiving the multi-wavelength PDW signals. The patient monitor may couple to the sensor cable and generate several single-wavelength PDW input signals by modulating a plurality of light sources. The monitor may include an optical switch configured to time-division multiplex the several single-wavelength PDW wave input signals by selecting one of the single-wavelength PDW signals at one time to produce a multi-wavelength PDW signal which is output from the monitor to the sensor via the sensor cable.
摘要翻译：提供了多波长光子密度波（PDW）医疗系统，方法和设备。在一个实施例中，多波长系统可以包括传感器，传感器电缆和患者监护仪。传感器可以具有发射器和检测器，其被配置为将多波长PDW输入信号传递到患者体内并且接收所得到的多波长PDW输出信号。传感器电缆可以耦合到传感器并且包括用于发射和接收多波长PDW信号的两条光缆。患者监视器可以耦合到传感器电缆并且通过调制多个光源来生成多个单波长PDW输入信号。监视器可以包括配置成通过一次选择一个单波长PDW信号来对多个单波长PDW波输入信号进行时分复用以产生从监视器输出的多波长PDW信号的光开关传感器通过传感器电缆。

2. 发明申请

WO2011034700A1 WAVELENGTH-DIVISION MULTIPLEXING IN A MULTI-WAVELENGTH PHOTON DENSITY WAVE SYSTEM 审中-公开
标题翻译：多波长光子密度波系统中的波长分割多路复用
公开(公告)号：WO2011034700A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/046686
申请日：2010-08-25
申请人： NELLCOR PURITAN BENNETT LLC , LI, Youzhi , LIN, Andy , MCKENNA, Edward
发明人： LI, Youzhi , LIN, Andy , MCKENNA, Edward
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0059 , A61B2562/223
摘要： Multi-wavelength photon density wave medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength photon density wave patient monitor includes multiple light sources, a driving circuit, a fiber coupler, a sensor cable connector, a wavelength demultiplexer, detectors, and data processing circuitry. The driving circuit may modulate the light sources to produce several single-wavelength input photon density wave signals, which the fiber coupler may join into a multi-wavelength input signal. The sensor cable connector may provide this multi-wavelength input signal to a sensor attached to the patient and receive a multi-wavelength output signal. The wavelength demultiplexer may separate the multi-wavelength output signal into single-wavelength output signals for detection by the detectors. Based on a comparison of one of the single-wavelength output signals to a corresponding one of the single-wavelength input signals, the data processing circuitry may determine a physiological parameter of the patient.
摘要翻译：提供了多波长光子密度波医疗系统，方法和装置。在一个实施例中，多波长光子密度波病人监视器包括多个光源，驱动电路，光纤耦合器，传感器电缆连接器，波长解复用器，检测器和数据处理电路。驱动电路可以调制光源以产生几个单波长输入光子密度波信号，光纤耦合器可以连接到多波长输入信号中。传感器电缆连接器可以将该多波长输入信号提供给附接到患者的传感器并且接收多波长输出信号。波长解复用器可以将多波长输出信号分离成单波长输出信号，以便由检测器检测。基于单波长输出信号之一与单波长输入信号中的相应一个的比较，数据处理电路可以确定患者的生理参数。

3. 发明申请

WO2010129158A1 TIME OF FLIGHT BASED TRACHEAL TUBE PLACEMENT SYSTEM AND METHOD 审中-公开
标题翻译：飞行时间管道放置系统及方法
公开(公告)号：WO2010129158A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/031443
申请日：2010-04-16
申请人： NELLCOR PURITAN BENNETT LLC , LI, Youzhi , MCKENNA, Edward , LIN, Andy , HAYMAN, Sarah
发明人： LI, Youzhi , MCKENNA, Edward , LIN, Andy , HAYMAN, Sarah
IPC分类号： A61M16/04 , G01S17/10 , G01S17/88
CPC分类号： A61M16/0488 , A61B1/267 , A61B5/0084 , A61B5/065 , A61B5/72 , A61B5/742 , A61B5/746 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M16/0486 , A61M2205/3306 , A61M2205/502 , A61M2205/6018 , G01S7/481 , G01S17/10 , G01S17/88
摘要： According to various embodiments, a tracheal tube (12) may employ optical sensing techniques for determining a distance between the inserted tube (12) and an anatomical structure, such as a carina (28). The distance information may provide an indication as to whether or not the tracheal tube (12) is properly placed within the trachea. The optical techniques may include time of flight techniques.
摘要翻译：根据各种实施例，气管管（12）可以采用光学感测技术来确定插入的管（12）和解剖结构（例如圆柱体（28））之间的距离。距离信息可以提供关于气管管（12）是否适当地放置在气管内的指示。光学技术可以包括飞行时间技术。

4. 发明申请

WO2011097291A1 CONTINUOUS LIGHT EMISSION PHOTOACOUSTIC SPECTROSCOPY 审中-公开
标题翻译：连续光发射光谱
公开(公告)号：WO2011097291A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023466
申请日：2011-02-02
申请人： NELLCOR PURITAN BENNETT LLC , MCKENNA, Edward , LI, Youzhi
发明人： MCKENNA, Edward , LI, Youzhi
IPC分类号： A61B5/00 , A61B8/00 , G01N21/17 , A61B5/1455
CPC分类号： G01N21/1702 , A61B5/0059 , A61B5/0095 , A61B5/02007 , A61B5/0261 , A61B5/14551 , A61B5/412 , A61B8/06 , G01N21/4795 , G01N2021/1706 , G01N2021/3144
摘要： Methods and systems are provided for analyzing microcirculation using photoacoustic spectroscopy by emitting continuous light at one or more frequencies. A photoacoustic spectroscopy monitor may utilize a slow modulation method to vaiy the wavelength of light emitted, such that different absorbers may be measured in a patient's tissue. The photoacoustic spectroscopy sensor may emit a lower power continuous light towards a patient's tissue. The acoustic response generated by the tissue may be sensed by a thin polymer sensing film at the detector of the sensor. Based on the amplitude and phase information of the acoustic response sensed by the detector, the monitor may determine a concentration of an absorber, as well as a location of the absorbers, in the patient's tissue.
摘要翻译：提供的方法和系统用于通过以一个或多个频率发射连续光来分析使用光声波光谱的微循环。光声光谱监测器可以利用缓慢的调制方法来消除所发射的光的波长，从而可以在患者的组织中测量不同的吸收剂。光声光谱传感器可以向患者的组织发射较低功率的连续光。由组织产生的声响应可以通过传感器检测器处的薄聚合物感测膜来感测。基于由检测器感测到的声学响应的振幅和相位信息，监测器可以确定吸收器的浓度以及吸收体在患者组织中的位置。

5. 发明申请

WO2011014297A1 PATIENT MONITORING SYSTEM AND METHOD UTILISING PHOTON DENSITY WAVES IN TRANSMISSION MODE 审中-公开
标题翻译：患者监测系统和使用传输模式的光子密度波的方法
公开(公告)号：WO2011014297A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/037571
申请日：2010-06-07
申请人： NELLCOR PURITAN BENNETT LLC , LI, Youzhi , LIN, Andy , MCKENNA, Edward
发明人： LI, Youzhi , LIN, Andy , MCKENNA, Edward
IPC分类号： A61B5/00
CPC分类号： A61B5/0261 , A61B5/14551 , A61B5/14552 , A61B5/6826 , A61B5/6838 , A61B5/7228
摘要： Present embodiments are directed to a monitor system, such as a pulse oximetry system. The system may include a detection feature, an emission feature capable of emitting light into a first side of tissue and arranged relative to the detection feature such that the detection feature is capable of detecting the light from a second side of the tissue generally opposite the first side after passing through the tissue, a modulator capable of modulating the light to generate photon density waves at a modulation frequency generally in a range of 50 MHz to 3 GHz, a detector communicatively coupled with the detection feature, wherein the detector is capable of detecting relative characteristics of the photon density waves including amplitude changes and phase shifts, and a processor capable of making determinations relating to a value of a physiologic parameter of the tissue based on the phase shifts and presenting the value to a user.
摘要翻译：本实施例涉及一种监测系统，例如脉搏血氧饱和度测定系统。该系统可以包括检测特征，能够将光发射到组织的第一侧并相对于检测特征布置的发射特征，使得检测特征能够检测来自组织的第二侧的光，大体上与第一通过组织的调制器，能够调制光以通常在50MHz至3GHz范围内的调制频率产生光子密度波的调制器，与检测特征通信耦合的检测器，其中检测器能够检测包括振幅变化和相位偏移的光子密度波的相对特性，以及能够基于相位偏移来确定与组织的生理参数相关的确定的处理器，并将该值呈现给用户。

6. 发明申请

WO2010117999A1 MEDICAL DEVICE AND TECHNIQUE FOR USING THE SAME 审中-公开
标题翻译：医疗设备及其使用技术
公开(公告)号：WO2010117999A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/030064
申请日：2010-04-06
申请人： NELLCOR PURITAN BENNETT LLC , MCKENNA, Edward , LI, Youzhi , LIN, Andy , HAYMAN, Sarah
发明人： MCKENNA, Edward , LI, Youzhi , LIN, Andy , HAYMAN, Sarah
IPC分类号： A61M16/04 , A61M25/01 , A61B5/00 , A61B1/267 , G01B9/02 , G01B11/02
CPC分类号： A61M16/0488 , A61B1/267 , A61B5/0084 , A61B5/06 , A61B5/065 , A61B5/742 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M2205/3306
摘要： According to various embodiments, a tracheal tube (12) may employ optical sensing techniques for determining a distance (d) between the inserted tube and an anatomical structure such as a carina (28). The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques -may include interf erometry.
摘要翻译：根据各种实施例，气管插管（12）可以采用光学感测技术来确定插入的管和解剖结构（例如圆柱体）之间的距离（d）（28）。距离信息可以提供关于气管管是否适当地放置在气管内的指示。光学技术可以包括界面测微。

7. 发明申请

WO2012166254A1 PHOTON DENSITY WAVE BASED DETERMINATION OF PHYSIOLOGICAL BLOOD PARAMETERS 审中-公开
标题翻译：基于光子密度波的生物学参数的确定
公开(公告)号：WO2012166254A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/033486
申请日：2012-04-13
申请人： NELLCOR PURITAN BENNETT LLC , LI, Youzhi , BAKER, Clark. R. , MCKENNA, Edward
发明人： LI, Youzhi , BAKER, Clark. R. , MCKENNA, Edward
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551
摘要： A method for measuring a physiological parameter of blood in a patient is presented. The method includes emitting light from a modulated light source into tissue of the patient to generate a photon density wave in the tissue, detecting the photon density wave during pulsatile perturbation of the tissue, and processing an amplitude and phase of the photon density wave over the pulsatile perturbation to determine a value of the physiological parameter.
摘要翻译：提出了一种测量患者血液生理参数的方法。该方法包括将来自调制光源的光发射到患者的组织中以在组织中产生光子密度波，在组织的脉动扰动期间检测光子密度波，以及处理光子密度波的振幅和相位脉动扰动来确定生理参数的值。

8. 发明申请

WO2012015566A1 LIGHT FOCUSING CONTINUOUS WAVE PHOTOACOUSTIC SPECTROSCOPY AND ITS APPLICATIONS TO PATIENT MONITORING 审中-公开
标题翻译：光聚焦连续波光学光谱及其应用于患者监测
公开(公告)号：WO2012015566A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/043029
申请日：2011-07-06
申请人： NELLCOR PURITAN BENNETT LLC , LI, Youzhi , MCKENNA, Edward , LINN, Andy
发明人： LI, Youzhi , MCKENNA, Edward , LINN, Andy
IPC分类号： A61B5/00 , G01N21/17
CPC分类号： A61B5/0059 , A61B5/0095 , A61B5/1455 , G01N21/1702
摘要： The present disclosure describes systems and methods that use spatial modulation to focus continuous wave light into a localized region of interest such as an individual blood vessel. In certain embodiments, intensity modulation techniques, such as linear frequency modulation, are used in conjunction with spatial modulation to achieve more precise measurements through otherwise scattering medium. The focused beam of continuous wave light is capable of penetrating several centimeters of tissue to deliver measurements and images associated with individual blood vessels and other discrete vascular components.
摘要翻译：本公开描述了使用空间调制以将连续波光聚焦到诸如个体血管的局部感兴趣区域中的系统和方法。在某些实施例中，诸如线性频率调制的强度调制技术与空间调制结合使用，以通过另外的散射介质实现更精确的测量。聚焦的连续波光束能够穿透几厘米的组织以提供与各个血管和其它离散的血管成分相关联的测量和图像。

9. 发明申请

WO2011097399A1 COMBINED PHYSIOLOGICAL SENSOR SYSTEMS AND METHODS 审中-公开
标题翻译：组合生理传感器系统和方法
公开(公告)号：WO2011097399A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023630
申请日：2011-02-03
申请人： NELLCOR PURITAN BENNETT LLC , MCKENNA, Edward , CHEN, Bo , LI, Youzhi , ADDISON, Paul
发明人： MCKENNA, Edward , CHEN, Bo , LI, Youzhi , ADDISON, Paul
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/024 , A61B5/0476 , A61B5/0478 , A61B5/1455
CPC分类号： A61B5/02055 , A61B5/01 , A61B5/0205 , A61B5/02433 , A61B5/14552 , A61B5/165 , A61B5/6814 , A61B5/6826 , A61B5/6838 , A61B5/7203 , A61B5/7257 , A61B5/726
摘要： A combined physiological sensor and methods for detecting one or more physiological characteristics of a subject are provided. The combined sensor (e.g., a forehead sensor) may be used to detect and/or calculate at least one of a pulse blood oxygen saturation level, a regional blood oxygen saturation level, a respiration rate, blood pressure, an electrical physiological signal (EPS), a pulse transit time (PTT), body temperature associated with the subject, a depth of consciousness (DOC) measurement, any other suitable physiological parameter, and any suitable combination thereof. The combined sensor may include a variety of individual sensors, such as electrodes, optical detectors, optical emitters, temperature sensors, and/or other suitable sensors, The sensors may be advantageously positioned in accordance with a number of different geometries. The combined sensor may also be coupled to a monitoring device, which may receive and/or process one or more output signals from the individual sensors to display information about the medical condition of the subject. In addition, several techniques may be employed to prevent or limit interference between the individual sensors and their associated input and/or output signals.
摘要翻译：提供组合的生理传感器和用于检测受试者的一种或多种生理特征的方法。组合的传感器（例如，前额传感器）可用于检测和/或计算脉搏血氧饱和度水平，区域血氧饱和度水平，呼吸速率，血压，电生理信号（EPS ），脉搏传播时间（PTT），与受试者相关的体温，意识深度（DOC）测量，任何其它合适的生理参数及其任何合适的组合。组合的传感器可以包括各种单独的传感器，例如电极，光学检测器，光发射器，温度传感器和/或其它合适的传感器。可以根据多个不同的几何形状有利地定位传感器。组合的传感器还可以耦合到监视设备，监视设备可以接收和/或处理来自各个传感器的一个或多个输出信号以显示关于对象的医疗状况的信息。此外，可以采用几种技术来防止或限制各个传感器及其相关的输入和/或输出信号之间的干扰。

10. 发明申请

WO2011060220A1 SYSTEMS AND METHODS FOR COMBINED PHYSIOLOGICAL SENSORS 审中-公开
标题翻译：组合生理传感器的系统和方法
公开(公告)号：WO2011060220A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056452
申请日：2010-11-12
申请人： NELLCOR PURITAN BENNETT LLC , LI, Youzhi , CHEN, Bo , MCKENNA, Edward , ADDISON, Paul
发明人： LI, Youzhi , CHEN, Bo , MCKENNA, Edward , ADDISON, Paul
IPC分类号： A61B5/024 , A61B5/0478
CPC分类号： A61B5/0478 , A61B5/02427 , A61B5/14551 , A61B2562/182
摘要： Systems and methods are provided for monitoring the physiological state of a subject. One or more physiological parameters of a subject may be determined from a photoplethysmograph (PPG) signal or signals obtained using at least one PPG sensor. In some embodiments, an electrical physiological signal (EPS) sensor may be located in or near a PPG sensor. A sensor configuration including both PPG sensors and EPS sensors may be advantageously used to detect a PPG signal or signals in combination with one or more EPS signal or signals. To reduce potential interference between an EPS sensor and a PPG sensor, fiber-optic input and output lines may be used to transmit optical signals from light generating circuitry and light detecting circuitry. In some embodiments, the generating and detecting circuitry may be located remotely from one another and may further be located remotely from the EPS sensor, PPG sensor, or both.
摘要翻译：提供了用于监测受试者的生理状态的系统和方法。受试者的一个或多个生理参数可以从光电容积描记器（PPG）信号或使用至少一个PPG传感器获得的信号来确定。在一些实施例中，电生理信号（EPS）传感器可以位于PPG传感器中或附近。包括PPG传感器和EPS传感器的传感器配置可以有利地用于检测与一个或多个EPS信号或信号结合的PPG信号或信号。为了减少EPS传感器和PPG传感器之间的潜在干扰，光纤输入和输出线路可用于从光生成电路和光检测电路传输光信号。在一些实施例中，生成和检测电路可以彼此远离地定位，并且可以进一步位于距离EPS传感器，PPG传感器或两者的位置。

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